An Early Bronze Age 'dagger grave' from Rameldry Farm, near Kingskettle, Fife

In February 2000, ploughing disturbed the capstone of a cist, located on the side of a prominent knowe at Rameldry Farm, near Kingskettle in central Fife. Excavation by Headland Archaeology Ltd on behalf of Historic Scotland revealed a short cist which contained the crouched inhumation of a man aged 40-50, who had suffered from arthritis, some tooth loss and possibly Paget's Disease. He had been buried wearing a garment adorned with six V-pelforated buttons. Five of these are of Whitby jet (including one with unique decoration including inlaid tin); the sixth is of the mineral lizardite, and has an enigmatic coating, possibly a glaze. Behind his shoulder was a dagger, of 'Milston type (East Kennet variant) it had had a fancy horn hilt and a scabbard lined with animal skin. The scabbard yielded two A MS radiocarbon dates, with a mean value of 2280-1970 cal Bc at 2

Improved Commuter Rail Workstation Table through Crash Energy Management

Workstation tables in commuter rail trains have been identified as an area for improving passenger safety during train collisions. The goal of this senior project was to create such a table using a composite sandwich structure designed to safely absorb energy. Testing of previous table designs was used to establish engineering specifications for the static loading, work surface durability, and impact performance requirements of the new table. Analytical and finite element models were used to analyze new concepts until a design was achieved that could meet all specifications. The tabletop developed consists of a crushable aluminum honeycomb core with fiberglass laminates on top and bottom. This sandwich structure uses a combination of E‐glass cloth and S‐glass unidirectional tape in a unique layup that lowers impact forces inflicted on the passenger while maintaining overall table strength during normal loading conditions. Four tables were built during the senior project. These tables were fabricated using a combination of fiberglass layup, metal working, welding, and adhesive bonding. Using these tables, four validation tests were conducted to evaluate the performance of the new design: work surface indent testing, vertical and horizontal static loading, quasi-static crush testing, and dynamic impact testing. The results of these tests showed that the new table met all of the engineering specifications outlined at the beginning of the project. The work surface was stronger than expected, showing deformation at a load of 175lbs; well above the requirement of 65lbs or more. The table easily withstood the 225lb vertical and 337lb horizontal static loading requirements at all critical locations. Quasi-static testing showed that a 1500‐2000lb edge load is needed to initiate crushing of the table. Although the desired goal of 800‐1000lb was not achieved, the facesheets did begin buckling in the unbounded sections as designed at about 1000lbs; only 100lbs from the 900lb buckling load predicted by FEA. Unfortunately, the tables continue to support load after initial buckling up to the witnessed 1500‐2000lbs. In dynamic impact testing, the table produced some of the lowest peak acceleration levels of any design to date. The peak acceleration levels recorded were 14g and 20g for the two impacting masses; well below the specification of 30g for any time period over 3ms. The tabletop structure also crushed evenly and the facesheets remained bonded and contained under the aluminum edging. The overall metal structure of the table also held its form, suggesting that the passenger would remain safe during such an impact. The new table costs about $475 and weighs 37lbs

Vinogradov's mean value theorem via efficient congruencing

We obtain estimates for Vinogradov's integral which for the first time approach those conjectured to be the best possible. Several applications of these new bounds are provided. In particular, the conjectured asymptotic formula in Waring's problem holds for sums of s kth powers of natural numbers whenever s is at least 2k^2+2k-3

Circumpolar Diversity and Geographic Differentiation of mtDNA in the Critically Endangered Antarctic Blue Whale (Balaenoptera musculus intermedia)

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work.\ud This is the publisher’s final pdf. The published article is copyrighted by the Public Library of Science and can be found at: http://www.plosone.org/home.action.The Antarctic blue whale (Balaenoptera musculus intermedia) was hunted to near extinction between 1904 and 1972, declining from an estimated initial abundance of more than 250,000 to fewer than 400. Here, we describe mtDNA control region diversity and geographic differentiation in the surviving population of the Antarctic blue whale, using 218 biopsy samples collected under the auspices of the International Whaling Commission (IWC) during research cruises from 1990-2009. Microsatellite genotypes and mtDNA sequences identified 166 individuals among the 218 samples and documented movement of a small number of individuals, including a female that traveled at least 6,650 km or 131 degrees longitude over four years. mtDNA sequences from the 166 individuals were aligned with published sequences from 17 additional individuals, resolving 52 unique haplotypes from a consensus length of 410 bp. From this minimum census, a rarefaction analysis predicted that only 72 haplotypes (95% CL, 64, 86) have survived in the contemporary population of Antarctic blue whales. However, haplotype diversity was relatively high (0.968 +/- 0.004), perhaps as a result of the longevity of blue whales and the relatively recent timing of the bottleneck. Despite the potential for circumpolar dispersal, we found significant differentiation in mtDNA diversity (F-ST = 0.032, p<0.005) and microsatellite alleles (F-ST = 0.005, p<0.05) among the six Antarctic Areas historically used by the IWC for management of blue whales

Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells

Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to address the mechanism of TIMP-3-driven apoptosis in human VSMCs we find that TIMP-3 increased activation of caspase-8 and apoptosis was inhibited by expression of Cytokine response modifier A (CrmA) and dominant negative FAS-Associated protein with Death Domain (FADD). TIMP-3 induced apoptosis did not cause mitochondrial depolarisation, increase activation of caspase-9 and was not inhibited by over-expression of B-cell Lymphoma 2 (Bcl2), indicating a mitochondrial independent/type-I death receptor pathway. TIMP-3 increased levels of the First Apoptosis Signal receptor (FAS) and depletion of FAS with shRNA showed TIMP-3-induced apoptosis was FAS dependent. TIMP-3 induced formation of the Death-Inducing Signalling Complex (DISC), as detected by immunoprecipitation and by immunofluorescence. Cellular-FADD-like IL-1 converting enzyme-Like Inhibitory Protein (c-FLIP) localised with FAS at the cell periphery in the absence of TIMP-3 and this localisation was lost on TIMP-3 expression with c-FLIP adopting a perinuclear localisation. Although TIMP-3 inhibited FAS shedding, this did not increase total surface levels of FAS but instead increased FAS levels within localised regions at the cell surface. A Disintegrin And Metalloproteinase 17 (ADAM17) is inhibited by TIMP-3 and depletion of ADAM17 with shRNA significantly decreased FAS shedding. However ADAM17 depletion did not induce apoptosis or replicate the effects of TIMP-3 by increasing localised clustering of cell surface FAS. ADAM17-depleted cells could activate caspase-3 when expressing levels of TIMP-3 that were otherwise sub-apoptotic, suggesting a partial role for ADAM17 mediated ectodomain shedding in TIMP-3 mediated apoptosis. We conclude that TIMP-3 induced apoptosis in VSMCs is highly dependent on FAS and is associated with changes in FAS and c-FLIP localisation, but is not solely dependent on shedding of the FAS ectodomain

Rational solutions of pairs of diagonal equations, one cubic and one quadratic

We obtain an essentially optimal estimate for the moment of order 32/3 of the exponential sum having argument $\alpha x^3+\beta x^2$. Subject to modest local solubility hypotheses, we thereby establish that pairs of diagonal Diophantine equations, one cubic and one quadratic, possess non-trivial integral solutions whenever the number of variables exceeds 10

Spheres of Earth: An Introduction to Making Observations of Earth Using an Earth System's Science Approach. Student Guide

Scientists from the Image Science and Analysis Laboratory (ISAL) at NASA's Johnson Space Center (JSC) work with astronauts onboard the International Space Station (ISS) who take images of Earth. Astronaut photographs, sometimes referred to as Crew Earth Observations, are taken using hand-held digital cameras onboard the ISS. These digital images allow scientists to study our Earth from the unique perspective of space. Astronauts have taken images of Earth since the 1960s. There is a database of over 900,000 astronaut photographs available at http://eol.jsc.nasa.gov . Images are requested by ISAL scientists at JSC and astronauts in space personally frame and acquire them from the Destiny Laboratory or other windows in the ISS. By having astronauts take images, they can specifically frame them according to a given request and need. For example, they can choose to use different lenses to vary the amount of area (field of view) an image will cover. Images can be taken at different times of the day which allows different lighting conditions to bring out or highlight certain features. The viewing angle at which an image is acquired can also be varied to show the same area from different perspectives. Pointing the camera straight down gives you a nadir shot. Pointing the camera at an angle to get a view across an area would be considered an oblique shot. Being able to change these variables makes astronaut photographs a unique and useful data set. Astronaut photographs are taken from the ISS from altitudes of 300 - 400 km (~185 to 250 miles). One of the current cameras being used, the Nikon D3X digital camera, can take images using a 50, 100, 250, 400 or 800mm lens. These different lenses allow for a wider or narrower field of view. The higher the focal length (800mm for example) the narrower the field of view (less area will be covered). Higher focal lengths also show greater detail of the area on the surface being imaged. Scientists from the Image Science and Analysis Laboratory (ISAL) at NASA s Johnson Space Center (JSC) work with astronauts onboard the International Space Station (ISS) who take images of Earth. Astronaut photographs, sometimes referred to as Crew Earth Observations, are taken using hand-held digital cameras onboard the ISS. These digital images allow scientists to study our Earth from the unique perspective of space. Astronauts have taken images of Earth since the 1960s. There is a database of over 900,000 astronaut photographs available at http://eol.jsc.nasa.gov . Images are requested by ISAL scientists at JSC and astronauts in space personally frame and acquire them from the Destiny Laboratory or other windows in the ISS. By having astronauts take images, they can specifically frame them according to a given request and need. For example, they can choose to use different lenses to vary the amount of area (field of view) an image will cover. Images can be taken at different times of the day which allows different lighting conditions to bring out or highlight certain features. The viewing angle at which an image is acquired can also be varied to show the same area from different perspectives. Pointing the camera straight down gives you a nadir shot. Pointing the camera at an angle to get a view across an area would be considered an oblique shot. Being able to change these variables makes astronaut photographs a unique and useful data set. Astronaut photographs are taken from the ISS from altitudes of 300 - 400 km (approx.185 to 250 miles). One of the current cameras being used, the Nikon D3X digital camera, can take images using a 50, 100, 250, 400 or 800mm lens. These different lenses allow for a wider or narrower field of view. The higher the focal length (800mm for example) the narrower the field of view (less area will be covered). Higher focal lengths also show greater detail of the area on the surface being imaged. There are four major systems or spheres of Earth. They are: Atmosphere, Biosphere, Hydrosphe, and Litho/Geosphere

Near-optimal mean value estimates for multidimensional Weyl sums

We obtain sharp estimates for multidimensional generalisations of Vinogradov's mean value theorem for arbitrary translation-dilation invariant systems, achieving constraints on the number of variables approaching those conjectured to be the best possible. Several applications of our bounds are discussed