Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

The Mid-Cenomanian Event in shallow marine environments: Influence on carbonate producers and depositional sequences (northern Aquitaine Basin, France)

International audienceThe Mid-Cenomanian Event was a positive carbon-isotope (δ13C) excursion recorded in hemipelagic basins of the western Tethyan Sea, North to Tropical Atlantic Ocean, and Japan. It is thought of as a prelude to the Oceanic Anoxic Event 2. However, the Mid-Cenomanian Event has never been studied in detail in shallow marine platform deposits and it is not known how it relates to carbonate production and stratigraphic geometry. To better understand how this carbon cycle disruption influenced the neritic biological communities in shallow carbonates during the Cenomanian, a facies, geochemical, diagenetic, and sequence stratigraphic study of the northern Aquitaine platform has been conducted. Seventy-six δ13C and δ18O measurements have been made on micrite, rudists, and diagenetic cements. Fifteen sedimentary facies have been arranged into four depositional environments. Three third-order sequences (CB, CC, CD) are defined from late early Cenomanian to early late Cenomanian and are well correlated with eustatic cycles in European basins. Two peaks of the Mid-Cenomanian Event (MCE1a, +1.2‰, and MCE1b, +1.7‰) have been identified for the first time in shallow marine carbonates. Analysis of diagenetic blocky calcite cements suggests that diagenesis did not affect the δ13C of micrite, which can be discussed in terms of the initial signal. The Mid-Cenomanian Event was synchronous with a turnover in neritic carbonate producers marking a transition from photozoan to heterozoan facies. This facies change resulted from the establishment of mesotrophic to eutrophic conditions at the early/mid-Cenomanian transition, reflecting a clear connection between the Mid-Cenomanian Event and neritic biological communities. Depositional geometry and carbonate production varied with δ13C during the Mid-Cenomanian Event on the Aquitaine platform. When δ13C values were between 2.5‰ and 3‰, the geometry was a flat platform with a high carbonate sedimentation rate leading to the formation of sandbars and rudist bioherms (Accommodation/Sedimentation ratio less than 1, A/S > 1). The general carbonate demise affecting the northern Aquitaine platform during the mid-Cenomanian can be explained by both a eustatic sea-level rise and the establishment of eutrophic conditions. The coincidence of the Mid-Cenomanian Event with both (1) the occurrence of mesotrophic to eutrophic conditions marked by carbonate producer turnover from photozoan to heterozoan facies and (2) the transgressive cycles, suggests that eustatic sea-level rise leading to high trophic conditions could explain this positive δ13C excursion in the Atlantic and western Tethyan domain. During the mid-Cenomanian, carbon cycle perturbations largely controlled the neritic biological communities on shallow carbonate platforms in a part of the western Tethyan domain

Impacts of changes in groundwater recharge on the isotopic composition and geochemistry of seasonally ice-covered lakes: insights for sustainable management

International audienceLakes are under increasing pressure due to widespread anthropogenic impacts related to rapid development and population growth. Accordingly, many lakes are currently undergoing a systematic decline in water quality. Recent studies have highlighted that global warming and the subsequent changes in water use may further exacerbate eutrophication in lakes. Lake evolution depends strongly on hydrologic balance, and therefore on groundwater connectivity. Groundwater also influences the sensitivity of lacustrine ecosystems to climate and environmental changes, and governs their resilience. Improved characterization of groundwater exchange with lakes is needed today for lake preservation, lake restoration, and sustainable management of lake water quality into the future. In this context, the aim of the present paper is to determine if the future evolution of the climate, the population, and the recharge could modify the geochemistry of lakes (mainly isotopic signature and quality via phosphorous load) and if the isotopic monitoring of lakes could be an efficient tool to highlight the variability of the water budget and quality. 'Small groundwater-connected lakes were chosen to simulate changes in water balance and water quality expected under future climate change scenarios, namely representative concentration pathways (RCPs) 4.5 and 8.5. Contemporary baseline conditions, including isotope mass balance and geochemical characteristics, were determined through an intensive field-based research program prior to the simulations. Results highlight that future lake geochemistry and isotopic composition trends will depend on four main parameters: lo-cation (and therefore climate conditions), lake catchment size (which impacts the intensity of the flux change), lake volume (which impacts the range of variation), and lake G index (i.e., the percentage of groundwater that makes up total lake inflows), the latter being the dominant control on water balance conditions, as revealed by the sensitivity of lake isotopic composition. Based on these model simulations, stable isotopes appear to be especially useful for detecting changes in recharge to lakes with a G index of between 50 and 80 %, but response is non-linear. Simulated monthly trends reveal that evolution of annual lake isotopic composition can be dampened by opposing monthly recharge fluctuations. It is also shown that changes in water quality in groundwater-connected lakes depend significantly on lake location and on the intensity of recharge change

Interactions between groundwater and seasonally ice-covered lakes: using water stable isotopes and radon-222 multi-layer mass balance models

International audienc

New insights into the ultrapotassic magmatism through xenoliths from the Eğirdir area, West Anatolia, Turkey

International audiencePlutonic xenoliths have been found within a pipe and a related phreatomagmatic leucitite deposit in the Eğirdir lake area, belonging to the Potassic-Ultrapotassic Afyon volcanic Province, West Anatolia. They consist of kamafugite-type, feldsparbearing syenite, pyroxenite, leucitolite, some small-sized melilitolite and garnet-rich xenoliths, and a carbonatite. A new occurrence of kalsilite is described as either homogeneous acicular crystals or tabular two phases-exsolved crystals in the kamafugite-type and melilitolite xenoliths. Rock textures and compositions indicate cumulates and near-liquid composition rocks corresponding to relatively evolved magmas. All the rocks are strongly silica-undersaturated, Ca-, Mg-, and K-rich, and Al-poor. The fractional crystallization model includes clinopyroxene, apatite, phlogopite, melilite and leucite. Fe-Ti oxides and garnet may be also concerned. The P H2O during crystallization and differentiation is not more than 0.8 GPa. Major elements, trace elements, and REE patterns for xenoliths, which indicate near-liquid compositions, are typical of ultrapotassic series in a post-collisional geodynamic context, as it is the case for the Roman and Central ultrapotassic Italian provinces. The stable isotope 13 C and 18 O values of the calcio-carbonatite plot close to the primary carbonatite field, whereas the carbonates of the feldspar-bearing syenite and the peperite matrix suggest a low-T extensive contamination process. The origin of the carbonatite from kamafugite-type magmas by immiscibility or by fractional crystallization remains questionable; an origin by fractionation-melting of a metasomatized mantle source should be tested in the future

Sedimentary architecture, depositional facies and diagenetic response to intracratonic deformation and climate change inferred from outcrops for a pivotal period (Jurassic/Cretaceous boundary, Paris Basin, France)

International audienceThe aim of this study is to decipher the respective influences of geodynamic and climate disturbances at the Jurassic/Cretaceous boundary on sedimentary facies and carbonate diagenesis in a stable intracratonic basin using isotopic geochemistry and subsidence quantification. Fourteen lithofacies were deposited in a (1) carbonate platform and (2) a delta plain environment. Climate change from cool and wet to warm and semi-arid conditions during the early Tithonian influenced the syn-sedimentary dolomitization process within the carbonate platform during the mid-Tithonian. Architecture and facies reconstructions well-constrained the Jurassic-Cretaceous Unconformity (JCU), which was an important local structural episode marked by (1) an 80 m uplift in the eastern Paris Basin and by (2) the formation of a NW–SE low wavelength 15 km-wide and 30 km-long flexure. This first tectonic event tended to maintain brine ponds and supratidal marsh environments in the platform during the late Tithonian and early Berriasian, forming Purbeckian facies and associated dolomitic facies. A major depositional change occurred between the early and late Berriasian from shallow carbonate platform environments to fluviatile-deltaic clastic deposits (Wealden facies). This facies change is underlain by a major unconformity corresponding to the Ryazanian unconformity. It is marked (1) by erosion processes, karstification of the carbonate substrate, and the development of ferruginous weathering products (goethite), followed by (2) incision processes in a fluvial-deltaic environment. This unconformity is consecutive to a 40 m uplift in the eastern Paris Basin. The rifting phase in the Bay of Biscay, in the Pyrenean Zone, and in the Artic-North Atlantic together with the opening of the Ligurian Sea had a major influence on the northern part of France by causing uplifts (120 m from the Tithonian) and flexuring. Geodynamics played a major role in carbonate demise in the Paris Basin leading to exposure and karstification of the carbonate platform. Added to the generalized uplift, western Tethyan cool and humid conditions from the late Berriasian caused terrigenous influx into large-scale marine domains which was detrimental and unfavorable to carbonate growth

Influence of vegetation‐induced water table seasonality on groundwater chloride concentration dynamics in a riparian fen peatland

International audiencePeatlands are environments that rely mainly on high water levels to accumulate organic matter. Depending on the chemical species observed, the lowering of the water table can change biogeochemical equilibriums, with various impacts. This paper aims to understand the effect of shallow groundwater seasonality on chloride concentrations in a French riparian peatland by combining water table monitoring, geochemical and stable water isotopes analysis. Water table levels and groundwater samples were recorded and collected for 3 years, every 2 months, in nine observation wells and the nearby river. Chloride concentrations were highly variable in space and time, ranging from 10 to 100 mg L À1. They are shown to be related to the wate

Influence of the balance of the intertropical front on seasonal variations of the isotopic composition in rainfall at Kisiba Masoko (Rungwe Volcanic Province, SW, Tanzania)

International audienceTropical rainfall isotopic composition results from complex processes. The climatological and environmental variability in East Africa increases this complexity. Long rainfall isotope datasets are needed to fill the lack of observations in this region. At Kisiba Masoko, Tanzania, rainfall and rain isotopic composition have been monitored during 6 years. Mean year profiles allow to analyse the seasonal variations. The mean annual rainfall is 2099mm with a rain-weighted mean composition of -3.2 parts per thousand for delta O-18 and -11.7 parts per thousand for delta H-2. The results are consistent with available data although they present their own specificity. Thus, if the local meteoric water line is delta H-2=8.6 delta O-18+14.8, two seasonal lines are observed. The seasonality of the isotopic composition in rain and deuterium excess has been compared with precipitating air masses backtracking trajectories to characterize a simple scheme of vapour histories. The three major oceanic sources have two moisture signatures with their own trajectory histories: one originated from the tropical Indian Ocean at the beginning of the rainy season and one from the Austral Ocean at its end. The presented isotopic seasonality depends on the balance of the intertropical front and provides a useful dataset to improve the knowledge about local processes

Tectonic Record of Deformation in Intraplate Domains: Case Study of Far-Field Deformation in the Grands Causses Area, France

International audienceAlthough tectonic plates are usually considered as rigid blocks, intraplate deformation such as lithospheric buckling or diffuse brittle deformation has been recognized for a long time. However, the origin of these deformations remains puzzling. Indeed, whereas the chronology of deformation at plate boundaries can be constrained by numerous methods (syntectonic sedimentary record, thermochronology, etc.), dating of brittle structures (faults, veins, and joints) in the far-field domains remains challenging, preventing a global interpretation of the system as a whole. In this contribution, we have combined a tectonic study with a synkinematical geochronological study of fault-related calcites of the Grands Causses intraplate domain, north of the Pyrenean orogeny. We show that these faults record a much longer history of deformation than previously thought. The Mesozoic extension, usually attributed to an early Jurassic Tethysian rifting event, probably lasted until the Barremian-Aptian epoch, in response to the Pyrenean basin's opening. The so-called "Pyrenean deformation" of the Grands Causses domain, usually associated with the paroxysm of deformation in the belt during the late Eocene, began much earlier, around 100 Ma, and lasted for more than 60-70 Ma. This study demonstrates the high sensitivity of an intraplate domain (Grands Causses area) to record extensional or compressional deformations occurring at the edge of neighbouring plates