Current status of plague and plague control in the United States

During the first quarter of the 20th century, massive rat-borne plague epidemics occurred in port cities of the United States in conjunction with the last world-wide pandemic which originated in China in 1893. By 1950, plague was found to be firmly established in wild rodent populations in states west of the 100th meridian. Presumably because of improved sanitation coupled with retreat of the world-wide pandemic, there have been no human cases in this country associated with urban rats since 1924. However, sporadic cases, fewer than 10 per year, are reported as due to contact with wild rodents, lagomorphs, rural rats, and/or their fleas. Recent observations suggest that: a) in the current decade there has been an increase in human plague cases; b) there continues to be a serious potential of a single undiagnosed and untreated case, which possibility is intensified by the very paucity of human cases decreasing the likelihood of a correct diagnosis and by changing patterns of life exhibited by members of our society (e.g., hippie communes and a generally increased mobility); and c) the apparent distribution of plague only in the area west of the 100th meridian might be found to represent an unrealistic generalization if adequate surveillance were carried out. At the present time human plague cases from wild animal sources tend to be isolated events both spatially and temporally and often cannot be attributed to confined and definable epizootic sources amenable to effective control programs. Improved means for epizootic control and long-term management of enzootic plague sources must be sought aggressively. These measures should include development of: a) a surveillance network to detect plague activity in rodent and lagomorph populations throughout the western United States; b) effective, yet ecologically sound, means of ectoparasite control, including suitable materials and methods of application; c) methods for management of plague-susceptible wild animal populations, particularly where they exist in contact with high use recreation and residential areas; and d) more extensive knowledge of enzootic plague and the factors that bring about epizootic plague and potential human contact

Sex Offender Treatment Program: Initial Recidivism Study

This report presents results of a recidivism study of participants in the Sex Offender Treatment Program at Hiland Mountain Correctional Center, Alaska Department of Corrections, from January 1987 to August 1995. The report provides an overview and history of sex offender treatment in Alaska as well as a literature review of other studies and findings on this area of treatment. The Alaska study, which was the first conducted of the treatment program, found that any level of treatment achieved resulted in less recidivism, with the longer the period of treatment, the lower the recidivism. The study also noted the high percentage of Alaska Natives in the program and the history of alcohol and substance abuse presented by many sex offenders. The majority of offenders in the program were guilty of assaulting children. The study discusses the program's cost benefits as well as the implications of its findings for probation and parole.Alaska Department of CorrectionsI. Introduction / II. Sex Offender Treatment in Alaska / III. Literature Review / IV. Methodology / V. Results / VI. Conclusions and Recommendations / VII. Reference

CURRENT STATUS OF PLAGUE AND PLAGUE CONTROL IN THE UNITED STATES

During the first quarter of the 20th century massive rat-borne plague epidemics occurred in port cities of the United States in conjunction with the last world-wide pandemic which originated in China in 1893. By 1950, plague was found to be firmly established in wild rodent populations in states west of the 100th meridian. Presumably because of improved sanitation coupled with retreat of the world-wide pandemic there have been no human cases in this country associated with urban rats since 1924. However, sporadic cases, fewer than 10 per year, are reported as due to contact with wild rodents, lagomorphs, rural rats, and/or their fleas. Recent observations suggest that: a) in the current decade there has been an increase in human plague cases; b) there continues to be a serious potential of a single undiagnosed and untreated case, which possibility is intensified by the very paucity of human cases decreasing the likelihood of a correct diagnosis and by changing patterns of life exhibited by members of our society (e.g., hippie communes and a generally increased mobility); and c) the apparent distribution of plague only in the area west of the 100th meridian might be found to represent an unrealistic generalization if adequate surveillance were carried out. At the present time human plague cases from wild animal sources tend to be isolated events both spatially and temporally and often cannot be attributed to confined and definable epizootic sources amenable to effective control programs. Improved means for epizootic control and long term management of enzootic plague sources must be sought aggressively. These measures should include development of: a) a surveillance network to detect plague activity in rodent and lagomorph populations throughout the western United States; b) effective, yet ecologically sound, means of ectoparasite control, including suitable materials and methods of application; c) methods for management of plague-susceptible wild animal populations, particularly where they exist in contact with high use recreation and residential areas; and d) more extensive knowledge of enzootic plague and the factors that bring about epizootic plague and potential human contact

Simulations of turbulent convection in rotating young solar-like stars: Differential rotation and meridional circulation

We present the results of three-dimensional simulations of the deep convective envelope of a young (10 Myr) one-solar-mass star, obtained with the Anelastic Spherical Harmonic code. Since young stars are known to be faster rotators than their main sequence counterparts, we have systematically studied the impact of the stellar rotation speed, by considering stars spinning up to five times as fast as the Sun. The aim of these nonlinear models is to understand the complex interactions between convection and rotation. We discuss the influence of the turbulence level and of the rotation rate on the intensity and the topology of the mean flows. For all of the computed models, we find a solar-type superficial differential rotation, with an equatorial acceleration, and meridional circulation that exhibits a multicellular structure. Even if the differential rotation contrast decreases only marginally for high rotation rates, the meridional circulation intensity clearly weakens according to our simulations. We have also shown that, for Taylor numbers above a certain threshold (Ta>10^9), the convection can develop a vacillating behavior. Since simulations with high turbulence levels and rotation rates exhibit strongly cylindrical internal rotation profiles, we have considered the influence of baroclinic effects at the base of the convective envelope of these young Suns, to see whether such effect can modify the otherwise near cylindrical profiles to produce more conical, solar-like profiles.Comment: 32 pages, 18 figures, 2 tables, to appear in Ap

"My Children and I Will no Longer Suffer from Malaria": A Qualitative Study of the Acceptance and Rejection of Indoor Residual Spraying to Prevent Malaria in Tanzania.

The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). This study was a series of qualitative, semi-structured, in-depth interviews and focus group discussions conducted from October 2010 to March 2011 on Mainland Tanzania and Zanzibar. Three groups of participants were targeted: acceptors of IRS (those who have already had their homes sprayed), refusers (those whose communities have been sprayed, but refused to have their individual home sprayed), and those whose houses were about to be sprayed as part of IRS scale-up. Interviews were also conducted with farmers, fishermen, women, community leaders and members of non-government organizations responsible for community mobilization around IRS. Results showed refusers are a very small percentage of the population. They tend to be more knowledgeable people such as teachers, drivers, extension workers, and other civil servants who do not simply follow the orders of the local government or the sprayers, but are skeptical about the process until they see true results. Refusal took three forms: 1) refusing partially until thorough explanation is provided; 2) accepting spray to be done in a few rooms only; and 3) refusing outright. In most of the refusal interviews, refusers justified why their houses were not sprayed, often without admitting that they had refused. Reasons for refusal included initial ignorance about the reasons for IRS, uncertainty about its effectiveness, increased prevalence of other insects, potential physical side effects, odour, rumours about the chemical affecting fertility, embarrassment about moving poor quality possessions out of the house, and belief that the spray was politically motivated. To increase IRS acceptance, participants recommended more emphasis on providing thorough public education, ensuring the sprayers themselves are more knowledgeable about IRS, and asking that community leaders encourage participation by their constituents rather than threatening punishment for noncompliance. While there are several rumours and misconceptions concerning IRS in Tanzania, acceptance is very high and continues to increase as positive results become apparent

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.

Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK

Netec Cold Crucible Induction Melter Demonstration for Srnl With Simulated Sludge Batch 4 Dwpf Waste

Cold Crucible Induction Melter (CCIM) Technology is being considered as a possible next generation melter for the Defense Waste Processing Facility (DWPF). Initial and baseline demonstrations that vitrified a Sludge Batch 4 (SB4) simulant at a waste loading of 50 weight percent (versus about 38 weight percent in the current DWPF Melter) were performed by the Nuclear Engineering and Technology Institute (NETEC) in South Korea via a subcontract from the Washington Savannah River Company (WSRC). This higher waste loading was achieved by using a CCIM which can run at higher glass processing temperatures (1250 C and higher) than the current DWPF Melter (1150 C). Higher waste loadings would result in less canisters being filled and faster waste throughput at the DWPF. The main demonstration objectives were to determine the maximum melt rate/waste throughput for the NETEC CCIM with a Sludge Batch 4 simulant as well as determine the viability of this technology for use in the DWPF

Long-distance frequency transfer over an urban fiber link using optical phase stabilization

We transferred the frequency of an ultra-stable laser over 86 km of urban fiber. The link is composed of two cascaded 43-km fibers connecting two laboratories, LNE-SYRTE and LPL in Paris area. In an effort to realistically demonstrate a link of 172 km without using spooled fiber extensions, we implemented a recirculation loop to double the length of the urban fiber link. The link is fed with a 1542-nm cavity stabilized fiber laser having a sub-Hz linewidth. The fiber-induced phase noise is measured and cancelled with an all fiber-based interferometer using commercial off the shelf pigtailed telecommunication components. The compensated link shows an Allan deviation of a few 10-16 at one second and a few 10-19 at 10,000 seconds