Tick-borne viruses and biological processes at the tick-host-virus interface

Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses some of which cause serious diseases in humans and animals world-wide. Several TBV impacting human or domesticated animal health have been found to emerge or re-emerge recently. In order to survive in nature, TBV must infect and replicate in both vertebrate and tick cells, representing very different physiological environments. Information on molecular mechanisms that allow TBV to switch between infecting and replicating in tick and vertebrate cells is scarce. In general, ticks succeed in completing their blood meal thanks to a plethora of biologically active molecules in their saliva that counteract and modulate different arms of the host defense responses (haemostasis, inflammation, innate and acquired immunity, and wound healing). The transmission of TBV occurs primarily during tick feeding and is a complex process, known to be promoted by tick saliva constituents. However, the underlying molecular mechanisms of TBV transmission are poorly understood. Immunomodulatory properties of tick saliva helping overcome the first line of defense to injury and early interactions at the tick-host skin interface appear to be essential in successful TBV transmission and infection of susceptible vertebrate hosts. The local host skin site of tick attachment, modulated by tick saliva, is an important focus of virus replication. Immunomodulation of the tick attachment site also promotes co-feeding transmission of viruses from infected to non-infected ticks in the absence of host viraemia (non-viraemic transmission). Future research should be aimed at identification of the key tick salivary molecules promoting virus transmission, and a molecular description of tick-host-virus interactions and of tick-mediated skin immunomodulation. Such insights will enable the rationale design of anti-tick vaccines that protect against disease caused by tick-borne viruses

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Vampires in the village Žrnovo on the island of Korčula: following an archival document from the 18th century

Središnja tema rada usmjerena je na raščlambu spisa pohranjenog u Državnom arhivu u Mlecima (fond: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) koji se odnosi na događaj iz 1748. godine u korčulanskom selu Žrnovo, kada su mještani – vjerujući da su se pojavili vampiri – oskvrnuli nekoliko mjesnih grobova. U radu se podrobno iznose osnovni podaci iz spisa te rečeni događaj analizira u širem društvenom kontekstu i prate se lokalna vjerovanja.The main interest of this essay is the analysis of the document from the State Archive in Venice (file: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) which is connected with the episode from 1748 when the inhabitants of the village Žrnove on the island of Korčula in Croatia opened tombs on the local cemetery in the fear of the vampires treating. This essay try to show some social circumstances connected with this event as well as a local vernacular tradition concerning superstitions

Surveillance of radicals in the United States, 1917-1941.

Bib 24982

New England women and their families in the 18th and 19th centuries [microform] : personal papers, letters and diaries.

Accompanied by a printed guide compiled by Randolph Boehm. Ser. A. Manuscript collections from the American Antiquarian Society. pt. 1. Selected New England collections (33 reels). pt. 2. The Dewey-Bliss family collection (17 reels). pt. 3. Main and Massachusetts collections (16 reels) -- Ser. B. Manuscript collections from the Newport Historical Society. pt. 1. William and Robinson collections (22 reels). pt. 2. Selected collections (44 reels) -- Ser. C. Manuscript collections from the Rhode Island Historical Society. pt. 1. Selected collections (26 reels). Bib 114250

A Guide to nuclear energy : basic documents on technological, economic, environmental, and legal issues, 1945-1979 / edited by Mark Fox, Randolph Boehm.

"A microfilm project of University Publications of America, inc." Contains indexes. Bib 15471

Minutes of the Executive Council of the American Federation of Labor

Microfilmed from the holdings of the George Meany Memorial Archives. Guide compiled by Randolph H. Boehm

Guide to the microfilm edition of The Black power movement. Part 4, The League of Revolutionary Black Workers, 1965-1976

Bib id: 4288367 "Black studies research sources."; "Microfilmed from the personal collection of General Gordon Baker, Jr., one of the lead figures in the League of Revolutionary Black Workers.

Records of the American Committee on Africa

Bib id: 789882 "Black studies research sources."; "Pt. 1. ACOA Executive Committee minutes and National Office memoranda, 1952-1975 -- Pt. 2. Correspondence and subject files on South Africa, 1953-1985.

Amiri Baraka, from Black arts to Black radicalism

Bib id: 3846470 "Black studies research sources.