Structural shape optimization of three dimensional acoustic problems with isogeometric boundary element methods

The boundary element method (BEM) is a powerful tool in computational acoustics, because the analysis is conducted only on structural surfaces, compared to the finite element method (FEM) which resorts to special techniques to truncate infinite domains. The isogeometric boundary element method (IGABEM) is a recent progress in the category of boundary element approaches, which is inspired by the concept of isogeometric analysis (IGA) and employs the spline functions of CAD as basis functions to discretize unknown physical fields. As a boundary representation approach, IGABEM is naturally compatible with CAD and thus can directly perform numerical analysis on CAD models, avoiding the cumbersome meshing procedure in conventional FEM/BEM and eliminating the difficulty of volume parameterization in isogeometric finite element methods. The advantage of tight integration of CAD and numerical analysis in IGABEM renders it particularly attractive in the application of structural shape optimization because (1) the geometry and the analysis can be interacted, (2) remeshing with shape morphing can be avoided, and (3) an optimized solution returns a CAD geometry directly without postprocessing steps. In the present paper, we apply the IGABEM to structural shape optimization of three dimensional exterior acoustic problems, fully exploiting the strength of IGABEM in addressing infinite domain problems and integrating CAD and numerical analysis. We employ the Burton–Miller formulation to overcome fictitious frequency problems, in which hyper-singular integrals are evaluated explicitly. The gradient-based optimizer is adopted and shape sensitivity analysis is conducted with implicit differentiation methods. The design variables are set to be the positions of control points which directly determine the shape of structures. Finally, numerical examples are provided to verify the algorithm

Chaste: an open source C++ library for computational physiology and biology

Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to "re-invent the wheel" with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials

Discovery of Very High Energy gamma-rays from 1ES 1011+496 at z=0.212

We report on the discovery of Very High Energy (VHE) gamma-ray emission from the BL Lacertae object 1ES1011+496. The observation was triggered by an optical outburst in March 2007 and the source was observed with the MAGIC telescope from March to May 2007. Observing for 18.7 hr we find an excess of 6.2 sigma with an integrated flux above 200 GeV of (1.58$\pm0.32) 10^{-11}$ photons cm$^{-2}$ s$^{-1}$. The VHE gamma-ray flux is >40% higher than in March-April 2006 (reported elsewhere), indicating that the VHE emission state may be related to the optical emission state. We have also determined the redshift of 1ES1011+496 based on an optical spectrum that reveals the absorption lines of the host galaxy. The redshift of z=0.212 makes 1ES1011+496 the most distant source observed to emit VHE gamma-rays up to date.Comment: 4 pages, 6 figures, minor changes to fit the ApJ versio

Characterizing the gamma-ray long-term variability of PKS 2155-304 with H.E.S.S. and Fermi-LAT

Studying the temporal variability of BL Lac objects at the highest energies provides unique insights into the extreme physical processes occurring in relativistic jets and in the vicinity of super-massive black holes. To this end, the long-term variability of the BL Lac object PKS 2155-304 is analyzed in the high (HE, 100 MeV 200 GeV) gamma-ray domain. Over the course of ~9 yr of H.E.S.S observations the VHE light curve in the quiescent state is consistent with a log-normal behavior. The VHE variability in this state is well described by flicker noise (power-spectral-density index {\ss}_VHE = 1.10 +0.10 -0.13) on time scales larger than one day. An analysis of 5.5 yr of HE Fermi LAT data gives consistent results ({\ss}_HE = 1.20 +0.21 -0.23, on time scales larger than 10 days) compatible with the VHE findings. The HE and VHE power spectral densities show a scale invariance across the probed time ranges. A direct linear correlation between the VHE and HE fluxes could neither be excluded nor firmly established. These long-term-variability properties are discussed and compared to the red noise behavior ({\ss} ~ 2) seen on shorter time scales during VHE-flaring states. The difference in power spectral noise behavior at VHE energies during quiescent and flaring states provides evidence that these states are influenced by different physical processes, while the compatibility of the HE and VHE long-term results is suggestive of a common physical link as it might be introduced by an underlying jet-disk connection.Comment: 11 pages, 16 figure

Detection of variable VHE gamma-ray emission from the extra-galactic gamma-ray binary LMC P3

Context. Recently, the high-energy (HE, 0.1-100 GeV) $\gamma$-ray emission from the object LMC P3 in the Large Magellanic Cloud (LMC) has been discovered to be modulated with a 10.3-day period, making it the first extra-galactic $\gamma$-ray binary. Aims. This work aims at the detection of very-high-energy (VHE, >100 GeV) $\gamma$-ray emission and the search for modulation of the VHE signal with the orbital period of the binary system. Methods. LMC P3 has been observed with the High Energy Stereoscopic System (H.E.S.S.); the acceptance-corrected exposure time is 100 h. The data set has been folded with the known orbital period of the system in order to test for variability of the emission. Energy spectra are obtained for the orbit-averaged data set, and for the orbital phase bin around the VHE maximum. Results. VHE $\gamma$-ray emission is detected with a statistical significance of 6.4 $\sigma$. The data clearly show variability which is phase-locked to the orbital period of the system. Periodicity cannot be deduced from the H.E.S.S. data set alone. The orbit-averaged luminosity in the $1-10$ TeV energy range is $(1.4 \pm 0.2) \times 10^{35}$ erg/s. A luminosity of $(5 \pm 1) \times 10^{35}$ erg/s is reached during 20% of the orbit. HE and VHE $\gamma$-ray emissions are anti-correlated. LMC P3 is the most luminous $\gamma$-ray binary known so far.Comment: 5 pages, 3 figures, 1 table, accepted for publication in A&

Star tracking for pointing determination of imaging Atmospheric Cherenkov Telescopes: Application to the large-sized telescope of the Cherenkov Telescope Array

Abe, K., et al.We present a novel approach to the determination of the pointing of Imaging Atmospheric Cherenkov Telescopes (IACTs) using the trajectories of the stars in their camera’s field of view. The method starts with the reconstruction of the star positions from the Cherenkov camera data, taking into account the point spread function of the telescope, to achieve a satisfying reconstruction accuracy of the pointing position. A simultaneous fit of all reconstructed star trajectories is then performed with the orthogonal distance regression (ODR) method. ODR allows us to correctly include the star position uncertainties and use the time as an independent variable. Having the time as an independent variable in the fit makes it better suitable for various star trajectories. This method can be applied to any IACT and requires neither specific hardware nor interface or special data-taking mode. In this paper, we use the Large-Sized Telescope (LST) data to validate it as a useful tool to improve the determination of the pointing direction during regular data taking. The simulation studies show that the accuracy and precision of the method are comparable with the design requirements on the pointing accuracy of the LST (≤14″). With the typical LST event acquisition rate of 10 kHz, the method can achieve up to 50 Hz pointing monitoring rate, compared to (1) Hz achievable with standard techniques. The application of the method to the LST prototype (LST-1) commissioning data shows the stable pointing performance of the telescope.This work was conducted in the context of the CTA-LST Project. We gratefully acknowledge financial support from the following agencies and organizations: Ministry of Education, Youth and Sports, MEYS LM2015046, LM2018105, LTT17006, EU/MEYS CZ.02.1.01/0.0/0.0/16_013/0001403, CZ.02.1.01/0.0/0.0/18_046/0016007 and CZ.02.1.01/0.0/0.0/16_019/0000754, Czech Republic; Max Planck Society, German Bundesministerium für Bildung und Forschung (Verbundforschung / ErUM), Deutsche Forschungsgemeinschaft (SFBs 876 and 1491), Germany; Istituto Nazionale di Astrofísica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), Italian Ministry for University and Research (MUR); ICRR, University of Tokyo, JSPS, MEXT, Japan; JST SPRING - JPMJSP2108; Narodowe Centrum Nauki, grant number 2019/34/E/ST9/00224, Poland; The Spanish groups acknowledge the Spanish Ministry of Science and Innovation and the Spanish Research State Agency (AEI) through the government budget lines PGE2021/28.06.000X.411.01, PGE2022/28.06.000X.411.01 and PGE2022/28.06.000X.711.04, and grants PGC2018-095512-B-I00, PID2019-104114RB-C31, PID2019-107847RB-C44, PID2019-104114RB-C32, PID2019-105510GB-C31, PID2019-104114RB-C33, PID2019-107847RB-C41, PID2019-107847RB-C43, PID2019-107988GB-C22; the “Centro de Excelencia Severo Ochoa” program through grants no. CEX2021-001131-S, CEX2019-000920-S; the “Unidad de Excelencia María de Maeztu” program through grants no. CEX2019-000918-M, CEX2020-001058-M; the “Juan de la Cierva-Incorporación” program through grant no. IJC2019-040315-I. They also acknowledge the “Programa Operativo” FEDER 2014-2020, Consejería de Economía y Conocimiento de la Junta de Andalucía (Ref. 1257737), PAIDI 2020 (Ref. P18-FR-1580) and Universidad de Jaén; “Programa Operativo de Crecimiento Inteligente” FEDER 2014-2020 (Ref. ESFRI-2017-IAC-12), Ministerio de Ciencia e Innovación, 15% co-financed by Consejería de Economía, Industria, Comercio y Conocimiento del Gobierno de Canarias; the “CERCA” program of the Generalitat de Catalunya; and the European Union’s “Horizon 2020” GA:824064 and NextGenerationEU; We acknowledge the Ramon y Cajal program through grant RYC-2020-028639-I and RYC-2017-22665; State Secretariat for Education, Research and Innovation (SERI) and Swiss National Science Foundation (SNSF), Switzerland; The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2013) under grant agreements nos. 262053 and 317446. This project is receiving funding from the European Union’s Horizon 2020 research and innovation programs under agreement no. 676134. ESCAPE – The European Science Cluster of Astronomy & Particle Physics ESFRI Research Infrastructures has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement no. 824064.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000918-M).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2020-001058-M).Peer reviewe

Efficacy and safety of acupuncture for the treatment of non-specific acute low back pain: a randomised controlled multicentre trial protocol [ISRCTN65814467]

BACKGROUND: Low back pain and its associated incapacitating effects constitute an important healthcare and socioeconomic problem, as well as being one of the main causes of disability among adults of working age. The prevalence of non-specific low back pain is very high among the general population, and 60–70% of adults are believed to have suffered this problem at some time. Nevertheless, few randomised clinical trials have been made of the efficacy and efficiency of acupuncture with respect to acute low back pain. The present study is intended to assess the efficacy of acupuncture for acute low back pain in terms of the improvement reported on the Roland Morris Questionnaire (RMQ) on low back pain incapacity, to estimate the specific and non-specific effects produced by the technique, and to carry out a cost-effectiveness analysis. METHODS/DESIGN: Randomised four-branch controlled multicentre prospective study made to compare semi-standardised real acupuncture, sham acupuncture (acupuncture at non-specific points), placebo acupuncture and conventional treatment. The patients are blinded to the real, sham and placebo acupuncture treatments. Patients in the sample present symptoms of non specific acute low back pain, with a case history of 2 weeks or less, and will be selected from working-age patients, whether in paid employment or not, referred by General Practitioners from Primary Healthcare Clinics to the four clinics participating in this study. In order to assess the primary and secondary result measures, the patients will be requested to fill in a questionnaire before the randomisation and again at 3, 12 and 48 weeks after starting the treatment. The primary result measure will be the clinical relevant improvement (CRI) at 3 weeks after randomisation. We define CRI as a reduction of 35% or more in the RMQ results. DISCUSSION: This study is intended to obtain further evidence on the effectiveness of acupuncture on acute low back pain and to isolate the specific and non-specific effects of the treatment

The High Energy cosmic-Radiation Detector (HERD) Trigger System

The High Energy cosmic-Radiation Detection (HERD) facility is a next generation spaceborne detector to be installed onboard the Chinese Space Station for about 10 years. HERD will address major problems in fundamental physics and astrophysics, providing precise measurements of charged-cosmic rays up to PeV energies, performing indirect searches for dark matter in the electron spectrum up to few tens of TeV and monitoring the gamma-ray skymap for surveys and transient searches. HERD is composed of a 3D imaging calorimeter (CALO) surrounded by a scintillating fiber tracker (FIT), a plastic scintillator detector (PSD) and a silicon charge detector (SCD). In addition, a transition radiation detector (TRD) is placed on a lateral side to provide accurate energy calibration. Based on this innovative design, the effective geometric factor of HERD will be one order of magnitud larger than that of current space-based detectors. The HERD trigger strategy is designed to accomplish the scientific goals of the mission, and is based on trigger definitions that rely on the energy deposited in CALO and the PSD. The trigger performances are evaluated using a detailed Monte Carlo simulation that includes the latest HERD geometry. In addition, alternative trigger definitions based on the event topology can be established thanks to the photodiode readout of CALO crystals. The feasibility of these topological triggers is also investigated and presented

The enhanced X-ray Timing and Polarimetry mission – eXTP: an update on its scientific cases, mission profile and development status

The enhanced X-ray Timing and Polarimetry mission (eXTP) is a flagship observatory for X-ray timing, spectroscopy and polarimetry developed by an International Consortium. Thanks to its very large collecting area, good spectral resolution and unprecedented polarimetry capabilities, eXTP will explore the properties of matter and the propagation of light in the most extreme conditions found in the Universe. eXTP will, in addition, be a powerful X-ray observatory. The mission will continuously monitor the X-ray sky, and will enable multiwavelength and multi-messenger studies. The mission is currently in phase B, which will be completed in the middle of 2022