The Cesàro operator in growth Banach spaces of analytic functions

[EN] The CesA ro operator C, when acting in the classical growth Banach spaces and , for , of analytic functions on , is investigated. Based on a detailed knowledge of their spectra (due to A. Aleman and A.-M. Persson) we are able to determine the norms of these operators precisely. It is then possible to characterize the mean ergodic and related properties of C acting in these spaces. In addition, we determine the largest Banach space of analytic functions on which C maps into (resp. into ); this optimal domain space always contains (resp. ) as a proper subspace.The research of the first two authors was partially supported by the projects MTM2013-43540-P and GVA Prometeo II/2013/013.Albanese, A.; Bonet Solves, JA.; Ricker, WJ. (2016). The Cesàro operator in growth Banach spaces of analytic functions. Integral Equations and Operator Theory. 86(1):97-112. https://doi.org/10.1007/s00020-016-2316-zS97112861Albanese A.A., Bonet J., Ricker W.J.: Convergence of arithmetic means of operators in Fréchet spaces. J. Math. Anal. Appl. 401, 160–173 (2013)Albanese, A.A., Bonet, J.,Ricker, W.J.: The Cesàro operator on power series spaces. Preprint (2016)Albrecht E., Miller T.L., Neumann M.M.: Spectral properties of generalized Cesàro operators on Hardy and weighted Bergman spaces. Archiv Math. 85, 446–459 (2005)Aleman A.: A class of integral operators on spaces of analytic functions. In: Proc. of the Winter School in Operator Theory and Complex Analysis, Univ. Málaga Secr. Publ., Málaga, pp. 3–30 (2007)Aleman A., Constantin O.: Spectra of integration operators on weighted Bergman spaces. J. Anal. Math. 109, 199–231 (2009)Aleman A., Persson A.-M.: Resolvent estimates and decomposable extensions of generalized Cesàro operators. J. Funct. Anal. 258, 67–98 (2010)Aleman A., Siskakis A.G.: An integral operator on H p . Complex Var. Theory Appl. 28, 149–158 (1995)Aleman A., Siskakis A.G.: Integration operators on Bergman spaces. Indiana Univ. Math. J. 46, 337–356 (1997)Bayart F., Matheron E.: Dynamics of Linear Operators. Cambridge University Press, Cambridge (2009)Bierstedt K.D., Bonet J., Galbis A.: Weighted spaces of holomorphic functions on balanced domains. Michigan Math. J. 40, 271–297 (1993)Bierstedt K.D., Bonet J., Taskinen J.: Associated weights and spaces of holomorphic functions. Studia Math. 127, 137–168 (1998)Bierstedt, K.D., Summers, W.H.: Biduals of weighted Banach spaces of analytic functions. J. Aust. Math. Soc. 54, 70–79 (1993)Bonet J., Domanski P., Lindström M.: Essential norm and weak compactness on weighted Banach spaces of analytic functions. Can. Math. Bull. 42, 139–148 (1999)Curbera G.P., Ricker W.J.: Extensions of the classical Cesàro operator on Hardy spaces. Math. Scand. 108, 279–290 (2011)Danikas N., Siskakis A.: The Cesàro operator on bounded analytic functions. Analysis 13, 295–299 (1993)Duren P.: Theory of H p Spaces. Academic Press, New York (1970)Dunford N., Schwartz J.T.:Linear Operators I: General Theory, 2nd Printing. Wiley Interscience Publ., New York (1964)Grosse-Erdmann K., Peris A.: Linear Chaos. Springer, London (2011)Harutyunyan A., Lusky W.: On the boundedness of the differentiation operator between weighted spaces of holomorphic functions. Studia Math. 184, 233–247 (2008)Hedenmalm H., Korenblum B., Zhu K.: Theory of Bergman Spaces. Grad. Texts in Math., vol. 199. Springer, New York (2000)Katzelson Y., Tzafriri L.: On power bounded operators. J. Funct. Anal. 68, 313–328 (1968)Krengel U.: Ergodic Theorems. de Gruyter Studies in Mathematics, vol. 6. Walter de Gruyter Co., Berlin (1985)Lin M.: On the uniform ergodic theorem. Proc. Am. Math. Soc. 43, 337–340 (1974)Lusky W.: On the isomorphism classes of weighted spaces of harmonic and holomorphic functions. Studia Math. 175(1), 19–40 (2006)Megginson R.E.: An Introduction to Banach Space Theory. Springer, New York (1998)Meise R., Vogt D.: Introduction to Functional Analysis. Clarendon Press, Oxford (1997)Persson A.-M.: On the spectrum of the Cesàro operator on spaces of analytic functions. J. Math. Anal. Appl. 340, 1180–1203 (2008)Rubel L.A., Shields A.L.: The second dual of certain spaces of analytic functions. J. Aust. Math. Soc. 11, 276–280 (1970)Shields A.L., Williams D.L.: Bounded projections, duality and multipliers in spaces of analytic functions. Trans. Am. Math. Soc. 162, 287–302 (1971)Siskakis A.: Volterra operators on spaces of analytic functions—a survey. In: Proc. of the First Advanced Course in Operator Theory and Complex Analysis, Univ. Sevilla Serc. Publ., Seville, pp. 51–68 (2006

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose-responsive hepatokine and regulator of glucose homeostasis. Acute intraperitoneal administration of SMOC1 improved glycemic control and insulin sensitivity in mice without changes in insulin secretion. SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3',5'-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output. Overexpression of SMOC1 in the liver or once-weekly intraperitoneal injections of a stabilized SMOC1-FC fusion protein induced durable improvements in glucose tolerance and insulin sensitivity in db/db mice, without adverse effects on adiposity, liver histopathology, or inflammation. Furthermore, circulating SMOC1 correlated with hepatic and systemic insulin sensitivity and was decreased in obese, insulin-resistant humans. Together, these findings identify SMOC1 as a potential pharmacological target for the management of glycemic control in type 2 diabetes.Magdalene K. Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta ... Scott L. Townley, Luke A. Selth ... et al

Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with behavior and reward in mouse models, as predicted by the domestication syndrome hypothesis. Our description of a previously unidentified allele for the gloving pigmentation pattern found in the Birman breed supports the hypothesis that cat breeds experienced strong selection on specific mutations drawn from random bred populations. Collectively, these findings provide insight into how the process of domestication altered the ancestral wildcat genome and build a resource for future disease mapping and phylogenomic studies across all members of the Felidae

Mass Transport in Porous Media with Variable Mass

We present a theoretical and numerical study of mass transport in a porous medium saturated with a fluid and characterised by an evolving internal structure. The dynamics of the porous medium and the fluid as well as their reciprocal interactions are described at a coarse scale, so that the fundamental tools of Mixture Theory and Continuum Mechanics can be used. The evolution of the internal structure of the porous medium, which is here primarily imputed either to growth or to mass exchange with the fluid, is investigated by enriching the space of kinematic variables of the mixture with a set of structural descriptors, each of which is power-conjugate to generalised forces satisfying a balance law. Establishing the influence of the structural change of the porous medium on the transport properties of the mixture and, thus, on the quantities characterising fluid flow is the crux of our contribution