89 research outputs found
Sophorolipids-functionalized iron oxide nanoparticles
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2013
- Field of study
International audienceFunctional iron oxide nanoparticles (NP) have been synthesized in a one and a two-step method using a natural functional glycolipid belonging to the family of sophorolipids (SL). These compounds, whose open acidic form is highly suitable for nanoparticle stabilization, are readily obtained by a fermentation process of the yeast Candida bombicola (polymorph Starmerella bombicola) in large amounts. The final carbohydrate coated iron oxide nanoparticles represent interesting potentially biocompatible materials for biomedical applications. According to the synthesis strategy, magnetic properties can eventually be tuned, thus putting in evidence the direct effect of the glycolipid on the final material's structure (maghemite and ferrihydrite have been obtained here). A combination of FT-IR, Dynamic Light Scattering (DLS) and UV-Vis experiments shows that SL complex the nanoparticle surface via their accessible COOH group thus forming stable colloids, whose hydrodynamic diameter mostly varies between 10 nm and 30 nm, both in water and in KCl-containing (0.01 M and 2 M) solutions. The materials can stand multiple filtration steps (up to 10) at different extents, where the largest recorded average aggregate size is 100 nm. In general, materials synthesized at T = 80 °C display better stability and smaller size distribution than those obtained at room temperature
Universal evaluation of MLC models in treatment planning systems based on a common set of dynamic tests
- Author
- Publication venue
- Elsevier
- Publication date
- 28/06/2023
- Field of study
Reference standards; Commission on professional and hospital activities; Radiotherapy, Intensity-ModulatedEstándares de referencia; Comisión sobre actividades profesionales y hospitalarias; Radioterapia de intensidad moduladaEstàndards de referència; Comissió sobre activitats professionals i hospitalàries; Radioteràpia d'intensitat moduladaPurpose: To demonstrate the feasibility of characterising MLCs and MLC models implemented in TPSs using a common set of dynamic beams.
Materials and methods: A set of tests containing synchronous (SG) and asynchronous sweeping gaps (aSG) was distributed among twenty-five participating centres. Doses were measured with a Farmer-type ion chamber and computed in TPSs, which provided a dosimetric characterisation of the leaf tip, tongue-and-groove, and MLC transmission of each MLC, as well as an assessment of the MLC model in each TPS. Five MLC types and four TPSs were evaluated, covering the most frequent combinations used in radiotherapy departments.
Results: Measured differences within each MLC type were minimal, while large differences were found between MLC models implemented in clinical TPSs. This resulted in some concerning discrepancies, especially for the HD120 and Agility MLCs, for which differences between measured and calculated doses for some MLC-TPS combinations exceeded 10%. These large differences were particularly evident for small gap sizes (5 and 10 mm), as well as for larger gaps in the presence of tongue-and-groove effects. A much better agreement was found for the Millennium120 and Halcyon MLCs, differences being within ± 5% and ± 2.5%, respectively.
Conclusions: The feasibility of using a common set of tests to assess MLC models in TPSs was demonstrated. Measurements within MLC types were very similar, but TPS dose calculations showed large variations. Standardisation of the MLC configuration in TPSs is necessary. The proposed procedure can be readily applied in radiotherapy departments and can be a valuable tool in IMRT and credentialing audits
Sophorolipids-functionalized iron oxide nanoparticles
- Author
- Alves
- Amstad
- Amstad
- Babes
- Baccile
- Baccile
- Bala
- Bardhan
- Barrientos
- Bee
- Binder
- Blackwell
- Blesa
- Bronstein
- Buskas
- Chen
- Dallas
- Develter
- Dhar
- Earhart
- Earhart
- El-Boubbou
- Fang
- Fu
- Gorityala
- Inge Van Bogaert
- Jambor
- Kandori
- Kanicky
- Kasture
- Kievit
- Kievit
- Krishnamurti
- Lang
- Laurent
- Lee
- Lis
- Lorenzo Stievano
- Lu
- M Eriksson
- Massart
- Massart
- Milić
- Nakamoto
- Niki Baccile
- Penfold
- Qi
- Romain Noiville
- Santoyo-Gonzalez
- Seeberger
- Shete
- Singh
- Tomoaia-Cotisel
- Van Bogaert
- Van des Woude
- Vidal-Vidal
- Vincent
- Wang
- Wang
- Weissenborn
- Xie
- Yano
- Yilmaz
- Zhang
- Zhou
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2013
- Field of study
Post retraction citations in context: a case study
- Author
- A Gatling
- A Marcus
- AV Neale
- BK Redman
- C Gross
- C Romain
- CA Kochan
- CR Madlock-Brown
- D Fanelli
- E Garfield
- E Wager
- FC Fang
- Gali Halevi
- H Bornemann-Cimenti
- J Fagan
- J Xia
- JL Furman
- JM Budd
- JM Campanario
- Judit Bar-Ilan
- JY Nau
- K Unger
- M Cokol
- MP Pfeifer
- P Bogaert Van
- RG Steen
- RG Steen
- RG Steen
- S Edú-Valsania
- S Seifirad
- ST Mayne
- UE Loening
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
- Author
- A'hern R
- A\u2019hern R
- Abe O
- Abe R
- Abu\u2010zahra Ht
- Af Trampe E
- Aft R
- Ahlgren J
- Ahn Jh
- Aihara T
- Albain K
- Albano J
- Alberro Ja
- Amadori D
- Anderson H
- Anderson S
- Andr\ue9 F
- Arnesson Lg
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Barlow W
- Barrett\u2010lee Pj
- Bartelink H
- Bartlett J
- Bartsch R
- Bass G
- Bastert G
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Bengtsson No
- Benraadt J
- Bergh J
- Bergsten\u2010nordstr\uf6m E
- Berry D
- Bighin C
- Bijker N
- Bishop H
- Blamey Rw
- Bliss J
- Bliss Jm
- Blohmer Ju
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesson T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell Vh
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brockschmidt J
- Brookes C
- Brown A
- Browne L
- Brufsky Am
- Bruzzi P
- Bryant Ajs
- Bryant J
- Bundred Nj
- Burrett Ja
- Buyse M
- Buzdar Au
- Caffier H.
- Calais G
- Camerini T
- Cameron D
- Camisa R
- Camphausen K
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter Jt
- Carrasco E
- Carstensen J
- Castiglione M
- Celebioglu F
- Chen Be
- Chen Zm
- Chetty U
- Chilvers Ced
- Chlebowski Rt
- Christiaens R
- Christiansen P
- Cirrincione C
- Clack G
- Clarke M
- Coates A
- Cocconi G
- Coleman R
- Coleman Re
- Colleoni M
- Collett V
- Collins J
- Comis Rl
- Coombes Rc
- Cooper Mr
- Corcoran N
- Correa C
- Costa A
- Costa Sd
- Costantino J
- Crossley E
- Crowley J
- Cufer T
- Cunningham Mp
- Cutter D
- Cuzick J
- D\u2019amico C
- Dafni U
- Dahlberg K
- Dalesio O
- Danforth D
- Davidson N
- Davidson Ne
- Davies C
- Davis Hl
- De La Huerta R
- De La Lande B
- De Lafontan B
- De Laurentiis M
- De Oliveira Cf
- De Pablo Jl
- De Placido S
- De Schryver A
- De Vries Ege
- Del Mastro L
- Delaloge S
- Delmestri A
- Delozier T
- Dent Dm
- Deshpande N
- Deulofeu P
- Deutsch Gp
- Di Blasio B
- Di Leo A
- Di Martino L
- Di Mauro Mg
- Di Palma M
- Dignam J
- Dixon Jm
- Dodwell D
- Dolci S
- Douglas P
- Dowsett M
- Dozin B
- Duane F
- Dubois Jb
- Dufmats M
- Dunn J
- Durand M
- Eidtmann H
- Eiermann W
- Ejlertsen B
- Ellis Io
- Ellis P
- Emdin S
- Enomoto K
- Erazo A
- Erikstein B
- Evans V
- Ewertz M
- Ewing Gh
- F\ue1bregas R
- Falkson Ci
- Fargeot P
- Fehm T
- Fentiman Is
- Fernando I
- Fesl C
- Firth La
- Fisher B
- Fitzal F
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes Jf
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- G\uf6ransson E
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet Jc
- Gelber R
- Gelber Rd
- Gelman Rs
- Gelmon K
- George Wd
- Gerber B
- Gerv\ue1sio H
- Gettins L
- Geyer C
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldstein Lj
- Goodwin P
- Gordilho J
- Gordon Nh
- Goss Pe
- Graham P
- Gralow J
- Gray R
- Greil R
- Griffon B
- Gubern Jm
- Gudgeon Ca
- Gundersen S
- H\uf8st H
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Hannisdal E
- Harbeck N
- Harris A
- Harris Jr
- Harvey Vj
- Hauer\u2010jensen M
- Hayat H
- Haybittle Jl
- Hayes Df
- Hayward Jl
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway Im
- Holli K
- Holmberg L
- Horiguchi J
- Horsman Jm
- Hortobagyi G
- Houghton J
- Howell A
- Hozumi Y
- Hsu L
- Hudis Ca
- Huovinen R
- Hupperets Psgj
- Iiristo M
- Ikeda T
- Inbar Mj
- Ingle J
- Ingle Jn
- Inokuchi K
- Ivanov V
- Iwata H
- J\ue4nicke F
- Jack W
- Jackisch C
- Jackson Im
- Jacobsen Ab
- Jagsi R
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen Mb
- Joensuu H
- Johansen H
- Johansson U
- Jonat W
- Jones Se
- Jonsson H
- Julien Jp
- Jung Kh
- Karlsson P
- Kaufmann M
- Kay Rg
- Kerbrat P
- Kerr A
- Kikuchi K
- Kilburn L
- Killander F
- Kissin M
- Klefstrom P
- Klijn Jgm
- Kohno N
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscielny S
- Koyama H
- Kreienberg R
- Krushen\u2010kosloski Jl
- Kunkler I
- Kwong Dlw
- L\uf6fgren L
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
- Leonard Cf
- Leone B
- Lester J
- Levine M
- Levine Mn
- Lichter A
- Liedtke C
- Liefers Gj
- Liljegren G
- Linderholm Bk
- Lindman H
- Lindsay Ma
- Lindtner A
- Lindtner J
- Lioce M
- Lippman M
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart Ha
- Lohrisch C
- Loibl S
- Lopez M
- Love Rr
- Luporsi E
- Lythgoe Jp
- Mace Lesec\u2019h J
- Mackey J
- Mackinnon E
- Maibach R
- Makris A
- Mallon E
- Malmstr\uf6m P
- Mamounas Ep
- Mannu G
- Mansel Re
- Margreiter R
- Markopoulos C
- Marshall Hc
- Martelli G
- Marth C
- Martin Al
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason Bh
- Masood Mb
- Masuda H
- Math\ue9 G
- Mauriac L
- Mavroudis D
- Mcardle Cs
- Mcgale P
- Mchugh T
- Meakin Jw
- Medina Jy
- Meier P
- Meisner C
- Michiels S
- Mihura J
- Misset Jl
- Mitchell Ak
- Miyashita M
- Mlineritsch B
- Monson K
- Monypenny Ij
- Moral A
- Morgan Dal
- Morimoto K
- Morris P
- Mouret\u2010fourme E
- Mouridsen H
- Mouridsen Ht
- Mukai H
- Murray E
- Murray N
- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen\u2010meyer R
- Nitz U
- Nogaret Jm
- Nomura Y
- Nordenskj\uf6ld B
- Norton L
- Notter G
- Oates Gd
- Ogawa M
- Ohashi Y
- Ohno S
- Osborne Ck
- Owen Jr
- Pai Vr
- Paik S
- Palmer Mk
- Palshof T
- Paltuev R
- Pan H
- Panieri E
- Pannuti F
- Panzarella T
- Paradiso A
- Paridaens R
- Parker D
- Parton M
- Parulekar W
- Passalacqua R
- Pastorino S
- Pater Jl
- Paterson Ahg
- Patnick J
- Pe\uf1alva G
- Peek U
- Pellegrini F
- Pennert K
- Perbeck L
- Peretz T
- Perez E
- Perrone F
- Peto R
- Petruzelka L
- Pfeiler G
- Philippson C
- Piccart M
- Piccart Mj
- Pierce L
- Pierce Lj
- Pinder S
- Pinder Se
- Pirozzoli Mc
- Poole C
- Poortmans P
- Portnoj Sm
- Possinger K
- Powell J
- Powles Tj
- Pribylova O
- Price Jj
- Price Kn
- Pritchard Ki
- Pronzato P
- Puig P
- Raina V
- Ramos M
- Rauschecker H
- Ravdin P
- Ravdin Pm
- Rea D
- Read S
- Redmond C
- Regan M
- Regan Mm
- Reid M
- Reinertsen Kv
- Ro J
- Robert N
- Robertson J
- Robertson Jfr
- Robinson E
- Roch\ue9 H
- Rodenhuis S
- Rojo R
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle Gt
- Rubagotti A
- Rubens Rd
- Rubino C
- Rudenstam Cm
- Rutgers E
- Ryd\ue9n L
- S\uf6derberg M
- Saarto T
- Sacco M
- Sadoon M
- Safra T
- Sainz Mg
- Sakai K
- Salmon Rj
- Sandelin K
- Santesteban P
- Sauer R
- Sauerbrei W
- Sawa K
- Sayer J
- Schauer A
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Segui Ma
- Seifert M
- Semiglazov V
- Senanayake F
- Senn Hj
- Serra C
- Sertoli Mr
- Sestak I
- Sevelda P
- Shan Y
- Shao Yf
- Shapiro Cl
- Shepherd Le
- Shien T
- Simmonds Pd
- Singer Cf
- Skilton D
- Skolyszewski J
- Skoog L
- Slamon D
- Sledge G
- Smart D
- Smith Dc
- Smith Ie
- Sohn Hc
- Sol\ue0 M
- Solarnau L
- Solin Lj
- Solomayer E
- Solsona J
- Sonoo H
- Sparano J
- Sparano Ja
- Spittle M
- Spooner D
- St\uf6ger H
- Stallard S
- Steger Gg
- Steinberg S
- Stewart Hj
- Stroner P
- Sugimachi K
- Suman Vj
- Svane G
- Swain S
- Swindell R
- Takao S
- Takatsuka Y
- Takei H
- Talbot D
- Taylor C
- Taylor M
- Th\ufcrlimann B
- Thomssen C
- Thuerlimann B
- Tinterri C
- Tobias Js
- Toi M
- Tominaga T
- Tormey Dc
- Trampisch Hj
- Treurniet\u2010donker Ad
- Tu D
- Tulusan Ah
- Tutt A
- Uchino J
- Ueo H
- Untch M
- Vakaet L
- Valagussa P
- Valentini M
- Vallejo Ct
- Van De Velde Ao
- Van De Velde Cjh
- Van Den Bogaert W
- Van Dongen Ja
- Van Poznak C
- Van Putten Wlj
- Van Tinteren H
- Varhaug Je
- Veloso E
- Venturini M
- Vermorken Jb
- Veronesi U
- Viale G
- Vidal S
- Vilcoq Jr
- Von Minckwitz G
- W\ue4rnberg F
- Wadstr\uf6m C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Weiss Rb
- Werner Id
- Whelan T
- Wickerham L
- Wilcken N
- Williams L
- Winer E
- Winter Mc
- Wittes R
- Wolmark N
- Wood W
- Yamashita J
- Yarnold Jr
- Yosef Hma
- Yoshida M
- Yoshimoto M
- Zambetti M
- Zhao Db
- Zielinski Cc
- Zwenger A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
- Author
- A'Hern R
- Abe O
- Abe O
- Abe R
- Abu-Zahra HT
- af Trampe E
- Aft R
- Ahlgren J
- Ahn J-H
- Albain K
- Albano J
- Alberro JA
- Amadori D
- Anderson H
- Andre F
- Arnesson L-G
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Bamia C
- Barlow W
- Barrett-Lee PJ
- Bartelink H
- Bartlett JMS
- Bartlett JMS
- Bartsch R
- Basso SMM
- Bastert G
- Bastiaannet E
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Benraadt J
- Bergh J
- Berry D
- Bijker N
- Bishop H
- Blamey RW
- Bliss J
- Bliss JM
- Blohmer JU
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesso T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell VH
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brookes C
- Brufsky AM
- Bryant AJS
- Bundred NJ
- Burrett JA
- Buyse M
- Buzdar AU
- Caffier H
- Calais G
- Camerini T
- Cameron D
- Cameron D
- Camisa R
- Canavese G
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter TJ
- Carrasco E
- Carstense J
- Castiglione M
- Castiglione M
- Celebiogl F
- Chen BE
- Chetty U
- Chetty U
- Chia SKL
- Chilvers CED
- Chlebowski RT
- Christiaens R
- Christiansen P
- Cirrincione C
- Clarke M
- Coates A
- Coleman RE
- Coleman RE
- Coleman RE
- Coles CE
- Colleoni M
- Collett V
- Collins J
- Comis RL
- Coombes RC
- Corcoran N
- Costa A
- Costa SD
- Crowley J
- Cufer T
- Cunningham MP
- Cutter D
- Cuzick J
- Cuzick J
- Dafni U
- Dahlberg K
- Dalesio O
- Davidson NE
- Davies C
- Davies C
- Davis HL
- de la Huerta R
- de La Lande B
- de Lafontan B
- De Laurentiis M
- de Oliveira CF
- de Pablo JL
- De Placido S
- De Salvo GL
- de Schryver A
- de Vries EGE
- Del Bianco P
- Delaloge S
- Delaloge S
- Delmestri A
- Delozier T
- Dent DM
- Deshpande N
- Deulofeu P
- Deutsch GP
- Di Leo A
- di Martino L
- Di Mauro MG
- Dixon JM
- Dodwell D
- Dodwell D
- Dolci S
- Douglas P
- Duane F
- Dubois JB
- Dufmats M
- Dunn J
- Durand M
- Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
- EBCTCG
- EBCTCG
- Eidtmann H
- Eierman W
- Ejlertsen B
- Ejlertsen B
- Ellis IO
- Ellis IO
- Ellis P
- Enomoto K
- Erazo A
- Evans V
- Ewertz M
- Ewing GH
- Fabregas R
- Fargeot P
- Fehm T
- Fentiman IS
- Fentiman IS
- Fernando I
- Fesl C
- Firth LA
- Fitzal F
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes JF
- Forbes JF
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Francis PA
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet JC
- Gelbe RD
- Gelman RS
- Gelmon K
- George WD
- George WS
- Gerber B
- Gervasio H
- Gettins L
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldhirsch A
- Goldstein LJ
- Goransson E
- Gordilho J
- Gordon NH
- Goss PE
- Gralow J
- Gray R
- Gray R
- Gray R
- Greil R
- Griffon B
- Gubern JM
- Gudgeon CA
- Hacking A
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Harbeck N
- Harbeck N
- Harris JR
- Harvey VJ
- Hayat H
- Haybittle JL
- Hayes D
- Hayes D
- Hayes D
- Hayward JL
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway IM
- Holli K
- Holmberg L
- Horiguchi J
- Horsman JM
- Hortobagyi G
- Host H
- Houghton J
- Howell A
- Hozumi J
- Hsu L
- Hudis CA
- Huovinen R
- Hupperets PSGJ
- Iiristo M
- Ikeda T
- Inbar MJ
- Inokuchi K
- Iwata H
- Jack W
- Jackisch C
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen M-B
- Jensen MB
- Joensuu H
- Johansson U
- Jonat W
- Jones SE
- Julien JP
- Jung KH
- Jänicke F
- Karlsson P
- Karpov A
- Kaufmann M
- Kaufmann M
- Kay RG
- Kerbrat P
- Kerr A
- Kikuchi K
- Kikuchi K
- Kilburn L
- Killander F
- Klefstrom P
- Klijn JGM
- Kohno N
- Koliou G-A
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscienly S
- Koyama H
- Kreienberg R
- Krushen-Kosloski JL
- Kunkler I
- Kwong DLW
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
- Leonard CF
- Leone B
- Lesec'h JM
- Lester J
- Levine MN
- Liedtke C
- Liefers GJ
- Linderholm BK
- Lindman H
- Lindsay MA
- Lindtner A
- Lindtner J
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart HA
- Lofgren L
- Lohrisch C
- Loib S
- Lopez M
- Love RR
- Lumachi F
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- Rea D
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- Rodenhuis S
- Rojo R
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle GT
- Rubagotti A
- Rubens RD
- Rubino C
- Rudenstam CM
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- Ryden L
- Saarto T
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- Safra T
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- Sakai K
- Salmon RJ
- Sandelin K
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- Schauer A
- Schem C
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Schumacher M
- Segui MA
- Seifert M
- Senanayake F
- Senn HJ
- Senn HJ
- Serra C
- Sestak I
- Sestak I
- Sevelda P
- Shan Y
- Shao YF
- Shapiro CL
- Shepherd LE
- Shien T
- Simmonds PD
- Singer CF
- Skilton D
- Skolyszewski J
- Skoog L
- Sledge G
- Smith DC
- Soderberg M
- Sohn HC
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- Solarnau L
- Solin LJ
- Solomayer E
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- Sonoo H
- Sparano JA
- Spittle M
- Spooner D
- Stallard S
- Steger GG
- Stewart HJ
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- Sugimachi K
- Sundqvist M
- Svane G
- Swindell R
- Takao S
- Takei H
- Taylor C
- Thomssen C
- Thuerlimann B
- Thurlimann B
- Tinterri C
- Tobias JS
- Toi M
- Tominaga T
- Tormey DC
- Trampisch HJ
- Treurniet-Donker AD
- Trialists GROCTA
- Tu D
- Tulusan AH
- Uchino J
- Untch M
- Untch M
- Vakaet L
- Valagussa P
- Valagussa P
- Valentini M
- Vallejo CT
- van de Velde AO
- van de Velde CJH
- van de Velde CJH
- van de Velde CJH
- Van den Bogaert W
- van Dongen JA
- van Putten WLJ
- van Tinteren H
- Veloso E
- Vermorken JB
- Veronesi U
- Viale G
- Vidal S
- Vilcoq JR
- von Minckwitz G
- Wadstrom C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Warnberg F
- Weiss RB
- Werner ID
- Whelan T
- Wilcken N
- Williams L
- Winer E
- Winter MC
- Wittes R
- Wood W
- Yamashita J
- Yarnold JR
- Yosef HMA
- Yoshida M
- Yoshimoto M
- Zavagno G
- Zhao DB
- Zielinski CC
- Zwenger A
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background
Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials.
Methods
We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality).
Findings
Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5–14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4–8·6]; rate ratio 1·37 [95% CI 1·17–1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92–1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95–1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94–1·15]; p=0·45).
Interpretation
Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered—eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Author
- Abdukahil Sheryl Ann
- Abdukahil Sheryl,
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abreu Julia,
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adrião Diana
- Ainscough Kate
- Akimoto Takako
- Al Qasim Eman
- Al-Dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Alidjnou Kazali Enagnon
- Alidjnou Kazali,
- Aliudin Jeffrey
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves Rita
- Amaral Maria
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- ANGOULVANT François
- Ansart Séverine
- Antonelli Massimo
- Arabi Yaseen
- Aragao Irene
- Arcadipane Antonio
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Artaud-Macari Elise
- Asensio Angel
- Assie Jean Baptiste
- Assie Jean,
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Azemar Laurène
- Azoulay Cécile
- Bach Benjamin
- Bachelet Delphine
- Baillie J. Kenneth,
- Bak Erica
- Bakakos Agamemnon
- Banisadr Firouzé
- Barbalho Renata
- Barclay Wendy,
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Basmaci Romain
- Bassi Gianluigi Li
- Bassi Gianluigi,
- Bedossa Alexandra
- Behilill Sylvie
- Bekken Gry Kloumann
- Bekken Gry,
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bhavsar Krishna
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Blanco-Schweizer Pablo
- Blot Mathieu
- Boccia Filomena
- Bogaert Debby
- Bompart François
- Booth Gareth
- Borges Diogo
- Borie Raphaël
- Bos Jeannet
- Bosse Hans Martin
- Bosse Hans,
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camille
- Boureau Anne-Sophie
- Bouscambert Maude
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brozzi Nicolas
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Bustos Ingrid,
- Butnaru Denis
- Cabie André
- Cabral Susana
- Caceres Eder
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Calvache Jose,
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carney Gayle
- Carpenter Chloe
- Carret Marie-Christine
- Carrier François Martin
- Carrier François,
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavalli Giulio,
- Cavayas Alexandros
- Ceccato Adrian
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chas Julie
- Chassin Camille
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheng Matthew,
- Cheret Antoine
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Hwa,
- Cho Sung Min
- Cho Sung,
- Choez Xavier Sánchez
- Choez Xavier,
- Choileain Orna Ni
- Choileain Orna,
- Cholley Bernard
- Cidade Jose Pedro
- Cidade Jose,
- Citarella Barbara Wanjiru
- Citarella Barbara,
- Ciullo Anna
- Clarke Jennifer
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Colombo Sebastiano,
- Combs Pamela
- Connelly J.,
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Cooke Graham,
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cormican Sarah
- Cornelis Sabine
- Corpuz Arianne Joy
- Corpuz Arianne,
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cucino Alberto
- Cullen Caroline
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curto Elena Gallego
- Curto Elena,
- Custodio Paula
- Cárcel Sheila
- Da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew,
- Dalton Heidi
- Dalton Jo
- Daneman Nick
- Dankwa Emmanuelle,
- Dantas Jorge
- De Araújo Mariz Carolline
- De Brito Carlos Alexandre Antunes
- De Brito Carlos,
- De Castro Nathalie
- De Mendoza Diego
- De Oliveira França Rafael Freitas
- De Oliveira França Rafael,
- De Rosa Rosanna
- De Silva Thushan
- De Vries Peter
- Dean David
- Debray Marie-Pierre
- Dechert William
- Deconninck Lauren
- Decours Romain
- Delacroix Isabelle
- Delavigne Karen
- Deligiannis Ionna
- Dell’amore Andrea
- Delobel Pierre
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Devouge Eglantine,
- Dewayanti Santi Rahayu
- Dewayanti Santi,
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose Diaz
- Diaz Juan,
- DIAZ Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie,
- Dominguez Carmen Infante
- Dominguez Carmen,
- Dong Andy
- Donnelly Christl,
- Donnelly Maria
- Donohue Chloe
- Dorival Céline
- Douglas James Joshua
- Douglas James,
- Douma Renee
- Dournon Nathalie
- Downer Triona
- Downing Mark
- Drake Tom
- Dubee Vincent
- DUBOS François
- Ducancelle Alexandra
- Dudman Susanne
- Dunning Jake
- Duranti Silvia
- Durham Lucian
- Dussol Bertrand
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Dyrhol-Riise Anne,
- D’aragon Frédérick
- D’Orleans Charles Crepy
- D’orleans Charles,
- D’Ortenzio Eric
- Eid Charbel Maroun
- Eid Charbel,
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Elkheir Natalie
- Ellerbroek Jacobien
- Ellis Rachael
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Everding Anna,
- Evers Mirjam
- Fabre Isabelle
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron,
- Faria Pedro
- Farshait Nataly
- Fatoni Arie Zainul
- Fatoni Arie,
- Faure Karine
- Fayed Mohamed
- Feely Niamh
- Fernandes Jorge
- Fernandes Marília
- Fernandes Susana
- Ferraz Mário
- Ferreira Benigno
- Ferrer-Roca Ricard
- Ferrão Joana
- Figueiredo-Mello Claudia
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Florio Letizia,
- Foley Claire
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Claudio,
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foti Giuseppe
- Fourn Erwan
- Fowler Rob
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Freire Marcela Vieira
- Freire Marcela,
- Friedrich Caren
- Fry Stéphane
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gachet Benoît
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- GarcÍa Ruth Noemí Jorge
- García Ruth,
- Garot Denis
- Garrait Valérie
- Gault Nathalie
- Gavin Aisling
- Gaymard Alexandre
- Gebauer Johannes
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Giaquinto Carlo
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gorenne Isabelle
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Grandin Edward,
- Granier Pascal
- Grasselli Giacomo
- Green Christopher,
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Grieco Domenico,
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haber Daniel
- Hakak Sheeba
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Hardwick Hayley
- Harley Kristen
- Harrison Ewen,
- Harrison Janet
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez-Montfort Jaime
- Herreros Jose Miguel Cisneros
- Herreros Jose,
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Hinton Samuel
- Hipólito-Reis Ana
- Hiraiwa Hiroaki
- Hiscox Julian,
- Ho Antonia Ying Wai
- Ho Antonia,
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holten Aleksander,
- Holter Jan Cato
- Holter Jan,
- Horby Peter
- Horcajada Juan Pablo
- Horcajada Juan,
- Hoshino Koji
- Hoshino Kota
- Hough Catherine,
- Hssain Ali Ait
- Hssain Ali,
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Humaid Felwa,
- Ijaz Samreen
- Illes Hajnal-Gabriela
- Inácio Hugo
- Iosifidis Elias
- Irvine Lacey
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaureguiberry Stéphane
- Javidfar Jeffrey
- Jean-Benoît Zabbe
- Jego Florence
- Jenum Synne
- Jimenez Juan Fernado Masa
- Jimenez Juan,
- Johal Simreen Kaur
- Johal Simreen,
- Joseph Cédric
- Joseph Mark
- Jouvet Philippe
- Jung Hanna
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandamby Darshana,
- Kandel Chris
- Kant Ravi
- Kartsonaki Christiana
- Kasugai Daisuke
- Katz Kevin
- Keating Sean
- Kelly Andrea
- Kelly Sadie
- Kennedy Lisa
- Kennon Kalynn
- Kerroumi Younes
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kho Michelle,
- Khoo Saye
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kildal Anders,
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Knight Stephen
- Kobbe Robin
- Korten Volkan
- Kosgei Caroline
- Krawczyk Karolina
- KUMAR Deepali
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kyriakoulis Konstantinos
- LACHATRE Marie
- Lacoste Marie
- Laffey John,
- Lagrange Marie
- Laine Fabrice
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Lantang Eka Yudha
- Lantang Eka,
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Launay Odile
- Lavie-Badie Yoan
- Law Andrew
- Le Bihan Clément
- Le Bris Cyril
- Le Coustumier Eve
- Le Falher Georges
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Van Tan
- Le Minh
- Leal Ema
- Lee James
- Lee Su Hwan
- Lee Su,
- Lee Todd
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefevre Benjamin
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemmink Gretchen
- Leone Michela
- Lepiller Quentin
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- León Rafael
- Liang Janet
- Lim Wei Shen
- Lim Wei,
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lopez-Colon Dalia
- Lordemann Anja Grosse
- Lordemann Anja,
- Loubet Paul
- Lucet Jean Christophe
- Lucet Jean,
- Luna Carlos,
- Lungu Olguta
- Luong Liem
- Luton Dominique
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Macdonald Sarah
- Machado Moïse
- Macheda Gabrielle
- Madhok Jai
- Mahieu Rafael
- Mahy Sophie
- Maier Lars Siegfrid
- Maier Lars,
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Maldonado Hugo Miranda
- Maldonado Hugo,
- Malfertheiner Maximilian
- Malik Nadia
- Maltez Fernando
- Malvy Denis
- MAMBERT Marina
- Manda Victoria
- Mandei Jose,
- Mangoni Emanuele Durante
- Mangoni Emanuele,
- Manning Edmund
- Manuel Aldric
- Marino Flávio
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshall John
- Martelli Celina Turchi
- Martelli Celina,
- Martin Dori-Ann
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martin-Quiros Alejandro
- Martinot Martin
- Martins Ana
- Martins João
- Martucci Gennaro
- Marwali Eva Miranda
- Marwali Eva,
- Maslove David
- Mason Sabina
- Matan Moshe
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Mc Evoy Natalie
- Mccarthy Aine
- Mccloskey Colin
- Mcconnochie Rachael
- Mcdermott Sherry
- McDonald Sarah
- Mcelwee Samuel
- Mcevoy Natalie
- McGeer Allison
- Mcguinness Niki
- Mclean Kenneth,
- Mcnicholas Bairbre
- Meaney Edel
- Mear-Passard Cécile
- Mechlin Maggie
- Mele Ferruccio
- Menon Kusum
- Mentré France
- Mentzer Alexander,
- Mercier Noémie
- Merckx Antoine
- Mergler Blake
- Merson Laura
- Mesquita António
- Meybeck Agnès
- Meynert Alison,
- Meyssonnier Vanina
- Meziane Amina
- Mezidi Medhi
- Michelanglei Céline
- Mihnovitš Vladislav
- Mohammed Nassima Si
- Mohammed Nassima,
- Moin Asma
- Molina David
- Molinos Elena
- Mone Mary
- Monteiro Agostinho
- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona,
- Morales-Cely Lina
- Morlaes Louis Gerbaud
- Morlaes Louis,
- Moro Lucia
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- Yazdanpanah Yazdan
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- Yokoyama Toshiki
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- Young Paul
- Yuliarto Saptadi
- Zabbe Marion
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- Zawadka Konrad
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Yang Le
- Yang Y. -C.
- Yang Yang
- Yang Yi
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- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
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- Andersen R.
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- Andrea Prodi Giovanni
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- Andrés-Carcasona Marc
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- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
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- Zevin Michael
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- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
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- MASCIOLI ADRIANO. FRATTALE.
- Massaro L.
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- MORALES ESTER. RUIZ.
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- Moraru D.
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- More Anupreeta
- More Surhud
- Moreno Claudia
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- Mérou Joan-René
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
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