Volumetria e sobrevivência de espécies nativas e exóticas no polo gesseiro do Araripe, PE

In the industrial and commercial sectors of the Araripe Region in Pernambuco, Brazil, fire wood is the used in processes of dehydration and production of gypsum with different technologies. Thus, this study aimed to find alternatives to supply the demand of firewood in the Gypsun Pole of Araripe in Pernambuco through the implementation of forest with native and exotic species. The experiment was installed at the Experimental Station of the Agronomic Institute of Pernambuco (IPA), using nine species, both native and exotic: (Imburana - Amburana cearense (Allemão) A.C. Sm.; Angico - Anadenanthera colubrina (Vell.) Brenan  var. cebil (Griseb.) Altschul; Jurema - Mimosa tenuiflora (Willd.) Poir.; Sabiá - Mimosa caesalpiniaefolia Benth.; Acácia - Senna siamea (Lam.) H.S. Irwin & Barneby; Leucena - Leucaena leucocephala (Lam.) R. de Wit.; Algaroba - Prosopis juliflora (Sw.) D.C.; Ipês - Tabebuia sp.1 e Tabebuia sp.2). The design was completely randomized with different numbers of replications. The following parameters were evaluated: volume in cubic meter (m³) and stereo meters (st) and survival. With regard to the volume in cubic meter, Sabia had the best production. The Jurema and the Sabiá were the heaviest species. In relation to survival, the Ipê 2 and the Imburana had the highest mortalities. Thus, the Sabiá and the Jurema are the species indicated for the production of wood in homogeneous commercial plantations in the Chapada Araripe in Pernambuco.Nos setores industriais e comerciais da região do Araripe, em Pernambuco, a utilização de combustíveis lenhosos está dirigida aos processos de desidratação da gipsita e produção de gesso em suas diferentes tecnologias. Dessa forma, o presente estudo teve como objetivo buscar opções para suprir a demanda por lenha no Polo Gesseiro do Araripe pernambucano, por meio da implantação de povoamentos florestais com espécies nativas e exóticas. O experimento foi instalado na Estação Experimental do Instituto Agrônomico de Pernambuco (IPA), utilizando nove espécies, entre nativas e exóticas: (Imburana - Amburana cearense (Allemão) A.C. Sm.; Angico - Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb.) Altschul; Jurema - Mimosa tenuiflora (Willd.) Poir.; Sabiá - Mimosa caesalpiniaefolia Benth.; Acácia - Senna siamea (Lam.) H.S. Irwin & Barneby; Leucena - Leucaena leucocephala (Lam.) R. de Wit.; Algaroba - Prosopis juliflora (Sw.) D.C.; Ipês - Tabebuia sp.1 e Tabebuia sp.2), em um delineamento inteiramente casualizado com diferentes números de repetições. Foram avaliados os seguintes parâmetros: volume em metro cúbico (m³) e sobrevivência. Com relação ao volume em metro cúbico, o Sabiá teve a melhor produtividade. O Sabiá e a Jurema foram as espécies mais pesadas. E em relação à sobrevivência, Ipê 2 e Imburana tiveram as maiores mortalidades. Desta forma, o Sabiá e a Jurema são as espécies mais indicadas para a produção de lenha em plantios comerciais homogêneos na Chapada do Araripe em Pernambuco

Polyphenol profile by UHPLC-MS/MS, anti-glycation, antioxidant and cytotoxic activities of several samples of propolis from the northeastern semi-arid region of Brazil

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORPropolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil – sample A from Ribeira do Pombal and B, from Tucano – were investigated, with new information regarding their biological activities. Objective: This paper55118841893CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIOR407963/2013-8458114/2014-6sem informaçã

A MÚSICA NO CONTROLE DA DOR E DA ANSIEDADE EM MULHERES DURANTE AS ETAPAS DO PARTO: REVISÃO SISTEMÁTICA

Introduction: Music is present in various rituals in society and its application in the stages of labor provides an improvement in the hemodynamic control of the pregnant woman and eases emotional factors. Objective: To assess the impact of music therapy on pain management during the stages of childbirth. Method: Systematic review, in which a bibliographic search was carried out in databases and virtual libraries: U.S. National Library of Medicine, Virtual Health Library, Latin American and Caribbean Literature in Health Sciences and Scientific Electronic Library Online. The Portuguese language Health Sciences Descriptors were used: pregnant women, music therapy, childbirth, “pain management” and “anxiety”. The GRADE system was used to assess the level of evidence of the eleven selected articles. Results: The information obtained in the surveys were all beneficial in terms of improved pain control during labor and postpartum, reduced anxiety and stress, positive impacts on the newborn's accommodation and satisfactory contribution to the experience maternal in childbirth. Conclusion: Music therapy resulted in benefits for the mother and newborn, attenuating anxiety and the experience of maternal pain, which directly affects the baby's development.      Introducción: La música está presente en diversos rituales de la sociedad y su aplicación en las etapas del parto proporciona una mejora en el control hemodinámico de las mujeres embarazadas y mitiga los factores emocionales. Objetivo: Evaluar el impacto de la musicoterapia en el manejo del dolor durante las etapas de parto. Método: Revisión sistemática, en la que se realizó investigación bibliográfica en bases de datos y bibliotecas virtuales: Biblioteca Nacional de Medicina de los Estados Unidos, Biblioteca Virtual en Salud, Literatura Latinoamericana y del Caribe en Ciencias de la Salud y Biblioteca Electrónica Científica en Línea. Los descriptores en las ciencias de la salud portugués: mujeres embarazadas, musicoterapia, parto, "manejo del dolor" y "ansiedad". Se utilizó el sistema GRADE para evaluar el nivel de evidencia de los once artículos seleccionados. Resultados: La información obtenida en las investigaciones fue beneficiosa en relación con la mejoría en el control del dolor durante el trabajo de parto y el posparto, la reducción de la ansiedad y el estrés, los impactos positivos en la acomodación del recién nacido y la contribución satisfactoria a la experiencia materna en el parto. Conclusión: La musicoterapia resultó en beneficios para la madre y el recién nacido, atenuando la ansiedad y la experiencia de dolor materno, que afecta directamente el desarrollo del bebé.Introdução: A música está presente em vários rituais da sociedade e sua aplicação nas etapas do trabalho de parto propicia um melhoramento no controle hemodinâmico da gestante e ameniza os fatores emocionais. Objetivo: Avaliar o impacto da musicoterapia no manejo da dor durante as etapas do parto. Método: Revisão sistemática, em que foi feita pesquisa bibliográfica nas bases de dados e bibliotecas virtuais: U.S. National Library of Medicine, Biblioteca Virtual de Saúde, Literatura Latino-Americana e do Caribe em Ciências da Saúde e Scientific Eletronic Library Online. Foram utilizados os Descritores em Ciências da Saúde idioma português: gestantes, musicoterapia, parto, “manejo da dor” e “ansiedade”. Utilizou-se o sistema GRADE para avaliar o nível de evidência dos onze artigos selecionados. Resultados: As informações obtidas nas pesquisas foram todas benéficas em relação a melhoria no controle da dor durante o trabalho de parto e no pós-parto, redução da ansiedade e do estresse, impactos positivos na acomodação do recém-nascido e contribuição satisfatória acerca da experiência materna no parto. Conclusão: A terapêutica música resultou em benefícios para a mãe e o recém-nascido, atenuando ansiedade e experiência da dor maternal, que repercute diretamente no desenvolvimento do bebê.    

Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression

Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (n = 18), and in a control group of healthy subjects with good (n = 21) and poor (n = 18) sleep quality. We observed that the patients had the lowest CAR and sleep duration of all three groups and a higher latency to sleep than the healthy volunteers with a good sleep profile. Besides, low CAR was correlated with more severe depressive symptoms and worse sleep quality. There was no difference in serum BDNF levels between groups with distinct sleep quality. Taken together, our results showed a relationship between changes in CAR and in sleep quality in patients with treatment-resistant depression, which were correlated with the severity of disease, suggesting that cortisol could be a physiological link between sleep disturbance and major depression

Volumetry and survival of native and exotic species in the gypsun pole of Araripe, PE

Nos setores industriais e comerciais da regi\ue3o do Araripe, em Pernambuco, a utiliza\ue7\ue3o de combust\uedveis lenhosos est\ue1 dirigida aos processos de desidrata\ue7\ue3o da gipsita e produ\ue7\ue3o de gesso em suas diferentes tecnologias. Dessa forma, o presente estudo teve como objetivo buscar op\ue7\uf5es para suprir a demanda por lenha no Polo Gesseiro do Araripe pernambucano, por meio da implanta\ue7\ue3o de povoamentos florestais com esp\ue9cies nativas e ex\uf3ticas. O experimento foi instalado na Esta\ue7\ue3o Experimental do Instituto Agr\uf4nomico de Pernambuco (IPA), utilizando nove esp\ue9cies, entre nativas e ex\uf3ticas: (Imburana \u2013 Amburana cearense (Allem\ue3o) A.C. Sm.; Angico \u2013 Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb.) Altschul; Jurema \u2013 Mimosa tenuiflora (Willd.) Poir.; Sabi\ue1 \u2013 Mimosa caesalpiniaefolia Benth.; Ac\ue1cia \u2013 Senna siamea (Lam.) H.S. Irwin & Barneby; Leucena \u2013 Leucaena leucocephala (Lam.) R. de Wit.; Algaroba \u2013 Prosopis juliflora (Sw.) D.C.; Ip\ueas \u2013 Tabebuia sp.1 e Tabebuia sp.2), em um delineamento inteiramente casualizado com diferentes n\ufameros de repeti\ue7\uf5es. Foram avaliados os seguintes par\ue2metros: volume em metro c\ufabico (m3) e sobreviv\ueancia. Com rela\ue7\ue3o ao volume em metro c\ufabico, o Sabi\ue1 teve a melhor produtividade. O Sabi\ue1 e a Jurema foram as esp\ue9cies mais pesadas. E em rela\ue7\ue3o \ue0 sobreviv\ueancia, Ip\uea 2 e Imburana tiveram as maiores mortalidades. Desta forma, o Sabi\ue1 e a Jurema s\ue3o as esp\ue9cies mais indicadas para a produ\ue7\ue3o de lenha em plantios comerciais homog\ueaneos na Chapada do Araripe em Pernambuco.In the industrial and commercial sectors of the Araripe Region in Pernambuco, Brazil, fire wood is the used in processes of dehydration and production of gypsum with different technologies. Thus, this study aimed to find alternatives to supply the demand of firewood in the Gypsun Pole of Araripe in Pernambuco through the implementation of forest with native and exotic species. The experiment was installed at the Experimental Station of the Agronomic Institute of Pernambuco (IPA), using nine species, both native and exotic: (Imburana - Amburana cearense (Allem\ue3o) A.C. Sm.; Angico - Anadenanthera colubrina (Vell.) Brenan var. cebil (Griseb.) Altschul; Jurema - Mimosa tenuiflora (Willd.) Poir.; Sabi\ue1 - Mimosa caesalpiniaefolia Benth.; Ac\ue1cia - Senna siamea (Lam.) H.S. Irwin & Barneby; Leucena - Leucaena leucocephala (Lam.) R. de Wit.; Algaroba - Prosopis juliflora (Sw.) D.C.; Ip\ueas - Tabebuia sp.1 e Tabebuia sp.2). The design was completely randomized with different numbers of replications. The following parameters were evaluated: volume in cubic meter (m3) and stereo meters (st) and survival. With regard to the volume in cubic meter, Sabia had the best production. The Jurema and the Sabi\ue1 were the heaviest species. In relation to survival, the Ip\uea 2 and the Imburana had the highest mortalities. Thus, the Sabi\ue1 and the Jurema are the species indicated for the production of wood in homogeneous commercial plantations in the Chapada Araripe in Pernambuco

Potential biomarkers of major depression diagnosis and chronicity

Background Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease's chronicity using regression models, and ROC curve. Results For diagnosis model, two groups were analyzed: Patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity. Conclusion These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice

Pathophysiology of major depression by clinical stages

The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression

Integrality in Brazil and Venezuela : similarities and complementarities

O presente estudo tem como objetivo comparar a Atenção Primária à Saúde (APS) no Brasil e na Venezuela, observando suas características quanto à integralidade. Possui abordagem qualitativa, por meio de análise documental, entrevistas semiestruturadas com informantes-chave e anotações em diário de campo. Observou-se as três dimensões de integralidade inseridas no processo de trabalho em saúde: o cuidado integral e holístico, visão do indivíduo como um ser complexo com múltiplas necessidades, exigindo a conexão de diversos saberes em saúde; a continuidade do cuidado na micropolítica institucional com articulação interprofissional, de forma a contemplar o cuidado singular; a continuidade do cuidado na macropolítica, quando é necessário um deslocamento aos demais níveis de atenção; incluiu-se ainda a intersetorialidade, quando as necessidades de um indivíduo e comunidade exigem uma articulação transetorial, com ação sobre os determinantes e condicionantes do processo saúde-doença. Ressalta-se ainda a tendência singular de inclusão de uma formação médica comunitária integral. Conclui-se que estes países, fortalecidos pela democracia, aproximam-se em suas práticas de integralidade, bem como na construção de políticas sociais e de saúde para as populações menos favorecidas, em favor da equidade.This study aims to compare Primary Health Care (PHC) in Brazil and Venezuela, considering its characteristics as to integrality. It has a qualitative approach, using documental analysis, semi-structured interviews with key informants and field diary notes. We observed the three realms of integrality inherent to the health work process: comprehensive and holistic care, the individual viewed as a complex being with multiple needs, requiring the connection of various health knowledge; continuity of care in institutional micro-policy with interprofessional articulation, in order to consider individual care; continuity of care in macro-policy, when a shift to other levels of care is needed; intersectoriality was also included, when the needs of an individual and community require a cross-sectoral coordination, with action on determinants and conditionants of the health-disease process. It is worth highlighting the natural tendency to include a comprehensive community medical training. We conclude that those countries strengthened by democracy draw their integrality practices closer, as well as the construction of social and health policies for underprivileged populations to achieve equity

Moderators of ayahuasca’s biological antidepressant action

IntroductionThe understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR).MethodsResults were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72).ResultsResults revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient’s CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group.DiscussionIn summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapy

Úlceras orais provocadas por metotrexato: Relato de caso / Oral ulcers caused by methotrexate: Case report

A ulceração oral grave provocada por uso de metotrexato apresenta-se como um dos efeitos adversos que a medicação pode ocasionar e geralmente não são identificadas pelos profissionais de saúde. A terapia com laser de baixa intensidade tem sido utilizada para tratamento coadjuvante de úlceras uma vez que gera aceleração na reparação dos tecidos, redução do edema e da dor, e apresenta efetiva ação anti-inflamatória com estimulação à proliferação de fibroblastos, regeneração tecidual, resposta imunológica e neovascularização. Este estudo é justificado devido aparecimento das ulcerações orais ocorrerem de 11% a 17% dos pacientes tratados com MTX e geralmente não são identificadas pelos profissionais de saúde como efeito colateral da medicação, ocasionando dificuldade no tratamento. Diante deste contexto, o artigo tem por objetivo relatar um caso clínico de diagnóstico e tratamento de ulceração oral provocada por uso de metotrexato por meio da interrupção da medicação e laserterapia como terapêutica coadjuvante. Foi possível obter resolução do quadro clínico, não havendo recidivas ou queixas álgicas após o tratamento