Primary lymphoepithelial carcinoma of the parotid gland in a North African woman

Lymphoepithelial carcinoma of the salivary glands is a rare neoplasm that is characterized by a non-neoplastic lymphocytic infiltration associated with an epithelial proliferation. It involves mainly the parotid gland. Racial and geographical factors contribute to the pathogenesis of this tumor. We report a case of a 70-year old woman from a non-endemic area who presented with several months history of swelling in the parotid region. Magnetic resonance imaging showed a parotid mass suggestive of a pleomorphic adenoma. The diagnosis of lymphoepithelial carcinoma of the parotid gland was performed on the surgical specimen. A primitive nasopharyngeal carcinoma was ruled out by random biopsies of the nasopharynx mucosa. The Epstein-Barr virus (EBV) was absent in neoplastic cells. We insist that, even in non-endemic areas and when clinical and radiological characteristics are not suggestive of malignancy, intra-operative frozen section analysis should be used in order to ensure the appropriate treatment

O letramento crítico e o ensino de inglês no 1º ano do ensino médio da Escola Estadual Quintela Cavalcanti em Arapiraca/Alagoas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESEm nosso trabalho, debruçar-nos-emos sobre questões de letramento crítico dentro e fora da escola, e como estes letramentos estão sendo abordados por professores de língua inglesa na atualidade. A pesquisa conta com o suporte teórico de pesquisadores que abordam o tema, como Franco e Tezza (2001), Leavis (1969), Carraher (1999), Monte Mór (2002), as OCEM (2006), Paulo Freire entre outros. O trabalho está dividido em dois momentos, no primeiro momento iremos tratar de uma reflexão sobre o letramento crítico no ensino, entendendo, portanto, como o letramento crítico pode contribuir na formação do ser crítico. Em nosso segundo momento, abordaremos o letramento crítico no ensino de inglês no ensino médio, em escola estadual participante do Programa Institucional de Bolsa de Iniciação à Docência/PIBID no interior de Alagoas. Através de leituras iniciais do aporte teórico utilizado neste trabalho, percebemos que em pleno século XXI, em muitas escolas, as aulas de línguas não abordam o letramento crítico, tornando-se então motivo de reflexão, uma vez que o letramento deve ser entendido como um processo de construção do conhecimento crítico que leve o aluno a usar esse conhecimento em suas práticas sociais.São Cristóvão, S

HPV types and variants among cervical cancer tumors in three regions of Tunisia

Cervical cancer is the second most common cancer among Tunisian women, and the incidence rates vary by region. Three Tunisian registries report age-standardized rates of 6.3/10 5 in the central region, 5.4/10 5 in the north, and 2.7/10 5 in the south. High-risk human papillomavirus (HPV) types and their variants differ in carcinogenic potential and geographic distribution. The HPV type and variant distribution could be a factor in the differing rates between regions of Tunisia. Tumor tissue was collected from 142 Tunisian cervical cancer patients. Demographic and reproductive characteristics of the patients were abstracted from cancer registry and hospital records. HPV type and variant analyses were performed using PCR-based Luminex and dot-blot hybridization assays. Eighty-three percent of tumors were infected with at least one HPV type. European variants of HPV16/18 were the most prevalent in tumors from all three regions, with all HPV18 infections and 64% of HPV16 infections being of European lineage. A higher frequency of HPV16 was present in Northern Tunisia (80%) than in Central (68%) or Southern Tunisia (50%) ( P  = 0.02). HPV18/45 was significantly more common in adenocarcinomas (50%) than in squamous cell carcinomas (11%) ( P  = 0.004). Frequent infection with European HPV variants most likely reflects the history of European migration to Tunisia. In addition to the importance of understanding the variants of HPV in Tunisia, behavioral and cultural attitudes towards screening and age-specific infection rates should be investigated to aid the development of future vaccination and HPV screening programs and policies. J. Med. Virol. 83:651–657, 2011. © 2011 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83181/1/22011_ftp.pd

Grenaillage ultrason : expériences et simulations

On étudie le procédé de grenaillage ultrason sous deux aspects : a) un modèle numérique 3D de la dynamique des billes dans l'enceinte de traitement basé sur la théorie des gaz granulaires, b) un dispositif expérimental développé pour mesurer la distribution des vitesses des billes dans l'enceinte et au niveau de la surface traitée. L'intérêt d'une telle étude est de proposer une méthode expérimentale qui donne accès aux trajectoires de billes et de valider le modèle numérique pour optimiser les paramètres de ce procédé, utilisé par exemple en aéronautique

A molecular insight into algal-oomycete warfare : cDNA analysis of Ectocarpus siliculosus infected with the basal oomycete Eurychasma dicksonii

Peer reviewedPublisher PD

Pituitary Adenylate Cyclase Activating Peptide (1-38) and its analog (Acetyl-[Ala15, Ala20] PACAP 38-polyamide) reverse methacholine airway hyperresponsiveness in rats

O objetivo deste estudo foi investigar funcionalmente e estruturalmente efeito broncodilatador do peptídeo ativador da adenilato ciclase pituitária (PACAP1-38) e da acetil-[Ala15, Ala20]PACAP 38-poliamida, potente análogo do PACAP-38, nos ratos desafiados pelo metacolina (MeCh). Ratos Wistar machos foram aleatoriamente divididos em cinco grupos. Grupos 1 e 2, inalando aerossóis de solução salina ou doses crescentes de MeCh (0,5, 1, 2,12, 4,25, 8,5, 17, 34 e 68 mg/L). Os outros grupos recebendo terbutalina (Terb) (250 µg/rato) (10-6M), PACAP-38 (50 µg/rato) (0.1 mM) ou análogo do PACAP-38 (50 µg/rato) associados a MeCh na dose de 4,25 mg/L. A resistência pulmonar total (RL) foi registrada antes e 2 min após a administração de Mech pelo equipamento pneumomultiteste. A administração MeCh induziu aumento significativo e dose dependente (pThe aim of this study was to investigate both functionally and structurally bronchodilator effects of Pituitary adenylate cyclase activating peptide (PACAP38) and acetyl-[Ala15, Ala20] PACAP38-polyamide, a potent PACAP38 analog, in rats challenged by methacholine (MeCh). Male Wistar rats were divided randomly into five groups. Groups 1 and 2 inhaled respectively aerosols of saline or increasing doses of MeCh (0.5, 1, 2.12, 4.25, 8.5, 17, 34 and 68mg/L). The other groups received terbutaline (Terb) (250 µg/rat) (10-6 M), PACAP38 (50 µg/rat) (0.1 mM) or PACAP38 analog (50 µg/rat) associated to MeCh from the dose of 4.25 mg/L. Total lung resistances (RL) were recorded before and 2 min after MeCh administration by pneumomultitest equipment. MeCh administration induced a significant and a dose-dependent increase (

Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial

Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402

Vergleichende histologische und molekularbiologische Untersuchungen eines Hypoxie-bedingten vaskulären Remodelings in der Lunge und der Dura mater von Mäusen (Mus musculus)

Unter hypoxischen Bedingungen entwickeln Mäuse Symptome einer pulmonalen Hypertonie (vaskuläres Remodeling (vR)). Zudem entwickeln sie eine erhöhte Sensitivität gegen den 5-HT2B/2C-Rezeptoragonisten meta-Chlorphenylpiperazin, der bei Migränikern Migräne-Attacken auslösen kann. Primär wurden histologische und molekularbiologische Untersuchungen von Hypoxie-induzierten Blutgefäßveränderungen in der Dura mater durchgeführt; Untersuchungen des vR in der Lunge wurden zu Vergleichszwecken durchgeführt (anatomische Positivkontrolle fürs vR). Die anatomischen und molekularbiologischen Ergebnisse zeigten, dass in der Dura mater kein vR im Sinne einer zunehmenden Muskularisierung stattfindet, das mit jenem in der Lunge vergleichbar wäre. Die Untersuchungen auf Protein-Ebene deuten auf andere Mechanismen für ein vR in der Dura mater hin. Hier kommt es anscheinend eher zu einer leichten Reduktion der Muskulatur, bei eventuell gleichzeitigen Veränderungen im Durchmesser arterieller Gefäßabschnitte