One-neutron removal reactions on neutron-rich psd-shell nuclei

A systematic study of high energy, one-neutron removal reactions on 23 neutron-rich, psd--shell nuclei (Z=5-9, A=12-25) has been carried out. The longitudinal momentum distributions of the core fragments and corresponding single-neutron removal cross sections are reported for reactions on a carbon target. Extended Glauber model calculations, weighted by the spectroscopic factors obtained from shell model calculations, are compared to the experimental results. Conclusions are drawn regarding the use of such reactions as a spectroscopic tool and spin-parity assignments are proposed for 15B, 17C, 19-21N, 21,23O, 23-25F. The nature of the weakly bound systems 14B and 15,17C is discussed.Comment: 11 pages + 2 figure

Initial State Dependence of the Breakup of Weakly Bound Carbon Isotopes

The one-neutron nuclear breakup from the Carbon isotopes $^{19}$C and $^{17}$C, is calculated as an example of application of the theory of transfer to the continuum reactions in the formulation which includes spin coupling. The effect of the energy sharing between the parallel and transverse neutron momentum distributions is taken into account thus resulting in a theory which is more general than sudden eikonal approaches. Both effects are necessary to understand properly the breakup from not too weakly bound $l_i>1$ orbitals. Breakup which leaves the core into an excited state below particle threshold is also considered. The core-target interaction is treated in the smooth cut-off approximation. By comparing to presently available experimental data we show how to make some hypothesis on the quantum numbers and occupancy of the neutron initial state. Possible ambiguities in the interpretation of inclusive cross sections are discussed.Comment: 22 RevTeX pages,3 ps figures. Phys. Rev. C, accepte

Projectile structure effects in the Coulomb breakup of one-neutron halo nuclei

We investigate the Coulomb breakup of neutron rich nuclei 11Be and (19,17,15)C within a theory developed in the framework of Distorted Wave Born Approximation. Finite range effects are included by a local momentum approximation, which allows incorporation of realistic wave functions for these nuclei in our calculations. Energy and angular as well as parallel momentum distributions of the fragments emitted in the breakup of these nuclei on heavy targets have been calculated using several structure models for their ground state. Comparison with the available experimental data shows that the results are selective about the ground state wave function of the projectile. Our investigations confirm that the nuclei 11Be, 19C and 15C have a one-neutron halo structure in their ground states. However, for 17C such a structure appears to be less likely. Calculations performed within our method have also been compared with those from an adiabatic model and the results are discussed.Comment: Minor corrections in a couple of references, Requires elsart.cls 33 pages including 16 figures, Nucl. Phys. A in Pres

Parallel momentum distribution of the 28^{28}Si fragments from 29^{29}P

Distribution of the parallel momentum of $^{28}$Si fragments from the breakup of 30.7 MeV/nucleon $^{29}$P has been measured on C targets. The distribution has the FWHM with the value of 110.5 $\pm$ 23.5 MeV/c which is consistent quantitatively with Galuber model calculation assuming by a valence proton in $^{29}$P. The density distribution is also predicted by Skyrme-Hartree-Fock calculation. Results show that there might exist the proton-skin structure in $^{29}$P.Comment: 4 pages, 4 figure

Macrophage Migration Inhibitory Factor Antagonist Blocks the Development of Endometriosis In Vivo

Endometriosis, a disease of reproductive age women, is a major cause of infertility, menstrual disorders and pelvic pain. Little is known about its etiopathology, but chronic pelvic inflammation is a common feature in affected women. Beside symptomatic treatment of endometriosis-associated pain, only two main suboptimal therapeutic approaches (hormonal and invasive surgery) are generally recommended to patients and no specific targeted treatment is available. Our studies led to the detection of a marked increase in the expression of macrophage migration inhibitory factor (MIF) in the eutopic endometrium, the peripheral blood and the peritoneal fluid of women with endometriosis, and in early, vascularized and active endometriotic lesions. Herein, we developed a treatment model of endometriosis, where human endometrial tissue was first allowed to implant into the peritoneal cavity of nude mice, to assess in vivo the effect of a specific antagonist of MIF (ISO-1) on the progression of endometriosis and evaluate its efficacy as a potential therapeutic tool. Administration of ISO-1 led to a significant decline of the number, size and in situ dissemination of endometriotic lesions. We further showed that ISO-1 may act by significantly inhibiting cell adhesion, tissue remodeling, angiogenesis and inflammation as well as by altering the balance of pro- and anti-apoptotic factors. Actually, mice treatment with ISO-1 significantly reduced the expression of cell adhesion receptors αv and ß3 integrins (P<0.05), matrix metalloproteinases (MMP) 2 and 9 (P<0.05), vascular endothelial cell growth factor (VEGF) (P<0.01), interleukin 8 (IL8) (P<0.05), cyclooxygenease (COX)2 (P<0.001) and the anti-apoptotic protein Bcl2 (P<0.01), but significantly induced the expression of Bax (P<0.05), a potent pro-apoptotic protein. These data provide evidence that specific inhibition of MIF alters endometriotic tissue growth and progression in vivo and may represent a promising potential therapeutic avenue

Drug-microbiota interactions and treatment response: Relevance to rheumatoid arthritis

Knowledge about associations between changes in the structure and/or function of intestinal microbes (the microbiota) and the pathogenesis of various diseases is expanding. However, interactions between the intestinal microbiota and different pharmaceuticals and the impact of these on responses to treatment are less well studied. Several mechanisms are known by which drug-microbiota interactions can influence drug bioavailability, efficacy, and/or toxicity. This includes direct activation or inactivation of drugs by microbial enzymes which can enhance or reduce drug effectiveness. The extensive metabolic capabilities of the intestinal microbiota make it a hotspot for drug modification. However, drugs can also influence the microbiota profoundly and change the outcome of interactions with the host. Additionally, individual microbiota signatures are unique, leading to substantial variation in host responses to particular drugs. In this review, we describe several known and emerging examples of how drug-microbiota interactions influence the responses of patients to treatment for various diseases, including inflammatory bowel disease, type 2 diabetes and cancer. Focussing on rheumatoid arthritis (RA), a chronic inflammatory disease of the joints which has been linked with microbial dysbiosis, we propose mechanisms by which the intestinal microbiota may affect responses to treatment with methotrexate which are highly variable. Furthering our knowledge of this subject will eventually lead to the adoption of new treatment strategies incorporating microbiota signatures to predict or improve treatment outcomes

Applying the Framework for Strategic Sustainable Development to Water management

A strategic management of water is integral for any society aiming at moving towards sustainability. This thesis aims to provide a common understanding of how water management should be considered within sustainability constraints, using ‘backcasting’ from basic sustainability principles as a compass. With a common language, a constructive dialogue is then possible to unify all stakeholders to move together towards sustainability. To answer the research question “How can an interaction with water stakeholders be strategically developed to progress toward the service of water in a sustainable society”, a methodology based on Sustainability Life Cycle Assessment, the Template for Sustainable Product Development and Multi-Stakeholder Platforms has been utilised within one domestic and one industrial water user case study in Blekinge, Southern Sweden. In this locality, water is regarded as abundant in volume. Yet it was revealed that what is consumed by society is not water as such; but the purity of water. Within this context, opportunities to move towards sustainability have arisen and the case study organizations were able to utilise improvements in reporting and operations. Economic activity such as new infrastructure, pollutant trading schemes and product accreditation are amongst the many concepts identified as potential steps towards the service of water in a sustainable society