11 research outputs found
Notas breves
- Author
- Aedo Carlos
- Afán Isabel
- Arevalo Sebastián
- Arista Montserrat
- Barra Lázaro Alfredo
- Bárbara Ignacio
- Calvo Marta Silvia
- Carrillo López Antonio Felix
- Carrión Vilches Miguel Ángel
- Cirujano Santos
- Cremades Ugarte Javier
- Devesa Juan Antonio
- Domingues de Almeida Joao
- Duro Tomás
- Escobar García Pedro
- Esteban Patricia
- Fernández Benito Margarita
- Fernández Casado Mª Ángeles
- Fernández González Federico
- Guillen Oterino Antonio
- Gutiérrez César
- Gómez-Vigide Fermín
- Gómiz Francisco
- Hernández González Antonio
- Horjales Marina
- Jiménez Martínez Juan Francisco
- Lastra Juan José
- Laínz Manuel
- Lobo Luis
- López Quintana Antonio
- López Rodríguez María del Carmen
- Martín Madrigal Eduardo
- Martín Marcos María Antonia
- Martínez González José
- Martínez- Laborde Juan B.
- Mayor Matias
- Medina Leopoldo
- Narbona Francisco Eduardo
- Nava Herminio S.
- Nelson Cirilo H.
- Orto Pedro Luis
- Pino Joan
- Pérez Prego José Manuel
- Pérez Luis Miguel
- Rabal Saura Gregorio
- Redondo Nieves
- Renovales Gustavo
- Ruiz Téllez Trinidad
- Sans Francesc Xavier
- Simoes da Silva Adriano
- Suárez Pérez Francisco Javier
- Sánchez Gómez Pedro
- Sánchez Rodríguez Juan Antonio
- Tarazona Lazarga Teresa
- Publication venue
- Consejo Superior de Investigaciones Científicas
- Publication date
- 01/06/2000
- Field of study
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
- Camacho Barbosa
- Camarena Ana Isabel Avellaneda
- Camargo-Parra Katherin
- Cammarata Emanuele
- Cammarata Francesco
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campennì Paola
- Campisi Giuseppina
- Campo Flaminia
- Campuzano Nicolas
- Cano-Trigueros Emiliano
- Capella Stefano
- Capitan-Morales Luis-Cristobal
- Capobianco Mattia
- Capolupo Gabriella Teresa
- Capozzi Enrico
- Cappuccio Micaela
- Capuano Marianna
- Carannante Filippo
- Carbone Fabio
- Carbone Ludovico
- Caretto Marta
- Caricato Chiara
- Caricato Marco
- Carpenter Holly
- Carreras-Castañer Anna
- Carretero Manuel Moriche
- Caruana Edward J.
- Carvello Michele
- Casagranda Biagio
- Cassese Gianluca
- Cassinotti Elisa
- Castagnini Francesco
- Castaldi Antonio
- Castaño Mario
- Castaño-Leon Ana M.
- Castillo Dayan Fanery Campino
- Castillo Monica Noguez
- Castro Ernes John
- Catarzi Lisa
- Caubet Maria Mercedes
- Caziuc Alexandra
- Ceelen Wim
- Celik Burak
- Cerovac Anis
- Cerovac Elmedina
- Chamakhi Amine
- Champagne Pierre-Olivier
- Chan Albert
- Chan Linda
- Chan Matthew
- Chaplin Helen
- Charalabopoulos Alexandros
- Chatzikomnitsa Paraskevi
- Chaudhary Muhammad Amjad
- Chaudhary Muhammad Hamid
- Chauhan Govind Singh
- Chauhan Munish
- Chean Chung Shen
- Cheetham Mark
- Cherbanyk Floryn
- Cheung Lok Ka
- Chevallay Mickael
- Chiaradia Angela
- Chin Synn Lynn
- Ching Laine Valerie Kongsun
- Chirca Alexandru
- Chisthi Meer
- Choong Peter
- Chopra Sharat
- Choron Rachel
- Choudhry Asad
- Chouliaras Christos
- Chowdhury Mahbub
- Chowdhury Sharfuddin
- Chowdhury Subhadip Pal
- Christidis Panagiotis
- Christodoulidis Gregory
- Christodoulou Prokopis
- Chrysovitsiotis Georgios
- Chu Michael Jen Jie
- Chukwu Isaac
- Chwat Carina
- Cianci Pasquale
- Cicerchia Pierfranco Maria
- Ciftci Ahmet Burak
- Cil Aylin Pelin
- Cillara Nicola
- Cina Caterina
- Ciniero Valeria
- Cioffi Stefano Piero Bernardo
- Cipolla Calogero
- Cisneros Juan Roberto Torres
- Ciubotaru Cezar
- Claireaux Henry
- Clancy Cillian
- Claret Guillem
- Clegg Rachael
- Clementi Marco
- Clerc Daniel
- Clune Edward
- Coates Amy
- Cobianchi Lorenzo
- Coccolini Federico
- Cockbain Andrew J.
- Cohnert Tina
- Coimbra Fernandez
- Cokan Andrej
- Colak Elif
- Colasanti Roberto
- Cole Simon
- Collins Michelle L.
- Colombari Renan Carlo
- Colombo Francesco
- Colucci Nicola
- Colás-Ruiz Enrique
- Consani Heitor
- Conso Christel
- Consorti Giuseppe
- Conte Luigi Eduardo
- Conti Alfredo
- Conti Luigi
- Contreras Sergio Marcos
- Coppola Alessandro
- Coppola Federico
- Corallino Diletta
- Cordova Adriana
- Cormio Gennaro
- Correia Inês
- Corte Emanuele La
- Costantino Andrea
- Costas-Chavarri Ainhoa
- Costea Radu
- Cotovio Manuel Damasio
- Coughlin Patrick
- Cox Daniel
- Cozens Joanne
- Creavin Ben
- Crichton Robert
- Critchley Rebecca
- Croghan Stefanie M.
- Cross George W. V.
- Cruz Ricardo Pedrini
- Cucinella Giuseppe
- Cullinane Carolyn
- Cullis Paul
- Cunha Miguel F.
- Cunningham Brian
- Currò Giuseppe
- Cuthbert Rory
- Cutmore Carina
- Czako Ladislav
- Cáceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
- D'Amore Anna
- D'Andrea Giancarlo
- D'Archi Sabatino
- D'Oria Mario
- D'Sa Prashanth
- Daddi Niccolo'
- Dagklis Themistoklis
- Dajani Khaled
- Dajti Irida
- Daketsey Elorm
- Daley Brian
- Dare Anna
- Daruwalla Jurstine
- Das Sunit
- Dasa Michael
- Dasanayake Lanka
- Davidescu Mihnea
- Davies Jessica
- Davies Mark
- Davies Richard Justin
- Davis Amelia
- Dawson Amanda Caroline
- Dawson Jonathon
- Dbouk Samer
- De Alarcón Jaime Rodríguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
- De Campos Prado Caio Antonio
- De Cillia Michael
- De Haro Jorge Irene
- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
- De La Infiesta García Carlos
- De La Medina Antonio Ramos
- De La Rosa-Estadella Marta
- De Nardi Paola
- De Oliveira Gabriel Paiva
- De Pastena Matteo
- De Simone Veronica
- De Sousa Álvaro Francisco Lopes
- De Vega Sánchez Blanca
- De Virgilio Armando
- De Zuanni Marco
- Dean Yomna
- Degarege Dawit
- Degener Stephan
- Dejeu George
- Del Amo María Dolores Arribas
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des Déserts Marc Danguy
- Desai Chaitya
- Desio Matteo
- Dessalegn Megbar
- Devarakonda Sreekar
- Dewan Michael
- Dewan Varun
- Dhaity Guipson Dhaity
- Dhondt Bert
- Di Bartolomeo Mattia
- Di Franco Gregorio
- Di Lascio Pierpaolo
- Di Martino Marcello
- Di Nuzzo Maria Michela
- Diaconescu Bogdan
- Dickson Kathryn
- Diehl Thomas
- Dif Elmes Saoussene
- Dimas Angelos
- Dimitrokallis Nikolaos
- Dincer Müserref Beril
- Dindyal Shiva
- Djama Zakarya
- Djedovic Gabriel
- Doerner Johannes
- Doherty Daniel
- Dolci Giampiero
- Domanin Maurizio
- Domingo Marta María Arroyo
- Dominguez-Rosado Ismael
- Don Cristine Pathirannehalage
- Donkin Ian
- Donmez Emin Erhan
- Donoghue Sophie
- Donovan Richard
- Dornseifer Mamun David
- Dorovinis Panagiotis
- Douglas Deborah
- Downey Candice
- Doyle Alex
- Doǧan Lütfi
- Dragisic Vedran
- Draman Mohd Rusdi
- Drasovean Radu
- Dreger Nici Markus
- Drozdov Evgeniy
- Duarte Carolina Lugo
- Dube Surya Kumar
- Dudi-Venkata Nagendra
- Duffy Caoimhe
- Dulskas Audrius
- Dunne Ben
- Dural Ahmet Cem
- Duran Erik Efrain Sosa
- Duro Agustin
- Durrani Abdullah
- Dyas Adam
- Dzhumabaev Khasan
- Dziakova Jana
- Dzogbefia Mawutor
- Díaz Jeancarlos Trujillo
- Dölker Theresa
- Eardley Nicola
- Ebrahim Abdulla
- Echieh Chidiebere Peter
- Edwards John
- Efetov Sergey
- Efremov Sergey
- Egan Richard
- Eiras Miguel Angel Freiria
- Eisa Elamin
- Ekor Oluwayemisi
- Ekwen Gerald
- Ekwunife Okechukwu Hyginus
- El Assaad Hadi
- El Boghdady Michael
- El Tayeb Essam Eldien Abuobaida Banaga Hag
- El-Boghdadly Kariem
- El-Hussuna Alaa
- El-Kassas Mohamed
- Elagili Ahmed
- Elahi Zain
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbe Peter
- Elboraei Rahma
- Eldabaa Mohamed
- Elebute Olumide
- Elfeki Hossam
- Elfiky Mahmoud
- Elgazar Amr
- Elghadban Hosam
- Elhadi Muhammed
- Elhassan Wael Atif Fadl
- Elkazaz Ahmed
- Ellafi Amera Ali Dakheel
- Elliot R.
- Elnour Moheyaldien Ahmed Elamin
- Elsadek Menan
- Elsahli Saifaleslam
- Elsalhawy Shady
- Elsayem Karam
- Elshahawy Mahmoud Abdelaziz Mohamed
- Elsherbiny Ahmed
- Eltayeb Momin
- Elzwai Suha
- Emara Moataz Maher
- Embarek Hussein
- Emile Sameh
- Emmanuel Muhawenimana
- Enciu Octavian
- English Camilla
- Enodien Bassey
- Enwerem Kenneth
- Erel Serap
- Ergenç Merve
- Ergenç Muhammer
- Erginöz Ergin
- Eroglu Atilla
- Escobar Pedro
- Escobedo Francisco Jose Barbosa
- Escrevente Ricardo
- Eskinazi Diego
- Esposito Sofia
- Eugene Muneza
- Ezanno Anne-Cecile
- Ezeanochie Michael
- Ezeme Constantine
- Ezenwa Ekene
- Ezomike Uchechukwu
- Fadalla Tarig
- Fadel Zahir T
- Fahim Margo Medhat Fouad
- Fahmy Ali
- Faiz Javaria
- Fajardo Rafael Torres
- Fakhradiyev Ildar
- Fallah Jean-Michel
- Familiari Pietro
- Fang Clarissa Ern Hui
- Faponle Folayemi
- Farhan-Alanie Muhamed
- Farid Shahzaib
- Farooq Muhammad
- Fatima Mishal
- Fayad Elsayed A.
- Federer Simon
- Federico Nicoletta Sveva Pipitone
- Feeney Kaylem
- Fehervari Matyas
- Fekaj Enver
- Fernandez Laura Gomez
- Fernández Julio Domenech
- Ferracci Federica
- Ferrara Francesco
- Ferrari Davide
- Ferrario Luca
- Ferreli Fabio
- Ferrer Antonio Perez
- Ferrer Ursula María Jariod
- Festa Bianca Maria
- Fiacchini Giacomo
- Figus Andrea
- Filipescu Daniela
- Fiore Marco
- Fiorelli Silvia
- Fitzgerald Conall
- Fleming Christina
- Fleming Fergal
- Fleres Francesco
- Flis Vojko
- Flores S.L.
- Florian Ioan-Alexandru
- Flumignan Carolina Dutra Queiroz
- Flumignan Ronald
- Flórez Luis Joaquín García
- Foessleitner Philipp
- Fontalis Andreas
- Forde Cillian
- Forneris Agustin Albani
- Fortuna Laura
- Fowler George
- Fozo Khaldoun
- Fragoso Marta
- Franceschini Gianluca
- Frankel Adam
- Fransvea Pietro
- Franza Mara
- Fraser Sheila
- Frasson Matteo
- Frisoni Tommaso
- Frolova Yulia
- Frontali Alice
- Frountzas Maximos
- Fruscio Robert
- Fujimoto Yuki
- Furey Joseph
- Fusario Daniele
- Fusini Federico
- Futaba Kaori
- Függer Reinhold
- Gabr Abdullah
- Gada Parth
- Gadelkareem Rabea
- Gafsi Besma
- Gahlot Nitesh
- Gahwagi Milad
- Gaino Francesca
- Galandarov Vagif
- Galandarova Aysuna
- Gallagher Brendan
- Galliard Katherine
- Gallo Oreste
- Galvan Armando
- Gananadha Sivakumar
- Garas George
- Garcia Carolina Soledad Romero
- Garcia Sean
- Garcia-Virto Virginia
- García Lucia Diego
- García Pablo Rodríguez
- García-Conde María
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- Yanowsky-Reyes Guillermo
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- Yates Elizabeth
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- Yeung Justin
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- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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- Vivancos L.G.
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- Vosinakis C.
- Vásquez J.A.G.
- Vázquez I.O.
- Vázquez P.J.G.
- Văcărașu A.B.
- Wade R.
- Wafi O.
- Wagner G.
- Wallis C.
- Wanjara S.
- Waqar S.H.
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- Warner C.
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- Wasserman I.
- Watcyn-Jones T.
- Waterson B.
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- Wijenayake W.
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- Wilkin R.
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- William T.G.
- Williams O.M.
- Williams S.
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- Winnand P.
- Wittmann M.
- Wolde A.
- Wolfenden J.W.D.
- Wong B.N.X.
- Wong E.
- Wong E.G.
- Wong G.K.C.
- Wong H.Y.F.
- Wong K.Y.
- Wormald J.
- Wright D.
- Wright J.
- Wu F.
- Wurm M.
- Xenaki S.
- Yadev I.
- Yahaya A.S.
- Yakubu M.
- Yang W.
- Yanık Ö
- Yanowsky-Reyes G.
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- Yenli E.M.T.-A.
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- Zaheen Z.
- Zahid Z.
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- Zancana G.
- Zani A.
- Zanin L.
- Zanini N.
- Zapardiel I.
- Zapata C.S.
- Zarif P.
- Zaránd A.
- Zehnder P.
- Zenger S.
- Zenha H.
- Zhu M.Z.L.
- Ziemann S.
- Zimak D.M.
- Zimak Z.
- Zivkovic D.
- Zizzo M.
- Zucker B.
- Zwain Y.
- Zyskowski M.
- Ávila C.C.
- Älgå A.
- Çakıcı MÇ
- Çelik E.
- Çelik M.N.
- Özçay N.
- Şevi̇k H.
- Šantak G.
- Šimko K.
- Žatecký J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Sa1902 Short- and Long-Term Outcomes of Infliximab Dose Intensification in Patients With Ulcerative Colitis
- Author
- Angel Ponferrada Diaz
- Carlos Taxonera
- Celia de Gracia
- Cristina Saro
- David Olivares
- Fermin Estremera Arevalo
- Fernando Bermejo
- Guillermo Bastida
- Ignacio Fernández-Blanco
- Ignacio Marin-Jimenez
- Javier P. Gisbert
- Juan L. Mendoza
- Manuel Barreiro-de Acosta
- Maria Chaparro
- Maria Dolores Martin Arranz
- Marta Calvo
- Pilar Martinez-Montiel
- R. Pajares
- Valle Garcia-Sánchez
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Ababneh Hazim
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abbo Olivier
- Abbott Tom
- Abd Elwahab Sami
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala'a
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abukhalaf Sadi A.
- Abuleil Amro
- Achalandabaso Boira Mar
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguiar Junior Samuel
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Alberdi San Roman Igor
- Albertsmeier Markus
- Alcaraz Fuentes Marta
- Alderazi Amer
- Aldressi Wafa
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alonso Mendoza Veronica
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Andre Benoit
- Andres Calvache Jose
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aqeelah Ahmed
- Aqil Sabra
- Arevalo Sandoval Danilo Alfonso
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Ataide Gomes Gustavo Mendonca
- Atnafu Bahru
- Aviles Jimenez Pablo Mijahil
- Awad Selmy
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Azevedo Jose
- Azevedo Jose
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baia Catarina
- Bains Lovenish
- Baiocchi Glauco
- Bajaj Ankur
- Balanta-Melo Julian
- Baliarsing Lipika
- Ball Alasdair
- Ballouhey Quentin
- Bankhead-Kendall Brittany
- Barillas Sabrina
- Barker John
- Barrena Lopez Cristina
- Barros Aldo Vieira
- Basu Somprakas
- Batista Sylvia
- Behzadi Abdollah
- Bekele Kebebe
- Bele Uros
- Bele Uros
- Bella Romera Susana
- Ben Amer Anass
- Ben Jouira Rayet al Islam
- Benson Ruth
- Bergeat Damien
- Bertrand Marta
- Bescos Coro
- Betalleluz Pallardel Jenner
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Biccard Bruce
- Blanco-Colino Ruth
- Boccalatte Luis
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bolivar Saenz Dinimo
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Bouche Pierre-Alban
- Boucher Sophie
- Bouhuwaish Ahmad
- Branquinho Rita
- Brar Amanpreet
- Breen Kerry
- Bright Tim
- Brown Wendy
- Brunaud Laurent
- Brunner Stefan M.
- Buarque Igor
- Buarque Igor Lima
- Bucyibaruta Georges
- Bukhari Syed Imran
- Burgan Dania
- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- Cabanero Sanchez Alberto
- Caiado Andre
- Caicedo Lina
- Caja Vivancos Patricia
- Cal Fernando Bonilla
- Calderon Arancibia Jose Alfredo
- Calvo Espino Pablo
- Canals Sin Ma Pilar
- Canno Velasco Jorge
- Cappeliez Serge
- Cardenas Puiggros Laura
- Cardoso Paulo
- Carlos Bernal-Sprekelsen Juan
- Carpio Colmenares Yahaira Tatiana
- Carrasco Prats Milagros
- Carrera Jacqueline
- Carreras-Castaner Anna
- Caruana Edward
- Castell Gomez Jose Tomas
- Catala Bauset Juan Carlos
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Navneet Kumar
- Chebaro Alexandre
- Chew Min Hoe
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
- Christensen Peter
- Chuan Alwin
- Chwat Carina
- Clancy Cillian
- Colas-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Corella Fernando
- Corripio-Sanchez Ramon
- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cox Daniel
- Creavin Ben
- Crego Vita Diana
- Cretolle Celia
- Cristina Rahy-Martin Aida
- Croghan Stefanie M.
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- D'Aulerio Giuliana
- Dajti Irida
- Daoud Hassan
- Davis Niall
- Dawson Amanda Caroline
- Dawson Brett E.
- De Andres-Asenjo Beatriz
- de Dieu Haragirimana Jean
- De Simone Belinda
- Degefa Eyueal
- Delgado Fernandez Juan
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- des Deserts Marc Danguy
- Desai Anant
- Deus Ana Claudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Diaz Martinez Eneida
- Diaz-Feijoo Berta
- Diego Garcia Lucia
- Diez Alonso Manuel
- Dimofte Mihail-Gabriel
- Dione Sacdalan Marie
- do Amaral Campos Heloisa Galvao
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duprat Neto Joao Pedreira
- Duran Sanchez Iran Irani
- Duran Irani
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Earley Helen
- Eberbach Helge
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Ekenze Sebastian
- Ekiti Ido
- El-Boghdadly Kariem
- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Emile Sameh
- Enjuto Diego
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espinosa-Bravo Martin
- Estaire Gomez Mercedes
- Evans Jonathan
- Evelyn R Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Falcon Pacheco Glenda Marina
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faustin Ntirenganya
- Fernandez Coimbra Felipe Jose
- Fernandez Martin Maria Teresa
- Fernandez Martinez Daniel
- Fernandez-Lopez Antonio-Jose
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Fotopoulou Christina
- Fowler Alexander
- Fredon Fabien
- Freiria Eiras Miguel Angel
- Fuentes Tyare
- Fujimoto Yuki
- Futaba Kaori
- Gahwagi Milad
- Gallo Gaetano
- Ganly Ian
- Garcia De Cortazar Unai
- Garcia Escudero Damian
- Garcia Laura Saura
- Garcia Soria Vanesa
- Garcia-Adamez Jorge
- Garcia-Montoya Oscar-Julian
- Gaujoux Sebastien
- Gavalda Pellice M. Teresa
- Gebreyohanes Mengistu
- Gempt Jens
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gil-Sala Daniel
- Ginghina Octav
- Girard Edouard
- Girard Noemie
- Gjata Arben
- Glasbey James C.
- Glasbey James C.
- Glowka Tim R.
- Gohar Muhammad
- Gomez Fernandez Laura
- Gomez Perez Beatriz
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez-Suarez Susana
- Gourlay Ralph
- Gousias Konstantinos
- Gouvas Nikolaos
- Grama Florin
- Griffiths Ewen
- Gronchi Alessandro
- Groot Gary
- Gross Jefferson
- Gujjuri Rohan R.
- Gulla Aiste
- Gupta Anand
- Gupta Rahul
- Gut Anna Eleonora
- Gutierrez Perdomo Valentina
- Gutierrez Ruiz Alitza
- Ha Jeong
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Haidar Hanan
- Haider Fayza
- Hailu Samuel
- Hailu Samuel
- Hakami Ibrahim
- Hamad Faten Reyad Bani
- Hamdun Intisar Hisham Said
- Hameed B. M. Zeeshan
- Haran Cheyaanthan
- Harper Luke
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Heredia Fernando
- Heriot Alexander
- Hervieux Erik
- Herzberg Jonas
- Hilmi Ahmed
- Hirschburger Markus
- Hodgson Russell
- Hoehn Philipp
- Hollington Paul
- Horch Raymund E.
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Husain Shatha
- Hutchinson Peter
- Hyman Gabriella Yael
- Ikele Hilary
- Imanishimwe Alphonsine
- Incorvia Joseph
- Ingabire Jc Allen
- Ionescu Sebastian
- Isik Arda
- Iskander Othman
- Jain Kavitha
- Jain Ritu
- Jamal Mohammad
- James Harelimana Grace
- Javadpour Mohsen
- Javed Saad
- Jaworska Natalia
- Jayarajah Umesh
- Jeandel Clement
- Jenkinson Michael
- Jimaale Elmi Ahmed Mohamed
- Jimenez Toscano Marta
- Jimenez Raul
- Jimenez Virginia
- Jin-Young Jang
- Jira Moa
- Jlassi Haithem
- Jones Conor S.
- Jonker Pascal
- Jorda Sole Misericordia
- Jose Gonzalez-Gimeno Maria
- Jose Martinez Maria
- Jouffret Lionel
- Julia Bergkvist David
- Kaafarani Haytham
- Kabir Syed Mohammad Umar
- Kache Stephen
- Kacimi Salah Eddine Oussama
- Kaidarova Dilyara
- Kaiser Julia Christina
- Kaman Lileswar
- Kamarajah Sivesh K.
- Kamphues Carsten
- Kandevani Naser Yousefzadeh
- Kannaiyan Lavanya
- Kannan Ravi
- Karout Lina
- Karthigeyan Madhivanan
- Kassir Radwan
- Kauppila Joonas H.
- Kavalaka Alfie
- Keatley James M.
- Kembuan Gabriele
- Keppler Alexander M.
- Keppler Lena
- Kerawala Asad Ali
- Khalifa Houda
- Khamees Almu'atasim
- Khan Tabassum
- Khokhar Muhammad Imran
- Khosravi Mohammad Hossein
- Kieser David
- King Jasmin
- Kirov Mikhail
- Klat Jaroslav
- Knight Stephen Richard
- Kochetkov Viktor
- Koenigsrainer Alfred
- Koh Cherry
- Koh Frederick
- Kolias Angelos
- Komen Niels
- Konate Ibrahima
- Konrads Christian
- Kopetskyi Slava
- Kopjar Tomislav
- Kosir Jurij Ales
- Kowalski Luiz Paulo
- Kpangon Cyrille
- Kronberger E.
- Kronberger Irmgard Elisabeth
- Kroon Hidde M.
- Kruijff Schelto
- Kruijff Schelto
- Kudsk-Iversen Soren
- Kulimbet Mukhtar
- Kulkarni Amruta
- Kumar Aruna
- Kumar Ashwani
- Kuroda Naoto
- Kwan Tsun Yu
- Laban Simon
- Lakkis Zaher
- Landaluce-Olavarria Aitor
- Latif Haider
- Laudani Veronica
- Lawal Taiwo Akeem
- Lawani Ismail
- Lawday Samuel
- Le Bian Alban Zarzavadjian
- Lederhuber Hans
- Lekuya Herve Monka
- Leung Elaine
- Leventoglu Sezai
- Li Elizabeth
- Lidder Surjit
- Lincango-Naranjo Eddy
- Lindert Judith
- Linz Valerie Catherine
- Litvin Andrey
- Litvin Andrey
- Llaquet Bayo Heura
- Loaloa Mohamed Reda
- Loeffler Markus
- Loeffler Markus W.
- Lohsiriwat Varut
- Losada Manuel
- Lott Natalie
- Lou Wenhui
- Lowey Megan
- Lucia Portilla Ana
- Lugo Duarte Carolina
- Lule Herman
- Luna Joaquin
- Mabood Waleed
- Macchiavello Roberto
- MacKenzie Shawn
- Madabhavi Irappa
- Madkhali Tariq
- Mahakalkar Chandrashekhar
- Maimbo Mayaba
- Maji Suvendu
- Majid Haroon Javaid
- Major Piotr
- Makdissi Fabiana
- Makkai-Popa Silviu Tiberiu
- Maldonado-Marcos Eloy
- Maleki Esmaeil Rezghi
- Malik Muhammad Usman
- Manceau Gilles
- Mann Harvinder
- Manuel Morales-Puebla Jose
- Marcal Andre
- Maria Trujillo Lina
- Marquez Lucila
- Marson Ella J.
- Marta Modolo Maria
- Martin Lucchini Sergio
- Martin Sole Oriol
- Martin Janet
- Martin-Laez Ruben
- Martinez Alonso Jesus Aaron
- Martinez Laura
- Marulanda Toro Carlos Andres
- Mas Melendez Robinson
- Mashbari Hassan
- Massoud John George
- Matai Anil
- Mateo-Sierra Olga
- Mayol Julio
- Mazingi Dennis
- McDonnell Brendan
- McGuinness Matthew James
- McIntosh Nick
- McKay Siobhan
- Mclean Kenneth A.
- McNestry Catherine
- Meara John G.
- Meelad Ayman
- Mege Diane
- Megersa Abebe
- Mehraj Asif
- Mejia Dolores
- Melo Miguel Rocha
- Mendes Filipa
- Mendiola Gian
- Mendoza Arango Maria Clara
- Mengesha Mengistu G.
- Mersich Tamas
- Metallidis Symeon
- Migliorelli Federico
- Mihanovic Jakov
- Mihanovic Jakov
- Milan Peiman Brouki
- Mills Emily
- Mimica Ximena
- Minaya Bravo Ana Maria
- Minaya Bravo Ana Maria
- Mironescu Aurel
- Mishra Tushar
- Misra Sanjeev
- Misrai Vincent
- Mittal Rohin
- Mitul Ashrarur Rahman
- Modabber Ali
- Mohammed Alsnosy Abdullah Khalefa
- Mohan Helen
- Mohsen Mustafa Abo
- Mohyieldin Omar
- Molitvin Yegor
- Montenegro Emileth
- Montferrer Estruch Nuria
- Morales Palacios Nelson
- Moreno Suarez Marcelo
- Morsy Amr
- Moss Jana-Lee
- Mostafa Badr
- Motas Natalia
- Moug Susan
- Moya-Angeler Joaquin
- Mozafari Masoud
- Mozel Michelle
- Msherghi Ahmed
- Muheilan Muheilan
- Munoz Vives Josep Maria
- Munyaneza Emmanuel
- Munyika Akutu
- Muralidharan Vijayaragavan
- Muthu Sathish
- Nagar Manoj
- Nakagawa Suely
- Nappi Francesco
- Naseem Muhammad Yasir
- Nashidengo Pueya Rashid
- Nayen Alejandra
- Ncogoza Isaie
- Ndayishyigikiye Marcel Didier
- Ndong Abdourahmane
- Negoi Ionut
- Negoi Ionut
- Negussie Abraham
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nessim Carolyn
- Ng-Kamstra Joshua
- Ngu James
- Niazi Sami Ullah
- Nidaw Melkamu
- Nieto Calvache Albaro Jose
- Nikolaieva Karine
- Niquen-Jimenez Milagros
- Nitschke Christine
- Nkembi Armande Subayi
- Nogueiro Jorge
- Noltes Milou
- Noltes Milou
- Norman Lisa
- Nouh Thamer
- Novysedlak Rene
- Nowak Kai
- Nunez Bernardo
- Nunez Jade
- Nunez Jorge
- Nurgozhin Talgat
- Nwegbu Chukwuemeka
- O'Brien Stephen
- Ofori Bernard
- Ojeda Thies Cristina
- Okereke Chukwuma
- Okunlola Abiodun
- Olaogun Julius
- Olaywah Noor
- Oliveira Joao
- Oliver Guillen Jose Ramon
- Olivos Maricarmen
- Olori Samson
- Omari Rand Y.
- Oosterlinck Wouter
- Ortega Vazquez Irene
- Ortiz Silva Camilo
- Osinaike Babatunde
- Otiniano Alvarado Carlos Eduardo
- Ots Riinu
- Outani Oumaima
- Outani Oumaima
- Pablo Alzate Juan
- Pacilli Maurizio
- Padmore Greg
- Palazon Bellver Pedro
- Pantoja Pachajoa Diana Alejandra
- Panyko Arpad
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Paucar Urbina Arazzelly Del Pilar
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- Zarour Ahmad
- Zarour Ahmad
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- Zhou Xuanyu
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- Zimmelman Natalie
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- Zmora Oded
- Publication venue
- Publication date
- 01/01/2021
- Field of study
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- Author
- Ababneh Hazim
- Abad-Motos Ane
- Abbas Ferial Mohamed Ali
- Abbo Olivier
- Abbott Tom
- Abbott Tom
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdoun Meriem
- Abdur-Rahman Lukman
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala A.
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abuawad Carla
- Abukhalaf Sadi A.
- Abuleil Amro
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agarwal Ketan
- Agastra Ervis
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguilera-Arevalo Maria-Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmadi Navid
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Aiken Taylor
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Islam Ben Jouira Rayet
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Raimi Ibrahim
- Al-Sabbagh Yusra
- Al-Shehari Mohammed
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- AlAmeer Ehab
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Albared Sara Maa
- Albertsmeier Markus
- Albertsmeier Markus
- Alderazi Amer
- Aldlyami Ehab
- Aldressi Wafa
- Alecci Anna
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhassoun Turki
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Allemand Carola
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alnachoukati Omar
- Alnahr Hareth
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Althumairi Azah
- Alvarado Carlos Eduardo Otiniano
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzate Juan Pablo
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Amor María Sol Crespi
- André Benoît
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aouabed Nesrine
- Aqeelah Ahmed
- Aqil Sabra
- Arancibia José Alfredo Calderón
- Arango Maria Clara Mendoza
- Arbane Gill
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Atnafu Bahru
- Aulerio Giuliana D.
- Aurora
- Awad Selmy
- Ayasra Faris
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Ayub Khurram
- Azevedo José
- Azevedo José
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baig Mariam
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- Baiocchi Glauco
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- Bergkvist David Julià
- Bernal-Sprekelsen Juan Carlos
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- Bertrand Marta
- Bescós Coro
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhangu Aneel
- Bhat Dhananjaya
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- Bhende Vishal
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- Bianco Agustín
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- Blanco-Colino Ruth
- Blanco-Colino Ruth
- Blasco Laura Sánchez
- Boccalatte Luis
- Boccalatte Luis
- Boccalatte Luis
- Boira Mar Achalandabaso
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bollano Enton
- Bonci Eduard-Alexandru
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Boretto Jorge G.
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Botero Marcela Velez
- Bouaoud Souad
- Bouche Pierre-Alban
- Bouchenak Kamel
- Boucher Sophie
- Boudou Rocio
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- Brandariz Rodrigo
- Branquinho Rita
- Brar Amanpreet
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- Buarque Igor Lima
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- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- C Ricci
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- Caicedo Lina
- Cal Fernando Bonilla
- Callcut Rachael
- Calvache Albaro José Nieto
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- Calvache Jose Andres
- Calvache Jose Andres
- Calzaretta Laura Gisela Alvarez
- Campana Juan Pablo
- Campos Heloisa Galvão do Amaral
- Capitaine Daniel
- Cappeliez Serge
- Cardoso Paulo
- Carmichael Heather
- Carminatti Tomas
- Carrera Jacqueline
- Carreras-Castañer Anna
- Caruana Edward
- Cereghini Julian
- Cerovac Anis
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chan Matthew
- Chandrasinghe Pramodh
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Daoud
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- Chauhan Govind Singh
- Chebaro Alexandre
- Chew Min Hoe
- Chin Theresa
- Chinyowa Simbarashe
- Chiuyari Jose Rios
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
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- Chwat Carina
- Chwat Carina
- Clancy Cillian
- Coimbra Felipe José Fernandez
- Coleman Julia
- Colmenares Yahaira Tatiana Carpio
- Colás-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Coonar Aman
- Corbett Harriet
- Corella Fernando
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- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cotta Estefanía
- Cox Daniel
- Cox Daniel
- Creavin Ben
- Croattini Roberto Sebastián
- Croghan Stefanie M.
- Crétolle Célia
- Cukier Moises
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- Cunha Miguel F.
- Dajti Irida
- Dajti Irida
- Dajti Irida
- Daoud Hassan
- Das Rishi
- Davies-Jones Gareth
- Davis Niall
- Dawson Amanda Caroline
- Dawson Amanda Caroline
- Dawson Brett E.
- Dbeis Rachel
- De Andrés-Asenjo Beatriz
- De Cortazar Unai Garcia
- de Dieu Haragirimana Jean
- de León Laura Román García
- De Simone Belinda
- Dean Benjamin
- Degefa Eyueal
- Del Pilar Paucar Urbina Arazzelly
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- Desai Anant
- Deus Ana Cláudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Di Vincenzo Marcela
- Diaz-Couselo Fernando
- Diehl Thomas
- Dimofte Mihail-Gabriel
- DiNome Maggie
- Djahida Bahraoui
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Frederick
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Duarte Carolina Lugo
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duran Irani
- Duric Natalie
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Déserts Marc Danguy des
- Díaz-Feijoo Berta
- Earley Helen
- Eberbach Helge
- Edwards John
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Eiras Miguel Angel Freiria
- Ekenze Sebastian
- El Helw Amin
- El Kafsi Jihène
- El-Boghdadly Kariem
- El-Boghdadly Kariem
- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Elwahab Sami Abd
- Emerson Hannah
- Emile Sameh
- Emile Sameh
- Enjuto Diego
- Escartin Jorge
- Escudero Damián García
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espino Pablo Calvo
- Espinosa-Bravo Martin
- Esquivel Carlos
- Estruch Nuria Montferrer
- Etchill Eric
- Evans Jonathan
- Evelyn Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Fakhradiyev Ildar
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faulkner Gemma
- Faustin Ntirenganya
- Fernandez Juan Delgado
- Fernandez Laura Gomez
- Fernandez Maria Sol
- Fernández Fátima Sánchez
- Fernández-López Antonio-José
- Ferrer Antonio Perez
- Ferry Jenny
- Figari Marcelo
- Figueroa Rodrigo
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Forneris Agustin Albani
- Fotopoulou Christina
- Fowler Alexander
- Fraidenraij Uriel
- Fredon Fabien
- Fuentes Marta Alcaraz
- Fuentes Tyare
- Fujimoto Yuki
- Futaba Kaori
- Gagnier Joel
- Gahwagi Milad
- Gallegos Diego
- Gallino Esteban Sebastian
- Gallo Gaetano
- Ganly Ian
- Garcia Manuel
- Garcia-Adamez Jorge
- García Lucia Diego
- García Pablo Martín
- García-Mansilla Agustín Maria
- García-Montoya Oscar-Julián
- Gaujoux Sebastien
- Gauna Guillermo Hernandez
- Gempt Jens
- Georgiades Fanourios
- Gerchunoff José Ignacio
- Ghani Muhammad Owais Abdul
- Ghazal Ahmad
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gialamas Eleftherios
- Gigena Cecilia
- Gil-Sala Daniel
- Ginghina Octav
- Giorgakis Emmanouil
- Girard Edouard
- Girard Noémie
- Gishanthan Shanthamoorthy
- Gjata Arben
- Gjyli Kostandin
- Glasbey James C.
- Glasbey James C.
- Glass Nina
- Glowka Tim R.
- Gohar Muhammad
- Golet Marta Roldón
- Gomes Gustavo Mendonça Ataíde
- Gomez Jose Tomas Castell
- Gomez-Fernandez Hugo
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- Gonzalez Diana Samantha
- Gonzalez Marcos
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- Goransky Jeremias
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- Gourlay Ralph
- Gousias Konstantinos
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- Greenhalgh Michael
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- Gujjuri Rohan R.
- Gujjuri Rohan R.
- Gulla Aiste
- Gunawansa Nalaka
- Gupta Anand
- Gupta Rahul
- Gurumeta Alfredo Abad
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- Gómez Mercedes Estaire
- Ha Jeong
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- Hailu Samuel
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- Hamdun Intisar Hisham Said
- Hameed Zeeshan
- Hammed Ali
- Hammond John
- Haran Cheyaanthan
- Hardie John
- Harper Luke
- Harrison Ewen M.
- Harrison Ewen M.
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- Hassan Ramy A.
- Hecker Andreas
- Henein Christin
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- Höhn Philipp
- Iascano Fernando Martinez
- Ikele Hilary
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- Incorvia Joseph
- Incorvia Joseph
- Infante Antonio Rodriguez
- Ingabire Jc Allen
- Ionescu Sebastian
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- Isik Arda
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- Jain Kavitha
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- Jauregui Esteban Gabriel
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- Jimenez Raul
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- Jiménez Pablo Mijahil Avilés
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- Jisry Ghassan
- Jlassi Haithem
- Johnson David
- Jones Conor S.
- Jonker Pascal
- Jouffret Lionel
- Júnior Samuel Aguiar
- Kaafarani Haytham
- Kaafarani Haytham
- Kaafarani Haytham
- Kabir Syed Mohammad Umar
- Kabweru Wilberforce M.
- Kache Stephen
- Kacimi Salah Eddine Oussama
- Kaidarova Dilyara
- Kaiser Julia Christina
- Kakeeto Andrew
- Kaman Lileswar
- Kamarajah Sivesh K.
- Kamarajah Sivesh K.
- Kamphues Carsten
- Kandevani Naser Yousefzadeh
- Kannan Ravi
- Karout Lina
- Karthigeyan Madhivanan
- Kassir Radwan
- Kauppila Joonas H.
- Kauppila Joonas H.
- Kaups-Fresno Krista
- Kavalakat Alfie
- Keatley James M.
- Kembuan Gabriele
- Keppler Alexander M.
- Keppler Lena
- Kerawala Asad Ali
- Kerawala Cyrus
- Kerpaci Jola
- Khadidja Kouidri
- Khalifa Houda
- Khalil Kareem S.
- Khamees Almu'atasim
- Khan Tabassum
- Khatri Chetan
- Kherani Safeena
- Khokhar Muhammad Imran
- Khosravi Mohammad
- Khosravi Mohammad Hossein
- Kieser David
- King Jasmin
- Kirov Mikhail
- Kiweewa Ronald
- Klat Jaroslav
- Knight Stephen Richard
- Kochetkov Viktor
- Koh Cherry
- Koh Frederick
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- Steinkamp Pieter
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- Trout Isobel M.
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- Usang Usang
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- Vagni Roberto
- Vaishnav Dhaivat
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- Vallve-Bernal Marc
- van Ramshorst Gabrielle
- van Ramshorst Gabrielle
- Vargas Lara
- Varghese Chris
- Varghese Chris
- Varghese Chris
- Varghese Chris
- Vartanian Jose Guilherme
- Vaughan-Shaw Peter
- Vayoth Sudheer Othiyil
- Vaysburg Dennis
- Vaysse Charlotte
- Velasco Jorge Caño
- Velasquez Enrique Jose Ruiz
- Venkatappa Sunil Kumar
- Venn Mary L.
- Verhaeghe Romain
- Verhaeghe Romain
- Vidal Rafael Perez
- Vidya Raghavan
- Vijayakumar Vijayakumar M.
- Villanueva Julio
- Vimalakanthan Thanusan
- Vita Diana Crego
- Vivancos Patricia Caja
- Viveiros Octavio
- Vives Inmaculada
- Vives Josep Maria Muñoz
- Vo Uyen Giao
- von Pusch Silke
- Vrapi Enxhi
- Vázquez Irene Ortega
- Wafi Omar
- Wagner Arthur
- Waissbluth Sofia
- Waqar Shahzad Hussain
- Watson David
- Watson Eleanor
- Watters David
- Weeraddana Prabuth Dulanjan
- Wells Cameron
- Welter Stefan
- Wettstein Dániel
- Wickramasinghe Dakshitha
- Wickramasinghe Dakshitha
- Wiegering Armin
- Wijeysundera Duminda
- Williams Emmanuel
- Williams Omolara
- Williams Omolara
- Wilson Michael
- Wolf Sebastian
- Wolfer Susanne
- Wong Enoch
- Wright Deborah
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Wuraola Funmilola
- Xaviour Okedi Francis
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Yip Sebastian Shu
- Youssef Mina
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zanoni Gerardo
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarnescu Narcis Octavian
- Zarour Ahmad
- Zarour Ahmad
- Zarour Ahmad
- Zarratea Celeste Soledad
- Zegarra Sergio
- Zequi Stenio C.
- Zezular Damaris Idara Anabel
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zijaj Lorena
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Zohra Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
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- Abbasciano Isabella
- Abrantes Catarina
- Accarino Simone
- Adler Sharon
- Adoberg Annika
- Afsari Rouzbeh
- Ahmad Syeda
- Ahmed Jafar
- Ahn Wooin
- Ajayi Bamidele
- Aksamit Dariusz
- Al Chalabi Saif
- Alamartine Eric
- Alchi Bassam
- Ali Mohammad
- Aliotta Roberta
- Almaani Salem
- Almeida Catarina
- Almeida Edgar
- Alpers Charles E
- Alvarez Francisco de la Prada
- Alves Patricia
- Annese Francesca
- Appel Gerald
- Arduan Alberto Ortiz
- Arena Maria
- Arevalo Marta Calvo
- Arfaania Dariush
- Arias Carlos
- Aristoy Emma Calatayud
- Asakiene Egle
- Ashley Sarah
- Assefi Ali
- Atenza Alba
- Auerbach Asta
- Augustyniak-Bartosik Hanna
- Avella Monroy
- Ayling-Smith Jonathan
- Ayoub Isabelle
- Ayvazyan Christine
- Baccaro Rocco
- Bailey Asha
- Baker Bruce
- Balamuthusamy Saravanan
- Ballarin Jose
- Barata Rui
- Barbic Jerko
- Barisic Dunja
- Barratt Jonathan
- Barreto Jose Carlos de Jesus
- Barrios Clara
- Belingheri Mirco
- Benesova Anna
- Bernabeu Ana Avila
- Bernhardt Wanja
- Bhadra Shamik
- Biancone Luigi
- Bieler Stewart
- Blanchard Anne
- Boaglio Elena
- Bolignano Davide
- Bomback Andrew
- Bonilla Gustavo Andres Useche
- Bordoli Monica
- Bose Bhadran
- Boudville Neil
- Brandon Donald
- Brown Karen
- Broyet Christian
- Bucknall Thomas
- Buffet Alexandre
- Bumblyte' Inga Arune
- Burdese Manuel
- Burgos Natalia Allende
- Burguet Laure
- Burtey Stephane
- Busch Martin
- Cakiroglu Figen
- Campbell Victoria
- Canetta Pietro
- Capaccio Flavia
- Carbonell Juan
- Cardoso Filipa
- Carro Clara Garcia
- Carroll Robert
- Carron Pierre-Louis
- Carullo Nazareno
- Cassia Matthias
- Caster Dawn
- Castillo Belen Vizcaino
- Catucci Davide
- Cavalli Andrea
- Chae Dong-Wan
- Chakera Aron
- Chan Anthony Ting Pong
- Chan Doris
- Chan Gary Chi Wang
- Chan Lai Wan
- Chang Jae Hyun
- Chang Ming-Shan
- Chapman Fiona
- Charytan Chaim
- Chaudhry Asghar
- Cheetham Melissa
- Chen Cheng-Hsu
- Chen Chien-Liang
- Chen Hsin-Yu
- Chen Hung-Chun
- Chen Hung-Yuan
- Chenine Leila
- Cheung Chee Kay
- Cheung Siu Fai
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- Chiu Ian
- Chiu Yen-Ling
- Chiu Yi-Wen
- Choi Hoon Young
- Chou Kang-Ju
- Chowdhury Paramit
- Chowdhury Pradip
- Chrysochou Constantina
- Chukwu Chukwuma
- Chun Ka Yeong
- Chung Wookyung
- Cieniawski Dominik
- Claisse Guillaume
- Clayton Philip
- Cleary Catalina Martín
- Clement Nisha
- Coates Toby
- Cogno Chiara
- Colla Loredana
- Collins Michael
- Colucci Marco
- Combe Christian
- Comi Nicolino
- Comunale Roderick
- Contreras Gabriel
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- Cunha Liliana
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- Delmas Yahsou
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- Dhelaria Ranjit
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- Dinic Miriana
- Dittmer Ian
- Diva Ulysses A
- Dobre Mirela
- Doctor Gabriel
- Donati Gabriele
- Doubel Peter
- Douthit Nicole
- Draganova Diliana
- Drexler Yelena
- Drinkovic Martin
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- Tumlin James A
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- Winiarska Agata
- Wirtz Nikolaus
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- Wolf Lothar
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- Wong Sze Ho Sunny
- Wong Yick Hei
- Workeneh Biruh
- Wu Hon-Yen
- Wu Ming-Ju
- Wyndham Roger
- Yang Jihyun
- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
- Bassam Alchi
- Belen Vizcaino Castillo
- Bernd Hohenstein
- Bert Vandewiele
- Bertrand Dussol
- Bhadran Bose
- Bhavna Pandya
- Biruh Workeneh
- Bogna Kwella
- Bojan Jelakovic
- Brad Rovin
- Bradley Nelson
- Brendon Neuen
- Brian Snow
- Britt Newsome
- Brittany Sheridan
- Bruce Baker
- Bruce Cooper
- Bruce Julian
- Bruce Spinowitz
- Camille Lanaret
- Caridad Martinez Villanueva
- Carlos Arias
- Carlos Gonzalez
- Carlotta Federica Zizzi
- Carmelita Marcantoni
- Carmen Sivo
- Carol Pollock
- Carole Philipponnet
- Caroline Dudreuilh
- Cassandra Kimber
- Catalina Martín Cleary
- Catarina Abrantes
- Catarina Almeida
- Catarina Teixeira
- Caterina Vita
- Catherine Janko
- Catherine Masset
- Cathylee Sly
- Celine Foote
- Chaim Charytan
- Chee Kay Cheung
- Chen Peh
- Cheng-Hsu Chen
- Cheuk Chun Szeto
- Chi Kwan Darwin Lam
- Chi-Chih Hung
- Chia-Tien Hsu
- Chiara Cogno
- Chien-Liang Chen
- Chien-Wei Huang
- Chih-Hsien Wang
- Chih-Yang Hsu
- Chii Yeap
- Christian Broyet
- Christian Combe
- Christiane Kettner
- Christine Ayvazyan
- Christophe Mariat
- Christopher Goldsmith
- Christopher Keller
- Chukwuma Chukwu
- Ciro Esposito
- Claire Rigothier
- Clara Barrios
- Clara Garcia Carro
- Clara Pardinhas
- Clarisse Greze
- Clement Dumond
- Clementine Nicolo
- Colin Geddes
- Constantina Chrysochou
- Cristina Medrano Villarroya
- Cyril Garrouste
- Damien Thibaudin
- Dan Pugh
- Dana Kim
- Dana Rizk
- Daniela Lopes
- Dariush Arfaania
- Dariusz Aksamit
- David Fouassier
- David Packham
- David Semple
- Davide Bolignano
- Davide Catucci
- Davina Ngoi Wah Lie
- Daw-Yang Hwang
- Dawn Caster
- Didem Tez
- Diliana Draganova
- Dimitrios Moutzouris
- Dita Maixnerova
- Djuro Plavljanic
- Dominik Cieniawski
- Donald Brandon
- Donald Brandon
- Dong Wan Chae
- Doris Chan
- Dorota Zielinska
- Drasko Pavlovic
- Dubravka Trajbar Kentric
- Dunja Barisic
- Dunja Vujcic
- Durga Kanigicherla
- Eamon Mahdi
- Eddie Tan
- Edgar Almeida
- Eduardo Gutierrez Martinez
- Eduardo Parra Moncasi
- Eduardo Verde Moreno
- Egle Asakiene
- Elaine Phua
- Elder Mendoza
- Elena Boaglio
- Elena Goma
- Elena Gutierrez Solis
- Eleni Stamellou
- Elizabeth Curry
- Elizabeth Hendren
- Elizabeth Stallworthy
- Ellen McCarthy
- Elsa Sofia Quadrado Soares
- Elviira Seppet
- Elzbieta Felicjanczuk
- Emily McQuarrie
- Emma Calatayud Aristoy
- Emma Diletta Stea
- Emma O'Lone
- Eric Alamartine
- Eric Firre
- Eric Koester
- Eric Thervet
- Erica Daina
- Erika Perez
- Esther Tamarit
- Eswari Vilayur
- Euan Noble
- Euan Noble
- Eva Rodriguez Garcia
- Evangelina Merida Herrero
- Ewa Satora
- Fabiola Alonso Garcia
- Fahameedah Kamal
- Faisal Fakih
- Faisal Fakih
- Farah Latif
- Farid Ghalli
- Federica Di Maio
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- Fernando Eduardo Barbosa Nolasco
- Fernando Nolasco
- Figen Cakiroglu
- Filipa Cardoso
- Fiona Chapman
- Flavia Capaccio
- Francesca Annese
- Francesca Deodato
- Francesco Giaroni
- Francisco de la Prada Alvarez
- Franziska Sarnow
- Gabriel Contreras
- Gabriel Doctor
- Gabriele Donati
- Gaia Coppock
- Gary Chi Wang Chan
- Gemma Patella
- Georg Schlieper
- Georgina Irish
- Gerald Appel
- Gerald Waters
- Gert Meeus
- Giuseppe Remuzzi
- Grant Luxton
- Guillaume Claisse
- Guillaume Jeantet
- Gunjan Garg
- Gunter Wolf
- Gustavo Andres Useche Bonilla
- Hajeong Lee
- Han Ro
- Hanna Augustyniak-Bartosik
- Hans Schmidt-Guertler
- Haresh Selvaskandan
- Harold Giles
- Heather Green
- Helen Pilmore
- Helena Marco Rusinol
- Helena Sousa
- Helena Sá
- Helmut Reichel
- Hernán Trimarchi MD b l
- Hesham Mohey
- Hon Tang
- Hon-Yen Wu
- Hoon Young Choi
- Howard Lifland
- Hsien-Fu Chiu
- Hsin-Yu Chen
- Hua-Chang Fang
- Hung-Chun Chen
- Hung-Tien Kuo
- Hung-Yuan Chen
- Hye Ryoun Jang
- Hyeong Cheon Park
- Hyung Wook Kim
- Hyung-seok Lee
- HyunHee Lee
- Ian Chiu
- Ian Dittmer
- Ian Fraser
- Iara Da Silva Santos
- Indranil Dasgupta
- Inga Arune Bumblyte'
- Ingrid Masson
- Ingrid Prkacin
- Irene Agraz Pamplona
- Irina Suyumova
- Isabella Abbasciano
- Isabelle Ayoub
- Ivan Durlen
- Ivan Kruljac
- Ivan Rychlik
- Ivana Mikacic
- Ivica Horvatic
- Ivon Maritza Bobadilla Rico
- Ivon Maritza Bobadilla Rico
- Jae Hyun Chang
- Jafar Ahmed
- Jai Radhakrishnan
- James Sullivan
- James Tumlin
- Jana Uhlinova
- Jane Waugh
- Jane Waugh
- Janson Leung
- Javad Mojarrab
- Jean-Emmanuel Serre
- Jeffrey Glaze
- Jeffrey Tsun Kit Ha
- Jer-Chia Tsai
- Jerko Barbic
- Jerry Meng
- Ji Yong Jung
- Jigar Kadakia
- Jihyun Yang
- Joana de Sousa Soares Felgueiras
- Joana Gameiro
- Joana Marques
- Johann Konstantin Herfurth
- Jonathan Ayling-Smith
- Jonathan Barratt
- Jonathan Erlich
- Jonathan Hogan
- Jonay Pantoja Perez
- Jong Cheol Jeong
- Jorge Enrique Monroy Avella
- Jose Antonio Lopes
- Jose Ballarin
- Jose Carlos de Jesus Barreto
- Jose Luño Fernandez
- Jose Nuno de Almeida Agapito Fonseca
- Josep Miquel Blasco Pelicano
- Joshua Storrar
- João Carlos Fernandes
- Ju-Yeh Yang
- Juan Carbonell
- Jula Inrig MD f
- Julia Piel
- Julita Gontarek-Kacprzak
- Jung Tak Park
- JungEun Lee
- Junseok Jeon
- Jurgen Floege
- Jusmin Patel
- Justyna Zbrzezniak
- Jwa-Kyung Kim
- Ka Fai Yim
- Ka Shun Samuel Fung
- Ka Yeong Chun
- Kadri Lilienthal
- Kadri Telling
- Kai-Hsiang Shu
- Kang-Ju Chou
- Kannaiyan Rabindranath
- Karen Brown
- Karen Wilder
- Karolina Kratka
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- Kassem Khalil
- Kathryn Klamm
- Kay Kyaw
- Kellyn McMahon
- Kenneth Yong
- Kerri McGreal
- Kevin Schulte
- Kieran McCafferty
- Kit Chung Jack Ng
- Klara Drinovska
- Kook-Hwan Oh
- Kristi Veermae
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Aaron Fearday (17386231)
- Abdallah Geara (17386297)
- Adam Morris (2043517)
- Adriana Fernandes (8856416)
- Adriana Sierra Ochoa (17386699)
- Aejin Kim (2175798)
- Agata Winiarska (17387086)
- Aine Maire De Bhailis (17386168)
- Ajay Dhaygude (10682946)
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- Zvonimir Sitas (17386936)
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.
Findings
Between Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.
Interpretation
Over 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function.</p
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
- Ashur-Fabian Osnat
- Atanasov Atanas G
- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H
- Baek Ahruem
- Baek Seung-Hoon
- Baek Sung Hee
- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xiyuan
- Bai Yidong
- Bairagi Nandadulal
- Baksi Shounak
- Balazadeh Salma
- Balbi Teresa
- Baldari Cosima T
- Balduini Walter
- Ballabio Andrea
- Ballester Maria
- Balzan Rena
- Bandopadhyay Rina
- Banerjee Sreeparna
- Banerjee Sulagna
- Bao Yan
- Baptista Mauricio S
- Baracca Alessandra
- Barbati Cristiana
- Bargiela Ariadna
- Barila Daniela
- Barlow Peter G
- Barmada Sami J
- Barreiro Esther
- Barrera Miguel Calvo-Rubio
- Barreto George E
- Bartek Jiri
- Bartel Bonnie
- Bartolome Alberto
- Barve Gaurav R
- Basagoudanavar Suresh H
- Bassham Diane C
- Basu Alakananda
- Batoko Henri
- Batten Isabella
- Baulieu Etienne E
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- Bayry Jagadeesh
- Beale Rupert
- Beau Isabelle
- Beaumatin Florian
- Bechara Luiz RG
- Beck George R Jr
- Beers Michael F
- Begun Jakob
- Behl Christian
- Behrends Christian
- Behrens Georg MN
- Bei Roberto
- Bejarano Eloy
- Bel Shai
- Belaid Amine
- Belgareh-Touze Naima
- Bellarosa Cristina
- Belleudi Francesca
- Bello Perez Melissa
- Bello-Morales Raquel
- Beltran Sebastian
- Benbrook Doris Mangiaracina
- Bendorius Mykolas
- Benitez Bruno A
- Benito-Cuesta Irene
- Bensalem Julien
- Berchtold Martin W
- Berezowska Sabina
- Bergamaschi Daniele
- Bergami Matteo
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- Bernard Amelie
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- Beyaert Rudi
- Bezbradica Jelena S
- Bharath MM Srinivas
- Bhaskar Kiran
- Bhatia-Kissova Ingrid
- Bhattacharya Resham
- Bhattacharya Sujoy
- Bhattacharyya Shalmoli
- Bhuiyan Md Shenuarin
- Bhutia Sujit Kumar
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- Binart Nadine
- Bincoletto Claudia
- Birgisdottir Asa B
- Bjorkoy Geir
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- Blas-Garcia Ana
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- Blum Janice S
- Boada-Romero Emilio
- Boban Mirta
- BoeszeBattaglia Kathleen
- Boeuf Philippe
- Boland Barry
- Bomont Pascale
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- Bootman Martin D
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- Bourdenx Mathieu
- Bourgeois Benjamin
- Bourke Nollaig M
- Bousquet Guilhem
- Boya Patricia
- Bozhkov Peter V
- Bozi Luiz HM
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- Bringer Marie-Agnes
- Briones-Herrera Alfredo
- Broaddus V Courtney
- Brodersen Peter
- Brodsky Jeffrey L
- Brody Steven L
- Bronson Paola G
- Bronstein Jeff M
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- Brown Rhoderick E
- Brum Patricia C
- Brumell John H
- Brunetti-Pierri Nicola
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- Bucci Cecilia
- Buch Shilpa
- Buchan J Ross
- Buchrieser Carmen
- Buckingham Erin M
- Budak Hikmet
- Budini Mauricio
- Bueno Marta
- Buitrago-Molina Laura Elisa
- Bultynck Geert
- Burada Florin
- Buraschi Simone
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- Buron M Isabel
- Bustos Victor
- Buttner Sabrina
- Butturini Elena
- Byrd Aaron
- Cabas Isabel
- Cabrera-Benitez Sandra
- Cadwell Ken
- Cai Jingjing
- Cai Lu
- Cai Qian
- Cairo Montserrat
- Calbet Jose A
- Caldwell Guy A
- Caldwell Kim A
- Call Jarrod A
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- Camougrand Nadine
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- Sue Carolyn M
- Sui Xinbing
- Summers Corey
- Sun Guangchao
- Sun Jun
- Sun Kang
- Sun Meng-xiang
- Sun Qiming
- Sun Yi
- Sun Zhongjie
- Sunahara Karen KS
- Sundberg Eva
- Susztak Katalin
- Sutovsky Peter
- Suzuki Hidekazu
- Sweeney Gary
- Symons J David
- Sze Stephen Cho Wing
- Szewczyk Nathaniel J
- Tabolacci Claudio
- Tacke Frank
- Taegtmeyer Heinrich
- Tafani Marco
- Tagaya Mitsuo
- Tai Haoran
- Tait Stephen WG
- Takahashi Yoshinori
- Takats Szabolcs
- Talwar Priti
- Tam Chit
- Tam Shing Yau
- Tampellini Davide
- Tamura Atsushi
- Tan Chong Teik
- Tan Eng-King
- Tan Ya-Qin
- Tanaka Masaki
- Tanaka Motomasa
- Tang Daolin
- Tang Jingfeng
- Tang Tie-Shan
- Tanida Isei
- Tao Zhipeng
- Taouis Mohammed
- Tatenhorst Lars
- Tavernarakis Nektarios
- Taylor Allen
- Taylor Gregory A
- Taylor Joan M
- Tchetina Elena
- Tee Andrew R
- Tegeder Irmgard
- Teis David
- Teixeira Natercia
- Teixeira-Clerc Fatima
- Tekirdag Kumsal A
- Tencomnao Tewin
- Tenreiro Sandra
- Tepikin Alexei V
- Testillano Pilar S
- Tettamanti Gianluca
- Tharaux PierreLouis
- Thedieck Kathrin
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- Thirumalaikumar VP
- Thomas Sufi Mary
- Thomes Paul G
- Thorburn Andrew
- Thukral Lipi
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- Thumm Michael
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- Titorenko Vladimir I
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- Tomas-Zapico Cristina
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- Torgersen Maria L
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- Torres-Lopez Liliana
- Torriglia Alicia
- Towers Christina G
- Towns Roberto
- Toyokuni Shinya
- Trajkovic Vladimir
- Tramontano Donatella
- Tran QuynhGiao
- Travassos Leonardo H
- Trelford Charles B
- Tremel Shirley
- Trougakos Ioannis P
- Tsao Betty P
- Tschan Mario P
- Tse Hung-Fat
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- Tsugawa Hitoshi
- Tsvetkov Andrey S
- Tumbarello David A
- Tumtas Yasin
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- Turcotte Sandra
- Turk Boris
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- Tyutereva Elena V
- Uchiyama Yasuo
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- Uhlig Holm H
- Ulasov Ilya V
- Umekawa Midori
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- Unno Rei
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- Uribe-Carretero Elisabet
- Ustun Suayib
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- Vaccari Thomas
- Vaccaro Maria I
- Vahsen Bjorn F
- Vakifahmetoglu-Norberg Helin
- Valdor Rut
- Valente Maria J
- Valko Ayelen
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- Valverde Angela M
- Van den Berghe Greet
- van Der Veen Stijn
- Van Kaer Luc
- van Loosdregt Jorg
- van Wijk Sjoerd JL
- Vandenberghe Wim
- Vanhorebeek Ilse
- Vannier-Santos Marcos A
- Vannini Nicola
- Vanrell M Cristina
- Vantaggiato Chiara
- Varano Gabriele
- Varela-Nieto Isabel
- Varga Mate
- Vasconcelos M Helena
- Vats Somya
- Vavvas Demetrios G
- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
- Velazquez Ariadna P
- Vellai Tibor
- Vellenga Edo
- Velotti Francesca
- Verdier Mireille
- Verginis Panayotis
- Vergne Isabelle
- Verkade Paul
- Verma Manish
- Verstreken Patrik
- Vervliet Tim
- Vervoorts Jorg
- Vessoni Alexandre T
- Victor Victor M
- Vidal Michel
- Vidoni Chiara
- Vieira Otilia V
- Vierstra Richard D
- Vigano Sonia
- Vihinen Helena
- Vijayan Vinoy
- Vila Miquel
- Vilar Marcal
- Villalba Jose M
- Villalobo Antonio
- Villarejo-Zori Beatriz
- Villarroya Francesc
- Villarroya Joan
- Vincent Olivier
- Vindis Cecile
- Viret Christophe
- Viscomi Maria Teresa
- Visnjic Dora
- Vitale Ilio
- Vocadlo David J
- Voitsekhovskaja Olga V
- Volonte Cinzia
- Volta Mattia
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- Wang Bo
- Wang Chao-Yung
- Wang Chen
- Wang Chenran
- Wang Chenwei
- Wang Cun-Yu
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- Wang Feng
- Wang Fengming
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- Wang Han
- Wang Hao
- Wang Hexiang
- Wang Hong-Gang
- Wang Jianrong
- Wang Jigang
- Wang Jiou
- Wang Jundong
- Wang Kui
- Wang Lianrong
- Wang Liming
- Wang Maggie Haitian
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- Wang Peipei
- Wang Pengwei
- Wang Ping
- Wang Ping
- Wang Qing
- Wang Qing Jun
- Wang Qing Kenneth
- Wang Qiong A
- Wang Wen-Tao
- Wang Wuyang
- Wang Xinnan
- Wang Xuejun
- Wang Yan
- Wang Yanchang
- Wang Yanzhuang
- Wang YenYun
- Wang Yihua
- Wang Yipeng
- Wang Yu
- Wang Yuqi
- Wang Zhe
- Wang Zhenyu
- Wang Zhouguang
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- Warnsmann Verena
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- Watanabe Eizo
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- Wu Jian
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- Wu Shan-Ying
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- Wu Xiaohong
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- Xia Hongguang
- Xia Lixin
- Xia Zhengyuan
- Xiang Ge
- Xiang Jin
- Xiang Mingliang
- Xiang Wei
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- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
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- Yu Seong-Woon
- Yu Victor C
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- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field