404 research outputs found
Chromatin meets RNA polymerase II
A report on the Cold Spring Harbor Laboratory meeting 'Mechanisms of eukaryotic transcription', Cold Spring Harbor, USA, 2 August-2 September 2007
A Hard X-ray Study of the Normal Star-Forming Galaxy M83 with NuSTAR
We present results from sensitive, multi-epoch NuSTAR observations of the
late-type star-forming galaxy M83 (d=4.6 Mpc), which is the first investigation
to spatially resolve the hard (E>10 keV) X-ray emission of this galaxy. The
nuclear region and ~ 20 off-nuclear point sources, including a previously
discovered ultraluminous X-ray (ULX) source, are detected in our NuSTAR
observations. The X-ray hardnesses and luminosities of the majority of the
point sources are consistent with hard X-ray sources resolved in the starburst
galaxy NGC 253. We infer that the hard X-ray emission is most likely dominated
by intermediate accretion state black hole binaries and neutron star low-mass
X-ray binaries (Z-sources). We construct the X-ray binary luminosity function
(XLF) in the NuSTAR band for an extragalactic environment for the first time.
The M83 XLF has a steeper XLF than the X-ray binary XLF in NGC 253, consistent
with previous measurements by Chandra at softer X-ray energies. The NuSTAR
integrated galaxy spectrum of M83 drops quickly above 10 keV, which is also
seen in the starburst galaxies NGC253, NGC 3310 and NGC 3256. The NuSTAR
observations constrain any AGN to be either highly obscured or to have an
extremely low luminosity of 10 erg/s (10-30 keV), implying it
is emitting at a very low Eddington ratio. An X-ray point source consistent
with the location of the nuclear star cluster with an X-ray luminosity of a few
times 10 erg/s may be a low-luminosity AGN but is more consistent with
being an X-ray binary.Comment: Accepted for publication in ApJ (25 pages, 17 figures
Blazars in the Fermi Era: The OVRO 40-m Telescope Monitoring Program
The Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope
provides an unprecedented opportunity to study gamma-ray blazars. To capitalize
on this opportunity, beginning in late 2007, about a year before the start of
LAT science operations, we began a large-scale, fast-cadence 15 GHz radio
monitoring program with the 40-m telescope at the Owens Valley Radio
Observatory (OVRO). This program began with the 1158 northern (declination>-20
deg) sources from the Candidate Gamma-ray Blazar Survey (CGRaBS) and now
encompasses over 1500 sources, each observed twice per week with a ~4 mJy
(minimum) and 3% (typical) uncertainty. Here, we describe this monitoring
program and our methods, and present radio light curves from the first two
years (2008 and 2009). As a first application, we combine these data with a
novel measure of light curve variability amplitude, the intrinsic modulation
index, through a likelihood analysis to examine the variability properties of
subpopulations of our sample. We demonstrate that, with high significance
(7-sigma), gamma-ray-loud blazars detected by the LAT during its first 11
months of operation vary with about a factor of two greater amplitude than do
the gamma-ray-quiet blazars in our sample. We also find a significant (3-sigma)
difference between variability amplitude in BL Lacertae objects and
flat-spectrum radio quasars (FSRQs), with the former exhibiting larger
variability amplitudes. Finally, low-redshift (z<1) FSRQs are found to vary
more strongly than high-redshift FSRQs, with 3-sigma significance. These
findings represent an important step toward understanding why some blazars emit
gamma-rays while others, with apparently similar properties, remain silent.Comment: 23 pages, 24 figures. Submitted to ApJ
POEMMA: Probe Of Extreme Multi-Messenger Astrophysics
The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) mission is being
designed to establish charged-particle astronomy with ultra-high energy cosmic
rays (UHECRs) and to observe cosmogenic tau neutrinos (CTNs). The study of
UHECRs and CTNs from space will yield orders-of-magnitude increase in
statistics of observed UHECRs at the highest energies, and the observation of
the cosmogenic flux of neutrinos for a range of UHECR models. These
observations should solve the long-standing puzzle of the origin of the highest
energy particles ever observed, providing a new window onto the most energetic
environments and events in the Universe, while studying particle interactions
well beyond accelerator energies. The discovery of CTNs will help solve the
puzzle of the origin of UHECRs and begin a new field of Astroparticle Physics
with the study of neutrino properties at ultra-high energies.Comment: 8 pages, in the Proceedings of the 35th International Cosmic Ray
Conference, ICRC217, Busan, Kore
Nonspecific Protein-DNA Binding Is Widespread in the Yeast Genome
Recent genome-wide measurements of binding preferences of ~200 transcription
regulators in the vicinity of transcription start sites in yeast, have provided
a unique insight into the cis- regulatory code of a eukaryotic genome (Venters
et al., Mol. Cell 41, 480 (2011)). Here, we show that nonspecific transcription
factor (TF)-DNA binding significantly influences binding preferences of the
majority of transcription regulators in promoter regions of the yeast genome.
We show that promoters of SAGA-dominated and TFIID-dominated genes can be
statistically distinguished based on the landscape of nonspecific protein-DNA
binding free energy. In particular, we predict that promoters of SAGA-dominated
genes possess wider regions of reduced free energy compared to promoters of
TFIID-dominated genes. We also show that specific and nonspecific TF-DNA
binding are functionally linked and cooperatively influence gene expression in
yeast. Our results suggest that nonspecific TF-DNA binding is intrinsically
encoded into the yeast genome, and it may play a more important role in
transcriptional regulation than previously thought
A Focused, Hard X-ray Look at Arp 299 with NuSTAR
We report on simultaneous observations of the local starburst system Arp 299
with NuSTAR and Chandra, which provides the first resolved images of this
galaxy up to energies of ~ 45 keV. Fitting the 3-40 keV spectrum reveals a
column density of ~ 4 x10^{24} cm^{-2}, characteristic of a
Compton-thick AGN, and a 10-30 keV luminosity of 1.2x 10^{43} ergs s^{-1}. The
hard X-rays detected by NuSTAR above 10 keV are centered on the western
nucleus, Arp 299-B, which previous X-ray observations have shown to be the
primary source of neutral Fe-K emission. Other X-ray sources, including Arp
299-A, the eastern nucleus which is also thought to harbor an AGN, as well as
X-ray binaries, contribute to the 10-20 keV emission from the
Arp 299 system. The lack of significant emission above 10 keV other than that
attributed to Arp 299-B suggests that: a) any AGN in Arp 299-A must be heavily
obscured ( > 10^{24} cm^{-2}) or have a much lower luminosity than
Arp 299-B and b) the extranuclear X-ray binaries have spectra that cut-off
above ~10 keV. Such soft spectra are characteristic of ultraluminous X-ray
(ULX) sources observed to date by NuSTAR.Comment: 9 pages; accepted for publication in Astrophysical Journa
Operations of and Future Plans for the Pierre Auger Observatory
Technical reports on operations and features of the Pierre Auger Observatory,
including ongoing and planned enhancements and the status of the future
northern hemisphere portion of the Observatory. Contributions to the 31st
International Cosmic Ray Conference, Lodz, Poland, July 2009.Comment: Contributions to the 31st ICRC, Lodz, Poland, July 200
Bright AGN Source List from the First Three Months of the Fermi Large Area Telescope All-Sky Survey
The first three months of sky-survey operation with the Fermi Gamma Ray Space
Telescope (Fermi) Large Area Telescope (LAT) reveals 132 bright sources at
|b|>10 deg with test statistic greater than 100 (corresponding to about 10
sigma). Two methods, based on the CGRaBS, CRATES and BZCat catalogs, indicate
high-confidence associations of 106 of these sources with known AGNs. This
sample is referred to as the LAT Bright AGN Sample (LBAS). It contains two
radio galaxies, namely Centaurus A and NGC 1275, and 104 blazars consisting of
57 flat spectrum radio quasars (FSRQs), 42 BL Lac objects, and 5 blazars with
uncertain classification. Four new blazars were discovered on the basis of the
LAT detections. Remarkably, the LBAS includes 10 high-energy peaked BL Lacs
(HBLs), sources which were so far hard to detect in the GeV range. Another 10
lower-confidence associations are found. Only thirty three of the sources, plus
two at |b|>10 deg, were previously detected with EGRET, probably due to the
variable nature of these sources. The analysis of the gamma-ray properties of
the LBAS sources reveals that the average GeV spectra of BL Lac objects are
significantly harder than the spectra of FSRQs. No significant correlation
between radio and peak gamma-ray fluxes is observed. Blazar log N - log S and
luminosity functions are constructed to investigate the evolution of the
different blazar classes, with positive evolution indicated for FSRQs but none
for BLLacs. The contribution of LAT-blazars to the total extragalactic
gamma-ray intensity is estimated.Comment: Submitted to ApJ. Not yet refereed. 61 pages, 26 figure
- âŠ