An observation of a mutual event between two satellites of Uranus

We present observations of the occultation of Umbriel by Oberon on 4 May, 2007. We believe this is the first observed mutual event between satellites of Uranus. Fitting a simple geometric model to the lightcurve, we measure the mid-event time with a precision of 4 seconds. We assume previously measured values for the albedos of the two satellites (Karkoschka 2001), and measure the impact parameter to be 500 +/- 80 km. These measurements are more precise than estimates based on current ephemerides for these satellites. Therefore observations of additional mutual events during the 2007-2008 Uranian equinox will provide improved estimates of their orbital and physical parameters.Comment: 4 pages, 3 figures, accepted for publication in MNRAS Letter

Cassini ISS mutual event astrometry of the mid-sized Saturnian satellites 2005-2012

Reproduced with permission from Astronomy & Astrophysics, © ES

Observational detection of eclipses of J5 Amalthea by the Galilean satellites

We carried out observations of the small jovian satellite Amalthea (J5) as it was being eclipsed by the Galilean satellites near the 2009 equinox of Jupiter in order to apply the technique of mutual event photometry to the astrometric determination of this satellite's position. The observations were carried out during the period 06/2009-09/2009 from the island of Maui, Hawaii and Siding Spring, Australia with the 2m Faulkes Telescopes North and South respectively. We observed in the near-infrared part of the spectrum using a PanStarrs-Z filter with Jupiter near the edge of the field in order to mitigate against the glare from the planet. Frames were acquired at rates >1/min during eclipse times predicted using recent JPL ephemerides for the satellites. Following subtraction of the sky background from these frames, differential aperture photometry was carried out on Amalthea and a nearby field star. We have obtained three lightcurves which show a clear drop in the flux from Amalthea, indicating that an eclipse took place as predicted. These were model-fitted to yield best estimates of the time of maximum flux drop and the impact parameter. These are consistent with Amalthea's ephemeris but indicate that Amalthea is slightly ahead of, and closer to Jupiter than, its predicted position by approximately half the ephemeris uncertainty in these directions. We argue that a ground-based campaign of higher-cadence photometry accurate at the 5% level or better during the next season of eclipses in 2014-15 should yield positions to within 0".5 and affect a corresponding improvement in Amalthea's ephemeris.Comment: Published in A&A in 2010; 6 pages, 2 figures, 3 table

Astrometric positions for 18 irregular satellites of giant planets from 23 years of observations

The irregular satellites of the giant planets are believed to have been captured during the evolution of the solar system. Knowing their physical parameters, such as size, density, and albedo is important for constraining where they came from and how they were captured. The best way to obtain these parameters are observations in situ by spacecrafts or from stellar occultations by the objects. Both techniques demand that the orbits are well known. We aimed to obtain good astrometric positions of irregular satellites to improve their orbits and ephemeris. We identified and reduced observations of several irregular satellites from three databases containing more than 8000 images obtained between 1992 and 2014 at three sites (Observat\'orio do Pico dos Dias, Observatoire de Haute-Provence, and European Southern Observatory - La Silla). We used the software PRAIA (Platform for Reduction of Astronomical Images Automatically) to make the astrometric reduction of the CCD frames. The UCAC4 catalog represented the International Celestial Reference System in the reductions. Identification of the satellites in the frames was done through their ephemerides as determined from the SPICE/NAIF kernels. Some procedures were followed to overcome missing or incomplete information (coordinates, date), mostly for the older images. We managed to obtain more than 6000 positions for 18 irregular satellites: 12 of Jupiter, 4 of Saturn, 1 of Uranus (Sycorax), and 1 of Neptune (Nereid). For some satellites the number of obtained positions is more than 50\% of what was used in earlier orbital numerical integrations. Comparison of our positions with recent JPL ephemeris suggests there are systematic errors in the orbits for some of the irregular satellites. The most evident case was an error in the inclination of Carme.Comment: 9 pages, with 3 being online materia

Observational detection of eight mutual eclipses and occultations between the satellites of Uranus

We carried out observations, with five different instruments ranging in aperture from 0.4m to 10m, of the satellites of Uranus during that planet's 2007 Equinox. Our observations covered specific intervals of time when mutual eclipses and occultations were predicted. The observations were carried out in the near-infrared part of the spectrum to mitigate the glare from the planet. Frames were acquired at rates > 1/min. Following modelling and subtraction of the planetary source from these frames, differential aperture photometry was carried out on the satellite pairs involved in the predicted events. In all cases but one, nearby bright satellites were used as reference sources. We have obtained fifteen individual lightcurves, eight of which show a clear drop in the flux from the satellite pair, indicating that a mutual event took place. Three of these involve the faint satellite Miranda. All eight lightcurves were model-fitted to yield best estimates of the time of maximum flux drop and the impact parameter. In three cases best-fit albedo ratios were also derived. We used these estimates to generate intersatellite astrometric positions with typical formal uncertainties of <0.01 arcsec, several times better than conventional astrometry of these satellites. The statistics of our estimated event midtimes show a systematic lag, with the observations later than predictions. In addition, lightcurves of two partial eclipses of Miranda show no statistically significant evidence of a light drop, at variance with the predictions. These indicate that new information about the Uranian satellite system is contained in observations of mutual events acquired here and by other groups.Comment: 8 pages, 3 figures, accepted for publication in Astronomy and Astrophysics Uses aa style packag

The Five Factor Model of personality and evaluation of drug consumption risk

The problem of evaluating an individual's risk of drug consumption and misuse is highly important. An online survey methodology was employed to collect data including Big Five personality traits (NEO-FFI-R), impulsivity (BIS-11), sensation seeking (ImpSS), and demographic information. The data set contained information on the consumption of 18 central nervous system psychoactive drugs. Correlation analysis demonstrated the existence of groups of drugs with strongly correlated consumption patterns. Three correlation pleiades were identified, named by the central drug in the pleiade: ecstasy, heroin, and benzodiazepines pleiades. An exhaustive search was performed to select the most effective subset of input features and data mining methods to classify users and non-users for each drug and pleiad. A number of classification methods were employed (decision tree, random forest, $k$-nearest neighbors, linear discriminant analysis, Gaussian mixture, probability density function estimation, logistic regression and na{\"i}ve Bayes) and the most effective classifier was selected for each drug. The quality of classification was surprisingly high with sensitivity and specificity (evaluated by leave-one-out cross-validation) being greater than 70\% for almost all classification tasks. The best results with sensitivity and specificity being greater than 75\% were achieved for cannabis, crack, ecstasy, legal highs, LSD, and volatile substance abuse (VSA).Comment: Significantly extended report with 67 pages, 27 tables, 21 figure

Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis

The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12 months, 88 osteoporotic postmenopausal women (mean age 63.7 ± 7.4) were randomized to strontium ranelate 2 g/day or alendronate 70 mg/week in a double-placebo design. Primary endpoints were changes in microstructure. Secondary endpoints included lumbar and hip areal bone mineral density (aBMD), and bone turnover markers. This trial is registered with http://www.controlled-trials.com, number ISRCTN82719233. Baseline characteristics of the two groups were similar. Treatment with strontium ranelate was associated with increases in mean cortical thickness (CTh, 5.3%), cortical area (4.9%) and trabecular density (2.1%) (all P < 0.001, except cortical area P = 0.013). No significant changes were observed with alendronate. Between-group differences in favor of strontium ranelate were observed for CTh, cortical area, BV/TV and trabecular density (P = 0.045, 0.041, 0.048 and 0.035, respectively). aBMD increased to a similar extent with strontium ranelate and alendronate at the spine (5.7% versus 5.1%, respectively) and total hip (3.3% versus 2.2%, respectively). No significant changes were observed in remodeling markers with strontium ranelate, while suppression was observed with alendronate. Within the methodological constraints of HR-pQCT through its possible sensitivity to X-ray attenuation of different minerals, strontium ranelate had greater effects than alendronate on distal tibia cortical thickness and trabecular volumetric density

The astrometric Gaia-FUN-SSO observation campaign of 99 942 Apophis

Astrometric observations performed by the Gaia Follow-Up Network for Solar System Objects (Gaia-FUN-SSO) play a key role in ensuring that moving objects first detected by ESA's Gaia mission remain recoverable after their discovery. An observation campaign on the potentially hazardous asteroid (99 942) Apophis was conducted during the asteroid's latest period of visibility, from 12/21/2012 to 5/2/2013, to test the coordination and evaluate the overall performance of the Gaia-FUN-SSO . The 2732 high quality astrometric observations acquired during the Gaia-FUN-SSO campaign were reduced with the Platform for Reduction of Astronomical Images Automatically (PRAIA), using the USNO CCD Astrograph Catalogue 4 (UCAC4) as a reference. The astrometric reduction process and the precision of the newly obtained measurements are discussed. We compare the residuals of astrometric observations that we obtained using this reduction process to data sets that were individually reduced by observers and accepted by the Minor Planet Center. We obtained 2103 previously unpublished astrometric positions and provide these to the scientific community. Using these data we show that our reduction of this astrometric campaign with a reliable stellar catalog substantially improves the quality of the astrometric results. We present evidence that the new data will help to reduce the orbit uncertainty of Apophis during its close approach in 2029. We show that uncertainties due to geolocations of observing stations, as well as rounding of astrometric data can introduce an unnecessary degradation in the quality of the resulting astrometric positions. Finally, we discuss the impact of our campaign reduction on the recovery process of newly discovered asteroids.Comment: Accepted for publication in A&

A Method for Analyzing the Ubiquitination and Degradation of Aurora-A

The cell cycle machinery consists of regulatory proteins that control the progression through the cell cycle ensuring that DNA replication alternates with DNA segregation in mitosis to maintain cell integrity. Some of these key regulators have to be degraded at each cell cycle to prevent cellular dysfunction. Mitotic exit requires the inactivation of cyclin dependent kinase1 (cdk1) and it is the degradation of the cyclin subunit that inactivates the kinase. Cyclin degradation has been well characterized and it was shown that it is ubiquitin proteasome pathway that leads to the elimination of cyclins. By now, many other regulatory proteins were shown to be degraded by the same pathway, among them members of the aurora kinase family, degraded many other regulatory proteins. Aurora kinases are involved in mitotic spindle formation as well as in cytokinesis. The abundance and activity of the kinase is precisely regulated during the cell cycle. To understand how proteolysis regulates transitions through the cell cycle we describe two assays for ubiquitination and degradation of xenopus aurora kinase A using extracts from xenopus eggs or somatic cell lines