Building quests for online games with virtual institutions

Abstract. This document describes how to re-purpose an existing agent technology called Virtual Institutions as a mechanism to define new "quest" elements in Massively Multiplayer Online Games based on MultiAgent Systems. Quests are a very important part of most Massive Online Games as they wield to flow and narrative of the game in a linear or nonlinear manner

Correlated response to selection for litter size environmental variability in rabbits' resilience

[EN] Resilience is the ability of an animal to return soon to its initial productivity after facing diverse environmental challenges. This trait is directly related to animal welfare and it plays a key role in fluctuations of livestock productivity. A divergent selection experiment for environmental variance of litter size has been performed successfully in rabbits over ten generations. The objective of this study was to analyse resilience indicators of stress and disease in the divergent lines of this experiment. The high line showed a lower survival rate at birth than the low line (-4.1%). After correcting by litter size, the difference was -3.2%. Involuntary culling rate was higher in the high than in the low line (+12.4%). Before vaccination against viral haemorrhagic disease or myxomatosis, concentration of lymphocytes, C-reactive protein (CRP), complement C3, serum bilirubin, triglycerides and cholesterol were higher in the high line than in the low line (difference between lines +4.5%, +5.6 mu g/ml, +4.6 mg/ml, +7.9 mmol/l, +0.3 mmol/l and +0.4 mmol/l). Immunological and biochemical responses to the two vaccines were similar. After vaccination, the percentage of lymphocytes and CRP concentration were higher in the low line than in the high one (difference between lines +4.0% and +13.1 mu g/ml). The low line also showed a higher increment in bilirubin and triglycerides than the high line (+14.2 v. +8.7 mmol/l for bilirubin and +0.11 v. +0.01 mmol/l for triglycerides); these results would agree with the protective role of bilirubin and triglycerides against the larger inflammatory response found in this line. In relation to stress, the high line had higher basal concentration of cortisol than the low line (+0.2ng/ml); the difference between lines increased more than threefold after the injection of ACTH 1 to 24, the increase being greater in the high line (+0.9 ng/ml) than in the low line (+0.4 ng/ml). Selection for divergent environmental variability of litter size leads to dams with different culling rate for reproductive causes and different kits' neonatal survival. These associations suggest that the observed fitness differences are related to differences in the inflammatory response and the corticotrope response to stress, which are two important components of physiological adaptation to environmental aggressions.This study is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) with the Projects AGL2014-55921, C2-1-P and C2-2-P, and AGL2017-86083, C2-1-P and C2-2-P.Argente, M.; Garcia, M.; Zbynovska, K.; Petruska, P.; Capcarova, M.; Blasco Mateu, A. (2019). 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Vaccine, 33(17), 2004-2008. doi:10.1016/j.vaccine.2015.03.019Blasco, A. (2017). Bayesian Data Analysis for Animal Scientists. doi:10.1007/978-3-319-54274-4Castellini, C., Dal Bosco, A., Arias-Álvarez, M., Lorenzo, P. L., Cardinali, R., & Rebollar, P. G. (2010). The main factors affecting the reproductive performance of rabbit does: A review. Animal Reproduction Science, 122(3-4), 174-182. doi:10.1016/j.anireprosci.2010.10.003Rosa Neto, N. S., & Carvalho, J. F. de. (2009). O uso de provas de atividade inflamatória em reumatologia. Revista Brasileira de Reumatologia, 49(4), 413-430. doi:10.1590/s0482-50042009000400008Argente, M. J., Calle, E. W., García, M. L., & Blasco, A. (2017). Correlated response in litter size components in rabbits selected for litter size variability. Journal of Animal Breeding and Genetics, 134(6), 505-511. doi:10.1111/jbg.12283Mirkena, T., Duguma, G., Haile, A., Tibbo, M., Okeyo, A. M., Wurzinger, M., & Sölkner, J. (2010). Genetics of adaptation in domestic farm animals: A review. Livestock Science, 132(1-3), 1-12. doi:10.1016/j.livsci.2010.05.003García, M. L., Blasco, A., & Argente, M. J. (2016). Embryologic changes in rabbit lines selected for litter size variability. Theriogenology, 86(5), 1247-1250. doi:10.1016/j.theriogenology.2016.04.065Feingold KR and Grunfeld C 2015. The effect of inflammation and infection on lipids and lipoproteins. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F and Vinik A. Endotext, South Dartmouth, MA, USA. Retrieved on 7 June 2018 from https://www.ncbi.nlm.nih.gov/books/NBK326741/.Minemura, M. (2014). Liver involvement in systemic infection. World Journal of Hepatology, 6(9), 632. doi:10.4254/wjh.v6.i9.632Knap, P. W. (2005). Breeding robust pigs. Australian Journal of Experimental Agriculture, 45(8), 763. doi:10.1071/ea05041Barcia, A. M., & Harris, H. W. (2005). 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Designing normative open virtual enterprises

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Enterprise Information Systems on 23/03/2016, available online: http://www.tandfonline.com/10.1080/17517575.2015.1036927.[EN] There is an increasing interest on developing virtual enterprises in order to deal with the globalisation of the economy, the rapid growth of information technologies and the increase of competitiveness. In this paper we deal with the development of normative open virtual enterprises (NOVEs). They are systems with a global objective that are composed of a set of heterogeneous entities and enterprises that exchange services following a specific normative context. In order to analyse and design systems of this kind the multi-agent paradigm seems suitable because it offers a specific solution for supporting the social and contractual relationships between enterprises and for formalising their business processes. This paper presents how the Regulated Open Multiagent systems (ROMAS) methodology, an agent-oriented software methodology, can be used to analyse and design NOVEs. ROMAS offers a complete development process that allows identifying and formalising of the structure of NOVEs, their normative context and the interactions among their members. The use of ROMAS is exemplified by means of a case study that represents an automotive supply chain.This work was partially supported by the projects [PROMETEOII/2013/019], [TIN2012-36586-C03-01], [FP7-29493], [TIN2011-27652-C03-00] and [CSD2007-00022], and the CASES project within the 7th European Community Framework Programme [grant agreement number 294931].Garcia Marques, ME.; Giret Boggino, AS.; Botti Navarro, VJ. (2016). Designing normative open virtual enterprises. Enterprise Information Systems. 10(3):303-324. https://doi.org/10.1080/17517575.2015.1036927S303324103Cardoso, H. L., Urbano, J., Brandão, P., Rocha, A. P., & Oliveira, E. (2012). ANTE: Agreement Negotiation in Normative and Trust-Enabled Environments. Advances on Practical Applications of Agents and Multi-Agent Systems, 261-264. doi:10.1007/978-3-642-28786-2_33Chu, X. N., Tso, S. K., Zhang, W. J., & Li, Q. (2002). Partnership Synthesis for Virtual Enterprises. The International Journal of Advanced Manufacturing Technology, 19(5), 384-391. doi:10.1007/s001700200028Davidsson, P., & Jacobsson, A. (s. f.). Towards Norm-Governed Behavior in Virtual Enterprises. Studies in Computational Intelligence, 35-55. doi:10.1007/978-3-540-88071-4_3DeLoach, S. A., & Ojeda, J. C. G. (2010). O-MaSE: a customisable approach to designing and building complex, adaptive multi-agent systems. International Journal of Agent-Oriented Software Engineering, 4(3), 244. doi:10.1504/ijaose.2010.036984DI MARZO SERUGENDO, G., GLEIZES, M.-P., & KARAGEORGOS, A. (2005). Self-organization in multi-agent systems. The Knowledge Engineering Review, 20(2), 165-189. doi:10.1017/s0269888905000494Dignum, V. 2003. “A Model for Organizational Interaction: Based on Agents, Founded in Logic.” PhD diss., Utrecht University.Dignum, V., and F. Dignum. 2006.A Landscape of Agent Systems for the Real World. Technical Report 44-CS-2006-061. Utrecht: Institute of Information and Computing Sciences, Utrecht University.Dignum, V., Meyer, J.-J. C., Dignum, F., & Weigand, H. (2003). Formal Specification of Interaction in Agent Societies. Lecture Notes in Computer Science, 37-52. doi:10.1007/978-3-540-45133-4_4Garcia, E. 2013. “Engineering Regulated Open Multiagent Systems.” PhD diss., Universitat Politecnica de Valencia.Garcia, E., Giret, A., & Botti, V. (s. f.). Software Engineering for Service-Oriented MAS. Lecture Notes in Computer Science, 86-100. doi:10.1007/978-3-540-85834-8_9Garcia, E., Giret, A., & Botti, V. (2013). A Model-Driven CASE tool for developing and verifying regulated open MAS. Science of Computer Programming, 78(6), 695-704. doi:10.1016/j.scico.2011.10.009Garcia, E., Giret, A., & Botti, V. (2011). Evaluating software engineering techniques for developing complex systems with multiagent approaches. Information and Software Technology, 53(5), 494-506. doi:10.1016/j.infsof.2010.12.012Garcia, E., Giret, A., & Botti, V. (2011). Regulated Open Multi-Agent Systems Based on Contracts. Information Systems Development, 243-255. doi:10.1007/978-1-4419-9790-6_20Garcia, E., Giret, A., & Botti, V. (2014). ROMAS Methodology. Handbook on Agent-Oriented Design Processes, 331-369. doi:10.1007/978-3-642-39975-6_11Hollander, C. D., & Wu, A. S. (2011). The Current State of Normative Agent-Based Systems. Journal of Artificial Societies and Social Simulation, 14(2). doi:10.18564/jasss.1750HORLING, B., & LESSER, V. (2004). A survey of multi-agent organizational paradigms. 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Genetic selection for ovulation rate and litter size in rabbits: estimation of genetic parameters and direct and correlated responses

The aim of this work was to estimate direct and correlated responses in survival rates in an experiment of selection for ovulation rate (OR) and litter size (LS) in a line of rabbits (OR_LS). From generation 0 to 6 (first selection period), females were selected only for second gestation OR estimated by laparoscopy. From generation 7 to 13 (second selection period), a 2-stage selection for OR and LS was performed. In stage 1, females having the greatest OR at second gestation were selected. In stage 2, selection was for the greatest average LS of the first 2 parities of the females selected in stage 1. Total selection pressure in females was about 30%. The line had approximately 17 males and 75 females per generation. Traits recorded were OR estimated as the number of corpora lutea in both ovaries, number of implanted embryos (IE) estimated as the number of implantation sites, LS estimated as total number of rabbits born recorded at each parity, embryo survival (ES) estimated as IE/OR, fetal survival (FS) estimated as LS/IE, and prenatal survival (PS) estimated as LS/OR. Data were analyzed using Bayesian methodology. The estimated heritabilities of LS, OR, IE, ES, FS, and PS were 0.07, 0.21, 0.10, 0.07, 0.12, and 0.16, respectively. Direct and correlated responses from this study were estimated in each period of selection as the difference between the average genetic values of last and first generation. In the first selection period, OR increased 1.36 ova, but no correlated response was observed in LS due to a decrease on FS. Correlated responses for IE, ES, FS, and PS in the first selection period were 1.11, 0.00, -0.04, and -0.01, respectively. After 7 generations of 2-stage selection for OR and LS, OR increased 1.0 ova and response in LS was 0.9 kits. Correlated responses for IE, ES, FS, and PS in the second selection period were 1.14, 0.02, 0.02, and 0.07, respectively. Two-stage selection for OR and LS can be a promising procedure to improve LS in rabbits.This study was supported by the Comision Interministerial de Ciencia y Tecnologia CICYT-AGL2005-07624-C03-01 CICYT-AGL2008-05514-C02-01 and by funds from Generalitat Valenciana research programme (Prometeo 2009/125).Ziadi, C.; Mocé Cervera, ML.; Laborda Vidal, P.; Blasco Mateu, A.; Santacreu Jerez, MA. (2013). Genetic selection for ovulation rate and litter size in rabbits: estimation of genetic parameters and direct and correlated responses. Journal of Animal Science. 91(7):3113-3120. https://doi.org/10.2527/jas.2012-6043S3113312091

A flexible coupling approach to multi-agent planning under incomplete information

The final publication is available at Springer via http://dx.doi.org/10.1007/s10115-012-0569-7Multi-agent planning (MAP) approaches are typically oriented at solving loosely coupled problems, being ineffective to deal with more complex, strongly related problems. In most cases, agents work under complete information, building complete knowledge bases. The present article introduces a general-purpose MAP framework designed to tackle problems of any coupling levels under incomplete information. Agents in our MAP model are partially unaware of the information managed by the rest of agents and share only the critical information that affects other agents, thus maintaining a distributed vision of the task. Agents solve MAP tasks through the adoption of an iterative refinement planning procedure that uses single-agent planning technology. In particular, agents will devise refinements through the partial-order planning paradigm, a flexible framework to build refinement plans leaving unsolved details that will be gradually completed by means of new refinements. Our proposal is supported with the implementation of a fully operative MAP system and we show various experiments when running our system over different types of MAP problems, from the most strongly related to the most loosely coupled.This work has been partly supported by the Spanish MICINN under projects Consolider Ingenio 2010 CSD2007-00022 and TIN2011-27652-C03-01, and the Valencian Prometeo project 2008/051.Torreño Lerma, A.; Onaindia De La Rivaherrera, E.; Sapena Vercher, O. (2014). A flexible coupling approach to multi-agent planning under incomplete information. 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Foro de debate: seguridad de las alternativas a la transfusión alogénica en el paciente quirúrgico y/o crítico

Estos últimos años han aparecido alertas de seguridad, no siempre bien sustentadas, que cuestionan el uso de algunas alternativas farmacológicas a la transfusión de sangre alogénica y/o lo restringen en indicaciones establecidas. Asistimos también a la preconización de otras alternativas, incluyendo productos hemáticos y fármacos antifibrinolíticos, sin que haya una base científica sólida que lo justifique. Por iniciativa del Grupo de Estudios Multidisciplinares sobre Autotransfusión y del Anemia Working Group Espana¿ se reunió a un panel multidisciplinar de 23 expertos del área de cuidados de la salud en un foro de debate para: 1) analizar las diferentes alertas de seguridad en torno a ciertas alternativas a la transfusión; 2) estudiar los antecedentes que las han propiciado, la evidencia que las sustentan y las consecuencias que conllevan para la práctica clínica, y 3) emitir una valoración argumentada de la seguridad de cada alternativa a la transfusión cuestionada, según el uso clínico de la misma. Los integrantes del foro mantuvieron contactos por vía telemática y una reunión presencial en la que presentaron y discutieron las conclusiones sobre cada uno de los elementos examinados. Se elaboró un primer documento que fue sometido a 4 rondas de revisión y actualización hasta alcanzar un consenso, unánime en la mayoría de los casos. Presentamos la versión final del documento, aprobada por todos los miembros del panel, esperando sea de utilidad para nuestros colegas

2013. Documento Sevilla de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica. Actualización del Documento Sevilla

La transfusión de sangre alogénica (TSA) no es inocua, y como consecuencia han surgido múltiples alternativas a la misma (ATSA). Existe variabilidad respecto a las indicaciones y buen uso de las ATSA. Dependiendo de la especialidad de los médicos que tratan a los pacientes, el grado de anemia, la política transfusional, la disponibilidad de las ATSA y el criterio personal, estas se usan de forma variable. Puesto que las ATSA tampoco son inocuas y pueden no cumplir criterios de coste-efectividad, la variabilidad en su uso es inaceptable. Las sociedades españolas de Anestesiología y Reanimación (SEDAR), Hematología y Hemoterapia (SEHH), Farmacia Hospitalaria (SEFH), Medicina Intensiva y Unidades Coronarias (SEMICYUC), Trombosis y Hemostasia (SETH) y Transfusiones Sanguíneas (SETS) han elaborado un documento de consenso para el buen uso de la ATSA. Un panel de expertos de las 6 sociedades ha llevado a cabo una revisión sistemática de la literatura médica y elaborado el 2013. Documento Sevilla de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica. Solo se contempla las ATSA dirigidas a disminuir la transfusión de concentrado de hematíes. Se definen las ATSA como toda medida farmacológica y no farmacológica encaminada a disminuir la transfusión de concentrado de hematíes, preservando siempre la seguridad del paciente. La cuestión principal que se plantea en cada ítem se formula, en forma positiva o negativa, como: «La ATSA en cuestión reduce/no reduce la tasa transfusional». Para formular el grado de recomendación se ha usado la metodología Grades of Recommendation Assessment, Development and Evaluation (GRADE)

miR-16 and miR-21 Expression in the Placenta Is Associated with Fetal Growth

BACKGROUND: Novel research has suggested that altered miRNA expression in the placenta is associated with adverse pregnancy outcomes and with potentially harmful xenobiotic exposures. We hypothesized that aberrant expression of miRNA in the placenta is associated with fetal growth, a measurable phenotype resulting from a number of intrauterine factors, and one which is significantly predictive of later life outcomes. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed 107 primary, term, human placentas for expression of 6 miRNA reported to be expressed in the placenta and to regulate cell growth and development pathways: miR-16, miR-21, miR-93, miR-135b, miR-146a, and miR-182. The expression of miR-16 and miR-21 was markedly reduced in infants with the lowest birthweights (p<0.05). Logistic regression models suggested that low expression of miR-16 in the placenta predicts an over 4-fold increased odds of small for gestational age (SGA) status (p = 0.009, 95% CI = 1.42, 12.05). Moreover, having both low miR-16 and low miR-21 expression in the placenta predicts a greater increase in odds for SGA than having just low miR-16 or miR-21 expression (p<0.02), suggesting an additive effect of both of these miRNA. CONCLUSIONS/SIGNIFICANCE: Our study is one of the first to investigate placental miRNA expression profiles associated with birthweight and SGA status. Future research on miRNA whose expression is associated with in utero exposures and markers of fetal growth is essential for better understanding the epigenetic mechanisms underlying the developmental origins of health and disease

IMPROVE 2022 International Meeting on Pathway‐Related Obesity: Vision of Excellence

Nearly 90 clinicians and researchers from around the world attended the first IMPROVE 2022 International Meeting on Pathway-Related Obesity. Delegates attended in person or online from across Europe, Argentina and Israel to hear the latest scientific and clinical developments in hyperphagia and severe, early-onset obesity, and set out a vision of excellence for the future for improving the diagnosis, treatment, and care of patients with melanocortin-4 receptor (MC4R) pathway-related obesity. The meeting co-chair Peter Kühnen, Charité Universitätsmedizin Berlin, Germany, indicated that change was needed with the rapidly increasing prevalence of obesity and the associated complications to improve the understanding of the underlying mechanisms and acknowledge that monogenic forms of obesity can play an important role, providing insights that can be applied to a wider group of patients with obesity. World-leading experts presented the latest research and led discussions on the underlying science of obesity, diagnosis (including clinical and genetic approaches such as the role of defective MC4R signalling), and emerging clinical data and research with targeted pharmacological approaches. The aim of the meeting was to agree on the questions that needed to be addressed in future research and to ensure that optimised diagnostic work-up was used with new genetic testing tools becoming available. This should aid the planning of new evidence-based treatment strategies for the future, as explained by co-chair Martin Wabitsch, Ulm University Medical Center, Germany