149 research outputs found
Evolution of the cosmic ray anisotropy above 10^{14} eV
The amplitude and phase of the cosmic ray anisotropy are well established
experimentally between 10^{11} eV and 10^{14} eV. The study of their evolution
into the energy region 10^{14}-10^{16} eV can provide a significant tool for
the understanding of the steepening ("knee") of the primary spectrum. In this
letter we extend the EAS-TOP measurement performed at E_0 around 10^{14} eV, to
higher energies by using the full data set (8 years of data taking). Results
derived at about 10^{14} and 4x10^{14} eV are compared and discussed. Hints of
increasing amplitude and change of phase above 10^{14} eV are reported. The
significance of the observation for the understanding of cosmic ray propagation
is discussed.Comment: 4 pages, 3 figures, accepted for publication on ApJ Letter
Atmospheric Muon Flux at Sea Level, Underground, and Underwater
The vertical sea-level muon spectrum at energies above 1 GeV and the
underground/underwater muon intensities at depths up to 18 km w.e. are
calculated. The results are particularly collated with a great body of the
ground-level, underground, and underwater muon data. In the hadron-cascade
calculations, the growth with energy of inelastic cross sections and pion,
kaon, and nucleon generation in pion-nucleus collisions are taken into account.
For evaluating the prompt muon contribution to the muon flux, we apply two
phenomenological approaches to the charm production problem: the recombination
quark-parton model and the quark-gluon string model. To solve the muon
transport equation at large depths of homogeneous medium, a semi-analytical
method is used. The simple fitting formulas describing our numerical results
are given. Our analysis shows that, at depths up to 6-7 km w. e., essentially
all underground data on the muon intensity correlate with each other and with
predicted depth-intensity relation for conventional muons to within 10%.
However, the high-energy sea-level data as well as the data at large depths are
contradictory and cannot be quantitatively decribed by a single nuclear-cascade
model.Comment: 47 pages, REVTeX, 15 EPS figures included; recent experimental data
and references added, typos correcte
Large-Scale Sidereal Anisotropy of Galactic Cosmic-Ray Intensity Observed by the Tibet Air Shower Array
We present the large-scale sidereal anisotropy ofgalactic cosmic-ray
intensity in the multi-TeV region observed with the Tibet-IIIair shower array
during the period from 1999 through 2003. The sidereal daily variation of
cosmic rays observed in this experiment shows an excess of relative intensity
around hours local sidereal time, as well as a deficit around 12
hours local sidereal time. While the amplitude of the excess is not significant
when averaged over all declinations, the excess in individual declinaton bands
becomes larger and clearer as the viewing direction moves toward the south. The
maximum phase of the excess intensity changes from 7 at the northern
hemisphere to 4 hours at the equatorial region. We also show that both
the amplitude and the phase of the first harmonic vector of the daily variation
are remarkably independent of primary energy in the multi-TeV region. This is
the first result determining the energy and declination dependences of the full
24-hour profiles of the sidereal daily variation in the multi-TeV region with a
single air shower experiment.Comment: 13 pages, 3 figures, 1 table. Accepted for publication in ApJ
The primary cosmic ray composition between 10**15 and 10**16 eV from Extensive Air Showers electromagnetic and TeV muon data
The cosmic ray primary composition in the energy range between 10**15 and
10**16 eV, i.e., around the "knee" of the primary spectrum, has been studied
through the combined measurements of the EAS-TOP air shower array (2005 m
a.s.l., 10**5 m**2 collecting area) and the MACRO underground detector (963 m
a.s.l., 3100 m w.e. of minimum rock overburden, 920 m**2 effective area) at the
National Gran Sasso Laboratories. The used observables are the air shower size
(Ne) measured by EAS-TOP and the muon number (Nmu) recorded by MACRO. The two
detectors are separated on average by 1200 m of rock, and located at a
respective zenith angle of about 30 degrees. The energy threshold at the
surface for muons reaching the MACRO depth is approximately 1.3 TeV. Such muons
are produced in the early stages of the shower development and in a kinematic
region quite different from the one relevant for the usual Nmu-Ne studies. The
measurement leads to a primary composition becoming heavier at the knee of the
primary spectrum, the knee itself resulting from the steepening of the spectrum
of a primary light component (p, He). The result confirms the ones reported
from the observation of the low energy muons at the surface (typically in the
GeV energy range), showing that the conclusions do not depend on the production
region kinematics. Thus, the hadronic interaction model used (CORSIKA/QGSJET)
provides consistent composition results from data related to secondaries
produced in a rapidity region exceeding the central one. Such an evolution of
the composition in the knee region supports the "standard" galactic
acceleration/propagation models that imply rigidity dependent breaks of the
different components, and therefore breaks occurring at lower energies in the
spectra of the light nuclei.Comment: Submitted to Astroparticle Physic
Nota Científica: ultrafiltração de efluente da indústria de laticínios para recuperação de nutrientes: efeito da pressão e da velocidade tangencial
Human Analogue Safe Haven Effect of the Owner : Behavioural and Heart Rate Response to Stressful Social Stimuli in Dogs
The secure base and safe haven effects of the attachment figure are central features of the human attachment theory. Recently, conclusive evidence for human analogue attachment behaviours in dogs has been provided, however, the owner’s security-providing role in danger has not been directly supported. We investigated the relationship between the behavioural and cardiac response in dogs (N = 30) while being approached by a threatening stranger in separation vs. in the presence of the owner, presented in a balanced order. Non-invasive telemetric measures of heart rate (HR) and heart rate variability (HRV) data during the threatening approaches was compared to periods before and after the encounters. Dogs that showed distress vocalisation during separation (N = 18) and that growled or barked at the stranger during the threatening approach (N = 17) were defined as behaviourally reactive in the given situation. While characteristic stress vocalisations were emitted during separations, the absence of the owner did not have an effect on dogs’ mean HR, but significantly increased the HRV. The threatening approach increased dogs’ mean HR, with a parallel decrease in the HRV, particularly in dogs that were behaviourally reactive to the encounter. Importantly, the HR increase was significantly less pronounced when dogs faced the stranger in the presence of the owner. Moreover, the test order, whether the dog encountered the stranger first with or without its owner, also proved important: HR increase associated with the encounter in separation seemed to be attenuated in dogs that faced the stranger first in the presence of their owner. We provided evidence for human analogue safe haven effect of the owner in a potentially dangerous situation. Similarly to parents of infants, owners can provide a buffer against stress in dogs, which can even reduce the effect of a subsequent encounter with the same threatening stimuli later when the owner is not present
Transcultural adaptation of the Emotion Matching Task: an emotion neuropsychological assessment
Emotions play a central role in children’s relationships. Deficits in emotional understanding have been associated with several neuropsychiatric disorders. In Brazil, however, few psychological instruments are available to assess young children’s emotional development. The objective of the present study was to make a transcultural adaptation of the Emotion Matching Task (EMT). The EMT was translated and adapted by a team of bilingual researches and then back-translated to English. The preliminary versions were assessed by EMT’s authors and by Brazilians specialized judges. The final version was applied in a sample of 50 children between three and six years of age and answered by nine judges in three Brazilian states. The results indicate good semantic equivalence and good agreement with the answers provided (κ= 0.88, Z=95.2, p<0.001). The final version of the EMT was considered appropriate and satisfactory
A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full
<p>Abstract</p> <p>Background</p> <p>We assessed the prevalence, and potential impact of, trials of pharmacological agents for acute stroke that were completed but not published in full. Failure to publish trial data is to be deprecated as it sets aside the altruism of participants' consent to be exposed to the risks of experimental interventions, potentially biases the assessment of the effects of therapies, and may lead to premature discontinuation of research into promising treatments.</p> <p>Methods</p> <p>We searched the Cochrane Stroke Group's Specialised Register of Trials in June 2008 for completed trials of pharmacological interventions for acute ischaemic stroke, and searched MEDLINE and EMBASE (January 2007 - March 2009) for references to recent full publications. We assessed trial completion status from trial reports, online trials registers and correspondence with experts.</p> <p>Results</p> <p>We identified 940 trials. Of these, 125 (19.6%, 95% confidence interval 16.5-22.6) were completed but not published in full by the point prevalence date. They included 16,058 participants (16 trials had over 300 participants each) and tested 89 different interventions. Twenty-two trials with a total of 4,251 participants reported the number of deaths. In these trials, 636/4251 (15.0%) died.</p> <p>Conclusions</p> <p>Our data suggest that, at the point prevalence date, a substantial body of evidence that was of relevance both to clinical practice in acute stroke and future research in the field was not published in full. Over 16,000 patients had given informed consent and were exposed to the risks of therapy. Responsibility for non-publication lies with investigators, but pharmaceutical companies, research ethics committees, journals and governments can all encourage the timely publication of trial data.</p
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study
Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection
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