Investigating associations between social determinants, self-efficacy measurement of sleep apnea and CPAP adherence: the SEMSA study

Study objectivesThe prospective Self-Efficacy Measure for Sleep Apnea study (SEMSAS) is investigating thresholds for health literacy, self-efficacy and precariousness at obstructive sleep apnea (OSA) diagnosis to predict CPAP adherence. This paper describes the study protocol and presents baseline data from the ongoing study.MethodsEligible individuals had confirmed OSA and were referred to a homecare provider for continuous positive airway pressure (CPAP) therapy initiation. Data on patient characteristics and comorbidities were collected, along with baseline evaluations of self-efficacy [15-item Self-Efficacy Measure for Sleep Apnea tool (SEMSA-15)], precariousness [Deprivation in Primary Care Questionnaire (DipCareQ)], and health literacy (Health Literacy Questionnaire). CPAP adherence over 12 months of follow-up will be determined using remote monitoring of CPAP device data. The primary objective is to define an optimal SEMSA-15 score threshold to predict CPAP adherence at 3- and 12-month follow-up.ResultsEnrollment of 302 participants (71% male, median age 55 years, median body mass index 31.6 kg/m2) is complete. Low self-efficacy (SEMSA-15 score ≤ 2.78) was found in 93/302 participants (31%), and 38 (12.6%) reported precariousness (DipCareQ score > 1); precariousness did not differ significantly between individuals with a SEMSA-15 score ≤ 2.78 versus >2.78. Health literacy was generally good, but was significantly lower in individuals with versus without precariousness, and with low versus high self-efficacy.ConclusionSEMSAS is the first study using multidimensional baseline assessment of self-efficacy, health literacy and precariousness, plus other characteristics, to determine future adherence to CPAP, including CPAP adherence trajectories. Collection of follow-up data is underway

An optimisation framework for improving supply chain performance: case study of a bespoke service provider

A service supply chain can be described as a system of systems with a highly interactive and complex network of suppliers, service providers, OEMs and customers. Supply chain management could create value for bespoke service providers, customers and stakeholders cooperating through the supply chain. Bespoke service provider companies are responsible for managing their asset based on different service contracts and possibly through the end of the asset lifetime. Providing a through-life service requires tailored strategic dimensions to measure the supply chain performance. The performance can be evaluated with regards to several supply chain elements such as demand management, procurement, logistics, etc. This article takes a different angle to the current supply chain performance frameworks by discussing performance through DMAIC cycle. Considering a through-life service, this paper presents a performance optimization framework to improve the supply chain performance in terms of an asset or component availability and cost of service. Moreover, an exhaustive list of KPIs to evaluate the supply chain performance are identified. A case study of fleet management for a bespoke service provider is considered to test the validity of the framework. The DMAIC technique has demonstrated to be an effective method to improve supply chain strategies and performance.Cranfield Universit

Seroprevalence of anti-SARS-CoV-2 IgG at the first epidemic peak in French Guiana, July 2020.

Funder: National Research AgencyFunder: Regional Health Agency of French GuianaFunder: Institut Pasteur Urgence COVID-19 fundraisingBACKGROUND: While Latin America has been heavily affected by the pandemic, only a few seroprevalence studies have been conducted there during the first epidemic wave in the first half of 2020. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was performed between 15 July 2020 and 23 July 2020 among individuals who visited 4 medical laboratories or 5 health centers for routine screening or clinical management, with the exception of symptomatic suggestive cases of covid-19. Samples were screened for the presence of anti-SARS-CoV-2 IgG directed against domain S1 of the SARS-CoV-2 spike protein using the anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from Euroimmun. CONCLUSIONS/SIGNIFICANCE: The overall seroprevalence was 15.4% [9.3%-24.4%] among 480 participants, ranging from 4.0% to 25.5% across the different municipalities. The seroprevalence did not differ according to gender (p = 0.19) or age (p = 0.51). Among SARS-CoV-2 positive individuals, we found that 24.6% [11.5%-45.2%] reported symptoms consistent with COVID-19. Our findings revealed high levels of infection across the territory but a low number of resulting deaths, which can be explained by French Guiana's young population structure

Deciphering the complex role of thrombospondin-1 in glioblastoma development

We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased with glioma grades. Mechanistically, we show that the TGFβ canonical pathway transcriptionally regulates THBS1, through SMAD3 binding to the THBS1 gene promoter. THBS1 silencing inhibits tumour cell invasion and growth, alone and in combination with anti-angiogenic therapy. Specific inhibition of the THBS1/CD47 interaction using an antagonist peptide decreases cell invasion. This is confirmed by CD47 knock-down experiments. RNA sequencing of patient-derived xenograft tissue from laser capture micro-dissected peripheral and central tumour areas demonstrates that THBS1 is one of the gene with the highest connectivity at the tumour borders. All in all, these data show that TGFβ1 induces THBS1 expression via Smad3 which contributes to the invasive behaviour during GBM expansion. Furthermore, tumour cell-bound CD47 is implicated in this process

"Let's Meet and Work it Out": Understanding and Mitigating Encountered-Type of Haptic Devices Failure Modes in VR

International audienceEncountered-type of Haptic devices (ETHD) are robotic interfaces physically overlaying virtual counterparts prior to a user interaction in Virtual Reality. They theoretically reliably provide haptics in Virtual environments, yet they raise several intrinsic design challenges to properly display rich haptic feedback and interactions in VR applications. In this paper, we use a Failure Mode and Effects Analysis (FMEA) approach to identify, organise and analyse the failure modes and their causes in the different stages of an ETHD scenario and highlight appropriate solutions from the literature to mitigate them. We help justify these interfaces' lack of deployment, to ultimately identify guidelines for future ETHD designers

"Let's Meet and Work it Out": Understanding and Mitigating Encountered-Type of Haptic Devices Failure Modes in VR

International audienceEncountered-type of Haptic devices (ETHD) are robotic interfaces physically overlaying virtual counterparts prior to a user interaction in Virtual Reality. They theoretically reliably provide haptics in Virtual environments, yet they raise several intrinsic design challenges to properly display rich haptic feedback and interactions in VR applications. In this paper, we use a Failure Mode and Effects Analysis (FMEA) approach to identify, organise and analyse the failure modes and their causes in the different stages of an ETHD scenario and highlight appropriate solutions from the literature to mitigate them. We help justify these interfaces' lack of deployment, to ultimately identify guidelines for future ETHD designers

"Let's Meet and Work it Out": Understanding and Mitigating Encountered-Type of Haptic Devices Failure Modes in VR

International audienceEncountered-type of Haptic devices (ETHD) are robotic interfaces physically overlaying virtual counterparts prior to a user interaction in Virtual Reality. They theoretically reliably provide haptics in Virtual environments, yet they raise several intrinsic design challenges to properly display rich haptic feedback and interactions in VR applications. In this paper, we use a Failure Mode and Effects Analysis (FMEA) approach to identify, organise and analyse the failure modes and their causes in the different stages of an ETHD scenario and highlight appropriate solutions from the literature to mitigate them. We help justify these interfaces' lack of deployment, to ultimately identify guidelines for future ETHD designers

"Participación ciudadana, desarrollo territorial, juegos serios, experiencias enFrancia"

International audiencelos talleres realizados en Francia, incluidos los habitantes de los campos de investigación en Francia basados en la consulta y la metodología de co-construcción (juegos serios)

Application de la méthode HACCP en abattoir (bilan de deux annéees de mise en œuvre)

Les plans de surveillance et d'épidémiosurveillance montrent que les bactéries pathogènes sont le danger essentiel lors de consommation de viande. En conséquence, les abattoirs doivent produire des carcasses peu contaminées. Ainsi, la méthode HACCP y est désormais obligatoire, dans le but de maîtriser l'hygiène des conditions de production. Bien que la création d'un plan HACCP théorique soit possible, les particularités de production d'un abattoir, rendent difficiles la décision des CCP, des limites critiques et des systèmes de surveillances. De plus les contrôles bactériologiques sont imposés par la loi, alors que les autocontrôles devraient être décidés par l'abattoir dans le cadre du plan HACCP. Enfin, l'enquête révèle que sa mise en application rencontre de nombreux obstacles. Mais pour les abattoirs qui peuvent les surmonter, la méthode HACCP apporte des résultats satisfaisantsTOULOUSE3-BU Santé-Centrale (315552105) / SudocTOULOUSE-EN Vétérinaire (315552301) / SudocSudocFranceF