2,832 research outputs found
Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes there is a vast array of Hsp70 isoforms that may facilitate adaption to a particular cellular compartment and distinct biological role. Emerging data indicate a novel type of interaction between Hsp70 and client protein that does not fit with the classical Hsp70 ATP regulated substrate mechanism. In this review, we highlight Hsp70 ATPase domain interactions with binding partners from various biological systems that we refer to as Hsp70 ATPase alternative binding proteins or HAAB proteins. We identify common mechanistic features that may define how Hsp70 operates when associating with proteins in this alternative HAAB mode of action
Poster 350: Neurosarcoidosis Presenting as a Central Cord Syndrome: A Case Report
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146922/1/pmr2s256a.pd
Thermodynamics and heavy quark potential in N_f=2 dynamical QCD
We study N_f=2 lattice QCD with nonperturbatively improved Wilson fermions at
finite temperature on 16^3 \cdot 8 lattices. We determine the transition
temperature at m_{\pi}/m_{\rho} \sim 0.8 and lattice spacing as small as
0.12fm. The string breaking at T < T_c is also studied. We find that the static
potential can be fitted by a simple expression involving string model potential
at finite temperature.Comment: 6 pages, 6 figures, contribution to Lattice 2002(topology
Study of correlation effects on stability of many-body complexes in III-V nitride quantum dots
Abstract The aim of this work is to analyze theoretically the correlation energies, for neutral, positive and negative excitons and bi-excitons in the III-V nitride In x Ga 1Àx N/GaN quantum dot; where x=17.5% denotes the indium concentration. So, we propose a model consistent with experimental observations that is small In x Ga 1Àx N truncated pyramids with circular base lying on wetting layer, both buried into GaN matrix. The correlation energies of many-body complexes X, X À , X + and XX are investigated as a function of the quantum dot radius r c and the intrinsic electric field. r 2004 Elsevier B.V. All rights reserved
Inducible Nucleosome Depletion at OREBP-Binding-Sites by Hypertonic Stress
Background: Osmotic Response Element-Binding Protein (OREBP), also known as TonEBP or NFAT5, is a unique transcription factor. It is hitherto the only known mammalian transcription factor that regulates hypertonic stress-induced gene transcription. In addition, unlike other monomeric members of the NFAT family, OREBP exists as a homodimer and it is the only transcription factor known to bind naked DNA targets by complete encirclement in vitro. Nevertheless, how OREBP interacts with target DNA, also known as ORE/TonE, and how it elicits gene transcription in vivo, remains unknown. Methodology: Using hypertonic induction of the aldose reductase (AR) gene activation as a model, we showed that OREs contained dynamic nucleosomes. Hypertonic stress induced a rapid and reversible loss of nucleosome(s) around the OREs. The loss of nucleosome(s) was found to be initiated by an OREBP-independent mechanism, but was significantly potentiated in the presence of OREBP. Furthermore, hypertonic induction of AR gene was associated with an OREBPdependent hyperacetylation of histones that spanned the 59 upstream sequences and at least some exons of the gene. Nevertheless, nucleosome loss was not regulated by the acetylation status of histone. Significance: Our findings offer novel insights into the mechanism of OREBP-dependent transcriptional regulation and provide a basis for understanding how histone eviction and transcription factor recruitment are coupled. © 2009 Tong et al.published_or_final_versio
Adult Hypophosphatasia : a disease where the clinical complications could be avoided by careful evaluation of patients
This is the author accepted manuscript. The final version is available from Springer via the DOI in this recordOsteoporosis Conference 2018 Birmingham, UK 2 – 4 December 201
A cost effectiveness analysis of salt reduction policies to reduce coronary heart disease in four Eastern Mediterranean countries.
BACKGROUND: Coronary Heart Disease (CHD) is rising in middle income countries. Population based strategies to reduce specific CHD risk factors have an important role to play in reducing overall CHD mortality. Reducing dietary salt consumption is a potentially cost-effective way to reduce CHD events. This paper presents an economic evaluation of population based salt reduction policies in Tunisia, Syria, Palestine and Turkey. METHODS AND FINDINGS: Three policies to reduce dietary salt intake were evaluated: a health promotion campaign, labelling of food packaging and mandatory reformulation of salt content in processed food. These were evaluated separately and in combination. Estimates of the effectiveness of salt reduction on blood pressure were based on a literature review. The reduction in mortality was estimated using the IMPACT CHD model specific to that country. Cumulative population health effects were quantified as life years gained (LYG) over a 10 year time frame. The costs of each policy were estimated using evidence from comparable policies and expert opinion including public sector costs and costs to the food industry. Health care costs associated with CHDs were estimated using standardized unit costs. The total cost of implementing each policy was compared against the current baseline (no policy). All costs were calculated using 2010 PPP exchange rates. In all four countries most policies were cost saving compared with the baseline. The combination of all three policies (reducing salt consumption by 30%) resulted in estimated cost savings of 39,000,000 and 31674 LYG in Syria; 1,3000,000,000 and 378439 LYG in Turkey. CONCLUSION: Decreasing dietary salt intake will reduce coronary heart disease deaths in the four countries. A comprehensive strategy of health education and food industry actions to label and reduce salt content would save both money and lives
Temporal Dynamics and Impact of Climate Factors on the Incidence of Zoonotic Cutaneous Leishmaniasis in Central Tunisia
Old world cutaneous leishmaniasis is a vector-borne disease occurring in rural areas of developing countries. The main reservoirs are the rodents Psammomys obesus and Meriones shawi. Zoonotic Leishmania transmission cycle is maintained in the burrows of rodents where the sand fly Phlebotomus papatasi finds the ideal environment and source of blood meals. In the present study we showed seasonality of the incidence of disease during the same cycle with an inter-epidemic period ranging from 4 to 7 years. We evaluated the impact of climate variables (rainfall, humidity and temperature) on the incidence of zoonotic cutaneous leishmaniais in central Tunisia. We confirmed that the risk of disease is mainly influenced by the humidity related to the months of July to September during the same season and mean rainfall lagged by 12 to 14 months
Beaconing Approaches in Vehicular Ad Hoc Networks: A Survey
A Vehicular Ad hoc Network (VANET) is a type of wireless ad hoc network that facilitates
ubiquitous connectivity between vehicles in the absence of fixed infrastructure. Beaconing approaches
is an important research challenge in high mobility vehicular networks with enabling safety applications.
In this article, we perform a survey and a comparative study of state-of-the-art adaptive beaconing
approaches in VANET, that explores the main advantages and drawbacks behind their design. The
survey part of the paper presents a review of existing adaptive beaconing approaches such as adaptive
beacon transmission power, beacon rate adaptation, contention window size adjustment and Hybrid
adaptation beaconing techniques. The comparative study of the paper compares the representatives of
adaptive beaconing approaches in terms of their objective of study, summary of their study, the utilized
simulator and the type of vehicular scenario. Finally, we discussed the open issues and research
directions related to VANET adaptive beaconing approaches.Ghafoor, KZ.; Lloret, J.; Abu Bakar, K.; Sadiq, AS.; Ben Mussa, SA. (2013). Beaconing Approaches in Vehicular Ad Hoc Networks: A Survey. Wireless Personal Communications. 73(3):885-912. doi:10.1007/s11277-013-1222-9S885912733ITS-Standards (1996) Intelligent transportation systems, U.S. Department of Transportation, http://www.standards.its.dot.gov/about.aspCheng, L., Henty, B., Stancil, D., Bai, F., & Mudalige, P. (2005). Mobile vehicle-to-vehicle narrow-band channel measurement and characterization of the 5.9 Ghz dedicated short range communication (DSRC) frequency band. IEEE Transactions on Selected Areas in Communications, 25(8), 1501–1516.van Eenennaam, E., Wolterink, K., Karagiannis, G., & Heijenk, G. (2009). Exploring the solution space of beaconing in vanets. In Proceedings of the 2009 IEEE international vehicular networking conference, Tokyo (pp. 1–8).Torrent-Moreno, M. (2007). Inter-vehicle communications: Assessing information dissemination under safety constraints. In Proceedings of the 2007 IEEE conference wireless on demand network systems and services, Austria (pp. 59–64).Lloret, J., Canovas, A., Catalá, A., & Garcia, M. (2012). Group-based protocol and mobility model for vanets to offer internet access. Journal of Network and Computer Applications 2224–2245 doi: 10.1016j.jnca.2012.02.009 .Nzouonta, J., Rajgure, N., Wang, G., & Borcea, C. (2009). Vanet routing on city roads using real-time vehicular traffic information. IEEE Transactions on Vehicular Technology, 58(7), 3609–3626.Fukui, R., Koike, H., & Okada, H. (2002). Dynamic integrated transmission control(ditrac) over inter-vehicle communications. In Proceedings of the 2002 IEEE vehicular technology conference, Birmingham (pp. 483–487).Schmidt, R., Leinmuller, T., Schoch, E., Kargl, F., & Schafer, G. (2010). Exploration of adaptive beaconing for efficient intervehicle safety communication. IEEE Network, 24(1), 14–19.Ghafoor, K., Bakar, K., van Eenennaam, E., Khokhar, R., Gonzalez, A. A fuzzy logic approach to beaconing for vehicular ad hoc networks, Accepted for publication in Telecommunication Systems Journal.Ghafoor, K., & Bakar, K. (2010). A novel delay and reliability aware inter vehicle routing protocol. Network Protocols and Algorithms, 2(2), 66–88.Mittag, J., Thomas, F., Härri, J., & Hartenstein, H. (2009). A comparison of single-and multi-hop beaconing in vanets. In Proceedings of the 2009 ACM international workshop on vehicular internetworking, Beijing (pp. 69–78).Sommer, C., Tonguz, O., & Dressler, F. (2010). Adaptive beaconing for delay-sensitive and congestion-aware traffic information systems. In Proceedings of the 2010 IEEE international vehicular networking conference (VNC), New Jersey (pp. 1–8).Guan, X., Sengupta, R., Krishnan, H., & Bai, F. (2007). A feedback-based power control algorithm design for vanet. In Proceedings of the 2007 IEEE international conference on mobile networking for vehicular environments, USA (pp. 67–72).AL-Hashimi, H., Bakar, K., & Ghafoor, K. (2011). Inter-domain proxy mobile ipv6 based vehicular network. Network Protocols and Algorithms, 2(4), 1–15.Rawat, D., Popescu, D., Yan, G., & Olariu, S. (2011). Enhancing vanet performance by joint adaptation of transmission power and contention window size. Transactions on Parallel and Distributed Systems, 22(9), 1528–1535.European-ITS (2009) Eits-technical report 102 638 v1.1.1, European Telecommunications Standards Institute (ETSI), http://www.etsi.org/WebSite/homepage.aspxNHTSA, I. Joint program office”, report to congress on the national highway traffic safety administration its program, program progress during 1992–1996 and strategic plan for 1997–2002, US Department of Transportation, Washington, DC.Godbole, D., Sengupta, R., Misener, J., Kourjanskaia, N., & Michael, J. (1998). Benefit evaluation of crash avoidance systems. Transportation Research, 1621(1), 1–9.Reinders, R., van Eenennaam, M., Karagiannis, G., & Heijenk, G. (2004). Contention window analysis for beaconing in vanets. In Proceedings of the 2011 IEEE international conference on wireless communications and mobile computing (IWCMC), Istanbul (pp. 1481–1487).Yang, L., Guo, J., & Wu, Y. (2008). Channel adaptive one hop broadcasting for vanets. In Proceedings of the 2008 IEEE international conference on intelligent transportation systems, Beijing (pp. 369–374).Tseng, Y., Ni, S., Chen, Y., & Sheu, J. (2002). The broadcast storm problem in a mobile ad hoc network. Wireless Networks, 8(2), 153–167.van Eenennaam, E. M., Karagiannis, G., & Heijenk, G. (2010). Towards scalable beaconing in vanets. In Proceedings of the 2010 ERCIM workshop on eMobility, Lulea (pp. 103–108).Ros, F., Ruiz, P., & Stojmenovic, I. (2012). Acknowledgment-based broadcast protocol for reliable and efficient data dissemination in vehicular ad-hoc networks. IEEE Transactions on Mobile Computing, 11(1), 33–46.Torrent-Moreno, M., Santi, P., & Hartenstein, H. (2006). Distributed fair transmit power adjustment for vehicular ad hoc networks. In Proceedings of the 2007 IEEE international conference on sensor and ad hoc communications and networks, Reston, VA (pp. 479–488).Artimy, M. (2007). Local density estimation and dynamic transmission-range assignment in vehicular ad hoc networks. IEEE Transactions on Intelligent Transportation Systems, 8(3), 400–412.Caizzone, G., Giacomazzi, P., Musumeci, L., & Verticale, G. (2005). A power control algorithm with high channel availability for vehicular ad hoc networks. In Proceedings of the 2005 IEEE international conference on communications, Seoul (pp. 3171–3176).Torrent-Moreno, M., Santi, P., & Hartenstein, H. (2009). Vehicle-to-vehicle communication: Fair transmit power control for safety critical information. IEEE Transaction for Vehicular Technology, 58(7), 3684–3703.Torrent-Moreno, M., Schmidt-Eisenlohr, F., Fubler, H., & Hartenstein, H. (2006). Effects of a realistic channel model on packet forwarding in vehicular ad hoc networks. In Proceedings of the 2007 IEEE conference on wireless communications and networking, USA (pp. 385–391).NS, Network simulator (June 2011). http://nsnam.isi.edu/nsnam/index.php/MainPageNakagami, M. (1960). The m-distribution: A general formula of intensity distribution of rapid fadinge. In W. C. Hoffman (Ed.), Statistical method of radio propagation. New York: Pergamon Press.Narayanaswamy, S., Kawadia, V., Sreenivas, R., & Kumar, P. (2002). Power control in ad-hoc networks: Theory, architecture, algorithm and implementation of the compow protocol. In Proceedings of the 2002 European wireless conference next generation wireless networks: technologies, protocols, Italy (pp. 1–6).Cheng, P., Lee, K., Gerla, M., & Harri, J. (2010). Geodtn+ nav: Geographic dtn routing with navigator prediction for urban vehicular environments. Mobile Networks and Applications, 15(1), 61–82.Gomez, J., & Campbell, A. (2004). A case for variable-range transmission power control in wireless multihop networks. In Proceedings twenty-third annual joint conference of the IEEE computer and communications societies, Hong kong (pp. 1425–1436).Ramanathan, R., & Rosales-Hain, R. (2000). Topology control of multihop wireless networks using transmit power adjustment. In Proceedings nineteenth annual joint conference of the IEEE computer and communications societies, Hong kong (pp. 404–413).Artimy, M., Robertson, W., & Phillips, W. (2005). Assignment of dynamic transmission range based on estimation of vehicle density. In Proceedings of the 2nd ACM international workshop on vehicular ad hoc networks, Germany (pp. 40–48).Samara, G., Ramadas, S., & Al-Salihy, W. (2010). Safety message power transmission control for vehicular ad hoc networks. Computer Science, 6(10), 1027–1032.Rezaei, S., Sengupta, R., Krishnan, H., Guan, X., & Student, P. (2008). Adaptive communication scheme for cooperative active safety system.Rezaei, S., Sengupta, R., Krishnan, H., & Guan, X. (2007). Reducing the communication required by dsrc-based vehicle safety systems. In Proceedings of the 2007 IEEE international conference on intelligent transportation systems, Bellevue, WA (pp. 361–366).Sommer, C., Tonguz, O., & Dressler, F. (2011). Traffic information systems: Efficient message dissemination via adaptive beaconing. IEEE Communications Magazine, 49(5), 173–179.Thaina, C., Nakorn, K., & Rojviboonchai, K. (2011). A study of adaptive beacon transmission on vehicular ad-hoc networks. In Proceeding of the 2011 IEEE 13th international conference on communication technology (ICCT), Vancouver (pp. 597–602).Boukerche, A., Rezende, C., & Pazzi, R. (2009). Improving neighbor localization in vehicular ad hoc networks to avoid overhead from periodic messages. In Proceedings of the 2009 IEEE global telecommunications conference, USA (pp. 1–6).Bai, F., Sadagopan, N., & Helmy, A. (2008). Important: A framework to systematically analyze the impact of mobility on performance of routing protocols for adhoc networks. In Proceedings of the 2003 22th annual joint conference of the IEEE computer and communications, USA (pp. 825–835).Nguyen, H., Bhawiyuga, A., & Jeong, H. (2012). A comprehensive analysis of beacon dissemination in vehicular networks. In Proceedings of the 75th IEEE vehicular technology conference, Korea (pp. 1–5).Djahel, S., & Ghamri-Doudane, Y. (2012). A robust congestion control scheme for fast and reliable dissemination of safety messages in vanets. In Proceeding of the 2012 IEEE conference wireless communications and networking, Paris, France (pp. 2264–2269).O. Technologies (Augast 2012) Opnet modeler, http://www.opnet.com/Huang, C., Fallah, Y., Sengupta, R., & Krishnan, H. (2010). Adaptive intervehicle communication control for cooperative safety systems. IEEE Network, 24(1), 6–13.OPNET (June 2012) Opnet modeler, http://www.opnet.com/Kerner, B. (2004). The physics of traffic: Empirical freeway pattern features, engineering applications, and theory. Berlin: Springer.Vinel, A., Vishnevsky, V., & Koucheryavy, Y. (2008). A simple analytical model for the periodic broadcasting in vehicular ad-hoc networks. In Proceedings of the 2008 IEEE international GLOBECOM workshops, Philadelphia, PA (pp. 1–5).Mariyasagayam, N., Menouar, H., & Lenardi, M. (2009). An adaptive forwarding mechanism for data dissemination in vehicular networks. In Proceedings of the 2009 IEEE Vehicular Networking Conference, Boston (pp. 1–5).Hung, C., Chan, H., & Wu, E. (2008). Mobility pattern aware routing for heterogeneous vehicular networks. In Proceedings of the 2008 international conference on wireless communications and networking, Las Vegas (pp. 2200–2205).Yang, K., Ou, S., Chen, H., & He, J. (2007). A multihop peer-communication protocol with fairness guarantee for ieee 802.16-based vehicular networks. IEEE Transactions on Vehicular Technology, 56(6), 3358–3370.Lequerica, I., Ruiz, P., & Cabrera, V. (2010). Improvement of vehicular communications by using 3G capabilities to disseminate control information. IEEE Network Magazine, 24(1), 32–38.Oh, D., Kim, P., Song, J., Jeon, S., & Lee, H. (2005). Design considerations of satellite-based vehicular broadband networks. IEEE Wireless Communications Magazine, 12(5), 91–97.Ko, Y., Sim, M., & Nekovee, M. (2006). Wi-fi based broadband wireless access for users on the road. BT Technology Journal, 24(2), 123–129.Choffnes, D., & Bustamante, F. (2005). An integrated mobility and traffic model for vehicular wireless networks. In Proceedings of the 2005 ACM international workshop on vehicular ad hoc networks, Cologne (pp. 69–78).TIGER (October 2010) Topologically integrated geographic encoding and referencing system, http://www.census.gov/geo/www/tiger/Mittag, J., Thomas, F., Harri, J., & Hartenstein, H. (2009). A comparison of single and multi-hop beaconing in vanets. In Proceedings of the 2009 ACM international workshop on vehiculaar internetworking, Beijing (pp. 69–78).Rappaport, T. (1996). Wireless communications: Principles and practice (2nd ed.). New Jersey: Prentice Hall PTR
- …