Accurate aeroacoustic measurements in closed-section hard-walled wind tunnels

Noise emissions from aircraft are of major concern to aircraft manufacturers. There are various analytical, empirical and numerical tools to help in the design of quieter aircraft, however aeroacoustic measurements in wind tunnels are still required. There is a growing interest in simultaneous aerodynamic and aeroacoustic measurements in hard-walled closed-section wind tunnels. The research hypothesis of this work is whether accurate aeroacoustic measurements are possible in this type of wind tunnel. Two issues are of particular concern: the reverberation sound field and high background noise levels. De-reverberation, based on an Image Source Model (ISM), is proposed to tackle the first issue by incorporating the reflections in the focused beamformer. This technique is computationally fast and easy to implement. Source Power Integration and deconvolution techniques are shown to be still valid in de-reverberation. Measurements in a closed section wind tunnel have shown that an ISM gives a better estimate of the Green's functions, when compared to free-space Green's functions. Furthermore de-reverberation yielded more accurate source strength estimates from the beamformer. Qualitatively, de-convolved results were no different than when using free-space Green's functions. Simulations have shown that the ISM can become unstable at high frequencies if position errors are present. It is therefore recommended to limit the application of the ISM to frequencies below 10 kHz. At low frequencies the accuracy of beamforming levels is highly dependent on the level of noise contamination of the input data. Removing the diagonal of the cross spectral matrix might not be sufficient to eliminate this noise

Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses

<p>Abstract</p> <p>Background</p> <p>The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is now well established. It raises concerns for the interpretation of risks arising from exposure to low doses of ionizing radiation. However, the regulatory mechanisms involved in the bystander response have not been well elucidated. To provide insight into the signaling pathways responding in bystanders, we have measured global gene expression four hours after bystander and direct alpha particle exposure of primary human lung fibroblasts.</p> <p>Results</p> <p>Although common p53-regulated radiation response genes like <it>CDKN1A </it>were expressed at elevated levels in the directly exposed cultures, they showed little or no change in the bystanders. In contrast, genes regulated by NFκB, such as <it>PTGS2 </it>(cyclooxygenase-2), <it>IL8 </it>and <it>BCL2A1</it>, responded nearly identically in bystander and irradiated cells. This trend was substantiated by gene ontology and pathway analyses of the microarray data, which suggest that bystander cells mount a full NFκB response, but a muted or partial p53 response. In time-course analyses, quantitative real-time PCR measurements of <it>CDKN1A </it>showed the expected 4-hour peak of expression in irradiated but not bystander cells. In contrast, <it>PTGS2, IL8 </it>and <it>BCL2A1 </it>responded with two waves of expression in both bystander and directly irradiated cells, one peaking at half an hour and the other between four and six hours after irradiation.</p> <p>Conclusion</p> <p>Two major transcriptional hubs that regulate the direct response to ionizing radiation are also implicated in regulation of the bystander response, but to dramatically different degrees. While activation of the p53 response pathway is minimal in bystander cells, the NFκB response is virtually identical in irradiated and bystander cells. This alteration in the balance of signaling is likely to lead to different outcomes in irradiated cells and their bystanders, perhaps leading to greater survival of bystanders and increased risk from any long-term damage they have sustained.</p

Halo ellipticity of GAMA galaxy groups from KiDS weak lensing

We constrain the average halo ellipticity of ~2 600 galaxy groups from the Galaxy And Mass Assembly (GAMA) survey, using the weak gravitational lensing signal measured from the overlapping Kilo Degree Survey (KiDS). To do so, we quantify the azimuthal dependence of the stacked lensing signal around seven different proxies for the orientation of the dark matter distribution, as it is a priori unknown which one traces the orientation best. On small scales, the major axis of the brightest group/cluster member (BCG) provides the best proxy, leading to a clear detection of an anisotropic signal. In order to relate that to a halo ellipticity, we have to adopt a model density profile. We derive new expressions for the quadrupole moments of the shear field given an elliptical model surface mass density profile. Modeling the signal with an elliptical Navarro-Frenk-White (NFW) profile on scales < 250 kpc, which roughly corresponds to half the virial radius, and assuming that the BCG is perfectly aligned with the dark matter, we find an average halo ellipticity of e_h=0.38 +/- 0.12. This agrees well with results from cold-dark-matter-only simulations, which typically report values of e_h ~ 0.3. On larger scales, the lensing signal around the BCGs does not trace the dark matter distribution well, and the distribution of group satellites provides a better proxy for the halo's orientation instead, leading to a 3--4 sigma detection of a non-zero halo ellipticity at scales between 250 kpc and 750 kpc. Our results suggest that the distribution of stars enclosed within a certain radius forms a good proxy for the orientation of the dark matter within that radius, which has also been observed in hydrodynamical simulations

KiDS-450: testing extensions to the standard cosmological model

We test extensions to the standard cosmological model with weak gravitational lensing tomography using 450 deg$^2$ of imaging data from the Kilo Degree Survey (KiDS). In these extended cosmologies, which include massive neutrinos, nonzero curvature, evolving dark energy, modified gravity, and running of the scalar spectral index, we also examine the discordance between KiDS and cosmic microwave background measurements from Planck. The discordance between the two datasets is largely unaffected by a more conservative treatment of the lensing systematics and the removal of angular scales most sensitive to nonlinear physics. The only extended cosmology that simultaneously alleviates the discordance with Planck and is at least moderately favored by the data includes evolving dark energy with a time-dependent equation of state (in the form of the $w_0-w_a$ parameterization). In this model, the respective $S_8 = \sigma_8 \sqrt{\Omega_{\rm m}/0.3}$ constraints agree at the $1\sigma$ level, and there is `substantial concordance' between the KiDS and Planck datasets when accounting for the full parameter space. Moreover, the Planck constraint on the Hubble constant is wider than in LCDM and in agreement with the Riess et al. (2016) direct measurement of $H_0$. The dark energy model is moderately favored as compared to LCDM when combining the KiDS and Planck measurements, and remains moderately favored after including an informative prior on the Hubble constant. In both of these scenarios, marginalized constraints in the $w_0-w_a$ plane are discrepant with a cosmological constant at the $3\sigma$ level. Moreover, KiDS constrains the sum of neutrino masses to 4.0 eV (95% CL), finds no preference for time or scale dependent modifications to the metric potentials, and is consistent with flatness and no running of the spectral index. The analysis code is public at https://github.com/sjoudaki/kids450Comment: 22 pages, 16 figures, results unchanged, version accepted for publication by MNRA

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

KiDS-450: the tomographic weak lensing power spectrum and constraints on cosmological parameters

We present measurements of the weak gravitational lensing shear power spectrum based on $450$ sq. deg. of imaging data from the Kilo Degree Survey. We employ a quadratic estimator in two and three redshift bins and extract band powers of redshift auto-correlation and cross-correlation spectra in the multipole range $76 \leq \ell \leq 1310$. The cosmological interpretation of the measured shear power spectra is performed in a Bayesian framework assuming a $\Lambda$CDM model with spatially flat geometry, while accounting for small residual uncertainties in the shear calibration and redshift distributions as well as marginalising over intrinsic alignments, baryon feedback and an excess-noise power model. Moreover, massive neutrinos are included in the modelling. The cosmological main result is expressed in terms of the parameter combination $S_8 \equiv \sigma_8 \sqrt{\Omega_{\rm m}/0.3}$ yielding $S_8 = \ 0.651 \pm 0.058$(3 z-bins), confirming the recently reported tension in this parameter with constraints from Planck at$3.2\sigma$ (3 z-bins). We cross-check the results of the 3 z-bin analysis with the weaker constraints from the 2 z-bin analysis and find them to be consistent. The high-level data products of this analysis, such as the band power measurements, covariance matrices, redshift distributions, and likelihood evaluation chains are available at http://kids.strw.leidenuniv.nl/Comment: 23 pages, 18 figures, 5 tables; results unchanged, version accepted for publication by MNRAS. Data products available at http://kids.strw.leidenuniv.nl

SotonArray: Southampton University wind tunnel microphone array system guide

This report shall serve as an introductory background to SotonArray, the microphone array system at the University of Southampton. It covers the practical aspects only; namely the instrumentation setup and the beamforming software. It aims to give a basic level of understanding of the system to the researcher who wants to use it, and especially to highlight both the capabilities and limitations of the system. Since the microphone array system is a new capability for the Aerodynamics and Flight Mechanics research group (AFM), the hardware and software is constantly being upgraded, and the details given here are correct only at the time of going to print