Il fantasma della tragedia

Since Aristophanes and Aristotle up to Romanticism, critics have always been praising the harmony of classical tragedy compared to the modern “philosophical” tragedy, whose disharmony constitutes its very content and form. Euripides expressed the crisis of a long fin de siècle with the crisis of the tragical form itself: the impossibility of an harmonic tragedy is precisely the answer of the less classical among the tragedians of that time. Without rejecting myth, he escaped the established form shaped by his predecessors, thus creating a "new" tragedy, of which Helen is probably the most famous example. As a matter of fact, Helen has received a wide variety of definitions across time such as: «the most entertaining among the tragedies»; «a mere entertainment for the audience»; «everything but a tragedy»; «a good achievement, but without the greatness pertaining to tragedy»; «the greatest among the euripidean tragedies». The aim of my paper is to demonstrate how Helen is actually inserted in a coherent elaboration of the tragic form made by Euripides: it is thanks to the happy ending and to the admission of buffoonish elements within drama – that is to say, by mastering both comedy and tragedy, as suggested by Socrates at the end of the Symposium (223d 3-6) – that the poet managed to be “the most tragic among tragedians”, as Aristotle defined him (Poetics 1453a 30).Since Aristophanes and Aristotle up to Romanticism, critics have always been praising the harmony of classical tragedy compared to the modern “philosophical” tragedy, whose disharmony constitutes its very content and form. Euripides expressed the crisis of a long fin de siècle with the crisis of the tragical form itself: the impossibility of an harmonic tragedy is precisely the answer of the less classical among the tragedians of that time. Without rejecting myth, he escaped the established form shaped by his predecessors, thus creating a "new" tragedy, of which Helen is probably the most famous example. As a matter of fact, Helen has received a wide variety of definitions across time such as: «the most entertaining among the tragedies»; «a mere entertainment for the audience»; «everything but a tragedy»; «a good achievement, but without the greatness pertaining to tragedy»; «the greatest among the euripidean tragedies». The aim of my paper is to demonstrate how Helen is actually inserted in a coherent elaboration of the tragic form made by Euripides: it is thanks to the happy ending and to the admission of buffoonish elements within drama – that is to say, by mastering both comedy and tragedy, as suggested by Socrates at the end of the Symposium (223d 3-6) – that the poet managed to be “the most tragic among tragedians”, as Aristotle defined him (Poetics 1453a 30)

Social environment and attitudes toward COVID-19 anti-contagious measures: an explorative study from Italy

Social and cultural aspects (i.e., political decision making, discourses in the public sphere, and people’s mindsets) played a crucial role in the ways people responded to the COVID-19 pandemic. Framed with the Semiotic-Cultural Psychological Theory (SCPT), the present work aims to explore how individual ways of making sense of their social environment affected individuals’ perception of government measures aimed at managing the pandemic and the adherence to such measures. An online survey was administered from January to April 2021 to the Italian population. Retrieved questionnaires (N = 378) were analyzed through a Multiple Correspondence Analysis (MCA) to detect the factorial dimensions underpinning (dis)similarities in the respondents’ ways of interpreting their social environment. Extracted factors were interpreted as markers of Latent Dimensions of Sense (LDSs) organizing respondents’ worldviews. Finally, three regression models tested the role of LDSs in supporting the individual satisfaction with the measures adopted to contain the social contagion defined at national level, individual adherence to the containment measures and the perception of the population’s adherence to them. Results highlight that all the three measures are associated with a negative view of the social environment characterized by a lack of confidence in public institutions (health system, government), public roles and other people. Findings are discussed on the one hand to shed light on the role of deep-rooted cultural views in defining personal evaluations of government measures and adherence capacity. On the other hand, we suggest that taking into account people’s meaning-making can guide public health officials and policy makers to comprehend what favors or hinders adaptive responses to emergencies or social crises

Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters

Wastewater-based epidemiology (WBE) was applied for the first time in seven cities across Europe with the aim of estimating quinolones consumption via the analysis of human urinary metabolites in wastewater. This report is also the first pan-European study focussed on the enantiomeric profiling of chiral quinolones in wastewater. By considering loads of (fluoro)quinolones in wastewater within the context of human stereoselective metabolism, we identified cities in Southern Europe characterised by both high usage and direct disposal of unused ofloxacin. In Northern European cities, S-(-)-ofloxacin loads were predominant with respect to R-(+)-ofloxacin. Much more potent, enantiomerically pure S-(-)-ofloxacin was detected in wastewaters from Southern European cities, reflecting consumption of the enantiomerically pure antibiotic. Nalidixic acid, norfloxacin and lomefloxacin were detected in wastewater even though they were not prescribed according to official prescription data. S,S-(-)-moxifloxacin and S,S-(-)-moxifloxacin-N-sulphate were detected in wastewater due to metabolism of moxifloxacin. For the first time, average population-normalised ulifloxacin loads of 22.3 and 1.5 mg day 1000 people were reported for Milan and Castellón as a result of prulifloxacin metabolism. Enrichment of flumequine with first-eluting enantiomer in all the samples indicated animal metabolism rather than its direct disposal. Fluoroquinolone loads were compared with qnrS gene encoding quinolone resistance to correlate usage of fluoroquinolone and prevalence of resistance. The highest daily loads of the qnrS gene in Milan corresponded with the highest total quinolone load in Milan proving the hypothesis that higher usage of quinolones is linked with higher prevalence of quinolone resistance genes. Utrecht, with the lowest quinolones usage (low daily loads) had also one of the lowest daily loads of the qnrS gene. However, a similar trend was not observed in Oslo nor Bristol where higher qnrS gene loads were observed despite low quinolone usage

Biometric Measures, Body Score and Body Mass Index Evaluation in Wild Coatis (Nasua Nasua) Living in the South-Central Region of São Paulo State, Brazil

Background: Coatis (Nasua nasua) have easy interaction with man, besides being sociable and curious animals. The proximity to urbanized areas encourages them to intake food from anthropogenic sources, and it can change their eating habits and make them prone to obesity. The body condition evaluates the animals’ energetic status and measures variations in their body fat reserves. There are direct-invasive methods and indirect methods that rely on size and body mass to evaluate the body condition, like body condition score and body mass index. Thus, the aim of the present study was to assess different methods to determine the body condition of wild coatis (Nasua nasua) living in urban areas.Materials, Methods & Results: Sixteen (16) wild coatis (Nasua nasua), nine females and seven males, were captured at Faculty of Veterinary Medicine and Animal Science (FMVZ) of São Paulo State University, Botucatu, in pitfalls. The animals were anesthetized with ketamine and midazolam and subjected to biometric evaluation after physical exams proved normal. The following variables were analyzed: body weight, body condition score (BCS) based on the five-point scale for dogs, thoracic and abdominal circumference, height at the withers, spine length and distance from the patella to the calcaneus. Two body mass index (BMI) were calculated from these data, one was based on dogs (BMI1) and another one on cats (BMI2), as well as the body fat percentage (%BF). Results showed that 25% of the assessed coatis were overweight. Body weight, thoracic and abdominal circumference, height at the withers, spine length and distance from the patella to the calcaneus were significantly higher in males than in females and the other assessed parameters did not present differences between sexes. The correlation between fat percentage and body weight was significant, and that between fat percentage and BCS was not. There was closer correlation between BMI2 and body weight, and BCS, than between BMI1 and these two parameters.Discussion: Anthropogenic interactions could change the body condition of these animals and make them prone to obesity, since their body condition scores were altered. With regard to the nutritional body condition, although males were bigger than females, the measures did not show significant differences between them. Results of this parameter varied in different studies with coatis, some studies have shown that males have body mass 1/3 higher than that of females and others have not recorded any difference between sexes. Fat percentage estimated through the metrics used in cats is not a good method when it is applied alone in body condition evaluations. A study that has correlated body mass, body condition score, body fat estimates, body mass index and abdominal circumference recorded positive results between these two evaluation methods. Such finding corroborated with the present study, but it was differed from it in abdominal circumference, which did not correlate to the two body mass indices and to body fat percentage. Therefore, it is possible saying that there is biometric difference between male and female coatis. The body condition score adopted for dogs was efficient for coatis (Nasua nasua), as well as the body mass index used for dogs and cats – the one used for cats was even more efficient. The proximity wild coatis (Nasua nasua) have to humans could change the body condition of these animals and make them prone to obesity

Gas structure inside dust cavities of transition disks: Ophiuchus IRS 48 observed by ALMA

List of DEGs between hypothalamus and ovary. Positive value in the LogFC column refers to genes over-expressed in the vary; negative values indicates genes over-expressed in hypothalamus. (XLSX 1257 kb

Comparison of pharmaceutical, illicit drug, alcohol, nicotine and caffeine levels in wastewater with sale, seizure and consumption data for 8 European cities

Background: Monitoring the scale of pharmaceuticals, illicit and licit drugs consumption is important to assess the needs of law enforcement and public health, and provides more information about the different trends within different countries. Community drug use patterns are usually described by national surveys, sales and seizure data. Wastewater-based epidemiology (WBE) has been shown to be a reliable approach complementing such surveys. Method: This study aims to compare and correlate the consumption estimates of pharmaceuticals, illicit drugs, alcohol, nicotine and caffeine from wastewater analysis and other sources of information. Wastewater samples were collected in 2015 from 8 different European cities over a one week period, representing a population of approximately 5 million people. Published pharmaceutical sale, illicit drug seizure and alcohol, tobacco and caffeine use data were used for the comparison. Results: High agreement was found between wastewater and other data sources for pharmaceuticals and cocaine, whereas amphetamines, alcohol and caffeine showed a moderate correlation. methamphetamine and 3,4- methylenedioxymethamphetamine (MDMA) and nicotine did not correlate with other sources of data. Most of the poor correlations were explained as part of the uncertainties related with the use estimates and were improved with other complementary sources of data. Conclusions: This work confirms the promising future of WBE as a complementary approach to obtain a more accurate picture of substance use situation within different communities. Our findings suggest further improvements to reduce the uncertainties associated with both sources of information in order to make the data more comparable.Jose Antonio Baz Lomba, Stefania Salvatore, Richard Bade, Erika Castrignanò, Ana Causanilles, Juliet Kinyua, Ann-Kathrin McCall, Pedram Ramin, Nikolaos I. Rousis, and Yeonsuk Ryu acknowledge the EU Marie-Skłodowska Curie Initial Training Network SEWPROF (Marie Curie-FP7-PEOPLE, grant number 317205) for their Early Stage Researcher grant and Emma Gracia-Lor for her Experienced Researcher grant. We thank the people and agencies who assisted in the collection of the wastewater samples, in particular Pia Ryrfors and colleagues at Vestfjorden Avløpselskap (VEAS, Oslo, Norway)

Sewage-based epidemiology requires a truly transdisciplinary approach

If asked whether you had consumed illicit drugs recently, would you admit it? If yes, could you precisely recall types of drug, times and amounts used? If you were the person commissioned with the task of quantifying drug use, what approach would you use given the social stigma attached with such behavior? We measure drug residues in sewage, which represents urine of entire populations, to provide an objective estimate of total drug use in a region. In transdisciplinary projects, sewage-based results provide valuable information at unrivaled spatiotemporal resolution complementing traditional data

Sex-Specific Considerations in Degenerative Aortic Stenosis for Female-Tailored Transfemoral Aortic Valve Implantation Management

The impact of sex on pathophysiological processes, clinical presentation, treatment options, as well as outcomes of degenerative aortic stenosis remain poorly understood. Female patients are well represented in transfemoral aortic valve implantation (TAVI) trials and appear to derive favorable outcomes with TAVI. However, higher incidences of major bleeding, vascular complications, and stroke have been reported in women following TAVI. The anatomical characteristics and pathophysiological features of aortic stenosis in women might guide a tailored planning of the percutaneous approach. We highlight whether a sex-based TAVI management strategy might impact on clinical outcomes. This review aimed to evaluate the impact of sex from diagnosis to treatment of degenerative aortic stenosis, discussing the latest evidence on epidemiology, pathophysiology, clinical presentation, therapeutic options, and outcomes. Furthermore, we focused on technical sex-oriented considerations in TAVI including the preprocedural screening, device selection, implantation strategy, and postprocedural management