Evidence of shared bovine viral diarrhea infections between red deer and extensively raised cattle in south-central Spain

Bovine viral diarrhea virus (BVDV) is a pestivirus that affects cattle production worldwide and that can infect other ungulates such as cervids and even wild boar (Sus scrofa). It is believed that domestic livestock can become infected through contact with wild animals, though it is known that infection can spread among wild animals in the absence of contact with livestock. Little is known about the sharing of BVDV infection between wild and domestic animals in the same habitat, which is important for designing eradication campaigns and preventing outbreaks, especially on hunting estates with high animal densities

COVID-19 y las Bibliotecas especializadas en Ciencias de la Salud de hospitales públicos en España

The COVID-19 Pandemic has ostensibly affected the workability of libraries in all sectors, including health service libraries. The aim of this study is to analize the impact of this situation with a descriptive cross-sectional study carried out in specialized libraries of health sciences within public hospitals in Spain. Methodology: This study was carried out via an email questionnaire from june to november of 2020, comprising 35 items and it gathered data in reference to personnel, services and collections before and during phase 0 of the alarm state. Results: 137 libraries were identified and 100 were analyzed. During the phase 0 of the alarm state 72% remained closed and 76% of the staff combined working in person with working from home. The greatest demand was for research papers/documentation and bibliography searches, no change was experienced with regard to collections. More than half who have participated in collaborative work groups value it as very useful. According to the authors, while this situation has revealed that the librarians have had a great capacity to readapt, they conclude that it has also directly affected libraries with their temporary reconversion or in some cases their total closure.La pandemia de COVID-19 ha afectado al funcionamiento de las bibliotecas de todos los ámbitos, incluidas las sanitarias. El objetivo de este estudio es analizar su impacto en las bibliotecas especializadas de Ciencias de la Salud de hospitales públicos en España. Metodología: Estudio descriptivo transversal realizado desde junio a noviembre de 2020, mediante cuestionario de 35 ítems enviado por correo electrónico donde se recogieron datos respecto al funcionamiento de las bibliotecas, personal, servicios y colecciones antes y durante la fase 0 del estado de alarma. Resultados: Se identificaron 137 bibliotecas. Se analizaron 100. Durante la fase 0, un 72% de las bibliotecas permanecieron cerradas, el 76% del personal teletrabajó alternando con modalidad presencial. Los servicios más demandados fueron el de obtención de documentos y la búsqueda bibliográfica. Las colecciones no sufrieron cambios. Destacan las oportunidades colaborativas surgidas entre las bibliotecas. Conclusiones: El sistema bibliotecario hospitalario ha experimentado un proceso de adaptación y de reinvención que conlleva cambios en la relación con los usuarios, la forma de trabajo y de colaboración

Recensiones [Revista de Historia Económica Año XVIII Otoño-Invierno 2000 n. 3 pp. 687-734]

Editada en la Fundación Empresa PúblicaColl, S., y Guijarro, M.: Estadística aplicada a las Ciencias Sociales (Por Daniel Peña).-- Tedde de Lorca, P.: El Banco de San Femando (1829-1856) (Por Carlos Marichal).-- Comín Comín, F., y Martín Aceña, P.: Tabacalera y el estanco de tabaco en España (1636-1998) (Por Lina Gálvez Muñoz).-- Millán García-Várela, J.: El poder de la tierra. La sociedad agraria del bajo Segura en la época del liberalismo (Por Ricardo Robledo).-- Matés Barco, J. M.: La conquista del agua. Historia económica del abastecimiento urbano (Por Beatriz Mera González).-- Ortiz Batalla, J.: Los Bancos Centrales en América Latina (Por Raúl García Heras).-- Guirao, F.: Spain and the Reconstruction of Western Europe, 1945-57: Challenge and Response (Por Jordi Catalán).-- Aghion, P., y Howitt, P.: Endogenous Growth Theory (Por Joan R. Rosés).-- Dye, A. D.: Cuban Sugar in the Age of Mass Production. Technology and the Economics of Sugar Central, 1899-1929 (Por Antonio Santamaría García).-- Gourvish, T. R., y Tiratsoo, N. (eds.): Missionaries and managers: American influences on European management education, 1945-60 (Por Nuria Puig).-- Coastworth, J., y Taylor, A. (eds.): Latin America and the World Economy since 1800 (Por Gustavo A. del Ángel-Mobarak)Publicad

Genetic and clinical characterization of a novel FH founder mutation in families with hereditary leiomyomatosis and renal cell cancer syndrome

Hereditary leiomyomatosis and renal cell cancer syndrome is a rare autosomal dominant hereditary syndrome. Previously, we published the largest cohort of FH mutation carriers in Spain and observed a highly recurrent missense heterozygous variant, FH(NM_000143.4):c.1118A > G p.(Asn373Ser), in 104 individuals from 31 apparently unrelated families. Here, we aimed to establish its founder effect and characterize the associated clinical phenotype. Results Haplotype analysis confirmed that families shared a common haplotype (32/38 markers) spanning 0.61-0.82 Mb, indicating this recurrent variant was inherited from a founder ancestor. Cutaneous and uterine leiomyomatosis were diagnosed in 64.6% (64/99) and 98% (50/51) of patients, respectively, and renal cell cancer was present in 10.4% (10/96). The pathogenic FH_c.1118A > G variant is a Spanish founder mutation that originated 12-26 generations ago. We estimate that the variant may have appeared between 1370 and 1720. Individuals carrying this founder mutation had similar frequency of renal cell cancer and a higher frequency of renal cysts and leiomyomas than those in other cohorts of this syndrome. Conclusions In the Spanish province of Alicante there is a high prevalence of HLRCC because of the founder mutation FH c.1118A > G; p.(Asn373Ser). The characterization of founder mutations provides accurate and specific information regarding their penetrance and expressivity. In individuals with suspected HLRCC from the province of Alicante, genetic testing by direct analysis of the founder FH c.1118A > G; p.(Asn373Ser) mutation may be a faster and more efficient diagnostic tool compared with complete gene sequencing

Innovative Approaches for Organizing an Inclusive Optics and Photonics Conference in Virtual Format

The COVID pandemic is forcing the renewal of scientific conferences, offering opportunities to introduce technological and inclusive developments. Our analysis focuses on the implementation of inclusive practices for female and early-career researchers in a virtual scientific conference. This organization approach was applied in the XIII Spanish Optical Meeting (RNO2021), which was also characterized by avatars interacting in an online metaverse. The effectiveness of inclusive policies and novel technological tools was evaluated using the participation data and a post-conference survey. Our study reveals the high impact of inclusive actions and a strong interest in the scientific community to explore conference advances

El cáncer hereditario en mujeres

Most cases of cancer are sporadic, whereas 5-10% are hereditary and about 20-30% of cancers tend to cluster in families. Families and individuals who are suspected of suffering from hereditary cancer need to undergo a process known as genetic counseling, which is of considerable importance in the prevention and early detection of malignant tumours. The most common hereditary cancer syndromes are: hereditary breast-ovarian cancer syndrome, familial adenomatous polyposis and Lynch syndrome. Genetic diagnosis allows clinicians to estimate the risks of developing different cancers in order to make decisions over surveillance and prophylactic surgery to reduce these risks. The ultimate goal is to reduce cancer mortality through early diagnosis and prevention.La mayoría de los casos de cáncer son esporádicos, entre un 20-30% presentan agregación familiar, mientras que solo el 5 -10% son de carácter hereditario. Las familias e individuos en los que se sospecha que padecen cáncer hereditario deben someterse a un proceso de asesoramiento genético, que es de gran importancia para la prevención y detección temprana de tumores malignos. Los síndromes más frecuentes de cáncer hereditario son el síndrome de mama-ovario hereditario, la poliposis adenomatosa familiar y el síndrome de Lynch. El diagnóstico genético facilita realizar una estimación de los riesgos de desarrollar diferentes cánceres, permitiendo tomar decisiones de vigilancia y preventivas que reducen estos riesgos. El objetivo final es reducir la mortalidad por cáncer mediante el diagnóstico precoz y la prevención

Hereditary Cancer In Women

[spa] La mayoría de los casos de cáncer son esporádicos, entre un 20-30% presentan agregación familiar, mientras que solo el 5 -10% son de carácter hereditario. Las familias e individuos en los que se sospecha que padecen cáncer hereditario deben someterse a un proceso de asesoramiento genético, que es de gran importancia para la prevención y detección temprana de tumores malignos. Los síndromes más frecuentes de cáncer hereditario son el síndrome de mama-ovario hereditario, la poliposis adenomatosa familiar y el síndrome de Lynch. El diagnóstico genético facilita realizar una estimación de los riesgos de desarrollar diferentes cánceres, permitiendo tomar decisiones de vigilancia y preventivas que reducen estos riesgos. El objetivo final es reducir la mortalidad por cáncer mediante el diagnóstico precoz y la prevención.[eng] Most cases of cancer are sporadic, whereas 5-10% are hereditary and about 20-30% of cancers tend to cluster in families. Families and individuals who are suspected of suffering from hereditary cancer need to undergo a process known as genetic counseling, which is of considerable importance in the prevention and early detection of malignant tumours. The most common hereditary cancer syndromes are: hereditary breast-ovarian cancer syndrome, familial adenomatous polyposis and Lynch syndrome. Genetic diagnosis allows clinicians to estimate the risks of developing different cancers in order to make decisions over surveillance and prophylactic surgery to reduce these risks. The ultimate goal is to reduce cancer mortality through early diagnosis and prevention

Prevalence of Lynch Syndrome among Patients with Newly Diagnosed Endometrial Cancers

Background: Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other cancers. The identification of endometrial cancer (EC) patients with LS has the potential to influence life-saving interventions. We aimed to study the prevalence of LS among EC patients in our population. Methods: Universal screening for LS was applied for a consecutive series EC. Tumor testing using microsatellite instability (MSI), immunohistochemistry (IHC) for mismatch-repair (MMR) protein expression and MLH1-methylation analysis, when required, was used to select LS-suspicious cases. Sequencing of corresponding MMR genes was performed. Results: One hundred and seventy-three EC (average age, 63 years) were screened. Sixty-one patients (35%) had abnormal IHC or MSI results. After MLH1 methylation analysis, 27 cases were considered suspicious of LS. From these, 22 were contacted and referred for genetic counseling. Nineteen pursued genetic testing and eight were diagnosed of LS. Mutations were more frequent in younger patients (<50 yrs). Three cases had either intact IHC or MSS and reinforce the need of implement the EC screening with both techniques. Conclusion: The prevalence of LS among EC patients was 4.6% (8/173); with a predictive frequency of 6.6% in the Spanish population. Universal screening of EC for LS is recommended.This study was supported by Conselleria Sanidad Comunidad Valenciana, Spain (AP/177/10) (http://www.san.gva.es/); Biomedical Research Foundations of the Alicante University Hospital (PI14/2006 and NI02/2011) (http://www.dep19.san.gva.es/); and the Elche University Hospital, Spain (FIBElx-CO11/03) (http://www.dep20.san.gva.es/)