Transmission measurement at 10.6 microns of Te2As3Se5 rib-waveguides on As2S3 substrate

The feasibility of chalcogenide rib waveguides working at lambda = 10.6 microns has been demonstrated. The waveguides comprised a several microns thick Te2As3Se5 film deposited by thermal evaporation on a polished As2S3 glass substrate and further etched by physical etching in Ar or CF4/O2 atmosphere. Output images at 10.6 microns and some propagation losses roughly estimated at 10dB/cm proved that the obtained structures behaved as channel waveguides with a good lateral confinement of the light. The work opens the doors to the realisation of components able to work in the mid and thermal infrared up to 20 microns and even more.Comment: The following article appeared in Vigreux-Bercovici et al., Appl. Phys. Lett. 90, 011110 (2007) and may be found at http://link.aip.org/link/?apl/90/01111

Eurasian house mouse (Mus musculus L.) differentiation at microsatellite loci identifies the Iranian plateau as a phylogeographic hotspot

Background: The phylogeography of the house mouse (Mus musculus L.), an emblematic species for genetic and biomedical studies, is only partly understood, essentially because of a sampling bias towards its most peripheral populations in Europe, Asia and the Americas. Moreover, the present-day phylogeographic hypotheses stem mostly from the study of mitochondrial lineages. In this article, we complement the mtDNA studies with a comprehensive survey of nuclear markers (19 microsatellite loci) typed in 963 individuals from 47 population samples, with an emphasis on the putative Middle-Eastern centre of dispersal of the species. Results: Based on correspondence analysis, distance and allele-sharing trees, we find a good coherence between geographical origin and genetic make-up of the populations. We thus confirm the clear distinction of the three best described peripheral subspecies, M. m. musculus, M. m. domesticus and M. m. castaneus. A large diversity was found in the Iranian populations, which have had an unclear taxonomic status to date. In addition to samples with clear affiliation to M. m. musculus and M. m. domesticus, we find two genetic groups in Central and South East Iran, which are as distinct from each other as they are from the south-east Asian M. m. castaneus. These groups were previously also found to harbor distinct mitochondrial haplotypes. Conclusion: We propose that the Iranian plateau is home to two more taxonomic units displaying complex primary and secondary relationships with their long recognized neighbours. This central region emerges as the area with the highest known diversity of mouse lineages within a restricted geographical area, designating it as the focal place to study the mechanisms of speciation and diversification of this species

APPLaUD: access for patients and participants to individual level uninterpreted genomic data.

BACKGROUND: There is a growing support for the stance that patients and research participants should have better and easier access to their raw (uninterpreted) genomic sequence data in both clinical and research contexts. MAIN BODY: We review legal frameworks and literature on the benefits, risks, and practical barriers of providing individuals access to their data. We also survey genomic sequencing initiatives that provide or plan to provide individual access. Many patients and research participants expect to be able to access their health and genomic data. Individuals have a legal right to access their genomic data in some countries and contexts. Moreover, increasing numbers of participatory research projects, direct-to-consumer genetic testing companies, and now major national sequencing initiatives grant individuals access to their genomic sequence data upon request. CONCLUSION: Drawing on current practice and regulatory analysis, we outline legal, ethical, and practical guidance for genomic sequencing initiatives seeking to offer interested patients and participants access to their raw genomic data

Fixed Effect Estimation of Large T Panel Data Models

This article reviews recent advances in fixed effect estimation of panel data models for long panels, where the number of time periods is relatively large. We focus on semiparametric models with unobserved individual and time effects, where the distribution of the outcome variable conditional on covariates and unobserved effects is specified parametrically, while the distribution of the unobserved effects is left unrestricted. Compared to existing reviews on long panels (Arellano and Hahn 2007; a section in Arellano and Bonhomme 2011) we discuss models with both individual and time effects, split-panel Jackknife bias corrections, unbalanced panels, distribution and quantile effects, and other extensions. Understanding and correcting the incidental parameter bias caused by the estimation of many fixed effects is our main focus, and the unifying theme is that the order of this bias is given by the simple formula p/n for all models discussed, with p the number of estimated parameters and n the total sample size.Comment: 40 pages, 1 tabl

Formation of convective cells in the scrape-off layer of the CASTOR tokamak

Understanding of the scrape-off layer (SOL) physics in tokamaks requires diagnostics with sufficient temporal and spatial resolution. This contribution describes results of experiments performed in the SOL of the CASTOR tokamak (R=40 cm, a = 6 cm) by means of a ring of 124 Langmuir probes surrounding the whole poloidal cross section. The individual probes measure either the ion saturation current of the floating potential with the spatial resolution up to 3 mm. Experiments are performed in a particular magnetic configuration, characterized by a long parallel connection length in the SOL, L_par ~q2piR. We report on measurements in discharges, where the edge electric field is modified by inserting a biased electrode into the edge plasma. In particular, a complex picture is observed, if the biased electrode is located inside the SOL. The poloidal distribution of the floating potential appears to be strongly non-uniform at biasing. The peaks of potential are observed at particular poloidal angles. This is interpreted as formation of a biased flux tube, which emanates from the electrode along the magnetic field lines and snakes q times around the torus. The resulting electric field in the SOL is 2-dimensional, having the radial as well as the poloidal component. It is demonstrated that the poloidal electric field E_pol convects the edge plasma radially due to the E_pol x B_T drift either inward or outward depending on its sign. The convective particle flux is by two orders of magnitude larger than the fluctuation-induced one and consequently dominates.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004, Nice (France

The secondary eclipses of WASP-19b as seen by the ASTEP 400 telescope from Antarctica

The ASTEP (Antarctica Search for Transiting ExoPlanets) program was originally aimed at probing the quality of the Dome C, Antarctica for the discovery and characterization of exoplanets by photometry. In the first year of operation of the 40 cm ASTEP 400 telescope (austral winter 2010), we targeted the known transiting planet WASP-19b in order to try to detect its secondary transits in the visible. This is made possible by the excellent sub-millimagnitude precision of the binned data. The WASP-19 system was observed during 24 nights in May 2010. The photometric variability level due to starspots is about 1.8% (peak-to-peak), in line with the SuperWASP data from 2007 (1.4%) and larger than in 2008 (0.07%). We find a rotation period of WASP-19 of 10.7 +/- 0.5 days, in agreement with the SuperWASP determination of 10.5 +/- 0.2 days. Theoretical models show that this can only be explained if tidal dissipation in the star is weak, i.e. the tidal dissipation factor Q'star > 3.10^7. Separately, we find evidence for a secondary eclipse of depth 390 +/- 190 ppm with a 2.0 sigma significance, a phase consistent with a circular orbit and a 3% false positive probability. Given the wavelength range of the observations (420 to 950 nm), the secondary transit depth translates into a day side brightness temperature of 2690(-220/+150) K, in line with measurements in the z' and K bands. The day side emission observed in the visible could be due either to thermal emission of an extremely hot day side with very little redistribution of heat to the night side, or to direct reflection of stellar light with a maximum geometrical albedo Ag=0.27 +/- 0.13. We also report a low-frequency oscillation well in phase at the planet orbital period, but with a lower-limit amplitude that could not be attributed to the planet phase alone, and possibly contaminated with residual lightcurve trends.Comment: Accepted for publication in Astronomy and Astrophysics, 13 pages, 13 figure

Full background decomposition of the CONUS experiment

The CONUS experiment is searching for coherent elastic neutrino nucleus scattering of reactor anti-neutrinos with four low energy threshold point-contact high-purity germanium spectrometers. An excellent background suppression within the region of interest below 1keV (ionization energy) is absolutely necessary to enable a signal detection. The collected data also make it possible to set limits on various models regarding beyond the standard model physics. These analyses benefit as well from the low background level of ~10d$^{-1}$kg$^{-1}$below 1keV and at higher energies. The low background level is achieved by employing a compact shell-like shield, that was adapted to the most relevant background sources at the shallow depth location of the experiment: environmental gamma-radiation and muon-induced secondaries. Overall, the compact CONUS shield including the active anti-coincidence muon-veto reduces the background by more than four orders of magnitude. The remaining background is described with validated Monte Carlo simulations which include the detector response. It is the first time that a full background decomposition in germanium operated at reactor-site has been achieved. Next to remaining muon-induced background, $^{210}$Pb within the shield and cryostat end caps, cosmogenic activation and air-borne radon are the most relevant background sources. The reactor-correlated background is negligible within the shield. The validated background model together with the parameterization of the noise are used as input to the likelihood analyses of the various physics cases

First upper limits on neutrino electromagnetic properties from the CONUS experiment

We report first constraints on neutrino electromagnetic properties from neutrino-electron scattering using data obtained from the CONUS germanium detectors, i.e. an upper limit on the effective neutrino magnetic moment and an upper limit on the effective neutrino millicharge. The electron antineutrinos are emitted from the 3.9 GW$_\mathrm{th}$ reactor core of the Brokdorf nuclear power plant in Germany. The CONUS low background detectors are positioned at 17.1 m distance from the reactor core center. The analyzed data set includes 689.1 kg$\cdot$d collected during reactor ON periods and 131.0 kg$\cdot$d collected during reactor OFF periods in the energy range of 2 to 8 keV. With the current statistics, we are able to determine an upper limit on the effective neutrino magnetic moment $\mu_\nu < 7.5\cdot10^{-11}\,\mu_B$ at 90% confidence level. From this first magnetic moment limit we can derive an upper bound on the neutrino millicharge of $\vert$q$_{\nu}\vert < 3.3\cdot10^{-12}\,e_0$

Direct measurement of the ionization quenching factor of nuclear recoils in germanium in the keV energy range

This article reports the measurement of the ionization quenching factor in germanium for nuclear recoil energies between 0.4 and 6.3 keV$_{nr}$. Precise knowledge of this factor in this energy range is relevant for coherent elastic neutrino-nucleus scattering and low mass dark matter searches with germanium-based detectors. Nuclear recoils were produced in a thin high-purity germanium target with a very low energy threshold via irradiation with monoenergetic neutron beams. The energy dependence of the ionization quenching factor was directly measured via kinematically constrained coincidences with surrounding liquid scintillator based neutron detectors. The systematic uncertainties of the measurements are discussed in detail. With measured quenching factors between 0.16 and 0.23 in the [0.4, 6.3] keV$_{nr}$ energy range, the data are compatible with the Lindhard theory with a parameter $k$ of 0.162 $\pm$ 0.004 (stat+sys)