The radio structure of 3C 316, a galaxy with double-peaked narrow optical emission lines

The galaxy 3C\,316 is the brightest in the radio band among the optically-selected candidates exhibiting double-peaked narrow optical emission lines. Observations with the Very Large Array (VLA), Multi-Element Remotely Linked Interferometer Network (e-MERLIN), and the European VLBI Network (EVN) at 5\,GHz have been used to study the radio structure of the source in order to determine the nature of the nuclear components and to determine the presence of radio cores. The e-MERLIN image of 3C 316 reveals a collimated coherent east-west emission structure with a total extent of about 3 kpc. The EVN image shows seven discrete compact knots on an S-shaped line. However, none of these knots could be unambiguously identified as an AGN core. The observations suggest that the majority of the radio structure belongs to a powerful radio AGN, whose physical size and radio spectrum classify it as a compact steep-spectrum source. Given the complex radio structure with radio blobs and knots, the possibility of a kpc-separation dual AGN cannot be excluded if the secondary is either a naked core or radio quiet.Comment: 12 pages, 3 figures, 2 tables. Accepted for publication in the MNRA

Letter from the Consistory of Rijssen to Rev. A. C. Van Raalte

A letter from the consistory in Rijsen to Rev. Albertus C. Van Raalte releasing Van Raalte from his service to the Rijssen congregation. Apparently V.R. assisted this congregation in becoming established while he was serving the Ommen congregation.https://digitalcommons.hope.edu/vrp_1840s/1001/thumbnail.jp

A new period of activity in the core of NGC 660

The core of the nearby galaxy NGC 660 has recently undergone a spectacular radio outburst; using a combination of archival radio and Chandra X-ray data, together with new observations, the nature of this event is investigated. Radio observations made using e-MERLIN in mid-2013 show a new compact and extremely bright continuum source at the centre of the galaxy. High angular resolution observations carried out with the European VLBI Network show an obvious jet-like feature to the north east and evidence of a weak extension to the west, possibly a counter-jet. We also examine high angular resolution Hi spectra of these new sources, and the radio spectral energy distribution using the new wide-band capabilities of e-MERLIN. We compare the properties of the new object with possible explanations, concluding that we are seeing a period of new AGN activity in the core of this polar ring galaxy

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care

Purpose: A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative strategies to improve pharmaceutical care and the contextual factors and mechanisms through which these principles operate. Design/methodology/approach: The evaluation was informed by a realist methodology examining the links between PHM strategies, their outcomes and the contexts and mechanisms by which these strategies operate. Guiding principles were identified by grouping context-specific strategies with specific outcomes. Findings: In total, ten guiding principles were identified: create agreement and commitment based on a long-term vision; foster cooperation and representation at the board level; use layered governance structures; create awareness at all levels; enable interpersonal links at all levels; create learning environments; organize shared responsibility; adjust financial strategies to market contexts; organize mutual gains; and align regional agreements with national policies and regulations. Contextual factors such as shared savings influenced the effectiveness of the guiding principles. Mechanisms by which these guiding principles operate were, for instance, fostering trust and creating a shared sense of the problem. Practical implications: The guidin

Population health management guiding principles to stimulate collaboration and improve pharmaceutical care

Purpose: A range of strategies to improve pharmaceutical care has been implemented by population health management (PHM) initiatives. However, which strategies generate the desired outcomes is largely unknown. The purpose of this paper is to identify guiding principles underlying collaborative strategies to improve pharmaceutical care and the contextual factors and mechanisms through which these principles operate. Design/methodology/approach: The evaluation was informed by a realist methodology examining the links between PHM strategies, their outcomes and the contexts and mechanisms by which these strategies operate. Guiding principles were identified by grouping context-specific strategies with specific outcomes. Findings: In total, ten guiding principles were identified: create agreement and commitment based on a long-term vision; foster cooperation and representation at the board level; use layered governance structures; create awareness at all levels; enable interpersonal links at all levels; create learning environments; organize shared responsibility; adjust financial strategies to market contexts; organize mutual gains; and align regional agreements with national policies and regulations. Contextual factors such as shared savings influenced the effectiveness of the guiding principles. Mechanisms by which these guiding principles operate were, for instance, fostering trust and creating a shared sense of the problem. Practical implications: The guidin

Reorganizing and integrating public health, health care, social care and wider public services:A theory-based framework for collaborative adaptive health networks to achieve the triple aim

Forty-one studies were included. Eight components were identified: social forces, resources, finance, relations, regulations, market, leadership, and accountability. Each component consists of three or more subcomponents, providing insight into (1) the (sub)component-specific strategies that accelerate PHM development, (2) the necessary contextual factors and mechanisms for these strategies to be successful and (3) the extracted theories that underlie the (sub)component-specific SCMO configurations. These theories originate from a wide variety of scientific disciplines. We bring these (sub)components together into what we call the Collabroative Adaptive Health Network (CAHN) framework

Interferon-gamma DNA methylation is affected by mycophenolic acid but not by tacrolimus after T-cell activation

Immunosuppressive drug therapy is required to treat patients with autoimmune disease and patients who have undergone organ transplantation. The main targets of the immunosuppressive drugs tacrolimus and mycophenolic acid (MPA; the active metabolite of mycophenolate mofetil) are T cells. It is currently unknown whether these immunosuppressive drugs have an effect on DNA methylation-an epigenetic regulator of cellular function. Here, we determined the effect of tacrolimus and MPA on DNA methylation of the gene promoter region of interferon gamma (IFNγ), a pro-inflammatory cytokine. Total T cells, naive T cells (CCR7+CD45RO-), and memory T cells (CD45RO+ and CCR7-CD45RO-) were isolated from CMV seropositive healthy controls and stimulated with α-CD3/CD28 in the presence or absence of tacrolimus or MPA. DNA methylation of the IFNγ promoter region was quantified by pyrosequencing at 4 h, days 1, 3, and 4 after stimulation. In parallel, T-cell differentiation, and IFNγ protein production were analyzed by flow cytometry at days 1 and 3 after stimulation. Our results show that MPA induced changes in IFNγ DNA methylation of naive T cells; MPA counteracted the decrease in methylation after stimulation. Tacrolimus did not affect IFNγ DNA methylation of naive T cells. In the memory T cells, both immunosuppressive drugs did not affect IFNγ DNA methylation. Differentiation of naive T cells into a central-memory-like phenotype (CD45RO+) was inhibited by both immunosuppressive drugs, while differentiation of memory T cells remained unaffected by both MPA and tacrolimus. IFNγ protein production was suppressed by tacrolimus. Our results demonstrate that MPA influenced IFNγ DNA methylation of naive T cells after stimulation of T cells, while tacrolimus had no effect. Both tacrolimus and MPA did not affect IFNγ DNA methylation of memory T cells

OH main line masers in the M82 starburst

A study of the distribution of OH gas in the central region of the nearby active starburst galaxy M82 has confirmed two previously known bright masers and revealed several new main line masers. Three of these are seen only at 1665 MHz, one is detected only at 1667 MHz, while the rest are detected in both lines. Observations covering both the 1665 and 1667 MHz lines, conducted with both the Very Large Array (VLA) and the Multi-Element Radio Linked Interferometer Network (MERLIN), have been used to accurately measure the positions and velocities of these features. This has allowed a comparison with catalogued continuum features in the starburst such as HII regions and supernova remnants, as well as known water and satellite line OH masers. Most of the main line masers appear to be associated with known HII regions although the two detected only at 1665 MHz are seen along the same line of sight as known supernova remnants.Comment: MNRAS accepted. 16 pages, 13 figure