28 research outputs found
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
- J Hardy
- J Harris
- J Hatton
- J Hawes
- J Highgate
- J Hornsby
- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
- J Martin
- J Matthews
- J McCormick
- J Medhora
- J Melville
- J Moreno Cuesta
- J Morgan
- J Naisbitt
- J Norris
- J North
- J Parkin
- J Pendlebury
- J Perez
- J Perry
- J Pheby
- J Philbin
- J Pinnell
- J Queiroz
- J Radhakrishnan
- J Reid
- J Rhodes
- J Riches
- J Ritzema
- J Ruddy
- J Ryan-Smith
- J Scriven
- J Scriven
- J Scriven
- J Shiel
- J Singh
- J Singleton
- J Smith
- J Sowter
- J Strickley
- J Summers
- J Taylor
- J Tebbutt
- J Texeira
- J Thomas
- J Thrush
- J Tomlinson
- J Valentine
- J Whiteside
- J Wilkins
- J Willson
- J Zamikula
- Jake Dunning
- Jane Weaver
- Janet Harrison
- Janet T Scott
- Janie F Shelton
- Jen Meikle
- Jo Dalton
- Johnny Millar
- Jorge Esparza-Gordillo
- Jose E Krieger
- Julian A Hiscox
- K Archer
- K Austin
- K Baines
- K Bauchmuller
- K Beaumont
- K Beesley
- K Black
- K Burns
- K Burt
- K Cawley
- K Cawthron
- K Connolly
- K Convery
- K Criste
- K Dale
- K Darlington
- K Davies
- K Dent
- K Douglas
- K Duffy
- K Elliott
- K Elston
- K English
- K Fernandes
- K Fletcher
- K Gilbert
- K Golder
- K Hammerton
- K Hanson
- K Hanson
- K Hard
- K Harrington
- K Hayes
- K Holding
- K Holdroyd
- K Howard
- K Hugill
- K Inweregbu
- K Jackson-Lawrence
- K Karthik
- K King
- K Knowles
- K Lang
- K Liyanage
- K Manso
- K Netherton
- K Postlethwaite
- K Potts
- K Prager
- K Praman
- K Priestley
- K Pritchard
- K Puxty
- K Reid
- K Riches
- K Rooney
- K Sellick
- K Shuker
- K Simpson
- K Simpson
- K Slevin
- K Smith
- K Sollesta
- K Stammers
- K Stroud
- K Sweet
- K Tatham
- K Turner
- K Webster
- K White
- K Williams
- K Xavier
- Katarzyna Hafezi
- Keating Sean
- Kenneth A Mclean
- Kirstie Morrice
- Klaric Lucija
- Klenerman Paul
- Knight Julian
- Kousathanas Athanasios
- L Abel
- L Akeroyd
- L Allen
- L Armstrong
- L Barclay
- L Benham
- L Botfield
- L Bough
- L Brimfield
- L Bunni
- L Cabrelli
- L Cagova
- L Catlow
- L Ding
- L Ferguson
- L Folkes
- L Foster
- L Garner
- L Gemmell
- L George
- L Glass
- L Glass
- L Gledhill
- L Grauslyte
- L Grimmer
- L Gurr
- L Harrison
- L Hodgson
- L Hudig
- L Keating
- L Kittridge
- L Lankester
- L Lennon
- L Lim
- L Ma
- L Marshall
- L Matupe
- L McMorrow
- L McQuillan
- L Mew
- L Mostoles
- L Mwaura
- L Newey
- L O'Brien
- L O'Malley
- L O'Neill
- L Ortiz-Ruiz de Gordoa
- L Ortiz-Ruiz de Gordoa
- L Park
- L Pippard
- L Prentice
- L Rad
- L Ramos
- L Riddles
- L Roche
- L Roche
- L Rooney
- L Rosaroso
- L Shaw
- L Smith
- L Stevenson
- L Symon
- L Thomis
- L Thornton
- L Thrasyvoulou
- L Ting
- L Tonks
- L Turner
- L van Koutrik
- L Wilcox
- L Wild
- L Wilding
- L Woods
- L Wren
- L Zitter
- Lance C W Turtle
- Laura Bergantini
- Laura Di Sarno
- Laura Marsh
- Laura Merson
- Law Andrew
- Leonardo Croci
- Lia Crotti
- Ling Lowell
- Lisa Norman
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Louise Sigfrid
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
- M Abdelrazik
- M Al-Moasseb
- M Balasubramaniam
- M Bates
- M Bellamy
- M Birt
- M Blunt
- M Bokhari
- M Bolton
- M Brady
- M Breekes
- M Brett
- M Bromley
- M Bruce
- M Brunton
- M Burton
- M Callaghan
- M Carmody
- M Carnahan
- M Casey
- M Caswell
- M Chablani
- M Clapham
- M Clark
- M Clark
- M Coulding
- M Croft
- M Cunningham
- M Davey
- M Davies
- M Davies
- M Edward
- M Elhassan
- M Elsaadany
- M Faulkner
- M Forsey
- M Frise
- M Gellamucho
- M Gill
- M Gummadi
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- M Harkins
- M Hill
- M Hobrok
- M Holland
- M Home
- M Hussain
- M Jackson
- M K Phull
- M Kent
- M Khan
- M Latif
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- M Lopez Martinez
- M Lyons
- M MacMahon
- M Male
- M Marani
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- M Matharu
- M McLaughlin
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- M Meredith
- M Mpelembue
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- M Patel
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- M Poulaka
- M Purewal
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- M Smith
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- M Spivey
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- M Taylor
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- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
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- Nichol Alistair
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- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
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- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
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- Pereira Alexandre C
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- Pier Giorgio Scotton
- Pierpaolo Parravicini
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- Ponting Chris P
- Porteous David J
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- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
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- S Gurung Rai
- S Henderson
- S Hierons
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- S Hussain
- S Jenkins
- S Jhanji
- S Jones
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- S Kennedy-Hay
- S Kimber
- S Kumar
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- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
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- S McIvor
- S McKechnie
- S Melling
- S Mellor
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- S Mitchard
- S Mohamed Ally
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- S Moore
- S Morrison
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- S Mulla
- S Munt
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- S O'Sullivan
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- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
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- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
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- Diego Ripamonti
- Domenico A. Coviello
- Dorota Pasko
- Dorota Zarębska-Michaluk
- E. Abaleke
- E. Allan
- E. Anastasescu
- E. Andrews
- E. Apetri
- E. Beech
- E. Beranova
- E. Bevan
- E. Black
- E. Brinkworth
- E. Collins
- E. Combes
- E. Davies
- E. Dobson
- E. Dooks
- E. Fisher
- E. Gendall
- E. Goff
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- E. Gordon
- E. Heeney
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- E. Johnson
- E. Jude
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- E. London
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- E. McKenna
- E. Meadows
- E. Moncur
- E. Morino
- E. Mwaura
- E. Peasgood
- E. Perkins
- E. Radford
- E. Raith
- E. Salciute L. Grauslyte
- E. Smith
- E. Smithson
- E. Stoddard
- E. Stones
- E. Thomas
- E. Tilney
- E. Timlick
- E. Treus Gude
- E. Virgilio
- E. Watson
- E. Wilby
- E. Wraith
- Edoardo Conticini
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Elvina Gountouna
- Emanuele Catena
- Enrico Cabri
- Enrico Martinelli
- Erika Fiorentini
- Erola Pairo-Castineira
- Erola Pairo-Castineira
- Esther Duncan
- Eugenia Quiros-Roldan
- Eva C. Schulte
- Eva C. Schulte
- F. Anderson
- F. Auld
- F. Bibi
- F. Davies
- F. Farquhar
- F. Fisher
- F. Hurford
- F. Kibutu
- F. McNeela
- F. Moore
- F. Nasir
- F. Trim
- F. Wakinshaw
- F. Williams
- Fabian Brand
- Fabio Lena
- Faisal Almalki
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Fiona Griffiths
- Floriana Valentino
- Francesca Andretta
- Francesca Ariani
- Francesca Colombo
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Minnai
- Francesca Montagnani
- Francesca Vichi
- Francesco Bianchi
- Francesco Brancati
- Francesco Castelli
- Francesco Menichetti
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francis P. Crawley
- Franco Maggiolo
- Franco Marinangeli
- G. Andrew
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- G. Wray
- Gabriela Sokołowska
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- GEN-COVID Multicenter Study
- Genni Spargi
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- Giada Beligni
- Gian Piero Caldarelli
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- V. Crickmore
- V. Gopal
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- V. Krishnamurthy
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- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
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- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
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- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
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- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
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- Biscione Roberto R.
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- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
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- Bramall Jon
- Braschi Antonio
- Brazzi Luca
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- Briquet Anais
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- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
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- Brunettini Barbara
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- Buensuseso Juan A.
- Bugedo Guillermo
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- Bumbasierevic Vesna
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- Buzancais Gautier
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- Camsooksai Julie
- Canestrini Sergio
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- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
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- Carpentier Dorothée
- Carreño Nicolás G.
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- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
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- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
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- Clarkson Kevin
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- Cohen Jason E.
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- Combaux Daniele M.
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- Crapelli Giulia
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- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
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- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
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- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
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- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
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- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
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- Ellis Helen E.
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- Ezzouine Hanane
- Fan Eddy
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- Forteza Catalina
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- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
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- Zacharas Giannis A.
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- Zani Gianluca
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- Zazu Alan
- Zeggwagh Amine Ali
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- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
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- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Internal-external control as a determinant of information-seeking in a social influence situation1
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Early cognitive development and preschool education
- Author
- Anne Anastasi
- B. Pasamanick
- B. S. Bloom
- C. Bereiter
- Caldwell
- D. Krech
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- D. P. Weikart
- Diana Baumrind
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- N. E. Freeberg
- Nancy Bailey
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- R. Rosenthal
- R. Rosenthal
- S. A. Kirk
- S. Keller
- T. F. Pettigrew
- U. Bronfenbrenner
- W. Mischel
- Walter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
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- Universitat Autònoma de Barcelona
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- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
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- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie
- Zumaran Aguilar Ronald
- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
- Andersen Finn
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie
- Barberet Guillaume
- Baron Rebecca
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa
- Barros Nelson C.
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- Bauer Philippe
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- Beitler Jeremy R.
- Bellani Giacomo
- Beloncle Francois
- Benslama Abdellatif
- Beraldo Daniel O.
- Berghe Caroline
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- Graziani Romano
- Gregoretti Cesare
- Grelon Fabien
- Griffin Ruth
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey
- Grubissich Nicolas
- Gueret Renaud
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert
- Heunks Leo
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn
- Hutton Paula J.
- Ibañez-Santacruz Marco
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Jha Rajeev
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio
- Jochmans Sébastien
- Jog Sameer
- Jovanovic Bojan
- Judy Claine
- Jurado Maria Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada
- Kitch Barrett T.
- Knapman Karl
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Krabler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Lamb Keith
- Lanspa Michael
- Larsson Anders
- Larsson Niklas
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana
- Leon Yoshido Hector
- Li Bin
- Li Qingdong
- Li Qiong
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan
- Li-Xin Zhou
- Liew Kong
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing
- Liu Ling
- Llano Miguel
- Llinares Moya David
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan
- Lora Fredy
- Lora Pilar
- Lorente Jose A.
- Lorente Maria del Carmen
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- Macfadyen Rosaleen
- MacFie Caroline
- Madotto Fabiana
- Maeyama Hiroki
- Maghrabi Khalid
- Magret Monica
- Mahto Heera
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Marin Julien
- Marin Maria
- Martinez Felipe T.
- Marum Susan
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin
- Mcarthur Colin
- McAuley Daniel
- McAuley Danny
- Mccalman Katie
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni E.
- Mcleod Alex
- McNamee Lia
- Meaney Edel
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Mizuguchi Ichiko
- Moal Charlene Le
- Mochizuki Katsunori
- Mohr Nicholas
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo
- Monteiro Jorge
- Montero Laura Alvarez
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Máca Jan
- Nagy Eva
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre
- Nunci Lordian
- Nunes Silvia
- Nunomiya Shin
- Nutt Christopher
- Nuñez Edgardo
- Nygren Ingela
- O'Croinin Donall
- O'Muircheartaigh Aogan C.
- Occhipinti Giovanna
- Oetting Trevor W.
- Ogino Yasuaki
- Oikonomou Marina A.
- Okane Sinead
- Okuda Nao
- Oldroyd Matthew G.
- Olga Moreno F.
- Oliveira Bruno S.
- Oneill Orla
- Ortiz Claudia A.
- Oscanoa Fredy A. Montes
- Osman Emilio M.
- Oss Peteris
- Ouanes Islem
- Ourailogloy Vasilis
- Owens Robert L.
- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Papanikolaou Metaxia
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie
- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
- Pellicer Ana
- Penuelas Oscar
- Pereira Carlos
- Perez Cesar P.
- Perez Manuel
- Persson Linnea
- Pesenti Antonio
- Pham Tai
- Phan Nga T.
- Piacentini Enrique
- Pillai Suresh
- Pintado Maria
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter
- Prieto-González Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie
- Qiu Haibo
- Raaijmakers Monique
- Rabboni Francesca
- Rafael Sánchez I.
- Raimondi Ferdinando
- Raj Ashok
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Raponi Francesco
- Recio Noelia
- Reschreiter Henrik
- Reske Andreas
- Reuter Danielle
- Reynolds Claire
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- Roche-Campo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rojas Manuel A. González
- Rosa Jonas I.
- Roser Tomas
- Rossi Anna
- Roux Damien
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Brunei Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis
- Sanchez-Medina Jorge
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Aurelia Isabel
- Serra Carolina
- Setten Mariano G.
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John O.
- Shiozaki Kyoko
- Silesky Jimenez Juan
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne
- Sivashanmugavel Mageswaran
- Sjøbø Brit A.
- Sklienka Peter
- Smith Mark
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E.
- Sotillo Diaz Juan Carlos
- Sottiaux T.
- Souissi Asma Ben
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E.
- Staudinger Thomas
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Strauch Ulrich
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Sánchez Rocío Manzano
- Sánchez-Ballesteros Jesús
- Søreide Eldar
- Tabhan Edgardo
- Tabhan Edgardo E.
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C.
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terzi Nicolas
- Thibault Sandrine
- Thomas Matthew
- Thompson Marlus M.
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana
- Toribio Dácil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T. John
- Trinidad Olivia A.
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- Van Haren Frank
- Van Wezel Hellen M.
- Vargas Monica
- Vascotto Ettore
- Vasquez Daniela N.
- Vega Luis D.
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Villagomez Asisclo
- Villagomez Asisclo J.
- Villamagua Boris
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
- Vitale Michela N.
- Volta Carlo A.
- Wang Chunting
- Wang Hua
- Wang Shou H.
- Wang Wei
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David
- Wrigge Hermann
- Wu Ya
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
The Contributions of Parental, Academic, School, and Peer Factors to Differences by Socioeconomic Status in Adolescents’ Locus of Control
- Author
- Ahlin Eileen M.
- Bandura Albert
- Bandura Albert
- Bartkowski John P.
- Battle Esther S.
- Bonetti Debbie
- Boyd Danah
- Bradley Robert H.
- Bradley Robert H.
- Briley Daniel A.
- Brown George W.
- Bruce Marino A.
- Bursik Krisanne
- Bushman Brad J.
- Cappella Elise
- Chen Edith
- Cohen Deborah A.
- Coleman James
- Coleman James S.
- Coleman James S.
- Coleman James S.
- Cookson Peter W.
- Crosnoe Robert
- Curtin Thomas R.
- Duncan Greg J.
- Duval Thomas Shelley
- Eccles Jacquelynne S.
- Ellison Christopher G.
- Epstein Debbie
- Falci Christina D.
- Farkas George
- Fletcher Jason M.
- Frazier Patricia
- Freese Jeremy
- Gamoran Adam
- Gan Yiqun
- Garcia Emma
- Gecas Viktor
- Gecas Viktor
- Gecas Viktor
- Gould Stephen J.
- Gregoire Michele
- Grolnick Wendy S.
- Gross Elisheva F.
- Gurin Patricia
- Gándara Patricia
- Haertel Edward.
- Halaby Charles N.
- Hango Darcy
- Hanushek Eric A.
- Healy Kieran
- Heidemeier Heike
- Hoffman Diane M.
- Ingels Steven J.
- Jaffee Sara R.
- Judge Timothy A.
- Kalil Ariel
- Kelly Sean
- Kerr Margaret
- Kiviruusu Olli
- Kraus Michael W.
- Krieger Nancy
- Kroger Jane
- Lachman Margie E.
- Lareau Annette
- Lareau Annette
- Lever Joaquina Palomar
- Madon Stephanie
- Manning Wendy D.
- Maqsud Muhammad
- Marin Kelly A.
- Marks Lawrence I.
- Martin Molly A.
- Matjasko Jennifer L.
- McLeod Jane D.
- McNeal Ralph B.
- McNeal Ralph B.
- Menaghan Elizabeth G.
- Miller Peggy J.
- Mirowsky John
- Mirowsky John
- Mirowsky John
- Mittal Chiraag
- Moilanen Kristin L.
- Neckerman Kathryn M.
- Noguera Pedro A.
- Oakes Michael
- Oliver Melvin L.
- Orfield Gary
- O’Keeffe Gwenn Schurgin
- Pals Heili
- Perna Laura Walter
- Reardon Sean F.
- Roberts Brent W.
- Romagnoli Amy
- Ross Catherine E.
- Ross Catherine E.
- Ross Catherine E.
- Ross Catherine E.
- Ross Catherine E.
- Ross Catherine E.
- Rotter Julian B.
- Ruggiero Karen M.
- Sastry Jaya
- Schieman Scott
- Schieman Scott
- Schradie Jen
- Sechrist Gretchen B.
- Shifrer Dara
- Stokes Charles E.
- Subrahmanyam Kaveri
- Suh Suhyun
- Sui-Chu Esther Ho
- Thompson Suzanne C.
- Tough Paul
- Tourangeau Roger
- Vitaro Frank
- Ward Michael M.
- Whitbeck Les B.
- White Ian R.
- Williams David R.
- Wohlfarth Tamar
- Wolfle Lee M.
- York Benjamin N.
- Zytkoskee Adrian
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2018
- Field of study
An internal locus of control may be particularly valuable for youth with low socioeconomic status (SES), yet the mechanisms that externalize their control remain unclear. This study uses data on 16,450 US 8th graders surveyed for the National Education Longitudinal Study in 1988 and 1990. Results indicate family income is more closely associated with adolescents’ locus of control than parents’ occupations and educational attainment, and that race does not independently affect adolescents’ locus of control net of these other components of SES. Findings also indicate higher SES adolescents feel more internal locus of control in largest part because their parents discuss school more often with them, their homes have more books and other cognitive resources, they receive higher grades in middle school science and social studies, they are more likely to attend a private rather than public school, their friends are more academically oriented, and they feel more safe at school
Toward an Interdisciplinary Model of Political Behavior: A New Approach
- Author
- Agger Robert E.
- Almond Gabriel
- Bagley Christopher
- Battle Esther S.
- Bell Daniel
- Berelson Bernard
- Berelson Bernard
- Bernstein Saul
- Bryde John E.
- Bullough Bonnie
- Campbell Angus
- Campbell Angus
- Campbell Angus
- Dean Dwight G.
- Dubey Sumati
- Durkheim Emile
- Erbe William
- Fendrich James M.
- Festinger Leon
- Feuer Lewis S.
- Freeman Caroline B.
- Gamson William A.
- Ghaem-Maghami Farhat
- Ghaem-Maghami Farhat
- Gouldner Alvin W.
- Hajda Jan
- Heilbroner Robert L.
- Horton John A.
- Horton John A.
- Hyman Herbert H.
- James W. H.
- Kavolis Vytautas
- Keniston Kenneth
- Killian Lewis M.
- Kornhauser William
- Lane Robert
- Lefcourt Herbert M.
- Lipset Seymour Martin
- McClintock Charles G.
- McClleland David C.
- McDill Edward L.
- McLeod Jack
- Meier Dorothy L.
- Meszaros Istavan
- Milbrath Lester W.
- Mills Wright C.
- Mills Wright C.
- Mizruchi Ephraim H.
- Neal Arthur G.
- Neal Arthur G.
- Neal Arthur G.
- Nettler Gwynn
- Nisbet Robert A.
- Olsen Marvin E.
- Pappenheim Fritz
- Powell Elvin
- Rosenberg Morris
- Rotter Julian B.
- Rotter Julian B.
- Rotter Julian B.
- Rotter Julian B.
- Seeman Melvin
- Seeman Melvin
- Seeman Melvin
- Seeman Melvin
- Seeman Melvin
- Seeman Melvin
- Srole Leo
- Star Shirley A.
- Tumin Melvin M.
- Weber Max
- Wheelis Allen
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
ANGRY AGGRESSION AMONG THE "TRULY DISADVANTAGED" *
- Author
- Allport Gordon W.
- Averill James R.
- Baker R.K.
- Ball-Rokeach Sandra J.
- Bandura Albert
- Baron Robert A.
- Bartol Curt R.
- Battle Esther
- Berger Philip A.
- Berkowitz Leonard
- Berkowitz Leonard
- Berkowitz Leonard
- Berkowitz Leonard
- Berkowitz Leonard
- Berkowitz Leonard
- Bernard Thomas J.
- Bernardez-Bonesatti Teresa
- Blau Peter M.
- Blumenthal Monica D.
- Blumenthal Monica D.
- Brown George W.
- Brown George W.
- Burchfield Susan R.
- Buss Arnold H.
- Campbell Anne
- Cannon Walter B.
- Curtis Lynn A.
- Daly Martin
- Dembroski Theodore M.
- Dienstbier R.A.
- Elliott Glen R.
- Erlanger Howard S.
- Eysenck Hans
- Fisher Shirley
- Gastil Raymond D.
- Glass David C.
- Goldstein Arnold P.
- Hackney Sheldon
- Hamilton Vernon
- Hartmann Heinz
- Hodgins S.
- Huston Ted L.
- Kohn Melvin L.
- Kornhauser Ruth Rosner
- Lazarus Richard S.
- Lazarus Richard S.
- Lefcourt Herbert M.
- Lerner Hamet
- Lundsgaarde Henry P.
- Mark Vernon
- Mason John W.
- Mawson Anthony R.
- Mednick Sarnoff A.
- Mednick Sarnoff A.
- Mefferd Roy B.
- Megargee Edwin I.
- Nettler Gwynne
- Novaco Raymond W.
- Rotter Julian B.
- Rotter Julian B.
- Rutter Michael L.
- Schachter Stanley
- Seligman Martin E.P.
- Selye Hans
- Shah Saleem A.
- Shotland R. Lance
- Silberman Charles E.
- Sykes Gresham M.
- Tavris Carol
- Toch Hans
- Ursin Holger
- Ursin Holger
- Vance Elizabeth Taylor
- Vold George B.
- Weiss J.M.
- White Robert W.
- Wilbanks William
- Williams Robin
- Wilson James Q.
- Wilson William Julius
- Wolfgang Marvin E.
- Wolfgang Marvin E.
- Yablonsky Lewis
- Zillmann Dolf
- Zillmann Dolf
- Publication venue
- 'Wiley'
- Publication date
- Field of study