513 research outputs found
Observation of First-Order Metal-Insulator Transition without Structural Phase Transition in VO_2
An abrupt first-order metal-insulator transition (MIT) without structural
phase transition is first observed by current-voltage measurements and
micro-Raman scattering experiments, when a DC electric field is applied to a
Mott insulator VO_2 based two-terminal device. An abrupt current jump is
measured at a critical electric field. The Raman-shift frequency and the
bandwidth of the most predominant Raman-active A_g mode, excited by the
electric field, do not change through the abrupt MIT, while, they, excited by
temperature, pronouncedly soften and damp (structural MIT), respectively. This
structural MIT is found to occur secondarily.Comment: 4 pages, 4 figure
Current oscillations in Vanadium Dioxide: evidence for electrically triggered percolation avalanches
In this work, we experimentally and theoretically explore voltage controlled
oscillations occurring in micro-beams of vanadium dioxide. These oscillations
are a result of the reversible insulator to metal phase transition in vanadium
dioxide. Examining the structure of the observed oscillations in detail, we
propose a modified percolative-avalanche model which allows for
voltage-triggering. This model captures the periodicity and waveshape of the
oscillations as well as several other key features. Importantly, our modeling
shows that while temperature plays a critical role in the vanadium dioxide
phase transition, electrically induced heating cannot act as the primary
instigator of the oscillations in this configuration. This realization leads us
to identify electric field as the most likely candidate for driving the phase
transition
Submillimeter Line Emission from LMC 30Dor: The Impact of a Starburst on a Low Metallicity Environment
(Abridged) The 30 Dor region in the Large Magellanic Cloud (LMC) is the most
vigorous star-forming region in the Local Group. Star formation in this region
is taking place in low-metallicity molecular gas that is exposed to an extreme
far--ultraviolet (FUV) radiation field powered by the massive compact star
cluster R136. We used the NANTEN2 telescope to obtain high-angular resolution
observations of the 12CO 4-3, 7-6, and 13CO 4-3 rotational lines and [CI]
3P1-3P0 and 3P2-3P1 fine-structure submillimeter transitions in 30Dor-10, the
brightest CO and FIR-emitting cloud at the center of the 30Dor region. We
derived the properties of the low-metallicity molecular gas using an
excitation/radiative transfer code and found a self-consistent solution of the
chemistry and thermal balance of the gas in the framework of a clumpy cloud PDR
model. We compared the derived properties with those in the N159W region, which
is exposed to a more moderate far-ultraviolet radiation field compared with
30Dor-10, but has similar metallicity. We also combined our CO detections with
previously observed low-J CO transitions to derive the CO spectral-line energy
distribution in 30Dor-10 and N159W. The separate excitation analysis of the
submm CO lines and the neutral carbon fine structure lines shows that the mid-J
CO and [CI]-emitting gas in the 30Dor-10 region has a temperature of about 160
K and a H2 density of about 10^4 cm^-3. We find that the molecular gas in
30Dor-10 is warmer and has a lower beam filling factor compared to that of
N159W, which might be a result of the effect of a strong FUV radiation field
heating and disrupting the low--metallicity molecular gas. We use a clumpy PDR
model (including the [CII] line intensity reported in the literature) to
constrain the FUV intensity to about chi_0 ~ 3100 and an average total H
density of the clump ensemble of about 10^5 cm^-3 in 30Dor-10.Comment: 11 pages, 8 figures. Accepted for publication in A&
Infrared spectroscopy and nano-imaging of the insulator-to-metal transition in vanadium dioxide
We present a detailed infrared study of the insulator-to-metal transition
(IMT) in vanadium dioxide (VO2) thin films. Conventional infrared spectroscopy
was employed to investigate the IMT in the far-field. Scanning near-field
infrared microscopy directly revealed the percolative IMT with increasing
temperature. We confirmed that the phase transition is also percolative with
cooling across the IMT. We present extensive near-field infrared images of
phase coexistence in the IMT regime in VO2. We find that the coexisting
insulating and metallic regions at a fixed temperature are static on the time
scale of our measurements. A novel approach for analyzing the far-field and
near-field infrared data within the Bruggeman effective medium theory was
employed to extract the optical constants of the incipient metallic puddles at
the onset of the IMT. We found divergent effective carrier mass in the metallic
puddles that demonstrates the importance of electronic correlations to the IMT
in VO2. We employ the extended dipole model for a quantitative analysis of the
observed near-field infrared amplitude contrast and compare the results with
those obtained with the basic dipole model.Comment: 18 pages including 8 figure
Observation of Mott Transition in VO_2 Based Transistors
An abrupt Mott metal-insulator transition (MIT) rather than the continuous
Hubbard MIT near a critical on-site Coulomb energy U/U_c=1 is observed for the
first time in VO_2, a strongly correlated material, by inducing holes of about
0.018% into the conduction band. As a result, a discontinuous jump of the
density of states on the Fermi surface is observed and inhomogeneity inevitably
occurs. The gate effect in fabricated transistors is clear evidence that the
abrupt MIT is induced by the excitation of holes.Comment: 4 pages, 4 figure
TIMASSS: The IRAS16293-2422 Millimeter And Submillimeter Spectral Survey. I. Observations, calibration and analysis of the line kinematics
While unbiased surveys observable from ground-based telescopes have
previously been obtained towards several high mass protostars, very little
exists on low mass protostars. To fill up this gap, we carried out a complete
spectral survey of the bands at 3, 2, 1 and 0.8 mm towards the solar type
protostar IRAS16293-2422. The observations covered about 200\,GHz and were
obtained with the IRAM-30m and JCMT-15m telescopes. Particular attention was
devoted to the inter-calibration of the obtained spectra with previous
observations. All the lines detected with more than 3 sigma and free from
obvious blending effects were fitted with Gaussians to estimate their basic
kinematic properties. More than 4000 lines were detected (with sigma \geq 3)
and identified, yielding a line density of approximatively 20 lines per GHz,
comparable to previous surveys in massive hot cores. The vast majority (~2/3)
of the lines are weak and due to complex organic molecules. The analysis of the
profiles of more than 1000 lines belonging 70 species firmly establishes the
presence of two distinct velocity components, associated with the two objects,
A and B, forming the IRAS16293-2422 binary system. In the source A, the line
widths of several species increase with the upper level energy of the
transition, a behavior compatible with gas infalling towards a ~1 Mo object.
The source B, which does not show this effect, might have a much lower central
mass of ~0.1 Mo. The difference in the rest velocities of both objects is
consistent with the hypothesis that the source B rotates around the source A.
This spectral survey, although obtained with single-dish telescope with a low
spatial resolution, allows to separate the emission from 2 different
components, thanks to the large number of lines detected. The data of the
survey are public and can be retrieved on the web site
http://www-laog.obs.ujf-grenoble.fr/heberges/timasss.Comment: 41 pages (26 pages of online Tables), 7 Tables and 6 Figure
Intra-arterial delivery of triolein emulsion increases vascular permeability in skeletal muscles of rabbits
<p>Abstract</p> <p>Background</p> <p>To test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle.</p> <p>Methods</p> <p>Triolein emulsion was infused into the superficial femoral artery in rabbits (triolein group, n = 12). As a control, saline was infused (saline group, n = 18). Pre- and post-contrast T1-weighted MR images were obtained two hours after infusion. The MR images were qualitatively and quantitatively evaluated by assessing the contrast enhancement of the ipsilateral muscles. Histologic examination was performed in all rabbits.</p> <p>Results</p> <p>The ipsilateral muscles of the rabbits in the triolein group showed contrast enhancement, as opposed to in the ipsilateral muscles of the rabbits in the saline group. The contrast enhancement of the lesions was statistically significant (p < 0.001). Histologic findings showed that most examination areas of the triolein and saline groups had a normal appearance.</p> <p>Conclusion</p> <p>Rabbit thigh muscle revealed significantly increased vascular permeability with triolein emulsion; this was clearly demonstrated on the postcontrast MR images.</p
High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells
<p>Abstract</p> <p>Background</p> <p>Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the development of diabetes was recently reported in patients receiving long-term treatment with clevudine. In this study, we investigated the effects of clevudine on mitochondrial function and insulin release in a rat clonal β-cell line, INS-1E.</p> <p>Methods</p> <p>The mitochondrial DNA (mtDNA) copy number and the mRNA levels were measured by using quantitative PCR. MTT analysis, ATP/lactate measurements, and insulin assay were performed.</p> <p>Results</p> <p>Both INS-1E cells and HepG2 cells, which originated from human hepatoma, showed dose-dependent decreases in mtDNA copy number and cytochrome c oxidase-1 (Cox-1) mRNA level following culture with clevudine (10 μM-1 mM) for 4 weeks. INS-1E cells treated with clevudine had reduced total mitochondrial activities, lower cytosolic ATP contents, enhanced lactate production, and more lipid accumulation. Insulin release in response to glucose application was markedly decreased in clevudine-treated INS-1E cells, which might be a consequence of mitochondrial dysfunction.</p> <p>Conclusions</p> <p>Our data suggest that high-dose treatment with clevudine induces mitochondrial defects associated with mtDNA depletion and impairs glucose-stimulated insulin secretion in insulin-releasing cells. These findings partly explain the development of diabetes in patients receiving clevudine who might have a high susceptibility to mitochondrial toxicity.</p
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