Korrelationen messbarer Einflussfaktoren beim Erlernen und Anwenden einer Programmiersprache

Programmierung ist eine wichtige Fähigkeit in der digitalen Welt und wird in vielen technologischen Berufen benötigt. Um diese Fähigkeit zu erlernen, bieten immer mehr Hochschulen informationstechnische Studiengänge an. Doch welche Faktoren beeinflussen das Erlernen und Anwenden einer Programmiersprache? Eine Analyse nach dem studierendenzentrierten Ansatz zeigt, dass der Zeiteinsatz, Verständnis und Fähigkeiten, Erfolgserlebnisse und Spaß eine hohe positive Korrelation mit dem Klausurergebnis aufweisen. Eine förderliche Positivspirale kann in Gang gesetzt werden, indem man versucht, den Zeiteinsatz, die Fähigkeiten, die Erfolgserlebnisse oder den Spaß der Studierenden zu erhöhen. Der Artikel gibt Einblicke in die quantifizierten Einflussfaktoren und zeigt Ansatzpunkte für eine konstruktive Beeinflussung der Lehre der Programmierung auf. (Herausgeber)Programming is an important skill in the digital world and is needed in many technological professions. To learn this skill, more and more universities are offering information technology degree programs. But what factors influence learning and using a programming language? An analysis using the student-centered approach shows that time commitment, understanding and skills, sense of accomplishment, and enjoyment have a high positive correlation with exam scores. A conducive positive spiral can be set in motion by trying to increase students\u27 time use, skills, sense of achievement, or fun. The article provides insights into the quantified influencing factors and identifies starting points for constructively influencing the teaching of programming. (Editor

IAB-Betriebspanel Hessen 2005: Kurzfassung des Abschlussberichts

Das IAB-Betriebspanel ist eine jährliche Befragung im Auftrag des Instituts für Arbeitsmarkt- und Berufsforschung der Bundesagentur für Arbeit (IAB). Es ist eine Bestandsaufnahme betrieblicher Strukturen, Situationen und Problemzusammenhänge, sowie von Stimmungslagen und Einschätzungen der Betriebe. Die Ergebnisse beziehen sich auf die Beschäftigtenzahlen und die Beschäftigungsdynamik, die Einschätzung der wirtschaftlichen Situation, Personaleinstellungen (insbesondere von Geringqualifizierten) und die Strategien gegen Fachkräftemangel, Ausund Weiterbildung sowie die Tarifgebundenheit der Betriebe. (IAB

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk : a case-control study

Abstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Statistical influence of travelling distance on home advantage over 57 years in the men’s German first soccer division

AbstractA statistical analysis is presented that investigates the dependence of team cities’ geographical distances on the effect of home advantage (HA) for 57 years of the men’s German first soccer division (“Bundesliga”), including 17,376 matches (seasons starting from 1964 to 2020). The data shows that the HA can clearly be evidenced in the past and present (statistical p‑value &lt; 0.01) and that it also exists for negligible distances (p &lt; 0.01). The HA and the influence of distance on the HA both significantly decreased gradually over the last decades (p &lt; 0.01). For the first and only time, the HA reversed into an away advantage (AA) for the season 2019/2020 (p &lt; 0.01). The influence of distance on HA has been significant (p &lt; 0.01) in the past (before about 1990) and contributed roughly by about half, compared to a situation without HA or AA. It increases with distance and saturates at around 100 km. Such saturation behaviour is in line with results from higher divisions of other countries with similar travelling distances such as Italy, Turkey and England. However, the distance-dependent contribution to HA has been approximately halved and reduced to an insignificant amount today. Furthermore, the temporal HA reduction is significantly larger for large distances compared to short distances (p &lt; 0.01). Reporting and quantifying a reduction (p &lt; 0.01) of the distance-dependent contribution to HA over a time span of 57 years is novel.</jats:p