Nonlinear Klein-Gordon-Maxwell systems with Neumann boundary conditions on a Riemannian manifold with boundary

Let (M,g) be a smooth compact, n dimensional Riemannian manifold, n=3,4 with smooth n-1 dimensional boundary. We search the positive solutions of the singularly perturbed Klein Gordon Maxwell Proca system with homogeneous Neumann boundary conditions or for the singularly perturbed Klein Gordon Maxwell system with mixed Dirichlet Neumann homogeneous boundary conditions. We prove that stable critical points of the mean curvature of the boundary generates solutions when the perturbation parameter is sufficiently small.Comment: arXiv admin note: text overlap with arXiv:1410.884

Low Energy Solutions for the Semiclassical Limit of Schrodinger–Maxwell Systems

We show that the number of positive solutions of Schrodinger– Maxwell system on a smooth bounded domain depends on the topological properties of the domain. In particular we consider the Lusternik– Schnirelmann category and the Poincaré polynomial of the domain

Non-radial sign-changing solutions for the Schroedinger-Poisson problem in the semiclassical limit

We study the existence of nonradial sign-changing solutions to the Schroedinger-Poisson system in dimension N>=3. We construct nonradial sign-changing multi-peak solutions whose peaks are displaced in suitable symmetric configurations and collapse to the same point. The proof is based on the Lyapunov-Schmidt reduction

Stable standing waves for a class of nonlinear Schroedinger-Poisson equations

We prove the existence of orbitally stable standing waves with prescribed $L^2$-norm for the following Schr\"odinger-Poisson type equation \label{intro} %{%{ll} i\psi_{t}+ \Delta \psi - (|x|^{-1}*|\psi|^{2}) \psi+|\psi|^{p-2}\psi=0 \text{in} \R^{3}, %-\Delta\phi= |\psi|^{2}& \text{in} \R^{3},%. when $p\in \{8/3\}\cup (3,10/3)$. In the case $3<p<10/3$ we prove the existence and stability only for sufficiently large $L^2$-norm. In case $p=8/3$ our approach recovers the result of Sanchez and Soler \cite{SS} %concerning the existence and stability for sufficiently small charges. The main point is the analysis of the compactness of minimizing sequences for the related constrained minimization problem. In a final section a further application to the Schr\"odinger equation involving the biharmonic operator is given

On the stability of standing waves of Klein-Gordon equations in a semiclassical regime

We investigate the orbital stability and instability of standing waves for two classes of Klein-Gordon equations in the semi-classical regime.Comment: 9 page

The environmental dependence of the structure of outer galactic discs in STAGES spiral galaxies

We present an analysis of V-band radial surface brightness profiles for spiral galaxies from the field and cluster environments using Hubble Space Telescope/Advanced Camera for Surveys imaging and data from the Space Telescope A901/2 Galaxy Evolution Survey (STAGES). We use a large sample of ~330 face-on to intermediately inclined spiral galaxies and assess the effect of the galaxy environment on the azimuthally averaged radial surface brightness mu profiles for each galaxy in the outer stellar disc (24 < mu < 26.5 mag per sq arcsec). For galaxies with a purely exponential outer disc (~50 per cent), we determine the significance of an environmental dependence on the outer disc scalelength h_out. For galaxies with a broken exponential in their outer disc, either down-bending (truncation, ~10 per cent) or up-bending (anti-truncation, ~40 per cent), we measure the strength T (outer-to-inner scalelength ratio, log_10(h_out/h_in) of the mu breaks and determine the significance of an environmental dependence on break strength T. Surprisingly, we find no evidence to suggest any such environmental dependence on either outer disc scalelength h_out or break strength T, implying that the galaxy environment is not affecting the stellar distribution in the outer stellar disc. We also find that for galaxies with small effective radii (r_e < 3 kpc) there is a lack of outer disc truncations in both the field and cluster environments. Our results suggest that the stellar distribution in the outer disc of spiral galaxies is not significantly affected by the galaxy environment.Comment: Accepted to MNRAS. Appendix A available at http://www.nottingham.ac.uk/~ppxdtm/STAGES_profiles_appendix.pd

The MIRI Medium Resolution Spectrometer calibration pipeline

The Mid-Infrared Instrument (MIRI) Medium Resolution Spectrometer (MRS) is the only mid-IR Integral Field Spectrometer on board James Webb Space Telescope. The complexity of the MRS requires a very specialized pipeline, with some specific steps not present in other pipelines of JWST instruments, such as fringe corrections and wavelength offsets, with different algorithms for point source or extended source data. The MRS pipeline has also two different variants: the baseline pipeline, optimized for most foreseen science cases, and the optimal pipeline, where extra steps will be needed for specific science cases. This paper provides a comprehensive description of the MRS Calibration Pipeline from uncalibrated slope images to final scientific products, with brief descriptions of its algorithms, input and output data, and the accessory data and calibration data products necessary to run the pipeline.Comment: 10 pages, 8 figure

Future feed control – Tracing banned bovine material in insect meal

In the present study, we assessed if different legacy and novel molecular analyses approaches can detect and trace prohibited bovine material in insects reared to produce processed animal protein (PAP). Newly hatched black soldier fly (BSF) larvae were fed one of the four diets for seven days; a control feeding medium (Ctl), control feed spiked with bovine hemoglobin powder (BvHb) at 1% (wet weight, w/w) (BvHb 1%, w/w), 5% (BvHb 5%, w/w) and 10% (BvHb 10%, w/w). Another dietary group of BSF larvae, namely *BvHb 10%, was first grown on BvHb 10% (w/w), and after seven days separated from the residual material and placed in another container with control diet for seven additional days. Presence of ruminant material in insect feed and in BSF larvae was assessed in five different laboratories using (i) real time-PCR analysis, (ii) multi-target ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS), (iii) protein-centric immunoaffinity-LC-MS/MS, (iv) peptide-centric immunoaffinity-LC-MS/MS, (v) tandem mass spectral library matching (SLM), and (vi) compound specific amino acid analysis (CSIA). All methods investigated detected ruminant DNA or BvHb in specific insect feed media and in BSF larvae, respectively. However, each method assessed, displayed distinct shortcomings, which precluded detection of prohibited material versus non-prohibited ruminant material in some instances. Taken together, these findings indicate that detection of prohibited material in the insect-PAP feed chain requires a tiered combined use of complementary molecular analysis approaches. We therefore advocate the use of a combined multi-tier molecular analysis suite for the detection, differentiation and tracing of prohibited material in insect-PAP based feed chains and endorse ongoing efforts to extend the currently available battery of PAP detection approaches with MS based techniques and possibly δ13CAA fingerprinting.</p

Insight into genetic susceptibility to male breast cancer by multigene panel testing: Results from a multicenter study in Italy

Breast cancer (BC) in men is rare and genetic predisposition is likely to play a relevant role in its etiology. Inherited mutations in BRCA1/2 account for about 13% of all cases and additional genes that may contribute to the missing heritability need to be investigated. In our study, a well-characterized series of 523 male BC (MBC) patients from the Italian multicenter study on MBC, enriched for non-BRCA1/2 MBC cases, was screened by a multigene custom panel of 50 cancer-associated genes. The main clinical-pathologic characteristics of MBC in pathogenic variant carriers and non-carriers were also compared. BRCA1/2 pathogenic variants were detected in twenty patients, thus, a total of 503 non-BRCA1/2 MBC patients were examined in our study. Twenty-seven of the non-BRCA1/2 MBC patients were carriers of germline pathogenic variants in other genes, including two APC p.Ile1307Lys variant carriers and one MUTYH biallelic variant carrier. PALB2 was the most frequently altered gene (1.2%) and PALB2 pathogenic variants were significantly associated with high risk of MBC. Non-BRCA1/2 pathogenic variant carriers were more likely to have personal (p = 0.0005) and family (p = 0.007) history of cancer. Results of our study support a central role of PALB2 in MBC susceptibility and show a low impact of CHEK2 on MBC predisposition in the Italian population. Overall, our data indicate that a multigene testing approach may benefit from appropriately selected patients with implications for clinical management and counseling of MBC patients and their family members

Novel foods in the European Union: Scientific requirements and challenges of the risk assessment process by the European Food Safety Authority

The European Food Safety Authority (EFSA) has been involved in the risk assessment of novel foods since 2003. The implementation of the current novel food regulation in 2018 rendered EFSA the sole entity of the European Union responsible for such safety evaluations. The risk assessment is based on the data submitted by applicants in line with the scientific requirements described in the respective EFSA guidance document. The present work aims to elaborate on the rationale behind the scientific questions raised during the risk assessment of novel foods, with a focus on complex mixtures and whole foods. Novel foods received by EFSA in 2003–2019 were screened and clustered by nature and complexity. The requests for additional or supplementary information raised by EFSA during all risk assessments were analyzed for identifying reoccurring issues. In brief, it is shown that applications concern mainly novel foods derived from plants, microorganisms, fungi, algae, and animals. A plethora of requests relates to the production process, the compositional characterization of the novel food, and the evaluation of the product's toxicological profile. Recurring issues related to specific novel food categories were noted. The heterogeneous nature and the variable complexity of novel foods emphasize the challenge to tailor aspects of the evaluation approach to the characteristics of each individual product. Importantly, the scientific requirements for novel food applications set by EFSA are interrelated, and only a rigorous and cross-cutting approach adopted by the applicants when preparing the respective application dossiers can lead to scientifically sound dossiers. This is the first time that an in-depth analysis of the experience gained by EFSA in the risk assessment of novel foods and of the reasoning behind the most frequent scientific requests by EFSA to applicants is made