230 research outputs found
The Influence of Training and Gender in Mentoring on Novice School Administrators
The role of the principal, as an instructional leader is one of the most important roles in education today. The demands of high accountability that are placed on school principals have caused legislators and educational reformers to require more rigorous training for school leaders. Many states now have mandated state mentoring programs for entry year principals. The purpose of this study was to examine and describe the roles and relationships between mentors and their mentees in the training and professional development of school administrators. This research was important because mentoring programs are not standardized and until recently, the majority of principals in the United States have been while males. This research contains the perspectives of 4 novice administrators who all had a mentor in the development of their becoming a school administrator and 4 mentors who played the role of helping to develop the mentees. The methodology was based on the descriptive, lived experience of qualitative research, using the phenomenological model (Creswell, 1998). The results of this study contribute to the research that has been conducted on novice administrators, their training and gender significance of their mentor
The Influence of Training and Gender in Mentoring on Novice School Administrators
The role of the principal, as an instructional leader is one of the most important roles in education today. The demands of high accountability that are placed on school principals have caused legislators and educational reformers to require more rigorous training for school leaders. Many states now have mandated state mentoring programs for entry year principals. The purpose of this study was to examine and describe the roles and relationships between mentors and their mentees in the training and professional development of school administrators. This research was important because mentoring programs are not standardized and until recently, the majority of principals in the United States have been while males. This research contains the perspectives of 4 novice administrators who all had a mentor in the development of their becoming a school administrator and 4 mentors who played the role of helping to develop the mentees. The methodology was based on the descriptive, lived experience of qualitative research, using the phenomenological model (Creswell, 1998). The results of this study contribute to the research that has been conducted on novice administrators, their training and gender significance of their mentor
Designing Sustainable Technologies, Products and Policies
This open access book provides insight into the implementation of Life Cycle approaches along the entire business value chain, supporting environmental, social and economic sustainability related to the development of industrial technologies, products, services and policies; and the development and management of smart agricultural systems, smart mobility systems, urban infrastructures and energy for the built environment. The book is based on papers presented at the 8th International Life Cycle Management Conference that took place from September 3-6, 2017 in Luxembourg, and which was organized by the Luxembourg Institute of Science and Technology (LIST) and the University of Luxembourg in the framework of the LCM Conference Series
A spatio-temporal life cycle assessment framework for building renovation scenarios at the urban scale
Reducing the energy consumption of buildings is a priority for carbon emissions mitigation in urban areas. Building stock energy models have been developed to support decisions of public authorities in renovation strategies. However, the burdens of renovation interventions and their temporal distribution are mostly overlooked, leading to potential overestimation of environmental benefits. Life Cycle Assessment (LCA) provides a holistic estimation of environmental impacts, but further developments are needed to correctly consider spatio-temporal aspects.
We propose a spatio-temporal LCA framework to assess renovation scenarios of urban housing stocks, integrating: 1) a geospatial building-by-building stock model, 2) energy demand modelling, 3) product-based LCA, and 4) a scenario generator. Temporal aspects are considered both in the lifecycle inventory and the lifecycle impact assessment phases, by accounting for the evolution of the existing housing stock and applying time-adjusted carbon footprint calculation.
We apply the framework for the carbon footprint assessment of housing renovation in Esch-sur-Alzette (Luxembourg). Results show that the renovation stage represents 4%–16% of the carbon footprint in the residual service life of existing buildings, respectively after conventional or advanced renovations. Under current renovation rates, the carbon footprint reduction would be limited to 3–4% by 2030. Pushing renovation rates to 3%, enables carbon reductions up to 28% by 2030 when combined with advanced renovations. Carbon reductions in the operational stage of buildings are offset by 8–9% due to the impacts of renovation. Using time-adjusted emissions results in higher weight for the renovation stage and slightly lower benefits for renovation
El concepto de "pulso de inundación" en relación a las planicies aluviales del sistema fluvial Paraná-Paraguay
The present study deais with the floodplains occurring in the Paraná-Paraguay fluvial system, with special emphasis on their degree o f fitness to the “flood-pulse” concept proposed by Junk et al. (1989). “Fringe” floodplains o f different stretches of the Paraná river and o f the lower reach o f the Paraguay were found to keep many similarities. Instead. both the Upper Paraguay’s Pantanal and the Paraná’s Delta pose problems that require specific studies in order to interpret correctly, and eventuallyadjust, the “pulse” concept, as well as to better assess its effects on the river’s productivity.The present study deais with the floodplains occurring in the Paraná-Paraguay fluvial system, with special emphasis on their degree o f fitness to the “flood-pulse” concept proposed by Junk et al. (1989). “Fringe” floodplains o f different stretches of the Paraná river and o f the lower reach o f the Paraguay were found to keep many similarities. Instead. both the Upper Paraguay’s Pantanal and the Paraná’s Delta pose problems that require specific studies in order to interpret correctly, and eventuallyadjust, the “pulse” concept, as well as to better assess its effects on the river’s productivity
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promising new series of N-phenylpyrrolamides with low nanomolar IC50 values against DNA gyrase, and submicromolar IC50 values against topoisomerase IV from Escherichia coil and Staphylococcus aureus. The most potent compound in the series has an IC50 value of 13 nM against E. coil gyrase. Minimum inhibitory concentrations (MICs) against Gram-positive bacteria are in the low micromolar range. The oxadiazolone derivative with an IC50 value of 85 nM against E. coli DNA gyrase displays the most potent antibacterial activity, with MIC values of 1.56 mu M against Enterococcus faecalis, and 3.13 mu M against wild type S. aureus, methicillinresistant S. aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The activity against wild type E. coli in the presence of efflux pump inhibitor phenylalanine-arginine beta-naphthylamide (PA beta N) is 4.6 mu M. (C) 2018 Elsevier Masson SAS. All rights reserved.Peer reviewe
Surgical Management of Trigeminal Neuralgia in Children
Background
Trigeminal neuralgia (TN) is a well-recognized facial pain syndrome. Discrete forms with disparate pain symptoms include classic and atypical. However, atypical facial pain includes neuralgiform pain along a spectrum. Most cases of TN are diagnosed in the adult population. Case reports and series of children have presented TN as a similar entity, with treatment similar to that for adults. We reviewed the pertinent data and present 2 pediatric TN cases successfully treated with microvascular decompression (MVD).
Case Description
Two pediatric patients (age 12 and 15 years) with TN refractory to previous medical therapy were identified. Both patients were deemed appropriate surgical candidates and underwent MVD to manage their TN. TN compression was arterial in both cases and involved portions of the anterior inferior cerebellar artery. Patient 1 was pain free 6 months after the procedure. Patient 2 was pain free immediately after the procedure and had been weaned off preoperative symptomatic management at the latest follow-up visit. The most recent follow-up examination was 12 and 8 months for patients 1 and 2, respectively, with both experiencing continued freedom from pain.
Conclusions
Few studies have reported on the effectiveness of MVD in the pediatric population for the management of TN. The supporting data and our 2 cases have demonstrated that MVD is effective for pediatric patients to treat their TN. Furthermore, the side effects appear to be minimal, with excellent pain relief after MVD in this patient population
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors
ATP competitive inhibitors of DNA gyrase and topoisomerase IV have great therapeutic potential, but none of the described synthetic compounds has so far reached the market. To optimise the activities and physicochemical properties of our previously reported N-phenylpyrrolamide inhibitors, we have synthesized an improved, chemically variegated selection of compounds and evaluated them against DNA gyrase and topoisomerase IV enzymes, and against selected Gram-positive and Gram-negative bacteria. The most potent compound displayed IC50 values of 6.9 nM against Escherichia coli DNA gyrase and 960 nM against Staphylococcus aureus topoisomerase IV. Several compounds displayed minimum inhibitory concentrations (MICs) against Gram-positive strains in the 1-50 mu M range, one of which inhibited the growth of Enterococcus faecalis, Enterococcus faecium, S. aureus and Streptococcus pyogenes with MIC values of 1.56 mu M, 1.56 mu M, 0.78 mu M and 0.72 mu M, respectively. This compound has been investigated further on methicillin-resistant S. aureus (MRSA) and on ciprofloxacin non-susceptible and extremely drug resistant strain of S. aureus (MRSA VISA). It exhibited the MIC value of 2.5 mu M on both strains, and MIC value of 32 mu M against MRSA in the presence of inactivated human blood serum. Further studies are needed to confirm its mode of action. (C) 2019 Elsevier Masson SAS. All rights reserved.Peer reviewe
Observatoire de la Politique Climatique - Rapport annuel 2022
The cumulative scientific evidence is unequivocal: Climate change is a threat to human well-being and planetary health. Any further delay in concerted anticipatory
global action on adaptation and mitigation will miss a brief and rapidly closing window
of opportunity to secure a liveable and sustainable future for all.(very high confidence
- …