The Ursinus Weekly, November 15, 1948

Seniors to feature Bud Williams\u27 band at December ball • Philip to produce Handel\u27s Messiah for eleventh year • Wallick to leave in December; Will study at Edinburgh • WSSF starts campaign with goal set at $1,000 • Wallace claims UN is success despite Russian difficulties • Pre-meds offered much for money • Juniors to sponsor tux raffle as part of money-raising drive • What do you like best about Ursinus? • Applications due for grad exam • Y to conduct prejudice poll • Pettit appointed assistant registrar • Editorials: Varsity letters; Passing fancies • Letters to the editor • Alumni-society notes • Life of sea calls energetic students for vacation trips • Critic rings bell on Curtain Club\u27s local talent show • Curtain Club stages varied talent show • Don\u27t look now but here\u27s a fan of college males • Coed in top bunk describes 3 ways of making a bed • Haverford thumps Bruin booters 8-1 • Inside on intramurals • Loss of four stars from soccer squad to hurt \u2749 plans • Bruins to face Susquehanna as grid campaign concludes • Cadets wallop Grizzlies 31-0 for sixth triumph of season • Beaver bows 6-2 to Snell\u27s belles • Player of the week • Harriers place 12th in Allentown meet • Lehigh beaten 3-2 in 2nd soccer win • Jay-vees trip Beaver coeds 5-1 to maintain undefeated record • MacWilliams star of hockey win • Campus briefs: International Relations Club; Curtain Club; Phys Ed Club; Canterbury Club; Cub and Key; English Club; Beardwood Chemical Society; Glee Club; WSGA; French Club; German Club; Business Administration Clubhttps://digitalcommons.ursinus.edu/weekly/3127/thumbnail.jp

Session 2: Making Archives More Accessible: Integrating Digital Collections and Education Initiatives at the Delaware Historical Society

In this session, colleagues at the Delaware Historical Society (OHS) will discuss the development and implementation of their first digital collections platform, the integration of these collections into ongoing and emerging education initiatives, and continuing audience engagement and impact. The panelists will discuss the successes and challenges of integrating two developing projects-the implementation of a digital asset management system and Liberty in Our Grasp-to make archives more accessible and visible. In addition, they will discuss audience engagement and impact, cross-departmental collaboration within OHS, and the partnerships with vendors, corporate sponsors, non-profits, and teachers that made the projects possible

Weak selection and recent mutational changes influence polymorphic synonymous mutations in humans

Recent large-scale genomic and evolutionary studies have revealed the small but detectable signature of weak selection on synonymous mutations during mammalian evolution, likely acting at the level of translational efficacy (i.e., translational selection). To investigate whether weak selection, and translational selection in particular, plays any role in shaping the fate of synonymous mutations that are present today in human populations, we studied genetic variation at the polymorphic level and patterns of evolution in the human lineage after human–chimpanzee separation. We find evidence that neutral mechanisms are influencing the frequency of polymorphic mutations in humans. Our results suggest a recent increase in mutational tendencies toward AT, observed in all isochores, that is responsible for AT mutations segregating at lower frequencies than GC mutations. In all, however, changes in mutational tendencies and other neutral scenarios are not sufficient to explain a difference between synonymous and noncoding mutations or a difference between synonymous mutations potentially advantageous or deleterious under a translational selection model. Furthermore, several estimates of selection intensity on synonymous mutations all suggest a detectable influence of weak selection acting at the level of translational selection. Thus, random genetic drift, recent changes in mutational tendencies, and weak selection influence the fate of synonymous mutations that are present today as polymorphisms. All of these features, neutral and selective, should be taken into account in evolutionary analyses that often assume constancy of mutational tendencies and complete neutrality of synonymous mutations