643 research outputs found
Strain-gradient-induced switching of nanoscale domains in free-standing ultrathin films
We report first-principle atomistic simulations on the effect of local strain
gradients on the nanoscale domain morphology of free-standing PbTiO
ultrathin films. First, the ferroelectric properties of free films at the
atomic level are reviewed. For the explored thicknesses (10 to 23 unit cells),
we find flux-closure domain structures whose morphology is thickness dependent.
A critical value of 20 unit cells is observed: thinner films show structures
with 90 domain loops, whereas thicker ones develop, in addition,
180 domain walls, giving rise to structures of the Landau-Lifshitz
type. When a local and compressive strain gradient at the top surface is
imposed, the gradient is able to switch the polarization of the downward
domains, but not to the opposite ones. The evolution of the domain pattern as a
function of the strain gradient strength consequently depends on the film
thickness. Our simulations indicate that in thinner films, first the 90
domain loops migrate towards the strain-gradient region, and then the
polarization in that zone is gradually switched. In thicker films, instead, the
switching in the strain-gradient region is progressive, not involving
domain-wall motion, which is attributed to less mobile 180 domain
walls. The ferroelectric switching is understood based on the knowledge of the
local atomic properties, and the results confirm that mechanical
flexoelectricity provides a means to control the nanodomain pattern in
ferroelectric systems.Comment: 9 pages, 6 figure
Growth of quantum -symbols and applications to the volume conjecture
We prove the Turaev-Viro invariants volume conjecture for a "universal" class of cusped hyperbolic 3-manifolds that produces all 3-manifolds with empty or toroidal boundary by Dehn filling. This leads to two-sided bounds on the volume of any hyperbolic 3-manifold with empty or toroidal boundary in terms of the growth rate of the Turaev-Viro invariants of the complement of an appropriate link contained in the manifold. We also provide evidence for a conjecture of Andersen, Masbaum and Ueno (AMU conjecture) about certain quantum representations of surface mapping class groups. A key step in our proofs is finding a sharp upper bound on the growth rate of the quantum symbol evaluated at $q=e^{\frac{2\pi i}{r}}.
Janus II: a new generation application-driven computer for spin-system simulations
This paper describes the architecture, the development and the implementation
of Janus II, a new generation application-driven number cruncher optimized for
Monte Carlo simulations of spin systems (mainly spin glasses). This domain of
computational physics is a recognized grand challenge of high-performance
computing: the resources necessary to study in detail theoretical models that
can make contact with experimental data are by far beyond those available using
commodity computer systems. On the other hand, several specific features of the
associated algorithms suggest that unconventional computer architectures, which
can be implemented with available electronics technologies, may lead to order
of magnitude increases in performance, reducing to acceptable values on human
scales the time needed to carry out simulation campaigns that would take
centuries on commercially available machines. Janus II is one such machine,
recently developed and commissioned, that builds upon and improves on the
successful JANUS machine, which has been used for physics since 2008 and is
still in operation today. This paper describes in detail the motivations behind
the project, the computational requirements, the architecture and the
implementation of this new machine and compares its expected performances with
those of currently available commercial systems.Comment: 28 pages, 6 figure
The Effect of Statins on Mortality in Septic Patients: a Meta-Analysis of Randomized Controlled Trials
OBJECTIVE: Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful effects of sepsis on the coagulation system. We decided to perform a meta-analysis of all randomized controlled trials ever published on statin therapy in septic patients to evaluate their effect on survival and length of hospital stay.
DATA SOURCES AND STUDY SELECTION: Articles were assessed by four trained investigators, with divergences resolved by consensus. BioMedCentral, PubMed, Embase and the Cochrane Central Register of clinical trials were searched for pertinent studies. Inclusion criteria were random allocation to treatment and comparison of statins versus any comparator in septic patients.
DATA EXTRACTION AND SYNTHESIS: Data from 650 patients in 5 randomized controlled studies were analyzed. No difference in mortality between patients receiving statins versus control (44/322 [14%] in the statins group vs 50/328 [15%] in the control arm, RR = 0.90 [95% CI 0.65 to 1.26], p = 0.6) was observed. No differences in hospital stay (p = 0.7) were found.
CONCLUSIONS: Published data show that statin therapy has no effect on mortality in the overall population of adult septic patients. Scientific evidence on statins role in septic patients is still limited and larger randomized trials should be performed on this topic
Biochar-based cement pastes and mortars with enhanced mechanical properties
Nowadays, the environmental impact of cementitious material industry and more generally of building activities is matter of concern, especially in terms of their effects on climate change and consumption of natural resources. Within this context, the aim of this paper is the investigation of the role of biochar, a solid carbonaceous by-product material resulting from biomass pyrolysis/gasification of residual biomass, as a sustainable ingredient for the production of cementitious materials, combining carbon sink properties with enhanced mechanical behavior. Although biochar is mainly investigated as agricultural amendment, there is also evidence that biochar may be an eco-friendly material to improve the sustainable performance of cementitious materials. As outlined in literature, biochar can be used as filler to modify the nanogranular nature of cement matrix, or as substitute of clinker to reduce the emissions of greenhouse gases related to cement production. In this work, biochar is added as micro-nano particles in different cementitious composites, i.e. cement pastes and mortars, as a function of filler or partial substitute of cement. The main mechanical properties of biochar-based materials are then investigated to determine the optimal percentage of biochar addition
Development and operation of a pixel segmented liquid-filled linear array for radiotherapy quality assurance
A liquid isooctane (CH) filled ionization linear array for
radiotherapy quality assurance has been designed, built and tested. The
detector consists of 128 pixels, each of them with an area of 1.7 mm
1.7 mm and a gap of 0.5 mm. The small pixel size makes the detector ideal for
high gradient beam profiles like those present in Intensity Modulated Radiation
Therapy (IMRT) and radiosurgery. As read-out electronics we use the X-Ray Data
Acquisition System (XDAS) with the Xchip developed by the CCLRC.
Studies concerning the collection efficiency dependence on the polarization
voltage and on the dose rate have been made in order to optimize the device
operation.
In the first tests we have studied dose rate and energy dependences, and
signal reproducibility. Dose rate dependence was found lower than 2.5 % up to 5
Gy min, and energy dependence lower than 2.1 % up to 20 cm depth in
solid water. Output factors and penumbras for several rectangular fields have
been measured with the linear array and were compared with the results obtained
with a 0.125 cm air ionization chamber and radiographic film,
respectively. Finally, we have acquired profiles for an IMRT field and for a
virtual wedge. These profiles have also been compared with radiographic film
measurements. All the comparisons show a good correspondence. Signal
reproducibility was within a 2% during the test period (around three months).
The device has proved its capability to verify on-line therapy beams with
good spatial resolution and signal to noise ratio.Comment: 16 pages, 12 figures Submitted to Phys. Med. Bio
An in-depth view of the microscopic dynamics of Ising spin glasses at fixed temperature
Using the dedicated computer Janus, we follow the nonequilibrium dynamics of
the Ising spin glass in three dimensions for eleven orders of magnitude. The
use of integral estimators for the coherence and correlation lengths allows us
to study dynamic heterogeneities and the presence of a replicon mode and to
obtain safe bounds on the Edwards-Anderson order parameter below the critical
temperature. We obtain good agreement with experimental determinations of the
temperature-dependent decay exponents for the thermoremanent magnetization.
This magnitude is observed to scale with the much harder to measure coherence
length, a potentially useful result for experimentalists. The exponents for
energy relaxation display a linear dependence on temperature and reasonable
extrapolations to the critical point. We conclude examining the time growth of
the coherence length, with a comparison of critical and activated dynamics.Comment: 38 pages, 26 figure
Ianus: an Adpative FPGA Computer
Dedicated machines designed for specific computational algorithms can
outperform conventional computers by several orders of magnitude. In this note
we describe {\it Ianus}, a new generation FPGA based machine and its basic
features: hardware integration and wide reprogrammability. Our goal is to build
a machine that can fully exploit the performance potential of new generation
FPGA devices. We also plan a software platform which simplifies its
programming, in order to extend its intended range of application to a wide
class of interesting and computationally demanding problems. The decision to
develop a dedicated processor is a complex one, involving careful assessment of
its performance lead, during its expected lifetime, over traditional computers,
taking into account their performance increase, as predicted by Moore's law. We
discuss this point in detail
Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells
Standard of care for Epithelial Ovarian Cancer (EOC) patients relies on platinum-based therapy. However, acquired resistance to platinum occurs frequently and predicts poor prognosis. To understand the mechanisms underlying acquired platinum-resistance, we have generated and characterized three platinum-resistant isogenic EOC cell lines. Resistant cells showed 3-to 5- folds increase in platinum IC50. Cross-resistance to other chemotherapeutic agents commonly used in the treatment of EOC patients was variable and dependent on the cell line utilized. Gene expression profiling (GEP) of coding and non-coding RNAs failed to identify a common signature that could collectively explain the mechanism of resistance. However, we observed that all resistant cell lines displayed a decreased level of DNA platination and a faster repair of damaged DNA. Furthermore, all platinum resistant cell lines displayed a change in their morphology and a higher ability to grown on mesothelium. Overall, we have established and characterized three new models of platinum-resistant EOC cell lines that could be exploited to further dissect the molecular mechanisms underlying acquired resistance to platinum. Our work also suggests that GEP studies alone, at least when performed under basal culture condition, do not represent the optimal way to identify molecular alterations linked to DNA repair pathway defects
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