Naturaleza e influencia de los think tanks en el proceso político en España

Este artículo examina la realidad que define la acción política de los think tanks españoles, así como su evolución durante los últimos años. En primer lugar, se analiza de un modo sistemático cuáles son las principales características, objetivos, perfiles ideológicos, funcionamiento y recursos de los think tanks que operan en España. Posteriormente, mediante la administración de un cuestionario y la realización de entrevistas en profundidad analizamos el impacto que este tipo de organizaciones tienen en el proceso político español. Nuestros resultados indican que, pese a que la mayoría de think tanks son de creación reciente y tienen una influencia limitada, su número y tamaño han aumentado de manera notable en los últimos años, convirtiéndolos en un actor relevante, que ejerce de modo creciente un impacto significativo en el proceso político español

Of Echo Chambers and Contrarian Clubs:Exposure to Political Disagreement Among German and Italian Users of Twitter

Scholars have debated whether social media platforms, by allowing users to select the information to which they are exposed, may lead people to isolate themselves from viewpoints with which they disagree, thereby serving as political “echo chambers.” We investigate hypotheses concerning the circumstances under which Twitter users who communicate about elections would engage with (a) supportive, (b) oppositional, and (c) mixed political networks. Based on online surveys of representative samples of Italian and German individuals who posted at least one Twitter message about elections in 2013, we find substantial differences in the extent to which social media facilitates exposure to similar versus dissimilar political views. Our results suggest that exposure to supportive, oppositional, or mixed political networks on social media can be explained by broader patterns of political conversation (i.e., structure of offline networks) and specific habits in the political use of social media (i.e., the intensity of political discussion). These findings suggest that disagreement persists on social media even when ideological homophily is the modal outcome, and that scholars should pay more attention to specific situational and dispositional factors when evaluating the implications of social media for political communication

First approach to the intervention of the paleo-ichnological heritage on "La Virgen del Campo" site. Enciso, La Rioja (Spain)

[ES] En el presente trabajo. se analiza el estado de conservación del yacimiento paleoicnológico de La Virgen del Campo, situado en Enciso, La Rioja (España). En primer lugar, se realiza una revision bibliográfica y búsqueda de las intervenciones realizadas en el yacimiento y los materiales que se aplicaron. Por otro lado, se realize un studio del estado de conservación y las causas de deterioro y las patologías presentes en el yacimiento. Dichas patologías, se identifican y se asignan a una categoría concreta gracias al glosario del ICOMOS. Por otro lado, se realiza una propuesta de intervención. Esta propuesta de intervención se realiza gracias a la revision bibliográdica y los estudios preliminaries llevados a cabo en el laboratorio. Finalmente, se realiza un studio de los materiales de restauración, especialmente centrado en los diferentes tipos de morteros de cal, testeando la compatiblidad con la piedra del yacimiento en el laboratorio y durante la campaña de campo.[EN] In this paper, we analysed the state of conservation of the paleoichnological site of La Virgen del Campo located in Enciso, La Rioja, (Spain). First, a bibliographic review was carried out, researching about the interventions made on the site and the materials applied. We made a conservation study, in which we analysed the causes of deterioration, using different methods, and pathologies. These pathologies are identified and assigned to a defined category according to ICOMOS glossary. In addition, we carried out an intervention proposal. This has been done, thanks to the bibliographic review and the studies that we accomplished at the laboratory. Finally, we made a study of the restoration materials, specially focused on different lime mortars. We tested their suitability with the rock of the site at the laboratory and then during the field season.Ferrer Ventura, M.; Mas Barberà, X.; Torices, A.; San Juan-Palacios, R.; Navarro-Lorbés, P. (2020). First approach to the intervention of the paleo-ichnological heritage on "La Virgen del Campo" site. Enciso, La Rioja (Spain). Arché. (13 - 14 - 15):93-102. http://hdl.handle.net/10251/1563769310213 - 14 - 1

Livestock management at the Late Iron Age site of Baltarga (eastern Pyrenees): an integrated bio-geoarchaeological approach

Despite the important role of livestock farming amongst Iron Age communities living in mountain regions, there is little information about livestock management, and particularly stabling practises, breeding systems, and grazing/foddering patterns. The study of the ground floor of Building G in Tossal de Baltarga has provided valuable insights into these important issues and has given us a better understanding of the social and economic patterns involved in all these livestock activities. It revealed the existence of a stable from the Late Iron Age, thanks to unique in situ finds of the stabled animals, including four sheep, a goat, and a horse, in addition to a range of organic remains preserved by fire and penning deposits. It is the first documented to date in the northeastern Iberian Peninsula. Through an integrated bio-geoarchaeological approach, combining a range of analytic procedures, including osteology, dental microwear, stable isotopes, phytoliths, dung spherulite analyses, and thin-section micromorphology, for the first time, this study has provided new, high-resolution evidence of livestock management strategies. Specifically, the research shed light on animal penning and feeding practises, revealing variable herbivorous regimes between species, the practise of seasonal movements, and the possible use of fodder as the main dietary regime of the animals stabled there. At the same time, the Baltarga case-study illustrates an indoor production unit that could reveal possible private control of some domestic animals in the Pyrenean Late Iron Age.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. LC is currently supported by a Ramón y Cajal contract (RYC2019-026732-I-AEI/10.13039/ 501100011033). CM has the financial support of the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya and European Social Fund (ESF) “Investing in your future” (2022 FI_B2 00070). The funding for this research has been partially provided within the framework of the projects “Control, gestión y explotación del territorio en la Hispania romana”, PID2021-122879OB-I00, MICIN, and “PATCA-3”, Generalitat de Catalunya, 9071-55/2022

Instrumental drift removal in GC-MS data for breath analysis: the short-term and long term temporal validation of putative biomarkers for COPD

Breath analysis holds the promise of a non-invasive technique for the diagnosis of diverse respiratory conditions including COPD and lung cancer. Breath contains small metabolites that may be putative biomarkers of these conditions. However, the discovery of reliable biomarkers is a considerable challenge in the presence of both clinical and instrumental confounding factors. Among the latter, instrumental time drifts are highly relevant, as since question the short and long-term validity of predictive models. In this work we present a methodology to counter instrumental drifts using information from interleaved blanks for a case study of GC-MS data from breath samples. The proposed method includes feature filtering, and additive, multiplicative and multivariate drift corrections, the latter being based on Component Correction. Biomarker discovery was based on Genetic Algorithms in a filter configuration using Fisher´s ratio computed in the Partial Least Squares - Discriminant Analysis subspace as a figure of merit. Using our protocol, we have been able to find nine peaks that provide a statistically significant Area under the ROC Curve (AUC) of 0.75 for COPD discrimination. The method developed has been successfully validated using blind samples in short-term temporal validation. However, in the attempt to use this model for patient screening six months later was not successful. This negative result highlights the importance of increasing validation rigour when reporting biomarker discovery result

Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden

Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis

Background: The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both the impact of such timing throughout the first four pandemic waves and the influence of prior noninvasive respiratory support on outcomes. Methods: This is a secondary analysis of a multicentre, observational and prospective cohort study that included all consecutive patients undergoing invasive mechanical ventilation due to COVID-19 from across 58 Spanish intensive care units (ICUs) participating in the CIBERESUCICOVID project. The study period was between 29 February 2020 and 31 August 2021. Early intubation was defined as that occurring within the first 24 h of ICU admission. Propensity score matching was used to achieve a balance across baseline variables between the early intubation cohort and those patients who were intubated after the first 24 h of ICU admission. Differences in outcomes between early and delayed intubation were also assessed. We performed sensitivity analyses to consider a different time-point (48 h from ICU admission) for early and delayed intubation. Results: Of the 2725 patients who received invasive mechanical ventilation, a total of 614 matched patients were included in the analysis (307 for each group). In the unmatched population, there were no differences in mortality between the early and delayed groups. After propensity score matching, patients with delayed intubation presented higher hospital mortality (27.3% versus 37.1%; p=0.01), ICU mortality (25.7% versus 36.1%; p=0.007) and 90-day mortality (30.9% versus 40.2%; p=0.02) compared with the early intubation group. Very similar findings were observed when we used a 48-h time-point for early or delayed intubation. The use of early intubation decreased after the first wave of the pandemic (72%, 49%, 46% and 45% in the first, second, third and fourth waves, respectively; first versus second, third and fourth waves p<0.001). In both the main and sensitivity analyses, hospital mortality was lower in patients receiving high-flow nasal cannula (HFNC) (n=294) who were intubated earlier. The subgroup of patients undergoing noninvasive ventilation (n=214) before intubation showed higher mortality when delayed intubation was set as that occurring after 48 h from ICU admission, but not when after 24 h. Conclusions: In patients with COVID-19 requiring invasive mechanical ventilation, delayed intubation was associated with a higher risk of hospital mortality. The use of early intubation significantly decreased throughout the course of the pandemic. Benefits of such an approach occurred more notably in patients who had received HFNC

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Background: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. Methods: This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group. Results: Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR < 0.05). Cox regression analysis revealed that low expression levels of eight miRNAs were associated with a higher risk of death (HR from 1.56 to 2.61). LASSO regression for variable selection was used to construct a miRNA classifier. A 4-blood miRNA signature composed of miR-16-5p, miR-192-5p, miR-323a-3p and miR-451a predicts the risk of all-cause in-ICU mortality (HR 2.5). Kaplan‒Meier analysis confirmed these findings. The miRNA signature provides a significant increase in the prognostic capacity of conventional scores, APACHE-II (C-index 0.71, DeLong test p-value 0.055) and SOFA (C-index 0.67, DeLong test p-value 0.001), and a risk model based on clinical predictors (C-index 0.74, DeLong test-p-value 0.035). For 28-day and 90-day mortality, the classifier also improved the prognostic value of APACHE-II, SOFA and the clinical model. The association between the classifier and mortality persisted even after multivariable adjustment. The functional analysis reported biological pathways involved in SARS-CoV infection and inflammatory, fibrotic and transcriptional pathways. Conclusions: A blood miRNA classifier improves the early prediction of fatal outcomes in critically ill COVID-19 patients.11 página