261 research outputs found
Differential effect of denervation on free radical scavenging enzymes in slow and fast muscle of rat
To determine the effect of denervation on the free radical scavenging systems in relation to the mitochondrial oxidative metabolism in the slow twitch soleus and fast twitch extensor digitorum longus (EDL) muscles, the sciatic nerve of the rat was crushed in the mid-thigh region and the muscle tissue levels of 5 enzymes were studied 2 and 5 weeks following crush. Radioimmunoassays were utilized for the selective measurement of cuprozinc (cytosolic) and mangano (mitochondrial) superoxide dismutases. These data represent the first systematic report of free radical scavening systems in slow and fast muscles in response to denervation. Selective modification of cuprozinc and manganosuperoxide dismutases and differential regulation of GSH-peroxidase was demonstrated in slow and fast muscle
Evidence for the formation of magnetic moments in the cuprate superconductor HgCuBaCaCuO below seen by NQR
We report pure zero field nuclear magnetic resonance (NQR) measurements on
the optimally doped three layer high--compounds HgBaCaCuO and
HgBaCaCuO(F) with 134 K. Above two Cu NQR line pairs are
observed in the spectra corresponding to the two inequivalent Cu lattice sites.
Below the Cu NQR spectra show additional lines leading to the extreme
broadened Cu NQR spectra at 4.2 K well known for the HgBaCaCuO compounds. The
spin-lattice relaxation curves follow a triple exponential function with
coefficients depend onto the saturation time (number of saturation pulses),
whereas the spin-spin relaxation curve is described by a single exponential
function. From the spin-lattice relaxation we deduced a complete removal of the
Kramers degeneracy of the Cu quadrupole indicating that the additional lines
are due to a Zeemann splitting of the Cu lines due to the spontaneous
formation of magnetic moments within the CuO layers. Below 140 K, the spectra
are well fitted by a number of 6 Cu line pairs. From the number of
the Cu lines, the position of the lines relative to each other and the complete
removal of the Kramers degeneracy we deduced an orientation of the magnetic
moments parallel to the symmetry axis of the electric field gradient tensor
with magnitudes of the order of 1000 G. We also discuss the possible
microscopic origin of the observed internal magnetic fields.Comment: 11 pages, 12 figure
Observing the Sun with Atacama Large Millimeter/submillimeter Array (ALMA): High Resolution Interferometric Imaging
Observations of the Sun at millimeter and submillimeter wavelengths offer a
unique probe into the structure, dynamics, and heating of the chromosphere; the
structure of sunspots; the formation and eruption of prominences and filaments;
and energetic phenomena such as jets and flares. High-resolution observations
of the Sun at millimeter and submillimeter wavelengths are challenging due to
the intense, extended, low- contrast, and dynamic nature of emission from the
quiet Sun, and the extremely intense and variable nature of emissions
associated with energetic phenomena. The Atacama Large Millimeter/submillimeter
Array (ALMA) was designed with solar observations in mind. The requirements for
solar observations are significantly different from observations of sidereal
sources and special measures are necessary to successfully carry out this type
of observations. We describe the commissioning efforts that enable the use of
two frequency bands, the 3 mm band (Band 3) and the 1.25 mm band (Band 6), for
continuum interferometric-imaging observations of the Sun with ALMA. Examples
of high-resolution synthesized images obtained using the newly commissioned
modes during the solar commissioning campaign held in December 2015 are
presented. Although only 30 of the eventual 66 ALMA antennas were used for the
campaign, the solar images synthesized from the ALMA commissioning data reveal
new features of the solar atmosphere that demonstrate the potential power of
ALMA solar observations. The ongoing expansion of ALMA and solar-commissioning
efforts will continue to enable new and unique solar observing capabilities.Comment: 22 pages, 12 figures, accepted for publication in Solar Physic
Observing the Sun with the Atacama Large Millimeter-submillimeter Array (ALMA): Fast-Scan Single-Dish Mapping
The Atacama Large Millimeter-submillimeter Array (ALMA) radio telescope has
commenced science observations of the Sun starting in late 2016. Since the Sun
is much larger than the field of view of individual ALMA dishes, the ALMA
interferometer is unable to measure the background level of solar emission when
observing the solar disk. The absolute temperature scale is a critical
measurement for much of ALMA solar science, including the understanding of
energy transfer through the solar atmosphere, the properties of prominences,
and the study of shock heating in the chromosphere. In order to provide an
absolute temperature scale, ALMA solar observing will take advantage of the
remarkable fast-scanning capabilities of the ALMA 12m dishes to make
single-dish maps of the full Sun. This article reports on the results of an
extensive commissioning effort to optimize the mapping procedure, and it
describes the nature of the resulting data. Amplitude calibration is discussed
in detail: a path that utilizes the two loads in the ALMA calibration system as
well as sky measurements is described and applied to commissioning data.
Inspection of a large number of single-dish datasets shows significant
variation in the resulting temperatures, and based on the temperature
distributions we derive quiet-Sun values at disk center of 7300 K at lambda=3
mm and 5900 K at lambda=1.3 mm. These values have statistical uncertainties of
order 100 K, but systematic uncertainties in the temperature scale that may be
significantly larger. Example images are presented from two periods with very
different levels of solar activity. At a resolution of order 25 arcsec, the 1.3
mm wavelength images show temperatures on the disk that vary over about a 2000
K range.Comment: Solar Physics, accepted: 24 pages, 13 figure
Odd Frequency Pairing in the Kondo Lattice
We discuss the possibility that heavy fermion superconductors involve
odd-frequency pairing of the kind first considered by Berezinskii. Using a toy
model for odd frequency triplet pairing in the Kondo lattice we are able to
examine key properties of this new type of paired state. To make progress
treating the strong constraint in the Kondo lattice model we use the
technical trick of a Majorana representation of the local moments, which
permits variational treatments of the model without a Gutzwiller approximation.
The simplest mean field theory involves the development of bound states between
the local moments and conduction electrons, characterized by a spinor order
parameter. We show that this state is a stable realization of odd frequency
triplet superconductivity with surfaces of gapless excitations whose spin and
charge coherence factors vanish linearly in the quasiparticle energy. A
NMR relaxation rate coexists with a linear specific heat. We discuss possible
extensions of our toy model to describe heavy fermion superconductivity.Comment: 67 page
Is there still a place for the cemented titanium femoral stem?: 10,108 cases from the Norwegian Arthroplasty Register
An Overview of the 2014 ALMA Long Baseline Campaign
A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to
make accurate images with resolutions of tens of milliarcseconds, which at
submillimeter (submm) wavelengths requires baselines up to ~15 km. To develop
and test this capability, a Long Baseline Campaign (LBC) was carried out from
September to late November 2014, culminating in end-to-end observations,
calibrations, and imaging of selected Science Verification (SV) targets. This
paper presents an overview of the campaign and its main results, including an
investigation of the short-term coherence properties and systematic phase
errors over the long baselines at the ALMA site, a summary of the SV targets
and observations, and recommendations for science observing strategies at long
baselines. Deep ALMA images of the quasar 3C138 at 97 and 241 GHz are also
compared to VLA 43 GHz results, demonstrating an agreement at a level of a few
percent. As a result of the extensive program of LBC testing, the highly
successful SV imaging at long baselines achieved angular resolutions as fine as
19 mas at ~350 GHz. Observing with ALMA on baselines of up to 15 km is now
possible, and opens up new parameter space for submm astronomy.Comment: 11 pages, 7 figures, 2 tables; accepted for publication in the
Astrophysical Journal Letters; this version with small changes to
affiliation
Efficacy of olmesartan/amlodipine combination therapy in reducing ambulatory blood pressure in moderate-to-severe hypertensive patients not controlled by amlodipine alone
Efficacy of olmesartan/amlodipine combination therapy in reducing ambulatory blood pressure in moderate-to-severe hypertensive patients not controlled by amlodipine alon
Influence of surgical approach on component positioning in primary total hip arthroplasty
Background: Minimal invasive surgery (MIS) has gained growing popularity in total hip arthroplasty (THA) but concerns exist regarding component malpositioning. The aim of the present study was to evaluate femoral and acetabular component positioning in primary cementless THA comparing a lateral to a MIS anterolateral approach. Methods: We evaluated 6 week postoperative radiographs of 52 hips with a minimal invasive anterolateral approach compared to 54 hips with a standard lateral approach. All hips had received the same type of implant for primary cementless unilateral THA and had a healthy hip contralaterally. Results: Hip offset was equally restored comparing both approaches. No influence of the approach was observed with regard to reconstruction of acetabular offset, femoral offset, vertical placement of the center of rotation, stem alignment and leg length discrepancy. However, with the MIS approach, a significantly higher percentage of cups (38.5 %) was malpositioned compared to the standard approach (16.7 %) (p = 0.022). Conclusions: The MIS anterolateral approach allows for comparable reconstruction of stem position, offset and center of rotation compared to the lateral approach. However, surgeons must be aware of a higher risk of cup malpositioning for inclination and anteversion using the MIS anterolateral approach
The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial
<p>Abstract</p> <p>Background</p> <p>With an ageing population, older persons become a larger part of the hospital population. The incidence of delirium is high in this group, and experiencing delirium has major short- and long-term sequelae, which makes prevention crucial. During delirium, a disruption of the sleep-wake cycle is frequently observed. Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium. The aim of this article is to describe the design of a randomised, placebo controlled double-blind trial that is currently in progress and that investigates the effects of melatonin versus placebo on delirium in older, postoperative hip fracture patients.</p> <p>Methods/Design</p> <p>Acutely hospitalised patients aged 65 years or older admitted for surgical repair of hip fracture are randomised (n = 452) into a treatment or placebo group. Prophylactic treatment consists of orally administered melatonin (3 mg) at 21:00 h on five consecutive days. The primary outcome is the occurrence of delirium, to be diagnosed according to the Confusion Assessment Method, within eight days after start of the study medication. Secondary outcomes are delirium severity, measured by the Delirium Rating Scale; duration of delirium; differences in subtypes of delirium; differences in total length of hospital stay; total dose of antipsychotics and/or benzodiazepine use during delirium; and in-hospital complications. In the twelve-month follow up visit, cognitive function is measured by a Mini-Mental state examination and the Informant Questionnaire on Cognitive Decline in the Elderly. Functional status is assessed with the Katz ADL index score (patient and family version) and grip strength measurement. The outcomes of these assessments are compared to the outcomes that were obtained during admission.</p> <p>Discussion</p> <p>The proposed study will contribute to our knowledge because studies on the prophylactic treatment of delirium with long term follow up remain scarce. The results may lead to a prophylactic treatment for frail older persons at high risk for delirium that is safe, effective, and easily implementable in daily practice.</p> <p>Trial registration</p> <p>Dutch Clinical Trial Registry: <a href="http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1576">NTR1576</a></p
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