Perception of Japanese Encephalitis and Its Vaccination: An Experience from a Rural Area of Hooghly District, West Bengal

Background: Japanese Encephalitis (JE) is endemic in Hooghly district of West Bengal. A mass vaccination program among 15–65 year old people was planned and implemented during the month of December, 2015. In this background, the present study was conducted to find out the knowledge regarding JE, and the perceived reasons for receiving vaccination among the beneficiaries.Materials and Methods: 135 beneficiaries were interviewed during vaccination sessions (held in December, 2015) at three camps located at three different villages of Singur block of Hooghly district using structured Bengali questionnaire. After obtaining informed consent, each person was approached for interview at the entry point for receiving the vaccine.Results: Majority (36%) came to receive vaccine because others in the neighborhood did so. Only 59 persons (43.7%) had ever heard of the disease. A little over 50% of those 59 participants perceived themselves susceptible to JE and felt that vaccination would help. Major sources of JE-related information were from teachers (45.7%) and health personnel (22%).Conclusion: Perception regarding the basic aspects of JE among those for whom the vaccination program was targeted was unsatisfactory. Therefore, any such public health initiative should be preceded by appropriate and effective community awareness program

Does Women Empowerment Predict Contraceptive Use? A Study in a Rural Area of Hooghly District, West Bengal

Background: India launched the world’s first national family planning programme in 1952. Unfortunately, considerable numbers of eligible couples in India are still not using any method of contraception in spite of the fact that knowledge related to contraceptives are not lacking. Studies reported that the status of the women in the family and largely in the community, represented by a measure ‘women empowerment’ plays a role in determining contraceptive use. However, there is dearth of literature in this regards especially among women of reproductive age of West Bengal. Aims & Objectives: To find out the current contraceptive use and its relationship, if any with women empowerment among adult married women of reproductive age group in a rural area of West Bengal. Material & Methods: Community based cross-sectional study was conducted among 151 WRA using interviewer-administered questionnaire. Current use of contraceptive was the outcome variable. The main explanatory variable was ‘empowerment score’-a summed measure of four domains: ‘financial autonomy’, ‘freedom of movement’, ‘involvement in household level decision making’ and ‘woman’s power in sexual and reproductive decision making’. Results: 63.6% study participants were using any method of contraception at the time of study. Women empowerment [AOR (CI): 1.11 (1.02-1.22)] and education of women [AOR (CI): 2.56 (1.13-5.85)] were significantly associated with contraceptive use, even after adjustment with other independent variables. Conclusion: Educating women and empowering them will improve the family planning practices. This will, in long run play a pivotal role in improving family and community health

Perception of prevention of Japanese Encephalitis with emphasis on its vaccination programme: a community based study in a slum of Kolkata

Introduction Japanese Encephalitis (JE) is a mosquito borne disease with epidemic potential. There is no specific treatment available till date and apart from vector control, vaccination of individuals is considered as a safe and effective measure for prevention. Vaccination campaign among 1-15 years is being carried out with full vigour from 2015 onwards in West Bengal. Objectives This study was conducted to assess the knowledge of the care givers of 1-15 years old children about JE and its prevention and to find out the factors associated with vaccination status of the children. Methods A cross sectional, community based study was conducted from May-June 2016 in a slum of Chetla, Kolkata, which is within the service area of Urban Health Unit and Training Centre (UHU&TC), Chetla of All India Institute of Hygiene and Public Health, Kolkata, where the campaign prior to the study was completed in March 2016. Care givers of 90 children of aged 1-15 years were interviewed with a pre-designed, pre-tested, structured schedule. Results Mean age of the surveyed children was 6.34 years (SD 3.76) and 88% of them were vaccinated during the campaign. 56.7% of the caregivers had poor knowledge about JE and 84.95% were sensitized about the campaign by relatives/friends followed by health workers (33.7%). Low socio-economic status and good knowledge of JE had significant association with vaccination of the child after adjusting with other factors (age and sex of the child, education and occupation of parents, type of family). Conclusions Enhancement of knowledge and awareness about JE with appropriate health education programmes and special emphasis on sensitization campaigns for JE vaccination at both mass and individual level would prevent emergence of JE epidemics in future

Determinants of Modern Contraceptive Usage among Married Women: A Mixed-Methods Study in a Rural Community of India

Objective: A woman’s multifaceted feelings, knowledge, and perceptions of their intimate relations greatly influence their contraceptive behavior. In addition, women empowerment has been increasingly recognized as a key factor in family planning and reproductive health outcomes. This study aimed to assess modern contraceptive usage and its determinants among currently married women of reproductive-age (WRA) in rural Bengal. Materials and Methods: This mixed-method study was conducted in a rural area of Hooghly District, West Bengal from April to September 2021. The quantitative strand of the study was conducted by interviewing 210 currently married WRA. The qualitative strand was conducted via focussed group discussions among husbands/mothersin-law and in-depth interviews with healthcare workers. SPSS software was utilized for quantitative data analysis and factors associated with contraceptive usage were analyzed using logistic regression models. Qualitative data were analyzed thematically. Result: Currently 114 (54.8%) study participants were using modern contraceptive methods. Education (aOR=7.65, 95% CI=1.85-31.67), empowerment through freedom from family domination (aOR=5.56, 95% CI=1.30-23.66), attitude on contraception (aOR=4.67, 95% CI=1.26-17.19), and family planning counselling (aOR=4.41, 95% CI=1.12-17.33) were found to be significantly associated with modern contraceptive usage. Lack of couple counselling, family support, and knowledge gap was identified as the major barriers to contraceptive usage. Conclusion: Since a woman’s decision-making ability significantly affects their sexual and reproductive health outcomes, effective measures should be undertaken to empower them by creating awareness regarding their rights and freedom to make strategic life choices. Couple counselling should be prioritized to enhance male involvement and eliminate perceived barriers

Utilisation of adolescent reproductive and sexual health services in a rural area of West Bengal: A mixed-method study

Introduction: Despite policy actions and strategic efforts for improving the reproductive and sexual health of adolescents by promoting the uptake of adolescent reproductive and sexual health (ARSH) services, the utilisation rate remains significantly low, especially in rural areas of India. This study aimed to assess the utilisation of these services by adolescents in rural West Bengal and its associated determinants. Methods: This mixed-method study was conducted from May to September 2021 in the Gosaba rural block of South 24 Parganas, West Bengal. Quantitative data were collected from 326 adolescents using a pre-tested structured questionnaire. Qualitative data were collected via four focus group discussions among 30 adolescents and key-informant interviews among six healthcare workers. Quantitative data were analysed using SPSS, while qualitative data were analysed thematically. Results: Ninety-six (29.4%) adolescents had utilised ARSH services at least once during adolescence. The factors associated with non-utilisation of ARSH services were younger age, female sex, increasing reproductive health stigma and decreasing parent–adolescent communication related to sexual health. Qualitative exploration revealed that unawareness regarding services, perceived lack of privacy and confidentiality at healthcare facilities and disruption of services post-emergence of the COVID-19 pandemic were some major barriers to ARSH service utilisation. Conclusion: A multi-component strategy, including promotion of adolescent-friendly health clinics, community support interventions associated with motivation and counselling of parents regarding the importance of adolescent reproductive health, is needed to improve the utilisation of ARSH services. Necessary steps to correct the deficiencies at the facility level should also be prioritised

Analysis of protein sequence and interaction data for candidate disease gene prediction

Linkage analysis is a successful procedure to associate diseases with specific genomic regions. These regions are often large, containing hundreds of genes, which make experimental methods employed to identify the disease gene arduous and expensive. We present two methods to prioritize candidates for further experimental study: Common Pathway Scanning (CPS) and Common Module Profiling (CMP). CPS is based on the assumption that common phenotypes are associated with dysfunction in proteins that participate in the same complex or pathway. CPS applies network data derived from protein–protein interaction (PPI) and pathway databases to identify relationships between genes. CMP identifies likely candidates using a domain-dependent sequence similarity approach, based on the hypothesis that disruption of genes of similar function will lead to the same phenotype. Both algorithms use two forms of input data: known disease genes or multiple disease loci. When using known disease genes as input, our combined methods have a sensitivity of 0.52 and a specificity of 0.97 and reduce the candidate list by 13-fold. Using multiple loci, our methods successfully identify disease genes for all benchmark diseases with a sensitivity of 0.84 and a specificity of 0.63. Our combined approach prioritizes good candidates and will accelerate the disease gene discovery process

VLPs and particle strategies for cancer vaccines

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Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Diabetic Peripheral Neuropathy and its Association with Diabetes Self-care: A Clinic-based Study in an Urban Health Centre, Kolkata

Introduction: Diabetes mellitus is considered as silent epidemic worldwide including India. Peripheral neuropathy is one of the most common complications of diabetes mellitus. Diabetes Self-Management (DSM) is crucial in mitigating the afflictions of diabetes and it’s after effects. There was dearth of studies in view of Diabetic Peripheral Neuropathy (DPN) and diabetes self-management in Kolkata, West Bengal. Aim: To assess the associations between diabetes selfmanagement and DPN in Type 2 Diabetes Mellitus (T2DM) patients attending an urban health clinic in Kolkata. Materials and Methods: This study was conducted from December 2018 to March 2019 among known case of T2DM patients aged 30 years and above attending the NonCommunicable Disease (NCD) clinic at Chetla, under the purview of field practice areas of Urban Health Unit and Training centre (UHU and TC) of All India Institute of Hygiene and Public Health (AIIH and PH) Kolkata, West Bengal. A pre-designed and pretested schedule was used to collect data which were analysed using International Business Machines Statistical Product and Service Solutions (IBM SPSS) version 16.0 and represented using various tables. Results: The mean (SD) age of the participants was 54.89 (8.98) years. About 32.4% of the patients had DPN which was significantly associated with increased duration of T2DM {AOR (95% CI)}={1.52 (1.22-1.91)}, lower glucose management sub-scale score {AOR (95% CI)}={2.84 (1.42-5.67)} and lower healthcare use sub-scale score {AOR (95% CI)}={1.86 (1.05-3.31)}. Conclusion: Early screening and education regarding diabetes self-care would be helpful in glycaemic control and in prevention of DPN