631 research outputs found
Structure, tectonics and metamorphic development of the Sancti Spiritus Dome (eastern Escambray massif, Central Cuba)
The Sancti Spiritus Dome of the eastern Escambray (Cuba) represents a metamorphic fold and thrust structure which was part of the Cretaceous subduction-accretion complex of the Greater Antillean Arc. On the basis of structural data and pressure-temperature-time evolution the metamorphic complex can be subdivided into four units interpretable as nappes: a high-grade greenschist-facies unit (Pitajones unit), a high-pressure tectonic mélange (Gavilanes unit), high-pressure amphibolites (Yayabo unit) and - tectonically overlying - low-pressure metagabbros of the Greater Antillean Arc (Mabujina unit). The oldest rock fabrics are preserved in eclogite- and blueschist-facies rocks of the Gavilanes unit, indicating arc-parallel extension. Maximum metamorphic conditions are recorded in eclogites (16-20 kbar, 580-630 °C) and garnet-mica schists (16-23 kbar, 530-610 °C) of the Gavilanes unit. Field observations and fabric studies show that greenschist-facies dynamic indicators are dominated by top-to-NE tectonic transport in the lowermost nappes. The greenschist-facies shear zone between the Yayabo unit and the Mabujina unit is viewed as the main detachment zone between the subduction complex and the overlying arc complex. Active subduction ceased at about 70 Ma, followed by rapid uplift, exhumation and thrusting to the north
Perturbations of the local gravity field due to mass distribution on precise measuring instruments: a numerical method applied to a cold atom gravimeter
We present a numerical method, based on a FEM simulation, for the
determination of the gravitational field generated by massive objects, whatever
geometry and space mass density they have. The method was applied for the
determination of the self gravity effect of an absolute cold atom gravimeter
which aims at a relative uncertainty of 10-9. The deduced bias, calculated with
a perturbative treatment, is finally presented. The perturbation reaches (1.3
\pm 0.1) \times 10-9 of the Earth's gravitational field.Comment: 12 pages, 7 figure
Serum Peptidome Profiling Revealed Platelet Factor 4 as a Potential Discriminating Peptide Associated With Pancreatic Cancer
Purpose: Mass spectrometry-based serum peptidome profiling is a promising tool to identify novel disease-associated biomarkers, but is limited by preanalytical factors and the intricacies of complex data processing. Therefore, we investigated whether standardized sample protocols and new bioinformatic tools combined with external data validation improve the validity of peptidome profiling for the discovery of pancreatic cancer associated serum markers.
Experimental Design: For discovery study, two sets of sera from patients with pancreatic cancer (n=40) and healthy controls (n=40) were obtained from two different clinical centers. For external data validation, we collected an independent set of samples from patients (n=20) and healthy controls (n=20). Magnetic beads (MB) with different surface functionalities were used for peptidome fractionation followed by MALDI-TOF MS. Data evaluation was carried out comparing two different bioinformatic strategies. Following proteome database search the matching candidate peptide was verified by MALDI-TOF MS after specific antibody-based immunoaffinity chromatography and independently confirmed by an ELISA assay.
Results: Two significant peaks (m/z 3884; 5959) achieved a sensitivity of 86.3% and specificity of 97.6% for the discrimination of patients and healthy controls in the external validation set. Adding peak m/z 3884 to conventional clinical tumor markers (CA 19-9 and CEA) improved sensitivity and specificity as shown by ROC analysis (AUROCcombined=1.00). Mass spectrometry based m/z 3884 peak identification and following immunological quantitation revealed platelet factor 4 as the corresponding peptide.
Conclusions: MALDI-TOF MS based serum peptidome profiling allowed the discovery and validation of platelet factor 4 as a new discriminating marker in pancreatic cancer
Controlled generation of momentum states in a high-finesse ring cavity
A Bose-Einstein condensate in a high-finesse ring cavity scatters the photons
of a pump beam into counterpropagating cavity modes, populating a
bi-dimensional momentum lattice. A high-finesse ring cavity with a sub-recoil
linewidth allows to control the quantized atomic motion, selecting particular
discrete momentum states and generating atom-photon entanglement. The
semiclassical and quantum model for the 2D collective atomic recoil lasing
(CARL) are derived and the superradiant and good-cavity regimes discussed. For
pump incidence perpendicular to the cavity axis, the momentum lattice is
symmetrically populated. Conversely, for oblique pump incidence the motion
along the two recoil directions is unbalanced and different momentum states can
be populated on demand by tuning the pump frequency.Comment: Submitted to EPJ-ST Special Issue. 10 pages and 3 figure
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Production of π0 and η mesons in Cu+Au collisions at sNN =200 GeV
Production of π0 and η mesons has been measured at midrapidity in Cu+Au collisions at sNN=200GeV. Measurements were performed in π0(η)→γγ decay channel in the 1(2)-20GeV/c transverse momentum range. A strong suppression is observed for π0 and η meson production at high transverse momentum in central Cu+Au collisions relative to the p+p results scaled by the number of nucleon-nucleon collisions. In central collisions the suppression is similar to Au+Au with comparable nuclear overlap. The η/π0 ratio measured as a function of transverse momentum is consistent with mT-scaling parametrization down to pT=2GeV/c, its asymptotic value is constant and consistent with Au+Au and p+p and does not show any significant dependence on collision centrality. Similar results were obtained in hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions as well as in e+e- collisions in a range of collision energies sNN=3-1800 GeV. This suggests that the quark-gluon-plasma medium produced in Cu+Cu collisions either does not affect the jet fragmentation into light mesons or it affects the π0 and η the same way
Search for a Technicolor omega_T Particle in Events with a Photon and a b-quark Jet at CDF
If the Technicolor omega_T particle exists, a likely decay mode is omega_T ->
gamma pi_T, followed by pi_T -> bb-bar, yielding the signature gamma bb-bar. We
have searched 85 pb^-1 of data collected by the CDF experiment at the Fermilab
Tevatron for events with a photon and two jets, where one of the jets must
contain a secondary vertex implying the presence of a b quark. We find no
excess of events above standard model expectations. We express the result of an
exclusion region in the M_omega_T - M_pi_T mass plane.Comment: 14 pages, 2 figures. Available from the CDF server (PS with figs):
http://www-cdf.fnal.gov/physics/pub98/cdf4674_omega_t_prl_4.ps
FERMILAB-PUB-98/321-
Invariant-mass and [gamma]-ray spectroscopy using secondary, radioactive ion beams
Coulomb excitation of secondary beams (5 < Z < 20) at energies
around 250 .1 MeV was explored at GSI. For low-lying states, 7-ray spectroscopy
was utilized, while high-lying excitations were investigated by
means of invariant-mass spectroscopy
A Measurement of Rb using a Double Tagging Method
The fraction of Z to bbbar events in hadronic Z decays has been measured by
the OPAL experiment using the data collected at LEP between 1992 and 1995. The
Z to bbbar decays were tagged using displaced secondary vertices, and high
momentum electrons and muons. Systematic uncertainties were reduced by
measuring the b-tagging efficiency using a double tagging technique. Efficiency
correlations between opposite hemispheres of an event are small, and are well
understood through comparisons between real and simulated data samples. A value
of Rb = 0.2178 +- 0.0011 +- 0.0013 was obtained, where the first error is
statistical and the second systematic. The uncertainty on Rc, the fraction of Z
to ccbar events in hadronic Z decays, is not included in the errors. The
dependence on Rc is Delta(Rb)/Rb = -0.056*Delta(Rc)/Rc where Delta(Rc) is the
deviation of Rc from the value 0.172 predicted by the Standard Model. The
result for Rb agrees with the value of 0.2155 +- 0.0003 predicted by the
Standard Model.Comment: 42 pages, LaTeX, 14 eps figures included, submitted to European
Physical Journal
Lymphocyte Subsets Show Different Response Patterns to In Vivo Bound Natalizumab—A Flow Cytometric Study on Patients with Multiple Sclerosis
Natalizumab is an effective monoclonal antibody therapy for the treatment of relapsing- remitting multiple sclerosis (RRMS) and interferes with immune cell migration into the central nervous system by blocking the α4 subunit of very-late activation antigen-4 (VLA-4). Although well tolerated and very effective, some patients still suffer from relapses in spite of natalizumab therapy or from unwanted side effects like progressive multifocal leukoencephalopathy (PML). In search of a routine-qualified biomarker on the effectiveness of natalizumab therapy we applied flow cytometry and analyzed natalizumab binding to α4 and α4 integrin surface levels on T-cells, B-cells, natural killer (NK) cells, and NKT cells from 26 RRMS patients under up to 72 weeks of therapy. Four-weekly infusions of natalizumab resulted in a significant and sustained increase of lymphocyte-bound natalizumab (p<0.001) which was paralleled by a significant decrease in detectability of the α4 integrin subunit on all lymphocyte subsets (p<0.001). We observed pronounced natalizumab accumulations on T and B cells at single measurements in all patients who reported clinical disease activity (n = 4). The natalizumab binding capacity of in vitro saturated lymphocytes collected during therapy was strongly diminished compared to treatment-naive cells indicating a therapy-induced reduction of α4. Summing up, this pilot study shows that flow cytometry is a useful method to monitor natalizumab binding to lymphocytes from RRMS patients under therapy. Investigating natalizumab binding provides an opportunity to evaluate the molecular level of effectiveness of natalizumab therapy in individual patients. In combination with natalizumab saturation experiments, it possibly even provides a means of studying the feasability of patient-tailored infusion intervals. A routine-qualified biomarker on the basis of individual natalizumab saturation on lymphocyte subsets might be an effective tool to improve treatment safety
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