Investigation of the utilization amount of the metacognitive strategies

The aim of the present research is investigating the application of metacognitive strategies by the high school students in mathematics major in Isfahan, Iran in academic year of 2012-2013. The methodology of this descriptive research was of measurement type, and data collection tool was Dawson & Mackinder’s Questionnaire (2004). The validity of this study was confirmed by the experts of the field. Its reliability was calculated as 0.81 using Alpha- Chronbach Coefficient. Making use of Cochrane’s formula, the sample volume was a number of 369 students, who were selected using the Cluster Random Sampling & Stratified Random Sampling, and the selection was proportional to the volume. To analyze the data, both the descriptive & inferential statistics were used. The results of this study showed that the amount of application of meta-cognitive strategies (planning strategy, control & supervision strategy, regulation strategy) by the high school mathematics students was above average and there was a significant difference between the score collections of the metacognitive strategies in their different dimensions. Keywords: metacognitive strategies, Planning strategies, control & supervision strategies, regulation strategies, high school perio

Biological properties of Pegylated PLA (PLA-PEG-PLA) and its capability for intracellular delivery of poor soluble peptide drug, gramicidin

Poly lactic acid-co-poly ethylene glycol-co-Poly lactic acid (PLA-PEG-PLA) co-polymer was synthesized and after determination of its biological properties was used for intracellular delivery of poor soluble peptide drug, gramicidin. Toxicity of this polymer on LNCaP cell line was determined by MTT assay. Treatment of cells with fluorescein isothiocyanate (FITC) loaded nanoparticles and fluorescence microscopy indicates ability of this carrier for intracellular delivery. PLA-PEG-PLA nanoparticles containing poor soluble peptide drug, gramicidin, was prepared by solvent evaporation method. In order to confirm loading of gramicidin on PLA-PEG-PLA nanoparticles, FT-IR, spectrofluoremeteric, circular dichroism (CD), and scanning electron microscopy (SEM) studies were carried out. Our studies revealed treatment of prostate cancer cell line, LNCaP, with gramicidin loaded nanoparticles was more effective than gramicidin alone in killing cancer cells

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of myelin itself. Surprisingly, nerves of Schwann cell-specific Pex5 mutant mice were unaltered regarding axon numbers, axonal calibers, and myelin sheath thickness by electron microscopy. In search for a molecular mechanism, we revealed enhanced abundance and internodal expression of axonal membrane proteins normally restricted to juxtaparanodal lipid-rafts. Gangliosides were altered and enriched within an expanded lysosomal compartment of paranodal loops. We revealed the same pathological features in a mouse model of human Adrenomyeloneuropathy, preceding disease-onset by one year. Thus, peroxisomal dysfunction causes secondary failure of local lysosomes, thereby impairing the turnover of gangliosides in myelin. This reveals a new aspect of axon-glia interactions, with Schwann cell lipid metabolism regulating the anchorage of juxtaparanodal Kv1-channels

Biological properties of Pegylated PLA (PLA-PEG-PLA) and its capability for intracellular delivery of poor soluble peptide drug, gramicidin

Poly lactic acid-co-poly ethylene glycol-co-Poly lactic acid (PLA-PEG-PLA) co-polymer was synthesized and after determination of its biological properties was used for intracellular delivery of poor soluble peptide drug, gramicidin. Toxicity of this polymer on LNCaP cell line was determined by MTT assay. Treatment of cells with fluorescein isothiocyanate (FITC) loaded nanoparticles and fluorescence microscopy indicates ability of this carrier for intracellular delivery. PLA-PEG-PLA nanoparticles containing poor soluble peptide drug, gramicidin, was prepared by solvent evaporation method. In order to confirm loading of gramicidin on PLA-PEG-PLA nanoparticles, FT-IR, spectrofluoremeteric, circular dichroism (CD), and scanning electron microscopy (SEM) studies were carried out. Our studies revealed treatment of prostate cancer cell line, LNCaP, with gramicidin loaded nanoparticles was more effective than gramicidin alone in killing cancer cells

Genome-scale modeling of yeast: chronology, applications and critical perspectives

Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective on the overall genome-scale modeling procedure, underlining incomplete model validation and evaluation approaches and the quest for the integration of regulatory and kinetic information into yeast GSMMs. A summary of experimentally validated model-based metabolic engineering applications of yeast species is further emphasized, while the main challenges and future perspectives for the field are finally addressedThis work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of a Ph.D. grant (PD/BD/52336/2013), of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01–0145FEDER-006684) and also in the context of the EU-funded initiative ERA-NET for Industrial Biotechnology (ERA-IB-2/0003/2013), in addition to the BioTecNorte operation (NORTE-01–0145FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte.info:eu-repo/semantics/publishedVersio

Investigating the Images of Snake, Dragon and Their Accessories in Mowlavi's Sonnets

The subject of the present article is to study the images of the snake, dragon and their belongings in the Shams' Sonnets that Mowlavi introduces by these images and many complex concepts. For this purpose, first introductory material has been expressed with the titles of experience and image, the concepts and images of poetry and animal images. In the main part of the research, the relation of twenty four comparisons such as the beloved, lover, human, barrier, duality, world, sensuality, suffering and disaster, trapped, separation, language, wish, silver and gold, night, food, despair and God's attention are embodied with the limited component of the snake and dragon along with twenty five common similarities, such as destruction, fidget, sting, prevention, belongingness, duality, independency, humility and submission, life and death, strength, dignity, filth, excitement and pregnancy, movement and effort, and that it shows the maintaining deep mythological, religious and mystical patterns. Since the images of the dragon and the serpent in the Shams' sonnets, carries the dual meaning of positive and negative, rebellion and submission, grace and Fierce, hope and disappointment, suffering and happy, from the spirit and soulful experiences of excited and stressful of Mowlavi; This matter states the perfectionism, the breadth of thought, the exploitation of his contradictions and optimism. Unlike the banal experience, the reader based on Mowlana's positive view of the snake, understands the wise vision of this great poet, that all creatures are necessary in the best system of God

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of myelin itself. Surprisingly, nerves of Schwann cell-specific Pex5 mutant mice were unaltered regarding axon numbers, axonal calibers, and myelin sheath thickness by electron microscopy. In search for a molecular mechanism, we revealed enhanced abundance and internodal expression of axonal membrane proteins normally restricted to juxtaparanodal lipid-rafts. Gangliosides were altered and enriched within an expanded lysosomal compartment of paranodal loops. We revealed the same pathological features in a mouse model of human Adrenomyeloneuropathy, preceding disease-onset by one year. Thus, peroxisomal dysfunction causes secondary failure of local lysosomes, thereby impairing the turnover of gangliosides in myelin. This reveals a new aspect of axon-glia interactions, with Schwann cell lipid metabolism regulating the anchorage of juxtaparanodal Kv1-channels.status: publishe