25 research outputs found

    Something to Sneeze At: Nebraska\u27s Airborne Pollen

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    For those of us whose noses know (and don\u27t like) pollen, late October is a time for celebration in Nebraska because it is the end of the hay fever season. When one\u27s nose is a sensitive bio-detector of the presence of pollen, one\u27s brain usually appreciates putting a name to whatever is causing the itchy eyes and runny nose. The job of putting names on the types of pollen in the air has been done by a dedicated team of pollen counters in the Division of Botany, University of Nebraska State Museum. This group, led by Curator Peg Bolick, has been catching, counting, and identifying these allergens since 1990. They do this five days a week from late February through mid-October each year. Problem pollen almost always comes from plants that use wind to transport their pollen to another plant. The chance of an individual grain finding the flower of another plant of the same species is much smaller with wind pollination than it is with animal pollination. Wind-pollinated plants compensate for the lack of precision by producing millions of extra pollen grains, some of which land in noses. Pollen from animal-pollinated plants is sticky, usually forming clumps that are too large to remain in the air very long. However, Nebraska\u27s strong winds occasionally strip these sticky grains from flowers and carry them to noses or pollen samplers. Air-borne pollen has a more restricted size range than that carried by animals. Pollen grains are measured in microns, a unit that is one millionth of a meter. The largest pollen grains, produced by plants that use animals for pollination, are barely visible to the naked eye at about 250 microns (one fourth of a millimeter). The size range for pollen that is transported by wind is an order of magnitude smaller. Unless it has air bladders like pine pollen, grains that are much larger than 100 microns (the size of corn pollen) usually fall out of the air before traveling more than a few meters. At the other end of the scale, a pollen grain smaller than ten microns (the size of ragweed pollen) cannot be caught efficiently by plant stigmas, the part of the flower that leads to the ovule for fertilization

    A Listening Pedagogy: Insights of Pre-Service Elementary Teachers in Multi-cultural Classrooms

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    Although Texas schools are under the pedagogical constraints of both the Texas Assessment of Knowledge Skills (TAKS) and the national No Child Left Behind Act of 2001, it is morally incumbent upon Texas legislators and educators to listen to students’ voices to engage them with the “teaching and learning” technical core of schools (Hoy & Miskel, 2000, p. 75). Ironically, while Texas teacher certification standards mandate student-centered pedagogical practices, the current state and national pressure of a high-stakes accountability climate often lead to a teacher-centered pedagogy in which student voices are routinely excluded from the classroom (Kordalewski, 1999). This atmosphere leads to inauthentic instructional practices that are removed from students’ own experiences (McNeil & Valenzuela, 1998), which in turn lead to a perceived lack of student self-efficacy that is directly linked to disengagement from school (Bandura, 1993)

    Movement of Crop Transgenes into Wild Plants

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    Despite the great potential and increasing importance of other weed control options (Turner et al. 1992) and unwanted environmental side effects of some herbicides, herbicides constitute a very important means of weed control. The escape of herbicide resistance genes to wild, weedy plants could cause more severe weed problems, and presents a very real threat to the efficacy of herbicides as a weed control option. Therefore, management strategies that prevent, or reduce the likelihood and frequency of HRG escape through containment methods are advisable, as are mitigation plans in the event of HRG escape to wild plants

    Building a model of navigational strategies for queer undergraduate students in STEM

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    IntroductionThere is a critical need to foster inclusive educational spaces for Queer identifying students and to resist oppressive structures that seek to marginalize and inflict trauma on students because of their gender or sexual identity.MethodsDrawing on thematic analysis and Queer theory, we interviewed 11 Queer identifying STEM students to understand the navigational strategies they leveraged within higher education environments related to their Queer identity.ResultsWe developed a cyclical model of navigational strategies employed by Queer STEM students that involved evaluating the environments, performing psychological identity calculations, and engaging in behavioral actions. Students evaluated the environment by attending to the diversity of gender representation, presence of other Queer individuals, and contextual factors conveyed based on disciplinary expectations. Students engaged in psychological identity calculations whereby they assessed beliefs about the relevance, importance, and fears related to their Queer identity, with few perceiving any benefits. Behavioral actions resulted in students building a chosen community, disclosing or shelving their queer identity, and advocating for representation.DiscussionIn order to support Queer students to thrive in educational contexts, researchers and practitioners should examine ways to increase representation, use inclusive pedagogical strategies, and understand the relevance of Queerness within disciplinary fields. Questioning the relevance or presence of Queerness in higher education environments only further serves to oppress, inflict trauma, and marginalize Queer students

    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

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    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻ÂčÂČ) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻ÂčÂč) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻ÂčÂč) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻ÂčÂč), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

    Get PDF
    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻ÂčÂČ) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻ÂčÂč) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻ÂčÂč) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻ÂčÂč), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

    Something to Sneeze At: Nebraska\u27s Airborne Pollen

    Get PDF
    For those of us whose noses know (and don\u27t like) pollen, late October is a time for celebration in Nebraska because it is the end of the hay fever season. When one\u27s nose is a sensitive bio-detector of the presence of pollen, one\u27s brain usually appreciates putting a name to whatever is causing the itchy eyes and runny nose. The job of putting names on the types of pollen in the air has been done by a dedicated team of pollen counters in the Division of Botany, University of Nebraska State Museum. This group, led by Curator Peg Bolick, has been catching, counting, and identifying these allergens since 1990. They do this five days a week from late February through mid-October each year. Problem pollen almost always comes from plants that use wind to transport their pollen to another plant. The chance of an individual grain finding the flower of another plant of the same species is much smaller with wind pollination than it is with animal pollination. Wind-pollinated plants compensate for the lack of precision by producing millions of extra pollen grains, some of which land in noses. Pollen from animal-pollinated plants is sticky, usually forming clumps that are too large to remain in the air very long. However, Nebraska\u27s strong winds occasionally strip these sticky grains from flowers and carry them to noses or pollen samplers. Air-borne pollen has a more restricted size range than that carried by animals. Pollen grains are measured in microns, a unit that is one millionth of a meter. The largest pollen grains, produced by plants that use animals for pollination, are barely visible to the naked eye at about 250 microns (one fourth of a millimeter). The size range for pollen that is transported by wind is an order of magnitude smaller. Unless it has air bladders like pine pollen, grains that are much larger than 100 microns (the size of corn pollen) usually fall out of the air before traveling more than a few meters. At the other end of the scale, a pollen grain smaller than ten microns (the size of ragweed pollen) cannot be caught efficiently by plant stigmas, the part of the flower that leads to the ovule for fertilization

    Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor

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    Abstract—Monocyte recruitment and adhesion to vascular endothelium are key early events in atherosclerosis. We examined the role of sphingosine-1-phosphate (S1P) on modulating monocyte/endothelial interactions in the NOD/LtJ (NOD) mouse model of type 1 diabetes. Aortas from nondiabetic and diabetic NOD mice were incubated in the absence or presence of 100 nmol/L S1P. Fluorescently labeled monocytes were incubated with the aortas. Aortas from NOD diabetic mice bound 7-fold more monocytes than nondiabetic littermates (10ïżœ1 monocytes bound/field for nondiabetic mice vs 74ïżœ12 monocytes bound/field for diabetic mice, Pïżœ0.0001). Incubation of diabetic aortas with 100 nmol/L S1P reduced monocyte adhesion to endothelium by 90%. We found expression of S1P1, S1P2, and S1P3 receptors on NOD aortic endothelial cells. The S1P1 receptor-specific agonist SEW2871 inhibited monocyte adhesion to diabetic aortas. Studies in diabetic S1P3-deficient mice revealed that the S1P3 receptor did not play a pivotal role in this process. S1P reduced endothelial VCAM-1 induction in type 1 diabetic NOD mice, most likely through inhibition of nuclear factor ïżœB translocation to the nucleus. Thus, S1P activation of the S1P1 receptor functions in an antiinflammatory manner in type 1 diabetic vascular endothelium to prevent monocyte/endothelial interactions. S1P may play an important role in the prevention of vascular complications of type 1 diabetes. (Circ Res. 2006;99:731-739.) Key Words: endothelial ïżœ NF-ïżœB ïżœ type 1 diabetes ïżœ sphingosine-1-phosphate ïżœ adhesion molecules Atherosclerosis development is accelerated several-fold i
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