41 research outputs found
Vernetzte hybride Modellierung wasserbaulicher und morphologischer Themen am Alpenrhein
Aufsatz veröffentlicht in: "Wasserbau-Symposium 2021: Wasserbau in Zeiten von Energiewende, Gewässerschutz und Klimawandel, Zurich, Switzerland, September 15-17, 2021, Band 2" veröffentlicht unter: https://doi.org/10.3929/ethz-b-00049975
Discussion of "Skimming, Nonaerated Flow on Stepped Spillways over Roller Compacted Concrete Dams" by Ines Meireles, Floriana Renna, Jorge Matos, and Fabian Bombardelli
The nonaerated region may occupy a large portion of the skimming flow in steep, stepped spillways, particularly for relatively high unit flow rates. In spite of the numerous contributions on the hydraulic properties at both the inception point of air entrainment and the aerated region, much less is known regarding the flow in the nonaerated region. In this paper, new empirical evidence, based on an extensive data set obtained during several years in a large-scale facility, sheds light on the features of the nonaerated-flow region. Diverse ways to locate and estimate the main hydraulic properties at the inception point are first discussed and compared. Then, expressions capable of characterizing the main flow variables along the nonaerated region are presented, namely, the boundary-layer development, the velocity distribution, the equivalent clear-water depth, the characteristic depth taking into account the free-surface unsteadiness due to turbulence, and the energy dissipation. The energy dissipation is observed to be larger than that for smooth spillways, although much smaller than values typically reported for aerated flows at the toe of stepped spillways
Trajectories and air flow features of ski jump-generated jets
Ski jumps are frequently applied as spillways of high dams. The resulting jet impact location on the plunge pool surface is often distant from the dam toe so that the latter is protected from scouring. Furthermore, the jet disintegrates and disperses prior to its impact, thereby reducing the specific energy addition to the plunge pool. The present research addresses four aspects, based on three physical modelling campaigns: (1) geometry of upper and lower jet trajectories; (2) virtual jet take-off angles for the trajectory computations; (3) average and minimum cross-sectional air concentrations along the jet; and (4) general jet air concentration profiles. It is shown that the trajectory parabola may also be applied for negative jet take-off angles, and that these are smaller than the bucket angle. As for the air concentration distribution along the jet, tests indicate that the latter depends exclusively on the relative jet black-water core length
A Simplified Classification of the Relative Tsunami Potential in Swiss Perialpine Lakes Caused by Subaqueous and Subaerial Mass-Movements
Historical reports and recent studies have shown that tsunamis can also occur in lakes where they may cause large damages and casualties. Among the historical reports are many tsunamis in Swiss lakes that have been triggered both by subaerial and subaqueous mass movements (SAEMM and SAQMM). In this study, we present a simplified classification of lakes with respect to their relative tsunami potential. The classification uses basic topographic, bathymetric, and seismologic input parameters to assess the relative tsunami potential on the 28 Swiss alpine and perialpine lakes with a surface area >1km2. The investigated lakes are located in the three main regions “Alps,” “Swiss Plateau,” and “Jura Mountains.” The input parameters are normalized by their range and a k-means algorithm is used to classify the lakes according to their main expected tsunami source. Results indicate that lakes located within the Alps show generally a higher potential for SAEMM and SAQMM, due to the often steep surrounding rock-walls, and the fjord-type topography of the lake basins with a high amount of lateral slopes with inclinations favoring instabilities. In contrast, the missing steep walls surrounding lakeshores of the “Swiss Plateau” and “Jura Mountains” lakes result in a lower potential for SAEMM but favor inundation caused by potential tsunamis in these lakes. The results of this study may serve as a starting point for more detailed investigations, considering field data
Gefahrenabschätzung von durch Unterwasserhangrutschungen ausgelösten Tsunamis in Seen
Aufsatz veröffentlicht in: "Wasserbau-Symposium 2021: Wasserbau in Zeiten von Energiewende, Gewässerschutz und Klimawandel, Zurich, Switzerland, September 15-17, 2021, Band 1" veröffentlicht unter: https://doi.org/10.3929/ethz-b-00049975
Hochwasserschutz Sihl, Zürichsee, Limmat - Einlaufbauwerk Entlastungsstollen Thalwil
Aufsatz veröffentlicht in: "Wasserbau-Symposium 2021: Wasserbau in Zeiten von Energiewende, Gewässerschutz und Klimawandel, Zurich, Switzerland, September 15-17, 2021, Band 2" veröffentlicht unter: https://doi.org/10.3929/ethz-b-00049975
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells
Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). How foreign lipid antigens are delivered to APCs remains elusive. Since lipoproteins routinely bind glycosylceramides structurally similar to lipid antigens, we hypothesized that circulating lipoproteins form complexes with foreign lipid antigens. In this study, we used 2-color fluorescence correlation spectroscopy to show, for the first time to our knowledge, stable complex formation of lipid antigens α-galactosylceramide (αGalCer), isoglobotrihexosylceramide, and OCH, a sphingosine-truncated analog of αGalCer, with VLDL and/or LDL in vitro and in vivo. We demonstrate LDL receptor–mediated (LDLR-mediated) uptake of lipoprotein-αGalCer complexes by APCs, leading to potent complex-mediated activation of iNKT cells in vitro and in vivo. Finally, LDLR-mutant PBMCs of patients with familial hypercholesterolemia showed impaired activation and proliferation of iNKT cells upon stimulation, underscoring the relevance of lipoproteins as a lipid antigen delivery system in humans. Taken together, circulating lipoproteins form complexes with lipid antigens to facilitate their transport and uptake by APCs, leading to enhanced iNKT cell activation. This study thereby reveals a potentially novel mechanism of lipid antigen delivery to APCs and provides further insight into the immunological capacities of circulating lipoproteins
Mobility, Balance and Falls in Persons with Multiple Sclerosis
BACKGROUND: There is a lack of information concerning the relation between objective measures of gait and balance and fall history in persons with MS (PwMS). This investigation assessed the relation between demographic, clinical, mobility and balance metrics and falls history in persons with multiple sclerosis (MS). METHODS: 52 ambulatory persons with MS (PwMS) participated in the investigation. All persons provided demographic information including fall history over the last 12 months. Disease status was assessed with Expanded Disability Status Scale (EDSS). Walking speed, coordination, endurance and postural control were quantified with a multidimensional mobility battery. RESULTS: Over 51% of the participants fell in the previous year with 79% of these people being suffering recurrent falls. Overall, fallers were older, had a greater prevalence of assistive devices use, worse disability, decreased walking endurance, and greater postural sway velocity with eyes closed compared to non-fallers. Additionally, fallers had greater impairment in cerebellar, sensory, pyramidal, and bladder/bowel subscales of the EDSS. CONCLUSIONS: The current observations suggest that PwMS who are older, more disabled, utilize an assistive device, have decreased walking coordination and endurance and have diminished balance have fallen in the previous year. This suggests that individuals who meet these criteria need to be carefully monitored for future falls. Future research is needed to determine a prospective model of falls specific to PwMS. Additionally, the utility of interventions aimed at reducing falls and fall risk in PwMS needs to be established
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Vernetzte hybride Modellierung wasserbaulicher und morphologischer Themen am Alpenrhein
ISSN:0374-005