Kuzey levant baseninin hidrodinamiğini ve ekosistemini bütünleşik modelleme çalışması.

A three-dimensional ocean model, ROMS, has been utilized to simulate the hydrodynamics and the ecosystem dynamics of the Northern Levantine Basin circulation. The model is one-way nested inside a coarser resolution Mediterranean Sea eco-hydrodynamics model, forced with realistically updated surface and lateral fluxes of momentum, mass, heat and nutrients. Scenario runs representing present and future time-slices of 5 years each have been used to investigate sensitivity to climate in the near future. Other sensitivity tests depending on model parameters and options have been performed. It is revealed that the Asia Minor Current, dominating the basin circulation, divides the basin into the two basic regions of coastal and open sea characteristics. Although satisfactory results are reached for the general behaviour of the ecosystem, the model tends to overestimate the surface chlorophyll concentration. Sea surface patterns of variables predicted by the model are compared with satellite data indicate general agreement in the seasonal patterns. Based on the selected climate change scenario for 30-40 year difference of the time slices, rises of 0.33◦ C and 0.035 respectively in surface temperature and salinity are estimated in daily average properties. As a result, surface chlorophyll concentrations are increased by 8%. Moreover, significant changes in the periodicity of seasonal phytoplankton blooms are found. Results of the parameter and option sensitivity tests have revealed the need for better representation of surface fluxes and a careful tuning of the mixing achieved by the model, especially at the surface levels. Sensitivity runs also showed that the temperature and salinity at the surface were overestimated because of the need for better representation of the penetration of radiation in the surface waters. The results are promising, whereas there is need for further investigation of basic processes such as the Levantine Intermediate Water (LIW) formation.M.S. - Master of Scienc

The Effects of Thermal Procedure on Transformation Temperature, Crystal Structure and Microstructure of Cu-Al-Co Shape Memory Alloy

The purpose of this study is to investigate the effects of different thermal procedures of the Cu-Al-Co shape memory alloy on its crystal structure, transformation temperature and microstructure. The alloys were subjected to a heat treatment and then cooling was applied at four different conditions. After the thermal process, XRD, DSC, optical microscopy and micro-hardness measurements were carried out. The experimental studies showed that crystal structure, microstructure and transformation temperature of Cu-Al-Co alloy were changed from the cooling conditions

Analysis and Improvement of Tools and Methods Used in GraphQL Query Building Process

Günümüzde yaşanan teknolojik gelişmeler, İnternete bağlanan toplam cihaz tür ve sayısında büyük bir artışa yol açmıştır. Sunucu makineler daha fazla istek almaya başlamış hem ağ trafiği hem de sunucu yanıt süresi olumsuz etkilenmiştir. Bu sorunları çözmek için Facebook tarafından 2015 yılında duyurulan GraphQL teknolojisi tek bir istekle birden fazla tablo, koleksiyon veya veri tabanına erişim sağlayarak toplu veri sorgulama ve değiştirmeye imkân vermektedir. Bu sayede cihaz başına düşen istek sayısı ve cihazların belleklerinde tutulacak veri boyutu azalır. Ancak GraphQL yeni bir teknoloji olduğundan henüz kod geliştirme sürecini yöneten ve kolaylaştıran araçlar tam olarak gelişmemiştir. Sunucu kısmında sorguları oluşturmak ve çalıştırmak için önemli miktardaki kodun elle yazılması gerekmektedir. Bu da yazılım geliştiricilere önemli bir iş yükü oluşturmaktadır. Bu çalışmada GraphQL sorgu geliştirme süreci, bu süreci kolaylaştırmak veya otomatikleştirmek için kullanılan araçlar, bu araçların kullandığı yöntemler ve sorgu geliştirme maliyetleri analiz edilmiştir. Bu maliyeti azaltmak için kodları otomatik oluşturan bir yöntem önerilmiş ve bu yöntemi kullanan bir araç geliştirilmiştir. Geliştirilen yöntemin etkinliği diğer yöntemlerle karşılaştırılmış, sayısal olarak incelenmiş ve yazılımcıları önemli miktardaki kodu tekrar yazmaktan kurtararak zamandan tasarruf sağladığı görülmüştürNowadays, as a result of developing technology, increasing device diversity, and the total number of devices connected to the Internet, servers have started to receive more requests adversely affecting both network traffic and server response time. For eliminating these problems, in 2015, Facebook announced GraphQL technology allowing multiple tables, collections, or databases can be accessed instantly via a single request and a single answer. Therefore, the number of requests per device and the size of the data to be kept in the memory of the devices is reduced significantly. However, it is necessary to write code manually to create and run the GraphQL queries on the server part due to the lack of adequate code management and automation tools. Thus, it creates an additional workload for the developer. In this study, we have analyzed the tools used to automate or facilitate the query development process of GraphQL and compared the cost of query development. A new method and tool for generating GraphQL queries have been developed and its effectiveness has been compared to other methods and evaluated quantitively. The results show that the developers save time by avoiding the burden of writing many lines of code

Data assimilation using adaptive, non-conservative, moving mesh models

Numerical models solved on adaptive moving meshes have become increasingly prevalent in recent years. Motivating problems include the study of fluids in a Lagrangian frame and the presence of highly localized structures such as shock waves or interfaces. In the former case, Lagrangian solvers move the nodes of the mesh with the dynamical flow; in the latter, mesh resolution is increased in the proximity of the localized structure. Mesh adaptation can include remeshing, a procedure that adds or removes mesh nodes according to specific rules reflecting constraints in the numerical solver. In this case, the number of mesh nodes will change during the integration and, as a result, the dimension of the model's state vector will not be conserved. This work presents a novel approach to the formulation of ensemble data assimilation (DA) for models with this underlying computational structure. The challenge lies in the fact that remeshing entails a different state space dimension across members of the ensemble, thus impeding the usual computation of consistent ensemble-based statistics. Our methodology adds one forward and one backward mapping step before and after the ensemble Kalman filter (EnKF) analysis, respectively. This mapping takes all the ensemble members onto a fixed, uniform reference mesh where the EnKF analysis can be performed. We consider a high-resolution (HR) and a low-resolution (LR) fixed uniform reference mesh, whose resolutions are determined by the remeshing tolerances. This way the reference meshes embed the model numerical constraints and are also upper and lower uniform meshes bounding the resolutions of the individual ensemble meshes. Numerical experiments are carried out using 1-D prototypical models: Burgers and Kuramoto–Sivashinsky equations and both Eulerian and Lagrangian synthetic observations. While the HR strategy generally outperforms that of LR, their skill difference can be reduced substantially by an optimal tuning of the data assimilation parameters. The LR case is appealing in high dimensions because of its lower computational burden. Lagrangian observations are shown to be very effective in that fewer of them are able to keep the analysis error at a level comparable to the more numerous observers for the Eulerian case. This study is motivated by the development of suitable EnKF strategies for 2-D models of the sea ice that are numerically solved on a Lagrangian mesh with remeshing

The effectiveness of preemptive thoracic epidural analgesia in thoracic surgery

akdogan, ali/0000-0001-7592-3844; Erturk, Engin/0000-0002-5864-1754WOS: 000333347900001PubMed: 24745020Background. the aim of this study is to investigate the effectiveness of preemptive thoracic epidural analgesia (TEA) comparing conventional postoperative epidural analgesia on thoracotomy. Material and Methods. Forty-four patients were randomized in to two groups (preemptive: Group P, control: Group C). Epidural catheter was inserted in all patients preoperatively. in Group P, epidural analgesic solution was administered as a bolus before the surgical incision and was continued until the end of the surgery. Postoperative patient controlled epidural analgesia infusion pumps were prepared for all patients. Respiratory rates (RR) were recorded. Patient's analgesia was evaluated with visual analog scale at rest (VASr) and coughing (VASc). Number of patient's demands from the pump, pump's delivery, and additional analgesic requirement were also recorded. Results. RR in Group C was higher than in Group P at postoperative 1st and 2nd hours. Both VASr and VASc scores in Group P were lower than in Group C at postoperative 1st, 2nd, and 4th hours. Patient's demand and pump's delivery count for bolus dose in Group P were lower than in Group C in all measurement times. Total analgesic requirements on postoperative 1st and 24th hours in Group P were lower than in Group C. Conclusion. We consider that preemptive TEA may offer better analgesia after thoracotomy

Probabilistic forecasts of sea ice trajectories in the arctic: impact of uncertainties in surface wind and ice cohesion

We study the response of the Lagrangian sea ice model neXtSIM to the uncertainty in sea surface wind and sea ice cohesion. The ice mechanics in neXtSIM are based on a brittle-like rheological framework. The study considers short-term ensemble forecasts of Arctic sea ice from January to April 2008. Ensembles are generated by perturbing the wind inputs and ice cohesion field both separately and jointly. The resulting uncertainty in the probabilistic forecasts is evaluated statistically based on the analysis of Lagrangian sea ice trajectories as sampled by virtual drifters seeded in the model to cover the Arctic Ocean and using metrics borrowed from the search-and-rescue literature. The comparison among the different ensembles indicates that wind perturbations dominate the forecast uncertainty (i.e., the absolute spread of the ensemble), while the inhomogeneities in the ice cohesion field significantly increase the degree of anisotropy in the spread—i.e., trajectories drift divergently in different directions. We suggest that in order to obtain enough uncertainties in a sea ice model with brittle-like rheologies, to predict sea ice drift and trajectories, one should consider using ensemble-based simulations where at least wind forcing and sea ice cohesion are perturbed

Quercus pyrenaica honeydew honey with high phenolic contents cause dna damage, apoptosis, and cell death through generation of reactive oxygen species in gastric adenocarcinoma cells

Many studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics

The acorn honey used for a published study was mistakenly listed as quercus pyrenaica and should be corrected to quercus species

A critical review letter1 was published concerning the article “Quercus pyrenaica honeydew honey effects on gastric adenocarcinoma cells” published in Integrative Cancer Therapies in 2019.2 According to the letter, the authors reported that the Quercus pyrenaica mentioned in the study was neither found in Mount Ida nor within the borders of Turkey as stated in the study, therefore the results obtained in the study may belong to another Quercus species

Does Ozone Administration Have a Protective Effect Against Cisplatininduced Histological Changes in Rat Testis?

Objective:We investigated the protective and therapeutic effects of ozone therapy (OT) on cisplatin (CP)-induced testicular damage.Materials and Methods:Thirty healthy adult male Wistar rats were divided into five groups consisting of 6 animals each: 1) control, 2) CP, 3) OT, 4) OT + CP and 5) CP + OT groups. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and GSH peroxidase (GPx) levels were evaluated.Results:CP caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase and GPx levels were significantly lower in the CP group when compared to the control group. Pre- and post-CP OT significantly increased GSH, SOD, catalase and GPx levels and decreased TBARS level. Also, testicular weight and Johnsen score were increased with OT.Conclusion:The present study showed that OT is protective against CP-induced testicular damage. OT may be beneficial to patients who underwent CP chemotherapy