Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis

Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage. To define the role of TGFβ signaling in ovarian tumorigenesis, we created a mouse model expressing a constitutively active TGFβ receptor 1 (TGFBR1) in ovarian somatic cells using conditional gain-of-function approach. Remarkably, these mice developed ovarian sex cord-stromal tumors with complete penetrance, leading to reproductive failure and mortality. The tumors expressed multiple granulosa cell markers and caused elevated serum inhibin and estradiol levels, reminiscent of granulosa cell tumors. Consistent with the tumorigenic effect, overactivation of TGFBR1 altered tumor microenvironment by promoting angiogenesis and enhanced ovarian cell proliferation, accompanied by impaired cell differentiation and dysregulated expression of critical genes in ovarian function. By further exploiting complementary genetic models, we substantiated our finding that constitutively active TGFBR1 is a potent oncogenic switch in mouse granulosa cells. In summary, overactivation of TGFBR1 drives gonadal tumor development. The TGFBR1 constitutively active mouse model phenocopies a number of morphological, hormonal, and molecular features of human granulosa cell tumors and are potentially valuable for preclinical testing of targeted therapies to treat granulosa cell tumors, a class of poorly defined ovarian malignancies

Att översätta genitiver - parafras, latinisering eller grammatisk innovation

Uppsatsen undersöker hur den danske 1400-talsöversättaren av Thomas à Kempis’ Quattuor libri de imitatione Christi transformerar latinets genitivkonstruktioner till gammaldanska. Särskilt intresse vigs åt omskrivande översättningsförsök, i synnerhet dem medelst preposition. Det konstateras ett samband mellan omskrivning medelst preposition och latinska verbalsubstantiv resp. gerundier böjda i genitiv. Dessa samband sätts i perspektiv av en redogörelse för danskt skriftspråk och översättningspraxis under medeltiden. Det argumenteras därefter för att Kempis-översättningens tendens att byta ut komplexa latinska genitivkonstruktioner mot gammaldanska prepositionskonstruktioner pekar fram emot ett nytt rättesnöre för latinöversättning där ett grammatiskt och semantiskt abstrakt innehåll översätts till ett välfungerande, entydigt och idiomatiskt folkspråk

On medical travel

viii, 101 p. port. 24 cm. University Archives copy: gift of University Press of Kansas

Combination of superplasticizers with hydroxypropyl guar, effect on cement-paste properties

International audienceViscosity-modifying agent (VMA) are used in several applications of concrete, such as underwater con-crete, Self-Compacting Concrete (SCC) or Self-Levelling Underlayments (SLU) in order to improve thewashout resistance and the stability. The study focuses on the modifications of cement pastes propertiesimplied when a VMA (hydroxypropyl guars or HPG) and a superplasticizer are introduced together. Forreaching this objective, two chemically different polycarboxylate-based superplasticizers (PCE) andtwo HPGs exhibiting different molar substitution ratios (MSHP), were studied. A method, combining totalorganic carbon and size exclusion chromatography, was developed in order to quantify the adsorption ofthe both admixtures. The adsorption of HPGs appears being significantly lowered by the presence of PCE,while only the adsorption of the less charged PCE is slightly affected by the HPG. As consequence, strongmodifications of the rheological properties of cement pastes were noticed when HPG and PCE are com-bined. The desorption of HPG leads to higher yield stress and residual viscosity than with PCE alone

Human Resources Data Analytics – Evidence from an Irish Manufacturing Perspective

Industry is propelled by measurement and the transformative potential of data analysis as a driver of business success. Human Resource (HR) departments have not escaped this impetus, indeed it has gained momentum over the last decade. The promise of analytics is significant: to replace gut and intuition with data-based decision making and evidence-based strategies. HR analytics hails itself as a framework to temper HR intuition with objectivity. It promises rigour and validity to guide and prioritise human capital expenditure. Despite enormous interest, evidence of practical application has been scarce. This research adopts an inductive, interpretivist approach, using multiple case studies of Irish manufacturing firms, underpinned by interviews with HR Managers and industry experts. It contributes to research and practitioner knowledge with insights of industry led practical applications of HR analytics and the levels and application of HR analytics within companies. Furthermore, it reveals the factors impacting application outcomes in firms

Modification of water retention and rheological properties of fresh state cement-based mortars by guar gum derivatives

International audienceThe present study examines the influence of chemical composition and structure of guar gum derivatives on water retention capacity (WR) and rheological behavior of fresh state cement-based mortars. The investigation was also completed by adsorption isotherms. For this, original guar gum, three HydroxyPropyl Guars (HPG) and two hydrophobically modified HPGs were selected. The effect of the molar substitution (MSHP) and of hydrophobic substitution (DSAC) was investigated. The results highlight that chemical composition of HPGs has a remarkable effect on fresh state properties of mortars. The original guar gum does not impact on neither WR nor rheological behavior. Increasing MSHP leads to an improvement of the WR and the stability of mortars while the hydrophobic units further enhance WR and lead to a decrease in the yield stress and an increase in the resistance to the flow of admixed mortars

Effect of Guar Gum Derivatives on Fresh State Properties of Portland Cement-Based Mortars

International audienceMortars are traditionally made from a mixture of sand, a binder and water. However, modern factory-made mortars are currently, very complex materials. Indeed, to exhibit various properties from the fresh paste to the hardened material, mortar formulations are composed of many mineral and organic admixtures. Among organic admixtures, polysaccharides are widely used in mortar formulation to improve water retention capacity of the freshly-mixed materials. The water retention capacity is an essential property of mortars to enhance cement hydration and its adhesion to a substrate. Moreover, many polysaccharide admixtures, acting as viscosity-enhancing agents, prevent segregation and improve the homogeneity and workability of cement-based system. Indeed, the viscosity of the system strongly increases using polysaccharides. Nevertheless, polysaccharides, as sugars, act on cement hydration. The main drawback is the retarding effect in hydration mechanism and setting-time of the cement.The aim of this study is to focus on the effect of guar gum derivatives on fresh state properties of Portland cement-based mortars, such as water retention, rheological behavior and the hydration delay. This work focuses on the guar gum derivatives since their manufacturing process is low pollutant and they provide very good properties to cement-based mortars. The results highlight that the chemical composition of guar gum derivatives (MS, DS, additional alkyl chain) are the key levers to improve water retention of mortars and to adapt the rheological behavior of the cementitious paste to a specific application