SDSSJ143244.91+301435.3 at VLBI: a compact radio galaxy in a narrow-line Seyfert 1

We present VLBI observations, carried out with the European Very Long Baseline Interferometry Network (EVN), of SDSSJ143244.91+301435.3, a radio-loud narrow-line Seyfert 1 (RLNLS1) characterized by a steep radio spectrum. The source, compact at Very Large Array (VLA) resolution, is resolved on the milliarcsec scale, showing a central region plus two extended structures. The relatively high brightness temperature of all components (5x10^6-1.3x10^8 K) supports the hypothesis that the radio emission is non-thermal and likely produced by a relativistic jet and/or small radio lobes. The observed radio morphology, the lack of a significant core and the presence of a low frequency (230 MHz) spectral turnover are reminiscent of the Compact Steep Spectrum sources (CSS). However, the linear size of the source (~0.5kpc) measured from the EVN map is lower than the value predicted using the turnover/size relation valid for CSS sources (~6kpc). This discrepancy can be explained by an additional component not detected in our observations, accounting for about a quarter of the total source flux density, combined to projection effects. The low core-dominance of the source (CD<0.29) confirms that SDSSJ143244.91+301435.3 is not a blazar, i.e. the relativistic jet is not pointing towards the observer. This supports the idea that SDSSJ143244.91+301435.3 may belong to the "parent population" of flat-spectrum RLNLS1 and favours the hypothesis of a direct link between RLNLS1 and compact, possibly young, radio galaxies.Comment: 8 pages, 3 figures, accepted for publication in MNRA

Fast magnetoacoustic waves in a randomly structured solar corona

The propagation of fast magnetoacoustic waves in a randomly structured solar corona is considered in the linear and cold plasma limits. The random field is assumed to be static and associated with plasma density inhomogeneities only. A transcendental dispersion relation for the fast magnetoacoustic waves which propagate perpendicularly to the magnetic field is derived in the weak random field approximation. It is shown analytically that the fast magnetosonic waves experience acceleration, attenuation, and dispersion in comparison to the homogeneous case. These analytical findings are essentially confirmed by numerical simulations for a wide-spectrum pulse, except that the waves were found decelerated. It is concluded that the coronal Moreton waves can be applied to MHD seismology of the solar corona

Modelling of ultrasound transmission through a solid-liquid interface comprising a network of gas pockets

International audienceUltrasonic inspection of sodium-cooled fast reactor requires a good acoustic coupling between the transducer and the liquid sodium. Ultrasonic transmission through a solid surface in contact with liquid sodium can be complex due to the presence of microscopic gas pockets entrapped by the surface roughness. Experiments are run using substrates with controlled roughness consisting of a network of holes and a modeling approach is then developed. In this model, a gas pocket stiffness at a partially solid-liquid interface is defined. This stiffness is then used to calculate the transmission coefficient of ultrasound at the entire interface. The gas pocket stiffness has a static, as well as an inertial component, which depends on the ultrasonic frequency and the radiative mass

Developmental nmda receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity. Mutation of the depalmitoylating enzyme palmitoyl-protein thioesterase 1 (PPT1) causes infantile neuronal ceroid lipofuscinosis (CLN1), a pediatric neurodegenerative disease. However, the role of protein depalmitoylation in synaptic maturation is unknown. Therefore, we studied synapse development in Ppt1-/- mouse visual cortex. We demonstrate that the developmental N-methyl-D-aspartate receptor (NMDAR) subunit switch from GluN2B to GluN2A is stagnated in Ppt1-/- mice. Correspondingly, Ppt1-/- neurons exhibit immature evoked NMDAR currents and dendritic spine morphology in vivo. Further, dissociated Ppt1-/- cultured neurons show extrasynaptic, diffuse calcium influxes and enhanced vulnerability to NMDA-induced excitotoxicity, reflecting the predominance of GluN2B-containing receptors. Remarkably, Ppt1-/- neurons demonstrate hyperpalmitoylation of GluN2B as well as Fyn kinase, which regulates surface retention of GluN2B. Thus, PPT1 plays a critical role in postsynapse maturation by facilitating the GluN2 subunit switch and proteostasis of palmitoylated proteins

Optical polarization reveals colliding stellar stream shocks in a tidal disruption event

Supermassive black holes have been known to disrupt passing stars producing outbursts called Tidal Disruption Events offering a unique view on the early stages of accretion disk and jet formation. The advent of large scale optical time-domain surveys has significantly increased the number of known events and challenged our understanding of their dynamics and emission processes. Here, we present the linear polarization curve of the most polarized tidal disruption without any indication of contribution from a jet to the emission. Our observations demonstrate that optical TDE emission can be powered by tidal stream shocks.Comment: 36 pages, 7 figures, author's version of the paper accepted in Scienc

Pennsylvania Folklife Vol. 23, No. 4

• Cultural Learning Through Game Structure: A Study of Pennsylvania German Children\u27s Games • Nipsy : The Ethnography of a Traditional Game of Pennsylvania\u27s Anthracite Region • The Game as Creator of the Group in an Italian-American Community • Pennsylvania Town Views of a Century Ago • The Barber\u27s Ghost : A Legend Becomes a Folktale • Grain Harvesting in the Nineteenth Century • My Experience With the Dialect • Harvest on the Pennsylvania Farm: Folk-Cultural Questionnaire No. 34https://digitalcommons.ursinus.edu/pafolklifemag/1058/thumbnail.jp

Study of the three-dimensional shape and dynamics of coronal loops observed by Hinode/EIS

We study plasma flows along selected coronal loops in NOAA Active Region 10926, observed on 3 December 2006 with Hinode's EUV Imaging Spectrograph (EIS). From the shape of the loops traced on intensity images and the Doppler shifts measured along their length we compute their three-dimensional (3D) shape and plasma flow velocity using a simple geometrical model. This calculation was performed for loops visible in the Fe VIII 185 Ang., Fe X 184 Ang., Fe XII 195 Ang., Fe XIII 202 Ang., and Fe XV 284 Ang. spectral lines. In most cases the flow is unidirectional from one footpoint to the other but there are also cases of draining motions from the top of the loops to their footpoints. Our results indicate that the same loop may show different flow patterns when observed in different spectral lines, suggesting a dynamically complex rather than a monolithic structure. We have also carried out magnetic extrapolations in the linear force-free field approximation using SOHO/MDI magnetograms, aiming toward a first-order identification of extrapolated magnetic field lines corresponding to the reconstructed loops. In all cases, the best-fit extrapolated lines exhibit left-handed twist (alpha < 0), in agreement with the dominant twist of the region.Comment: 17 pages, 6 figure

Sildenafil improves microvascular O-2 delivery-to-utilization matching and accelerates exercise O-2 uptake kinetics in chronic heart failure

Sperandio PA, Oliveira MF, Rodrigues MK, Berton DC, Treptow E, Nery LE, Almeida DR, Neder JA. Sildenafil improves microvascular O-2 delivery-to-utilization matching and accelerates exercise O-2 uptake kinetics in chronic heart failure. Am J Physiol Heart Circ Physiol 303: H1474-H1480, 2012. First published September 28, 2012; doi:10.1152/ajpheart.00435.2012.-Nitric oxide (NO) can temporally and spatially match microvascular oxygen (O-2) delivery (QO(2mv)) to O-2 uptake (VO2) in the skeletal muscle, a crucial adjustment-to-exercise tolerance that is impaired in chronic heart failure (CHF). To investigate the effects of NO bioavailability induced by sildenafil intake on muscle QO(2mv)-to-O-2 utilization matching and VO2 kinetics, 10 males with CHF (ejection fraction = 27 +/- 6%) undertook constant work-rate exercise (70-80% peak). Breath-by-breath VO2, fractional O-2 extraction in the vastus lateralis {similar to deoxy-genated hemoglobin + myoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy}, and cardiac output (CO) were evaluated after sildenafil (50 mg) or placebo. Sildenafil increased exercise tolerance compared with placebo by similar to 20%, an effect that was related to faster on-and off-exercise VO2 kinetics (P 0.05). On-exercise [deoxy-Hb + Mb] kinetics were slowed by sildenafil (similar to 25%), and a subsequent response overshoot (n = 8) was significantly lessened or even abolished. in contrast, [deoxy-Hb + Mb] recovery was faster with sildenafil (similar to 15%). Improvements in muscle oxygenation with sildenafil were related to faster on-exercise VO2 kinetics, blunted oscillations in ventilation (n = 9), and greater exercise capacity (P < 0.05). Sildenafil intake enhanced intramuscular QO(2mv)-to-VO2 matching with beneficial effects on VO2 kinetics and exercise tolerance in CHF. the lack of effect on CO suggests that improvement in blood flow to and within skeletal muscles underlies these effects.Universidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, BrazilQueens Univ, Dept Med, Div Resp & Crit Care Med, Kingston, ON K7L 3N6, CanadaUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04020050 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit, BR-04020050 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04020050 São Paulo, BrazilWeb of Scienc

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines

Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite athletes and to identify the potential metabolic pathways underlying these differences. Methods: Metabolic profiling of serum samples from 191 elite athletes from different sports disciplines (121 high- and 70 moderate-endurance athletes, including 44 high- and 144 moderate-power athletes), who participated in national or international sports events and tested negative for doping abuse at anti-doping laboratories, was performed using non-targeted metabolomics-based mass spectroscopy combined with ultrahigh-performance liquid chromatography. Multivariate analysis was conducted using orthogonal partial least squares discriminant analysis. Differences in metabolic levels between high- and moderate-power and endurance sports were assessed by univariate linear models. Results: Out of 743 analyzed metabolites, gamma-glutamyl amino acids were significantly reduced in both high-power and high-endurance athletes compared to moderate counterparts, indicating active glutathione cycle. High-endurance athletes exhibited significant increases in the levels of several sex hormone steroids involved in testosterone and progesterone synthesis, but decreases in diacylglycerols and ecosanoids. High-power athletes had increased levels of phospholipids and xanthine metabolites compared to moderate-power counterparts. Conclusions: This pilot data provides evidence that high-power and high-endurance athletes exhibit a distinct metabolic profile that reflects steroid biosynthesis, fatty acid metabolism, oxidative stress, and energy-related metabolites. Replication studies are warranted to confirm differences in the metabolic profiles associated with athletes’ elite performance in independent data sets, aiming ultimately for deeper understanding of the underlying biochemical processes that could be utilized as biomarkers with potential therapeutic implications