Early Inscriptions of Āndhradeśa: Results of fieldwork in January and February 2016

International audienc

Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid

Host defense peptides or antimicrobial peptides (AMPs), e.g., cathelicidins, have recently been discussed as a potential new treatment option against bacterial infections. To test the efficacy of AMPs, standardized methods that closely mimic the physiological conditions at the site of infection are still needed. The aim of our study was to test the meningitis-causing bacteria Streptococcus suis and Escherichia coli for their susceptibility to cathelicidins in culture medium versus cerebrospinal fluid (CSF). Susceptibility testing was performed in analogy to the broth microdilution method described by the Clinical and Laboratory Standard Institute (CLSI) to determine minimum inhibitory concentrations (MICs) of antimicrobial agents. MICs were determined using cation-adjusted Mueller–Hinton broth (CA-MHB), lysogeny broth (LB), Roswell Park Memorial Institute medium (RPMI) or Dulbecco’s Modified Eagle’s Medium (DMEM) (the latter two supplemented with 5% CA-MHB or blood) and compared with MICs obtained in porcine or human CSF. Our data showed that MICs obtained in CA-MHB as recommended by CLSI do not reflect the MICs obtained in the physiological body fluid CSF. However, the MICs of clinical isolates of S. suis tested in RPMI medium supplemented with CA-MHB, were similar to those of the same strains tested in CSF. In contrast, the MICs in the human CSF for the tested E. coli K1 strain were higher compared to the RPMI medium and showed even higher values than in CA-MHB. This highlights the need for susceptibility testing of AMPs in a medium that closely mimics the clinically relevant conditions

Buddhist Translators Workbench (BTW)

This project will create an integrated suite of open-source tools for translators of Buddhist texts, the Buddhist Translators Workbench (BTW). BTW will gather data on source texts and translations across cultures and across time. It will support both real-time and offline collaboration on group translation projects by logging user threads and dialogs and creating “digital footnotes” that preserve and inspire new research. BTW will for the first time ground Buddhist translation work in a shared, easily accessible body of knowledge. At Level I the project will bring together scholars and IT experts to choose an initial set of 500-1,000 terms and design an alpha-level prototype, using selected Abhidharma texts as its initial resource. It will also address software-development needs, including creation of language agnostic searches, proximity searches, and computer recognition of word clusters (Tibetan) and individual words (Sanskrit)

Shayne Clarke (éd.), Vinaya Texts, New Delhi, The National Archives of India/Tokyo, The International Research Institute for Advanced Buddhology, Soka University, 2014 (Gilgit Manuscripts in the National Archives of India, Facsimile Edition, Volume I)

Baums Stefan. Shayne Clarke (éd.), Vinaya Texts, New Delhi, The National Archives of India/Tokyo, The International Research Institute for Advanced Buddhology, Soka University, 2014 (Gilgit Manuscripts in the National Archives of India, Facsimile Edition, Volume I). In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 103, 2017. pp. 495-501

Shayne Clarke (éd.), Vinaya Texts, New Delhi, The National Archives of India/Tokyo, The International Research Institute for Advanced Buddhology, Soka University, 2014 (Gilgit Manuscripts in the National Archives of India, Facsimile Edition, Volume I)

Baums Stefan. Shayne Clarke (éd.), Vinaya Texts, New Delhi, The National Archives of India/Tokyo, The International Research Institute for Advanced Buddhology, Soka University, 2014 (Gilgit Manuscripts in the National Archives of India, Facsimile Edition, Volume I). In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 103, 2017. pp. 495-501

Proposal for the Encoding of Brāhmī in Plane 1 of ISO/IEC 10646

This is a preliminary proposal to encode the historic Brahmi script in the international character encoding standard Unicode. A revised version of this proposal was submitted in 2008 () and was approved. The Brahmi script was published in Unicode Standard version 6.0 in October 2010. Subsequent changes to the characters proposed here have been made in Unicode, so users should check the latest code charts, which are accessible at:

Early Inscriptions of Āndhradeśa

Digital corpusThis digital publication aims to present the complete primary textual data along with metadata, including precise information on the whereabouts of the inscribed artefacts, annotated English translations, for a major Indian epigraphic corpus that has so far only been studied with pre-digital methods. Our aim has been to identify in the field, or in museums, all inscriptions falling within our purview, to document them photographically, to re-edit them from the originals whenever possible, and to exploit the full potential of a digital corpus approach to these historical documents.Initially focused on the inscriptions of Nagarjunakonda and the Ikṣvāku dynasty, on the one hand, and on post-Ikṣvāku documents for the history of Buddhism, on the other, the publication will eventually cover all records from the beginning of the epigraphic tradition in the part of India covered today by the states of Telangana and Andhra up to the rise of Telugu as epigraphical language of expression in the second half of the first millennium, as rough chronological cut-off point.In this early period, the epigraphic corpus of Āndhradeśa is primarily connected with the history of Buddhism. Our work on this corpus began as part of a collaborative research project ‘From Vijayapuri to Sriksetra? The Beginnings of Buddhist Exchange across the Bay of Bengal as Witnessed by Inscriptions from Andhra Pradesh and Myanmar’, which investigated the history of Buddhism across the Bay of Bengal based on the epigraphic records of Vijayapuri (modern Nagarjunakonda) in India and Sriksetra (near modern Pyay) in Myanmar. See also Credits.The data presented in this publication have been encoded in XML according to the EpiDoc schema compliant with the Text Encoding Initiative and processed through ODD in an eXist database

Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid

Host defense peptides or antimicrobial peptides (AMPs), e.g., cathelicidins, have recently been discussed as a potential new treatment option against bacterial infections. To test the efficacy of AMPs, standardized methods that closely mimic the physiological conditions at the site of infection are still needed. The aim of our study was to test the meningitis-causing bacteria Streptococcus suis and Escherichia coli for their susceptibility to cathelicidins in culture medium versus cerebrospinal fluid (CSF). Susceptibility testing was performed in analogy to the broth microdilution method described by the Clinical and Laboratory Standard Institute (CLSI) to determine minimum inhibitory concentrations (MICs) of antimicrobial agents. MICs were determined using cation-adjusted Mueller–Hinton broth (CA-MHB), lysogeny broth (LB), Roswell Park Memorial Institute medium (RPMI) or Dulbecco’s Modified Eagle’s Medium (DMEM) (the latter two supplemented with 5% CA-MHB or blood) and compared with MICs obtained in porcine or human CSF. Our data showed that MICs obtained in CA-MHB as recommended by CLSI do not reflect the MICs obtained in the physiological body fluid CSF. However, the MICs of clinical isolates of S. suis tested in RPMI medium supplemented with CA-MHB, were similar to those of the same strains tested in CSF. In contrast, the MICs in the human CSF for the tested E. coli K1 strain were higher compared to the RPMI medium and showed even higher values than in CA-MHB. This highlights the need for susceptibility testing of AMPs in a medium that closely mimics the clinically relevant conditions

Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid

Host defense peptides or antimicrobial peptides (AMPs), e.g., cathelicidins, have recently been discussed as a potential new treatment option against bacterial infections. To test the efficacy of AMPs, standardized methods that closely mimic the physiological conditions at the site of infection are still needed. The aim of our study was to test the meningitis-causing bacteria Streptococcus suis and Escherichia coli for their susceptibility to cathelicidins in culture medium versus cerebrospinal fluid (CSF). Susceptibility testing was performed in analogy to the broth microdilution method described by the Clinical and Laboratory Standard Institute (CLSI) to determine minimum inhibitory concentrations (MICs) of antimicrobial agents. MICs were determined using cation-adjusted Mueller–Hinton broth (CA-MHB), lysogeny broth (LB), Roswell Park Memorial Institute medium (RPMI) or Dulbecco’s Modified Eagle’s Medium (DMEM) (the latter two supplemented with 5% CA-MHB or blood) and compared with MICs obtained in porcine or human CSF. Our data showed that MICs obtained in CA-MHB as recommended by CLSI do not reflect the MICs obtained in the physiological body fluid CSF. However, the MICs of clinical isolates of S. suis tested in RPMI medium supplemented with CA-MHB, were similar to those of the same strains tested in CSF. In contrast, the MICs in the human CSF for the tested E. coli K1 strain were higher compared to the RPMI medium and showed even higher values than in CA-MHB. This highlights the need for susceptibility testing of AMPs in a medium that closely mimics the clinically relevant conditions