A new approach to the immobilisation of technetium and transuranics: Co-disposal in a zirconolite ceramic matrix

Technetium and transuranic elements (TRUs) are long-lived radionuclides, produced as a result of nuclear power generation. Co-immobilisation of these radionuclides in a ceramic wasteform is attractive as they are problematic for vitrification and would reduce the demand on a future geological disposal facility. A range of zirconolite ceramics have been produced via an oxide route using the surrogates Mo and Ce with a view to the co-immobilisation of Tc and TRUs. The resultant materials were characterised by XRD, SEM-EDX, TEM and XAS. Final phase assemblage was found to be affected by target stoichiometry, the Ca precursor used, processing temperature and processing atmosphere. Through appropriate optimisation of processing conditions and target stoichiometry, the results of this study show co-immobilisation of Tc and TRUs is a promising approach

Surface-wave imaging of the weakly-extended Malawi Rift from ambient-noise and teleseismic Rayleigh waves from onshore and lake-bottom seismometers

Located at the southernmost sector of the Western Branch of the East African Rift System, the Malawi Rift exemplifies an active, magma-poor, weakly extended continental rift. To investigate the controls on rifting, we image crustal and uppermost mantle structure beneath the region using ambient-noise and teleseismic Rayleigh-wave phase velocities between 9 and 100 s period. Our study includes six lake-bottom seismometers located in Lake Malawi (Nyasa), the first time seismometers have been deployed in any of the African rift lakes. Noise-levels in the lake are lower than that of shallow oceanic environments and allow successful application of compliance corrections and instrument orientation determination. Resulting phase-velocity maps reveal slow velocities primarily confined to Lake Malawi at short periods (T 25 s) a prominent low-velocity anomaly exists beneath the Rungwe Volcanic Province at the northern terminus of the rift basin. Estimates of phase-velocity sensitivity indicates these low velocities occur within the lithospheric mantle and potentially uppermost asthenosphere, suggesting that mantle processes may control the association of volcanic centers and the localization of magmatism. Beneath the main portion of the Malawi Rift, a modest reduction in velocity is also observed at periods sensitive to the crust and upper mantle, but these velocities are much higher than those observed beneath Rungwe

Growth analysis in the potato crop under different irrigation levels

Conduziu-se um experimento na Fazenda São Manoel, localizada em São Manuel, SP, pertencente à Faculdade de Ciências Agronômicas da Universidade Estadual Paulista, com o objetivo de avaliar os efeitos de diferentes lâminas de irrigação no crescimento da cultura da batata (Solanum tuberosum ssp. tuberosum), cultivar Aracy. O ensaio foi instalado em um Latossolo Vermelho-Escuro, textura arenosa, sob uma cobertura de plástico. O delineamento experimental utilizado foi o de blocos ao acaso, com cinco tratamentos, cinco coletas de plantas para fins de análise de crescimento, e quatro repetições. Os tratamentos consistiam em irrigar a batata quando a tensão da água no solo atingia 15, 35, 55, 75 e 1.500 kPa. O aumento nas lâminas de irrigação induz incremento no índice de área foliar, na duração da área foliar, na taxa de crescimento relativo e na taxa assimilatória líquida. _________________________________________________________________________________________ ABSTRACT: An experiment was carried out at Fazenda São Manoel, pertaining to the Faculdade de Ciências Agronômicas of the Universidade Estadual Paulista, São Manuel, SP, Brazil, to evaluate irrigation levels in the potato (Solanum tuberosum ssp. tuberosum) growth, cv. Aracy. This work was installed in a sandy Dark-Red Latosol, under a plastic cover. The experimental design was an entirely randomized block composed by irrigation in the potato plots when the soil water potential has reached 15, 35, 55, 75 and 1,500 kPa, and five plant sampling time with four replicates. It was found that higher irrigation levels led to increase of the leaf area index, leaf area duration, relative growth rate and net assimilation rate

Growth of pea plants (Pisum sativum L.) subjected to different soil water potentials : physiological indexes

A ervilha é cultivada no Brasil Central, durante o inverno seco, exigindo para o pleno êxito da cultura o uso da irrigação. Assim, o presente trabalho se propõe a avaliar os efeitos do potencial da água no solo nos índices fisiológicos da análise quantitativa de crescimento de plantas de ervilha (Pisum sativum L.). O experimento foi montado em casa de vegetação, em solos de textura argilosa, com delineamento experimental inteiramente casualizado, com quatro tratamentos decorrentes de potenciais mínimos da água no solo (-33, -100, -200 e -1500 kPa) em três repetições, cada qual contendo duas plantas de ervilha, cultivar Caprice. Os resultados obtidos evidenciaram que a redução do potencial água no solo, induziu o decréscimo na área foliar, sem interferir no comportamento da razão de massa foliar, razão de área foliar, taxa assimilatória líquida e taxa de crescimento relativo. _________________________________________________________________________________________ ABSTRACT: Peas are cultivated in the central region of Brazil, during the dry winter, demanding for the complete success the use of irrigation. Therefore, the present work has the aim of evaluating soil water potential effects on the indexes of physiological growth analysis of peas (Pisum sativum L.). The experiment was carried out in a greenhouse using soils of clayey texture, in a fully randomized design, with four treatments, based on minimum soil water potentials (-33, -100, -200 and -1500 kPa) in three replicates, each one containing two pea plants Caprice cultivar. The results obtained indicate that the reduction of soil water potential induced the decrease of leaf area, but did not interfer on the behaviour of leaf weight ratio, leaf area ratio, net assimilation rate and relative growth rate

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome