77 research outputs found
Frequent Graph Discovery : application to Line Drawing Document Images
In this paper a sequence of steps is applied to a graph representation of line drawings using concepts from data mining. This process finds frequent subgraphs and then association rules between these subgraphs. The distant aim is the automatic discovery of symbols and their relations, which are parts of the document model. The main outcome of our work is firstly an algorithm that finds frequent subgraphs in a single graph setting and secondly a modality to find rules and meta-rules between the discovered subgraphs. The searched structures are closed [1] and disjunct subgraphs. One aim of this study is to use the discovered symbols for classification and indexation of document images when a supervised approach is not at hand. The relations found between symbols can be used in segmentation of noisy and occluded document images. The results show that this approach is suitable for patterns, symbols or relation discovery
Frequent Graph Discovery: Application to Line Drawing Document Images
International audienceIn this paper a sequence of steps is applied to a graph representation of line drawings using concepts from data mining. This process finds frequent subgraphs and then association rules between these subgraphs. The distant aim is the automatic discovery of symbols and their relations, which are parts of the document model. The main outcome of our work is firstly an algorithm that finds frequent subgraphs in a single graph setting and secondly a modality to find rules and meta-rules between the discovered subgraphs. The searched structures are closed [1] and disjunct subgraphs. One aim of this study is to use the discovered symbols for classification and indexation of document images when a supervised approach is not at hand. The relations found between symbols can be used in segmentation of noisy and occluded document images. The results show that this approach is suitable for patterns, symbols or relation discovery
The Curatorial Incubator : v.12
"So boasts James Joyce in A Portrait of the Artist as a Young Man, that canonical tale of a sensitive, artistic youth coming of age. is year, e Curatorial Incubator, v.12 has asked emerging curators to get a little naughty and put a contemporary spin on this classic by considering media artworks that come together to create A Portrait of the Artist as a Young Brat. Happily, the programs they have assembled are as brash and fearless as Stephen Dedalus, hero of Joyceâs 1916 Modernist classic." -- p. 2
«La relation de limitation et dâexception dans le français dâaujourdâhui : exceptĂ©, sauf et hormis comme pivots dâune relation algĂ©brique »
Lâanalyse des emplois prĂ©positionnels et des emplois conjonctifs dâ âexceptĂ©â, de âsaufâ et dâ âhormisâ permet dâenvisager les trois prĂ©positions/conjonctions comme le pivot dâun binĂŽme, comme la plaque tournante dâune structure bipolaire. PlacĂ©es au milieu du binĂŽme, ces prĂ©positions sont forcĂ©es par leur sĂ©mantisme originaire dĂ»ment mĂ©taphorisĂ© de jouer le rĂŽle de marqueurs dâinconsĂ©quence systĂ©matique entre lâĂ©lĂ©ment se trouvant Ă leur gauche et celui qui se trouve Ă leur droite. Lâopposition qui surgit entre les deux Ă©lĂ©ments nâest donc pas une incompatibilitĂ© naturelle, intrinsĂšque, mais extrinsĂšque, induite. Dans la plupart des cas (emplois limitatifs), cette opposition prend la forme dâun rapport entre une « classe » et le « membre (soustrait) de la classe », ou bien entre un « tout » et une « partie » ; dans dâautres (emplois exceptifs), cette opposition se manifeste au contraire comme une attaque de front portĂ©e par un « tout » Ă un autre « tout ». De plus, lâinconsĂ©quence induite mise en place par la prĂ©position/conjonction paraĂźt, en principe, tout Ă fait insurmontable. Dans lâassertion « les Ă©cureuils vivent partout, sauf en Australie » (que lâon peut expliciter par « Les Ă©cureuils vivent partout, sauf [quâils ne vivent pas] en Australie »), la prĂ©position semble en effet capable dâimpliquer le prĂ©dicat principal avec signe inverti, et de bĂątir sur une telle implication une sorte de sous Ă©noncĂ© qui, Ă la rigueur, est totalement inconsĂ©quent avec celui qui le prĂ©cĂšde (si « les Ă©cureuils ne vivent pas en Australie », le fait quâils « vivent partout » est faux). NĂ©anmoins, lâanalyse montre quâalors que certaines de ces oppositions peuvent enfin ĂȘtre dĂ©passĂ©es, dâautres ne le peuvent pas. Câest, respectivement, le cas des relations limitatives et des relations exceptives. La relation limitative, impliquant le rapport « tout » - « partie », permet de rĂ©soudre le conflit dans les termes dâune somme algĂ©brique entre deux sous Ă©noncĂ©s pourvus de diffĂ©rent poids informatif et de signe contraire. Les valeurs numĂ©riques des termes de la somme Ă©tant dĂ©sĂ©quilibrĂ©es, le rĂ©sultat est toujours autre que zĂ©ro. La relation exceptive, au contraire, qui nâimplique pas le rapport « tout » - « partie », nâest pas capable de rĂ©soudre le conflit entre deux sous Ă©noncĂ©s pourvus du mĂȘme poids informatif et en mĂȘme temps de signe contraire : les valeurs numĂ©riques des termes de la somme Ă©tant symĂ©triques et Ă©gales, le rĂ©sultat sera toujours Ă©quivalent Ă zĂ©ro
Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in UK Biobank
Background: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-associated variation in other pathways. Here, we sought to investigate whether major depressive disorder polygenic risk scores derived from the NETRIN1 signaling pathway (NETRIN1-PRSs) and the whole genome, excluding NETRIN1 pathway genes (genomic-PRSs), were associated with white matter microstructure. Methods: We used two diffusion tensor imaging measures, fractional anisotropy (FA) and mean diffusivity (MD), in the most up-to-date UK Biobank neuroimaging data release (FA: n = 6401; MD: n = 6390). Results: We found significantly lower FA in the superior longitudinal fasciculus (ÎČ = â.035, p =.029) and significantly higher MD in a global measure of thalamic radiations (ÎČ =.029, p =.021), as well as higher MD in the superior (ÎČ =.034, p =.039) and inferior (ÎČ =.029, p =.043) longitudinal fasciculus and in the anterior (ÎČ =.025, p =.046) and superior (ÎČ =.027, p =.043) thalamic radiation associated with NETRIN1-PRS. Genomic-PRS was also associated with lower FA and higher MD in several tracts. Conclusions: Our findings indicate that variation in the NETRIN1 signaling pathway may confer risk for major depressive disorder through effects on a number of white matter tracts
RelatĂłrio de estĂĄgio em farmĂĄcia comunitĂĄria
RelatĂłrio de estĂĄgio realizado no Ăąmbito do Mestrado Integrado em CiĂȘncias FarmacĂȘuticas, apresentado Ă Faculdade de FarmĂĄcia da Universidade de Coimbr
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