Taking Malawi's option B+ programme from a B+ to an A+

In The Lancet HIV, Beth A Tippett Barr and colleagues present national estimates of early mother-to-child transmission (MTCT) of HIV and factors associated with early MTCT from the National Evaluation of Malawi’s Prevention of MTCT Program (NEMAPP) for the period 2014–16. Among HIV-exposed infants aged 4–12 weeks, the MTCT rate was 3·7% (95% CI 2·3–6·0) and consistent across all four subnational regions. A somewhat lower prevalence was observed among infants aged 4–7 weeks than among those aged 8–12 weeks (2·9% vs 5·2%; p=0·07). As expected, the mother’s antiretroviral therapy (ART) status during pregnancy was strongly associated with MTCT prevalence: it was 2·3% (95% CI 1·3–4·0) among those who were on ART during pregnancy compared with 19·6% (14·3–26·3) among those who were not on ART (p<0·0001

Axions and the Strong CP Problem

Current upper bounds of the neutron electric dipole moment constrain the physically observable quantum chromodynamic (QCD) vacuum angle $|\bar\theta| \lesssim 10^{-11}$. Since QCD explains vast experimental data from the 100 MeV scale to the TeV scale, it is better to explain this smallness of $|\bar\theta|$ in the QCD framework, which is the strong \Ca\Pa problem. Now, there exist two plausible solutions to this problem, one of which leads to the existence of the very light axion. The axion decay constant window, $10^9\ {\gev}\lesssim F_a\lesssim 10^{12} \gev$for a${\cal O}(1)$initial misalignment angle$\theta_1$, has been obtained by astrophysical and cosmological data. For$F_a\gtrsim 10^{12}$GeV with$\theta_1<{\cal O}(1)$, axions may constitute a significant fraction of dark matter of the universe. The supersymmetrized axion solution of the strong \Ca\Pa problem introduces its superpartner the axino which might have affected the universe evolution significantly. Here, we review the very light axion (theory, supersymmetrization, and models) with the most recent particle, astrophysical and cosmological data, and present prospects for its discovery.Comment: 47 pages with 32 figure

Cosmology, Oscillating Physics and Oscilllating Biology

According to recent reports there is an excess correlation and an apparent regularity in the galaxy one-dimensional polar distribution with a characteristic scale of 128 $h^{-1}$ Mpc. This aparent spatial periodicity can be naturally explained by a time oscillation of the gravitational constant $G$. On the other hand, periodic growth features of bivalve and coral fossiles appear to show a periodic component in the time dependence of the number of days per year. In this letter we show that a time oscillating gravitational constant with similar period and amplitude can explain such a feature.Comment: 9 pages. latex using revtex. This revised version is supposed to be free of e-mail nois

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase

Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and matrix metalloproteinases. Hence, the activities of NAD(P)H oxidase, matrix metalloproteinase-2, urokinase-type plasminogen activator (uPA), and tissue-type plasminogen activator (tPA), and superoxide anion levels, were assessed in human brain microvascular endothelial cells (HBMECs) exposed to oxygen–glucose deprivation (OGD) alone or OGD followed by reperfusion (OGD + R). The integrity of an in vitro model of BBB comprising HBMECs and astrocytes was studied by measuring transendothelial electrical resistance and the paracellular flux of albumin. OGD with or without reperfusion (OGD ± R) radically perturbed barrier function while concurrently enhancing uPA, tPA and NAD(P)H oxidase activities and superoxide anion release in HBMECs. Pharmacological inactivation of NAD(P)H oxidase attenuated OGD ± R-mediated BBB damage through modulation of matrix metalloproteinase-2 and tPA, but not uPA activity. Overactivation of NAD(P)H oxidase in HBMECs via cDNA electroporation of its p22-phox subunit confirmed the involvement of tPA in oxidase-mediated BBB disruption. Interestingly, blockade of uPA or uPA receptor preserved normal BBB function by neutralizing both NAD(P)H oxidase and matrix metalloproteinase-2 activities. Hence, selective targeting of uPA after ischaemic strokes may protect cerebral barrier integrity and function by concomitantly attenuating basement membrane degradation and oxidative stress

Having a lot of a good thing: multiple important group memberships as a source of self-esteem.

Copyright: © 2015 Jetten et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedMembership in important social groups can promote a positive identity. We propose and test an identity resource model in which personal self-esteem is boosted by membership in additional important social groups. Belonging to multiple important group memberships predicts personal self-esteem in children (Study 1a), older adults (Study 1b), and former residents of a homeless shelter (Study 1c). Study 2 shows that the effects of multiple important group memberships on personal self-esteem are not reducible to number of interpersonal ties. Studies 3a and 3b provide longitudinal evidence that multiple important group memberships predict personal self-esteem over time. Studies 4 and 5 show that collective self-esteem mediates this effect, suggesting that membership in multiple important groups boosts personal self-esteem because people take pride in, and derive meaning from, important group memberships. Discussion focuses on when and why important group memberships act as a social resource that fuels personal self-esteem.This study was supported by 1. Australian Research Council Future Fellowship (FT110100238) awarded to Jolanda Jetten (see http://www.arc.gov.au) 2. Australian Research Council Linkage Grant (LP110200437) to Jolanda Jetten and Genevieve Dingle (see http://www.arc.gov.au) 3. support from the Canadian Institute for Advanced Research Social Interactions, Identity and Well-Being Program to Nyla Branscombe, S. Alexander Haslam, and Catherine Haslam (see http://www.cifar.ca)

Development of the financial sector and growth of microfinance institutions: The moderating effect of economic growth

ABSTRAC: This article analyzes the moderating effect the degree of economic growth has on the relationship between the development of the financial system and the microfinance industry activity. The hypotheses proposed establish that the influence of the development of the financial system on the activity of the microfinance sector will be different depending on the level of economic growth. The estimates were made using the System-GMM methodology for panel data, which allows controlling the unobservable heterogeneity and the problems of endogeneity. We find that the degree of economic growth affects the relationship between the financial sector development and microfinance activity. Under negative economic growth conditions, the development of the financial sector has a negative impact on the activity of the microfinance sector, but when economic growth is high, the development of the financial sector positively influences the activity of the microfinance sector