Tratado de Patología esterna [sic] y de medicina operatoria : con resúmenes de anatomía de los tejidos y de las regiones

Copia digital : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

The Prometastatic Microenvironment of the Liver

The liver is a major metastasis-susceptible site and majority of patients with hepatic metastasis die from the disease in the absence of efficient treatments. The intrahepatic circulation and microvascular arrest of cancer cells trigger a local inflammatory reaction leading to cancer cell apoptosis and cytotoxicity via oxidative stress mediators (mainly nitric oxide and hydrogen peroxide) and hepatic natural killer cells. However, certain cancer cells that resist or even deactivate these anti-tumoral defense mechanisms still can adhere to endothelial cells of the hepatic microvasculature through proinflammatory cytokine-mediated mechanisms. During their temporary residence, some of these cancer cells ignore growth-inhibitory factors while respond to proliferation-stimulating factors released from tumor-activated hepatocytes and sinusoidal cells. This leads to avascular micrometastasis generation in periportal areas of hepatic lobules. Hepatocytes and myofibroblasts derived from portal tracts and activated hepatic stellate cells are next recruited into some of these avascular micrometastases. These create a private microenvironment that supports their development through the specific release of both proangiogenic factors and cancer cell invasion- and proliferation-stimulating factors. Moreover, both soluble factors from tumor-activated hepatocytes and myofibroblasts also contribute to the regulation of metastatic cancer cell genes. Therefore, the liver offers a prometastatic microenvironment to circulating cancer cells that supports metastasis development. The ability to resist anti-tumor hepatic defense and to take advantage of hepatic cell-derived factors are key phenotypic properties of liver-metastasizing cancer cells. Knowledge on hepatic metastasis regulation by microenvironment opens multiple opportunities for metastasis inhibition at both subclinical and advanced stages. In addition, together with metastasis-related gene profiles revealing the existence of liver metastasis potential in primary tumors, new biomarkers on the prometastatic microenvironment of the liver may be helpful for the individual assessment of hepatic metastasis risk in cancer patients

Resilience of benthic deep-sea fauna to mining activities

With increasing demand for mineral resources, extraction of polymetallic sulphides at hydrothermal vents, cobalt-rich ferromanganese crusts at seamounts, and polymetallic nodules on abyssal plains may be imminent. Here, we shortly introduce ecosystem characteristics of mining areas, report on recent mining developments, and identify potential stress and disturbances created by mining. We analyze species' potential resistance to future mining and perform meta-analyses on population density and diversity recovery after disturbances most similar to mining: volcanic eruptions at vents, fisheries on seamounts, and experiments that mimic nodule mining on abyssal plains. We report wide variation in recovery rates among taxa, size, and mobility of fauna. While densities and diversities of some taxa can recover to or even exceed pre-disturbance levels, community composition remains affected after decades. The loss of hard substrata or alteration of substrata composition may cause substantial community shifts that persist over geological timescales at mined sites. (C) 2017 Elsevier Ltd. All rights reserved.European Union Seventh Framework Programme (FP7) under the MIDAS project; FCT [IF/00029/2014/CP1230/CT0002, SFRH/ BPD/110278/2015]; Spanish RTD project NUREIEV [CTM2013-44598-R]; Ministry of Economy and Competitiveness [SGR 1068]; Generalitat de Catalunya autonomous government; European Union Horizon research and innovation programme [689518]; Fundacao para a Ciencia e a Tecnologia [UID/MAR/04292/2013]; German Ministry of Research (BMBF) [03F0707A-G]; Program Investigador FCT [IF/01194/2013/CP1199/CT0002]info:eu-repo/semantics/publishedVersio

I. Vieux noms de personnes, vieux noms de lieux de l'Albigeois (Suite et fin.)

Vidal Auguste. I. Vieux noms de personnes, vieux noms de lieux de l'Albigeois (Suite et fin.). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 34, N°135-136, 1922. pp. 401-415

Les comptes consulaires de Montagnac (Hérault). (Suite.)

Vidal Auguste. Les comptes consulaires de Montagnac (Hérault). (Suite.). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 18, N°69, 1906. pp. 69-80

La conversion des monnaies de l'Ancien Régime en monnaies du XIXe siècle

Vidal Auguste. La conversion des monnaies de l'Ancien Régime en monnaies du XIXe siècle. In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 43, N°170, 1931. pp. 160-179

Le prieuré de Bonnevaux, ses fiefs, la noblesse de la région (XIIe-XVIIIe siècles)

Vidal Auguste. Le prieuré de Bonnevaux, ses fiefs, la noblesse de la région (XIIe-XVIIIe siècles). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 41, N°163-164, 1929. pp. 113-167

II. Glanures lexicographiques d'après le registre des lausimes du chapitre de Saint-Salvi (Albi)

Vidal Auguste. II. Glanures lexicographiques d'après le registre des lausimes du chapitre de Saint-Salvi (Albi). In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 15, N°60, 1903. pp. 498-512

I. Vieux noms de personnes, vieux noms de lieux de l'Albigeois

Vidal Auguste. I. Vieux noms de personnes, vieux noms de lieux de l'Albigeois. In: Annales du Midi : revue archéologique, historique et philologique de la France méridionale, Tome 34, N°133-134, 1922. pp. 273-291