Tidal Power Optimization Using Two Bladder System

The kinetic and potential components of tidal energy can be utilized to generate electricity.The system discussed in the paper utilizes a head difference in generating electricity.This thesis presents the research work on the optimization of the nozzle, which will be used in a Closed Tidal Energy Conversion System for generating electricity. For this purpose, the relatively small-scale numerical simulation of the flow through the nozzle with 10 inches inlet diameter was executed using a computational fluid dynamics software, ANSYS. The inlet diameter and the length of the nozzle were kept constant, and the outlet diameters used are 7.5 inches, 6 inches, 5.75 inches, 5 inches, 4 inches, and 3 inches. The results showed that the nozzle with 10 inches outlet diameter and 5.75 inches inlet diameter set forth the desired velocity of this system, i.e., approximately 10 m/s. Also, it is assumed that the system holds the static pressure. The simulation of varying outlet pressure for the nozzle with 10 inches inlet diameter and 5.75 inches outlet diameter shows that the static pressure difference remains constant to obtain the same velocity. Again, mesh sensitivity analysis performed for the nozzle with 5.75 inches outlet diameter showed that the results between the fine mesh and the coarse mesh varies by 3%. Furthermore, it also includes the case study for Saint Augustine, where the size and number of bladders required for a closed system to meet energy demand for a small size population have been analyzed. The study suggests that ten bladders of size are required for generating 15 MW power to meet the demand of a small population size of approximately 14,000

Clinico-Pathological Evaluation of Palpable Breast Lump: Hospital Based Prospective Study

Introduction: Breast lump remains a common complaint of females attending a surgical outpatient department. Different types of lesions ranging from inflammation to carcinoma can be presented as a breast lump. A definitive diagnosis of breast lump must be made by histopathological examination. In case of breast cancer, an early and accurate diagnosis can save the patient from metastases and may thus reduce mortality and morbidity. Aim & Objective: The objective of the present study is to evaluate the clinical profile of patients who has palpable breast lumps and a wide range of breast diseases in palpable breast lumps. Histopathology was performed on these breast lumps. In addition to histopathology, clinico - pathological correlation was also done. Material and Methods: A prospective observational study was conducted for one year in the Department of Pathology, Vivekananda Polyclinic & Institute of Medical Sciences (VPIMS), Lucknow. All patients with discrete breast lumps have undergone a triple assessment to make an early diagnosis. Surgical resection specimen includes lumpectomy and mastectomy. They were received, processed, reported and recorded in the Pathology laboratory and the data was collected and analysed. Result: All the cases had a unilateral side of the breast lump and most of the cases had a breast lump on the right side. The majority had lesion size between 2-5 cm, firm consistency, single lump/mass, spread in the outer quadrant. The clinical diagnosis was benign in 19 cases (45.2%) and malignant/suspected of malignancy in 23 cases (54.8%). The histopathological diagnosis was benign in 14 cases (33.3%), borderline in 2 cases (4.8%) and malignant in 26 cases (61.9%). Fibroadenoma was the most common benign tumour and invasive ductal carcinoma was the most common malignant tumour. Conclusion: The final histopathological examination confirmed that the few cases of clinically suspected benign breast lumps were actually borderline and malignant breast lumps. These cases confirm that the histopathological examination of a breast lump is the gold standard to establish a correct diagnosis

Unveiling the Significance of FGF8 Overexpression in Orchestrating the Progression of Ovarian Cancer

The asymptomatic nature, high rate of disease recurrence, and resistance to platinum-based chemotherapy highlight the need to identify and characterize novel target molecules for ovarian cancer. Fibroblast growth factor 8 (FGF8) aids in the development and metastasis of ovarian cancer; however, its definite role is not clear. We employed ELISA and IHC to examine the expression of FGF8 in the saliva and tissue samples of epithelial ovarian cancer (EOC) patients and controls. Furthermore, various cell assays were conducted to determine how FGF8 silencing influences ovarian cancer cell survival, adhesion, migration, and invasion to learn more about the functions of FGF8. In saliva samples, from controls through low-grade to high-grade EOC, a stepped overexpression of FGF8 was observed. Similar expression trends were seen in tissue samples, both at protein and mRNA levels. FGF8 gene silencing in SKOV3 cells adversely affected various cell properties essential for cancer cell survival and metastasis. A substantial reduction was observed in the cell survival, cell adhesion to the extracellular matrix, migration, and adhesion properties of SKOV3 cells, suggesting that FGF8 plays a crucial role in the development of EOC. Conclusively, this study suggests a pro-metastatic function of FGF8 in EOC

A COMPREHENSIVE REVIEW ON PRONIOSOMES: A NEW CONCEPT IN OCULAR DRUG DELIVERY

The concept of novel drug delivery with the comparison of modern and conventional delivery system. The Ocular is the most challenging organ to deliver drugs after the brain and conventional delivery systems currently available in the arsenal have severe limitations thus there is a strong demand for an improved ocular delivery system and a suitable opinion is a novel drug delivery system. Noisome and liposome are dominant vesicular carriers in ocular drug delivery, as both systems improve the bioavailability of drugs and are well tolerated in ocular; however, both delivery systems have critical drawbacks of physicochemical stability during storage, lacking contain in dispersion and fusion of nanoparticles. The gel form is formulated by the coacervation phase’s parathion method. The material utilized for the formulation of proniosomes are non-ionic surfactant, cholesterol, carrier and alcohol are well tolerable and nontoxic in the ocular. The benefits offered to ocular drug delivery are prolonged retention time of formulation on the ocular surface, enhance ocular penetration to deliver effective therapeutic dosage, improve bioavailability of hydrophobic, lipophilic and herbal drugs, biocompatible, biodegradable, nontoxic and stable stored in pro-vesicle state. Hereby article will review proniosomes drug delivery from the perspective of ophthalmic delivery, discussing proniosomes as an ocular carrier, materials and methods their effect on ocular drug delivery and depth explanation of recent studies of proniosome in the ocular. Proniosomes are one of the sterile drug delivery systems that have seen a tremendous increase in popularity and are heavily utilized in cancer therapy. Researchers and academicians generally agree that incorporating the medicine into niosomes will improve its ability to target tissues where it is needed. Proniosomes created by academics and researchers. Niosomes that are produced from protostomes are a promising medication delivery system. They are well known for avoiding several issues related to aqueous noisome dispersion as well as issues with physical stability such aggregation, fusion, and leakage. They make transportation, distribution, storage, and dosage even more convenient. Proniosomes not only present a promising medication delivery method but also have the potential to speed up the skin barrier's repair