5 research outputs found
Influence of metals and metalloids on the composition and fluorescence quenching of the extracellular polymeric substances produced by the polymorphic fungus <i>Aureobasidium pullulans</i>
- Author
- A Jang
- B Bhadra
- D Zhang
- E Nakkeeran
- F Baldi
- F Cao
- G Guibaud
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GM Gadd
- GP Sheng
- H Chu
- H Lin
- H Liu
- J Li
- JA Sayer
- JH Huang
- JH Suh
- JH Suh
- JL Mowll
- JL Mowll
- K Yin
- K-C Cheng
- LM Ramsay
- M Fomina
- M Fomina
- M Fomina
- M Mejáre
- M Čertík
- MD Radulovic
- MM Naik
- MS Deshpande
- N Li
- NJ Kruger
- P Gupta
- P Prabhakaran
- PJ Newby
- R De Philippis
- RJF Bewley
- RY Saba
- S Comte
- S Prasongsuk
- SR Ravella
- SS Nielsen
- W Hou
- W Song
- W Song
- W Zhao
- WJ Song
- WL Wang
- X Liang
- X Wang
- Y Ma
- Y Wang
- Y Zhang
- YJ Rhee
- ZB Yue
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2020
- Field of study
Aureobasidium pullulansis a ubiquitous and widely distributed fungus in the environment, and exhibits substantial tolerance against toxic metals. However, the interactions between metals and metalloids with the copious extracellular polymeric substances (EPS) produced byA. pullulansand possible relationships to tolerance are not well understood. In this study, it was found that mercury (Hg) and selenium (Se), as selenite, not only significantly inhibited growth ofA. pullulansbut also affected the composition of produced EPS. Lead (Pb) showed little influence on EPS yield or composition. The interactions of EPS fromA. pullulanswith the tested metals and metalloids depended on the specific element and their concentration. Fluorescence intensity measurements of the EPS showed that the presence of metal(loid)s stimulated the production of extracellular tryptophan-like and aromatic protein-like substances. Examination of fluorescence quenching and calculation of binding constants revealed that the fluorescence quenching process for Hg; arsenic (As), as arsenite; and Pb to EPS were mainly governed by static quenching which resulted in the formation of a stable non-fluorescent complexes between the EPS and metal(loid)s. Se showed no significant interaction with the EPS according to fluorescence quenching. These results provide further understanding of the interactions between metals and metalloids and EPS produced by fungi and their contribution to metal(loid) tolerance
Characterization and Metal Detoxification Potential of Moderately Thermophilic Bacillus cereus from Geothermal Springs of Himalaya
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Microbial Biomass in Broad-Leaved Forest Soils
- Author
- A Miltner
- B Ulrich
- D Curtin
- D Parkinson
- DA Wardle
- DH Wall
- DS Jenkinson
- DS Jenkinson
- DS Jenkinson
- DU Hooper
- E Bååth
- E Bååth
- EA Kaiser
- EA Paul
- EB Knapp
- ED Vance
- EP Odum
- EP Odum
- EP Odum
- EV Blagodatskaya
- H Höper
- H Insam
- H Insam
- HW Hunt
- J Alphei
- J Skujins
- JA Van Veen
- JM Lynch
- JM Verstraten
- JPE Anderson
- JPE Anderson
- JPE Anderson
- JPE Anderson
- K Alef
- KH Domsch
- M Raubuch
- Mao Ding Ming
- MC Moscatelli
- MH Brown
- O Dilly
- R Ohtonen
- RJF Bewley
- RJF Bewley
- S Kreitz
- SJ Pirt
- SJ Pirt
- T Rosswall
- T-H Anderson
- T-H Anderson
- T-H Anderson
- T-H Anderson
- T-H Anderson
- T-H Anderson
- T-H Anderson
- T-H Anderson
- TA Langworthy
- W Gams
- WB McGill
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Calcium polysulphide, its applications and emerging risk of environmental pollution—a review article
- Author
- A Chen
- A Kamyshny
- A Kamyshny
- AJ Kamyshny
- AL Melander
- AM Zayed
- Anonymous
- B Pakzadeh
- BG Tweedy
- BJ Dippenaar
- BR Kim
- D Rai
- DC Adriano
- DC Dorman
- DH Moon
- DH Moon
- DL Freedman
- E Darakas
- EC Large
- EFSA (European Food Safety Authority)
- GH Kelsall
- HV Tartar
- IA Massalimov
- IA Massalimov
- IA Massalimov
- J Fruchter
- J Gun
- JA Salvato
- JG Farmer
- JJ Ganczarczyk
- JL Smilanick
- JM Tinjum
- JW Eckert
- JW Palmer
- K Chen
- K Freese
- K Yahikozawa
- KL Bailey
- KSB Kameshwari
- KSB Kameshwari
- L Palou
- L Smith
- L Zhong
- LM Levchenko
- M Chrysochoou
- M Chrysochoou
- M Chrysochoou
- M Chrysochoou
- M Chrysochoou
- M Chrysochoou
- M Hartmut
- M Lewis
- M Tabata
- M Wazne
- M Wazne
- MC Graham
- MH Haller
- N Mihara
- P Chandra
- P Storch
- PE Dresel
- PL Poulos
- PP Bosshard
- PT Takaoka
- Q Chen
- RH Borgwardt
- RJF Bewley
- S Nagib
- SA Katz
- Saad Mohammed Dahlawi
- Samreen Siddiqui
- SC Jagupilla
- SEA McCallan
- SJM Auld
- SP Maletić
- T Aratani
- T Aratani
- Y Lan
- Y Sun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
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- Amiya S
- Ampuero J
- Anan R
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- Anderson F
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- Anderson S
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- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
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- Andrikopoulos P
- Anedda F
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- Anemoli V
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- Antoni MD
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- Apetri E
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- Arimura K
- Armstrong J
- Armstrong JA
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- Artuso R
- Arumugam P
- Asakura T
- Asano K
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- Ashish A
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- Asiimwe IG
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- Bakthavatsalam D
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- Volland S
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- Vollenweider P
- Von Frenckell C
- von Hohenstaufen K
- von Mering C
- Vonk JM
- Voza A
- Vulesevic B
- Vuylsteke A
- Vuylsteke A
- Wacker EM
- Wackett T
- Wadams B
- Waddington N
- Waddy S
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wake R
- Wakefield P
- Wakinshaw F
- Walden A
- Waldron J
- Walker D
- Walker R
- Walker S
- Walker S
- Walker S
- Wall A
- Walsh T
- Walter J
- Walters RK
- Walton O
- Wang B
- Wang C
- Wang H
- Wang J
- Wang Q
- Wang X
- Wang X
- Ward G
- Ward K
- Ward L
- Ward M
- Warden S
- Warmerdam R
- Warren D
- Washington NL
- Wassall H
- Wasson C
- Watanabe H
- Watanabe K
- Watson E
- Watson G
- Watson J
- Watson N
- Watters M
- Waugh V
- Weaver J
- Webster A
- Webster D
- Webster K
- Wei S
- Weiss ST
- Weldon CH
- Wells C
- Welters I
- Welters ID
- Wendorff M
- Wendt FR
- Wery M
- Wesse T
- West J
- Weston H
- Wham M
- Wheeler M
- Whileman A
- Whitbread J
- White D
- White I
- White K
- White M
- White N
- White S
- Whitehouse T
- Whiteley S
- Whiteside J
- Whittaker P
- Whittington A
- Whittle H
- Whitton C
- Whyte C
- Wicks SJ
- Wienbrandt L
- Wiersinga WJ
- Wijesinghe M
- Wilby E
- Wilcock E
- Wilcox L
- Wilcox R
- Wild H
- Wild L
- Wild L
- Wilding L
- Wiles M
- Wilfling S
- Wilkin F
- Wilkins J
- Wilkinson A
- Wilkinson B
- Willer CJ
- Williams A
- Williams A
- Williams A
- Williams D
- Williams F
- Williams G
- Williams H
- Williams K
- Williams M
- Williams M
- Williams P
- Williams S
- Williams T
- Willis H
- Wills M
- Willson J
- Wilson A
- Wilson DJ
- Wilson J
- Wilson JF
- Wilson L
- Winchester S
- Winnard S
- Winter-Goodwin B
- Wiselka M
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford B
- Wolford B
- Wolterman RA
- Wolverson A
- Wong J
- Wood D
- Wood H-L
- Wood S
- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodyatt W
- Woolley AE
- Wooton DG
- Working UCLAHATLASDM
- Workman A
- Worner R
- Worsley L
- Wouters D
- Wozniak H
- Wray G
- Wren L
- Wright D
- Wright J
- Wright J
- Wright M
- Wrobel N
- Wrobel N
- Wu Y
- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang G
- Yang J
- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
- Zarate R
- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease