Use of radar data for winterly weather warnings at Deutscher Wetterdienst

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

An atraumatic symphysiolysis with a unilateral injured sacroiliac joint in a patient with Cushing’s disease: a loss of pelvic stability related to ligamentous insufficiency?

Glucocorticoids are well known for altering bone structure and elevating fracture risk. Nevertheless, there are very few reports on pelvic ring fractures, compared to other bones, especially with a predominantly ligamentous insufficiency, resulting in a rotationally unstable pelvic girdle.We report a 39-year-old premenopausal woman suffering from an atraumatic symphysiolysis and disruption of the left sacroiliac joint. She presented with external rotational pelvic instability and immobilization. Prior to the injury, she received high-dose glucocorticoids for a tentative diagnosis of rheumatoid arthritis over two months. This diagnosis was not confirmed. Other causes leading to the unstable pelvic girdle were excluded by several laboratory and radiological examinations. Elevated basal cortisol and adrenocorticotropic hormone levels were measured and subsequent corticotropin-releasing hormone stimulation, dexamethasone suppression test, and petrosal sinus sampling verified the diagnosis of adrenocorticotropic hormonedependent Cushing’s disease. The combination of adrenocorticotropic hormone-dependent Cushing’s disease and the additional application of exogenous glucocorticoids is the most probable cause of a rare atraumatic rotational pelvic instability in a premenopausal patient. To the authors’ knowledge, this case presents the first description of a rotationally unstable pelvic ring fracture involving a predominantly ligamentous insufficiency in the context of combined exogenous and endogenous glucocorticoid elevation

Anti-gravity treadmill rehabilitation improves gait and muscle atrophy in patients with surgically treated ankle and tibial plateau fractures after one year: A randomised clinical trial

To compare the one-year postoperative outcomes of anti-gravity treadmill rehabilitation with those of standard rehabilitation in patients with ankle or tibial plateau fractures

Phylogenetic relationships and biogeographical patterns in Circum-Mediterranean subfamily Leuciscinae (Teleostei, Cyprinidae) inferred from both mitochondrial and nuclear data

<p>Abstract</p> <p>Background</p> <p>Leuciscinae is a subfamily belonging to the Cyprinidae fish family that is widely distributed in Circum-Mediterranean region. Many efforts have been carried out to deciphering the evolutionary history of this group. Thus, different biogeographical scenarios have tried to explain the colonization of Europe and Mediterranean area by cyprinids, such as the "north dispersal" or the "Lago Mare dispersal" models. Most recently, Pleistocene glaciations influenced the distribution of leuciscins, especially in North and Central Europe. Weighing up these biogeographical scenarios, this paper constitutes not only the first attempt at deciphering the mitochondrial and nuclear relationships of Mediterranean leuciscins but also a test of biogeographical hypotheses that could have determined the current distribution of Circum-Mediterranean leuciscins.</p> <p>Results</p> <p>A total of 4439 characters (mitochondrial + nuclear) from 321 individuals of 176 leuciscine species rendered a well-supported phylogeny, showing fourteen main lineages. Analyses of independent mitochondrial and nuclear markers supported the same main lineages, but basal relationships were not concordant. Moreover, some incongruence was found among independent mitochondrial and nuclear phylogenies. The monophyly of some poorly known genera such as <it>Pseudophoxinus </it>and <it>Petroleuciscus </it>was rejected. Representatives of both genera belong to different evolutionary lineages. Timing of cladogenetic events among the main leuciscine lineages was gained using mitochondrial and all genes data set.</p> <p>Conclusions</p> <p>Adaptations to a predatory lifestyle or miniaturization have superimposed the morphology of some species. These species have been separated into different genera, which are not supported by a phylogenetic framework. Such is the case of the genera <it>Pseudophoxinus </it>and <it>Petroleuciscus</it>, which real taxonomy is not well known. The diversification of leuciscine lineages has been determined by intense vicariant events following the paleoclimatological and hydrogeological history of Mediterranean region. We propose different colonization models of Mediterranean region during the early Oligocene. Later vicariance events promoted Leuciscinae diversification during Oligocene and Miocene periods. Our data corroborate the presence of leuciscins in North Africa before the Messinian salinity crisis. Indeed, Messinian period appears as a stage of gradually Leuciscinae diversification. The rise of humidity at the beginning of the Pliocene promoted the colonization and posterior isolation of newly established freshwater populations. Finally, Pleistocene glaciations determined the current European distribution of some leuciscine species.</p

Hydrostatische Laser-Präzisionsschlauchwaage zur hochgenauen Ermittlung von Neigungen und Setzungen

Ein hydrostatisches, hochpräzises Schlauchwaagen-Messinstrument zur kombinierten Bestimmung von Setzungen und Neigungen wurde im Rahmen eines BMWK ZIM-Kooperationsprojektes zur Echtzeitmessung entwickelt. Zunächst wird ein Einblick in das Grundlagenprinzip des hydrostatischen Nivellements gegeben. Darauf aufbauend wird das entwickelte Messprinzip sowie die Systemkonzeption der Hard- und Software vorgestellt. Anhand der Grundlagenversuche wird das technische Know-how, die wissenschaftliche Arbeit der Projektpartner zur Optimierung des Messsystems sowie die Komplexität des Messprinzips dargestellt. Die Funktionalität des Gesamtsystems „HYDRO-LaWa“ sowie die ersten Ergebnisse im Praxiseinsatz werden in drei unterschiedlichen Anwendungsgebieten evaluiert. Das hydrostatische Messinstrument wurde in der dritten Entwicklungsstufe FG-SW-V2 mit hoher Messgenauigkeit und geringer Standardabweichung von 0,1 mm bis 0,2 mm weiterentwickelt. Somit steht in sehr naher Zukunft ein robustes, langzeitstabiles sowie ein in Echtzeit messendes Gesamtsystem für den Markteintritt zur Verfügung

Treatment of invasive fungal infections in clinical practice: a multi-centre survey on customary dosing, treatment indications, efficacy and safety of voriconazole

Invasive fungal infections are frequent and often deadly complications in patients with malignant hematological diseases. Voriconazole is a third generation triazole antifungal with broad activity against most clinically relevant fungal pathogens. Clinical practice often deviates from insights gained from controlled randomized trials. We conducted a multi-centre survey to evaluate efficacy, safety, treatment indications and dosing of voriconazole outside clinical trials. Patients receiving voriconazole were documented via electronic data capturing. An analysis was conducted after submission of 100 episodes from September 2004 to November 2005. Voriconazole was administered for suspected or proven invasive fungal infection (IFI) (57%), as empirical treatment in patients with fever of unknown origin (21%) and secondary (19%) as well as primary (3%) prophylaxis of IFI. Investigators’ assessment of fungal infection often diverted from EORTC/MSG 2002 criteria. A favorable response was reported in 61.4% for suspected or proven IFI and 52.4% for empirical treatment. Mortality was 15%, 26.7% of which was attributable to IFI. Breakthrough fungal infections occurred in four (21.1%) patients with voriconazole as secondary prophylaxis. Toxicity and adverse events comprised elevated liver enzymes and visual disturbances. Although indications frequently deviated from clinical evidence and legal approval, voriconazole showed efficacy and safety, comparable to major controlled clinical trials. Data from this survey demonstrate the difficulty of putting drugs to their approved use in IFI

First Search for Axion-Like Particles in a Storage Ring Using a Polarized Deuteron Beam

Based on the notion that the local dark-matter field of axions or axion-like particles (ALPs) in our Galaxy induces oscillating couplings to the spins of nucleons and nuclei (via the electric dipole moment of the latter and/or the paramagnetic axion-wind effect), we performed the first experiment to search for ALPs using a storage ring. For that purpose, we used an in-plane polarized deuteron beam stored at the Cooler Synchrotron COSY, scanning momenta near 970 MeV/c. This entailed a scan of the spin precession frequency. At resonance between the spin precession frequency of deuterons and the ALP-induced EDM oscillation frequency there will be an accumulation of the polarization component out of the ring plane. Since the axion frequency is unknown, the momentum of the beam and consequently the spin precession frequency were ramped to search for a vertical polarization change that would occur when the resonance is crossed. At COSY, four beam bunches with different polarization directions were used to make sure that no resonance was missed because of the unknown relative phase between the polarization precession and the axion/ALP field. A frequency window of 1.5-kHz width around the spin precession frequency of 121 kHz was scanned. We describe the experimental procedure and a test of the methodology with the help of a radiofrequency Wien filter located on the COSY ring. No ALP resonance was observed. As a consequence an upper limit of the oscillating EDM component of the deuteron as well as its axion coupling constants are provided.Comment: 25 pages, 24 figures, 7 tables, 67 reference