Copper(II) complexes of quinoline polyazamacrocyclic scorpiand-type ligands: X-ray, equilibrium and kinetic studies

The formation of Cu(II) complexes with two isomeric quinoline-containing scorpiand-type ligands has been studied. The ligands have a tetraazapyridinophane core appended with an ethylamino tail including 2-quinoline (L1) or 4-quinoline (L2) functionalities. Potentiometric studies indicate the formation of stable CuL2+ species with both ligands, the L1 complex being 3–4 log units more stable than the L2 complex. The crystal structure of [Cu(L1)](ClO4)2·H2O shows that the coordination geometry around the Cu2+ ions is distorted octahedral with significant axial elongation; the four Cu–N distances in the equatorial plane vary from 1.976 to 2.183 Å, while the axial distances are of 2.276 and 2.309 Å. The lower stability of the CuL22+ complex and its capability of forming protonated and hydroxo complexes suggest a penta-dentate coordination of the ligand, in agreement with the type of substitution at the quinoline ring. Kinetic studies on complex formation can be interpreted by considering that initial coordination of L1 and L2 takes place through the nitrogen atom in the quinoline ring. This is followed by coordination of the remaining nitrogen atoms, in a process that is faster in the L1 complex probably because substitution at the quinoline ring facilitates the reorganization. Kinetic studies on complex decomposition provide clear evidence on the occurrence of the molecular motion typical of scorpiands in the case of the L2 complex, for which decomposition starts with a very fast process (sub-millisecond timescale) that involves a shift in the absorption band from 643 to 690 nm

Estrategias para una dirección y supervisión eficaz de los trabajos de Fin de Grado y Fin de Master pertenecientes al Área de Derecho del Trabajo

La norma define el objetivo que ha de cumplir un Trabajo de Fin de Grado o de Fin de Master (TFG/TFM) señalando qué debe el alumno demostrar en él las competencias adquiridas a lo largo de todo el programa formativo y el nivel de aprendizaje alcanzado, pero nada dice acerca de la estrategia a seguir por el tutor del trabajo (PDI) para orientar al alumno en su elaboración. A partir de la experiencia vivida en el Área y de los problemas detectados hasta el momento, el trabajo pretende ofrecer una propuesta metodológica acerca del rol que el docente ha de cumplir, intentando delimitar cuáles son sus funciones, cómo debe enfocarse la autorización y qué puede exigirse al alumno

Características Sociodemográficas de las personas con conducta acumuladora/trastorno por acumulación (S. de Diógenes) en la ciudad de Madrid. Serie de casos.

Motivos. El trastorno de conducta poracumulación origina significativos riesgos para la saluddel acumulador y para la Salud Pública, problemas deconvivencia en el entorno familiar y vecinal y amenazaspara la seguridad motivada por el riesgo de incendios.Finalidad. El presente estudio tiene como objetivodescribir las características sociodemográficas de losacumuladores en la ciudad de Madrid.Método. Fueron seleccionados 295 casos de las 1147solicitudes de intervención por posibles situaciones deinsalubridad que entraron desde el 1 de enero de 2009al 31 de diciembre de 2012 a la Unidad Técnica deEntorno Urbano y Vivienda de Madrid Salud. Los casoscumplían todos o alguno de los criterios diagnósticosdel acumulador patológico descritos por Randy OFrost et al en 1993(1).Datos. Los acumuladores tienen una edad media de64.77 años, son hombres en el 55.9% de los casos y el47% son mayores de 65 años. Son españoles el 95.6%,y pensionistas 65.1%. En 129 casos se retiraron un total de 260.346 kgrs de basura y enseres.Conclusiones. El trastorno por acumulación, aunquepoco frecuente, provoca un grave problema a la personaque lo sufre, un riesgo para la Salud Pública y parala seguridad y un alto coste por la elevada cantidad derecursos que consume su atención y resolución.Nuestro trabajo añade argumentos para considerar eltrastorno de acumulación como una entidad independientecomo ya se clasifica en la DSM-5 de mayo de 2013

Planeamiento estratégico para la empresa Igardi Herramientas S.A.

El Perú mantiene hace algunos años una política económica que favorece el desarrollo del sector industrial, impulsando la inversión en los diferentes sectores empresariales que participan en la economía peruana. El segmento industrial al que pertenece Igardi Herramientas S.A., está evolucionando de manera positiva en los últimos años, lo que representa una excelente oportunidad para la comercialización de equipos y herramientas que mantiene en su portafolio. Se deben resaltar los proyectos de inversión actuales y a futuro en algunos segmentos de la industria como, Minería, Pesca y Energía donde Igardi participa activamente y donde debe reforzar su impacto en base al presente trabajo de investigación. Igardi Herramientas nace hace 65años como un emprendimiento familiar en busca de generar ingresos y participar en el mercado de herramientas en Lima, logrando alcanzar resultados favorables y posicionando a la empresa en un lugar privilegiado dentro del segmento en el que participa. El presente trabajo es un plan estratégico que busca mejorar la posición comercial y financiera de Igardi Herramientas S.A. con miras al 2030, con la finalidad de alcanzar la visión plantada por la compañía, se determinaron las estrategias generales y los objetivos a largo y corto plazo que ayudaran en el cumplimiento de dicha visión, los cuales están considerados en el tablero de control balanceado para realizar el seguimiento y control respectivo. Finalmente se plantean conclusiones y recomendaciones para la correcta ejecución del plan estratégico planteado.Peru has maintained for some years an economic policy that favors the development of the industrial sector, promoting investment in the different business sectors that take part in the Peruvian economy. The industrial sector to which Igardi Herramientas S.A. belongs has been evolving in a positive way during the last years, providing an excellent opportunity to commercialize the equipment and tools in its portfolio. It is worth highlighting current and future investment projects in some sectors of the industry such as Mining, Fishing and Energy where Igardi actively participates and where its impact must be reinforced based on this research paper. Igardi Herramientas S.A. was created 65 years ago as a family business with the aim to generate income and participate in the tool market of Lima, achieving favorable results and positioning the company in a privileged place in its sector. This paper is a strategic plan that seeks to improve the commercial and financial position of Igardi Herramientas S.A. for 2030. In order to achieve the vision established by the company, the general strategies and the long and short term objectives were defined to contribute to the fulfillment of this vision. These are considered in the balanced control panel to perform the respective monitoring and control. Finally, conclusions and recommendations are set forth for the correct execution of the strategic plan proposed.Tesi

Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure

The synthetic vitamin D3 analogue paricalcitol acts as a selective activator of the vitamin D receptor (VDR). While there is evidence for cardioprotective effects of paricalcitol associated with the VDR pathway, less information is available about the structural and functional cardiac effects of paricalcitol on established heart failure (HF) and particularly its effects on associated electrophysiological or Ca2+ handling remodelling. EXPERIMENTAL APPROACH: We used a murine model of transverse aortic constriction (TAC) to study the effect of paricalcitol on established HF. Treatment was initiated 4 weeks after surgery over five consecutive weeks, and mice were sacrificed 9 weeks after surgery. Cardiac MRI (CMRI) was performed 4 and 9 weeks after surgery. Hearts were used for biochemical and histological studies and to isolate ventricular myocytes for electrophysiological and calcium imaging studies. KEY RESULTS: CMRI analysis revealed that, compared with vehicle, paricalcitol treatment prevented the progression of ventricular dilation and hypertrophy after TAC and halted the corresponding decline in ejection fraction. These beneficial effects were related to the attenuation of intracellular Ca2+ mishandling remodelling, antifibrotic and antihypertrophic effects and potentially antiarrhythmic effects by preventing the reduction of K+ current density and the long QT, JT and TpTe intervals observed in HF animals. CONCLUSION AND IMPLICATIONS: The results suggest that paricalcitol treatment in established HF hampers disease progression and improves adverse electrophysiological and Ca2+ handling remodelling, attenuating the vulnerability to HF-associated ventricular arrhythmias. Paricalcitol may emerge as a potential therapeutic option in the treatment of HFThis work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2014- 57190R, SAF2017-84777-R), ISCIII (PI17/01093 and PI17/01344), European Regional Development Fund (FEDER), Sociedad Española de Cardiología (SEC), and CIBER-CV, a network funded by ISCIII. MF-V is a Miguel Servet II researcher of ISCIII (MSII16/00047 Carlos III Health Institute). GR-H is a Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). MT is a predoctoral fellow of the Spanish Ministry of Science, Innovation and Universities (FPU-17/06135

Evaluation of a Novel Αb Εxterno MicroShunt for the Treatment of Glaucoma

The surgical management of glaucoma has been revolutionized by the introduction of minimally invasive glaucoma surgery (MIGS). The various MIGS options aim to meaningfully lower intraocular pressure with a better safety profile than traditional glaucoma surgery. The key clinical attributes and the emerging potential of an ab externo MicroShunt (PreserFlo™) are reviewed in the context of published evidence and clinical experience. This novel MicroShunt consists of an 8.5-mm-long tube that is implanted in the eye via an ab externo approach enabling aqueous humor drainage into the sub-Tenon's space through the formation of a bleb, similar in appearance to that created by trabeculectomy. The efficacy and safety of this procedure, the concomitant use of antimetabolites, the impact of tube positioning, and its future value in clinical practice are critically reviewed. Recent evidence has demonstrated the MicroShunt to be less effective than traditional filtration surgery, but with a significant improvement in safety. Cumulative data suggest that the new implant provides tangible clinical benefits to selected patients with glaucoma in need of further intraocular pressure (IOP) lowering. Future research should delineate the precise role of this and other MIGS options in the rapidly evolving glaucoma treatment algorithm.Unidad Docente de Inmunología, Oftalmología y ORLDepto. de Inmunología, Oftalmología y ORLFac. de Óptica y OptometríaFac. de MedicinaTRUEpu

Actualización de nuevas técnicas de vendaje neuromuscular en podología

El concepto de kinesiology taping, o vendaje neuromuscular, ha llegado a incrementarse de manera popular en la última década. En Podología es una técnica interesante, como una alternativa más dentro del arsenal terapéutico de la patología del pie, considerando interesante su combinación con otras terapias. La finalidad y utilidad del vendaje neuromuscular están ya evaluadas y han sido objeto de muchos trabajos científicos. Con el presente trabajo queremos reparar y profundizar en el conjunto de técnicas que se utilizan, recopilándolas en las patologías más importantes del pie, como son el síndrome de predislocación (articulación metatarsofalángica), neuroma de Morton, metatarsalgia, hallux valgus, fascitis plantar, dedo en garra y esguince de tobillo, describiendo nuevos tratamientos y activando un enfoque más actualizado

Modulation of telomere protection by the PI3K/AKT pathway

Telomeres and the insulin/PI3K pathway are considered hallmarks of aging and cancer. Here, we describe a role for PI3K/AKT in the regulation of TRF1, an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1 telomeric foci and lead to increased telomeric DNA damage and fragility. We identify the PI3Kα isoform as responsible for this TRF1 inhibition. TRF1 is phosphorylated at different residues by AKT and these modifications regulate TRF1 protein stability and TRF1 binding to telomeric DNA in vitro and are important for in vivo TRF1 telomere location and cell viability. Patient-derived breast cancer PDX mouse models that effectively respond to a PI3Kα specific inhibitor, BYL719, show decreased TRF1 levels and increased DNA damage. These findings functionally connect two of the major pathways for cancer and aging, telomeres and the PI3K pathway, and pinpoint PI3K and AKT as novel targets for chemical modulation of telomere protection.We are indebted to D. Megias for microscopy analysis, to D. Calvo for protein purification as well as to J. Muñoz and F. García for LC/MS/MS analysis. The research was funded by project SAF2013-45111-R of Societal Changes Program of the Spanish Ministry of Economics and Competitiveness (MINECO) co-financed through the European Fund of Regional Development (FEDER), Fundación Botín, Banco Santander (Santander Universities Global Division) and Worldwide Cancer Research (WCR 16-1177).S