Effects of Water Contaminants on the Immune System of the Fathead Minnow

Award for Best Undergraduate Oral Presentation . Abstract Contaminants of emerging concern (CECs), including personal care products, pharmaceuticals, industrial agents and agricultural runoff, have shown adverse effects on aquatic survival species. Numerous CECs have potentially harmful effects, but have not been well studied. One of the most alarming studies was the treatment of an entire lake with a synthetic estrogen, found in birth control pills, which showed a near extinction of the fathead minnow population. My study looks at the potential effects of CECs on the immune system of fathead minnow. This study does not only show the potentially hazardous effects CECs have on aquatic species, but may give an insight on how some of these chemicals may affect us. An extensive literature search was performed, reading articles from areas of immunology, toxicology, comparative biology, ecology and chemistry. This project is an adaptation and expansion of existing ideas, but the tools used for assessment are new creations

A Study of Soil Erosion on a Steep Cultivated Slope in the Mt. Gongga Region near Luding, Sichuan, China, using the 137 Cs Technique

This paper reports the results of an investigation of soil erosion on a steep cultivated slope in the Mt Gongga region of the Upper Yangtze River Basin, Southwest China, using the 137Cs technique. The effective 137Cs reference inventory for the study field, estimated from the bottom layer of a 137Cs depth profile at the deposition zones, is 2373.9 Bq/m2, accounting for 65.8% the local 137Cs reference inventory of 3607.7 Bq/m2. It strongly indicates that a considerable amount of 137Cs input was lost prior to incorporation into the ploughing layer from the study field during the nuclear weapons testing period because of 137Cs surface enrichment. The average erosion rate is estimated to be 4914 t/km2 yr for a typical cultivated steep slope with an angle of 34°at the subtropical zone in the Mt Gongga region. It can reach to 22856 t/km2 yr for a failure slope under cultivation

Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle

This work was funded by UK NERC grants to M.G.R. and A.J.M. an NERC studentship to D.J.P. the University of Georgia and a US NSF grant to A.J.M. and M.G.R.Parenting in the burying beetle Nicrophorus vespilloides is complex and, unusually, the sex and number of parents that can be present is flexible. Such flexibility is expected to involve specialized behaviour by the two sexes under biparental conditions. Here, we show that offspring fare equally well regardless of the sex or number of parents present. Comparing transcriptomes, we find a largely overlapping set of differentially expressed genes in both uniparental and biparental females and in uniparental males including vitellogenin, associated with reproduction, and takeout, influencing sex-specific mating and feeding behaviour. Gene expression in biparental males is similar to that in non-caring states. Thus, being ‘biparental’ in N. vespilloides describes the family social organization rather than the number of directly parenting individuals. There was no specialization; instead, in biparental families, direct male parental care appears to be limited with female behaviour unchanged. This should lead to strong sexual conflict.Publisher PDFPeer reviewe

Transport between edge states in multilayer integer quantum Hall systems: exact treatment of Coulomb interactions and disorder

A set of stacked two-dimensional electron systems in a perpendicular magnetic field exhibits a three-dimensional version of the quantum Hall effect if interlayer tunneling is not too strong. When such a sample is in a quantum Hall plateau, the edge states of each layer combine to form a chiral metal at the sample surface. We study the interplay of interactions and disorder in transport properties of the chiral metal, in the regime of weak interlayer tunneling. Our starting point is a system without interlayer tunneling, in which the only excitations are harmonic collective modes: surface magnetoplasmons. Using bosonization and working perturbatively in the interlayer tunneling amplitude, we express transport properties in terms of the spectrum for these collective modes, treating electron-electron interactions and impurity scattering exactly. We calculte the conductivity as a function of temperature, finding that it increases with increasing temperature as observed in recent experiments. We also calculate the autocorrelation function of mesoscopic conductance fluctuations induced by changes in a magnetic field component perpendicular to the sample surface, and its dependence on temperature. We show that conductance fluctuations are characterised by a dephasing length that varies inversely with temperature.Comment: 13 pages, 10 figures, minor changes made for publicatio

Ce and U speciation in wasteforms for thermal treatment of plutonium bearing wastes, probed by L3 edge XANES

X-ray absorption spectroscopy was applied to understand the speciation of elements relevant to the immobilisation and disposal of radioactive plutonium bearing wastes, utilizing Ce as a Pu surrogate. Ce L3 XANES (X-ray Absorption Near Edge Structure) characterisation of a crystallised glass material produced by cold crucible plasma vitrification, at demonstration scale, evidenced incorporation as Ce3+ within the glass phase, providing an important validation of laboratory scale studies. U and Ce L3 XANES investigation of brannerite ceramics, U0.9Ce0.1Ti2O6, synthesized under oxidizing, neutral and reducing conditions, established the charge compensation mechanism as incorporation of Ce3+ through formation of U5+ and/or U6+ In each of these examples, X-ray Absorption Spectroscopy has provided a pivotal understanding of element speciation in relation to the mechanism of incorporation within the host wasteform intended for geological disposal

Do female association preferences predict the likelihood of reproduction?

Sexual selection acting on male traits through female mate choice is commonly inferred from female association preferences in dichotomous mate choice experiments. However, there are surprisingly few empirical demonstrations that such association preferences predict the likelihood of females reproducing with a particular male. This information is essential to confirm association preferences as good predictors of mate choice. We used green swordtails (<i>Xiphophorus helleri</i>) to test whether association preferences predict the likelihood of a female reproducing with a male. Females were tested for a preference for long- or short-sworded males in a standard dichotomous choice experiment and then allowed free access to either their preferred or non-preferred male. If females subsequently failed to produce fry, they were provided a second unfamiliar male with similar sword length to the first male. Females were more likely to reproduce with preferred than non-preferred males, but for those that reproduced, neither the status (preferred/non-preferred) nor the sword length (long/short) of the male had an effect on brood size or relative investment in growth by the female. There was no overall preference based on sword length in this study, but male sword length did affect likelihood of reproduction, with females more likely to reproduce with long- than short-sworded males (independent of preference for such males in earlier choice tests). These results suggest that female association preferences are good indicators of female mate choice but that ornament characteristics of the male are also important

A multivariate analysis of genetic constraints to life history evolution in a wild population of red deer.

Evolutionary theory predicts that genetic constraints should be widespread, but empirical support for their existence is surprisingly rare. Commonly applied univariate and bivariate approaches to detecting genetic constraints can underestimate their prevalence, with important aspects potentially tractable only within a multivariate framework. However, multivariate genetic analyses of data from natural populations are challenging because of modest sample sizes, incomplete pedigrees, and missing data. Here we present results from a study of a comprehensive set of life history traits (juvenile survival, age at first breeding, annual fecundity, and longevity) for both males and females in a wild, pedigreed, population of red deer (Cervus elaphus). We use factor analytic modeling of the genetic variance-covariance matrix ( G: ) to reduce the dimensionality of the problem and take a multivariate approach to estimating genetic constraints. We consider a range of metrics designed to assess the effect of G: on the deflection of a predicted response to selection away from the direction of fastest adaptation and on the evolvability of the traits. We found limited support for genetic constraint through genetic covariances between traits, both within sex and between sexes. We discuss these results with respect to other recent findings and to the problems of estimating these parameters for natural populations

Impact of the Affordable Care Act on Colorectal Cancer Screening, Incidence, and Survival in Kentucky

Background Kentucky ranks first in the US in cancer incidence and mortality. Compounded by high poverty levels and a high rate of medically uninsured, cancer rates are even worse in Appalachian Kentucky. Being one of the first states to adopt the Affordable Care Act (ACA) Medicaid expansion, insurance coverage markedly increased for Kentucky residents. The purpose of our study was to determine the impact of Medicaid expansion on colorectal cancer (CRC) screening, diagnosis, and survival in Kentucky. Study Design The Kentucky Cabinet for Health and Family Services and the Kentucky Cancer Registry were queried for individuals (≥20 years) undergoing CRC screening (per US Preventative Services Task-Force) or diagnosed with primary invasive CRC from January 1, 2011 to December 31, 2016. CRC screening rates, incidence, and survival were compared before (2011-2013) and after (2014-2016) ACA implementation. Results Colorectal cancer screening was performed in 930,176 individuals, and 11,441 new CRCs were diagnosed from 2011 to 2016. Screening for CRC increased substantially for Medicaid patients after ACA implementation (+230%, p \u3c 0.001), with a higher increase in screening among the Appalachian (+44%) compared with the non-Appalachian (+22%, p \u3c 0.01) population. The incidence of CRC increased after ACA implementation in individuals with Medicaid coverage (+6.7%, p \u3c 0.001). Additionally, the proportion of early stage CRC (stage I/II) increased by 9.3% for Appalachians (p = 0.09), while there was little change for non-Appalachians (−1.5%, p = 0.60). Colorectal cancer survival was improved after ACA implementation (hazard ratio 0.73, p \u3c 0.01), particularly in the Appalachian population with Medicaid coverage. Conclusions Implementation of Medicaid expansion led to a significant increase in CRC screening, CRC diagnoses, and overall survival in CRC patients with Medicaid, with an even more profound impact in the Appalachian population