Oficio artesano: la elaboración de la pasa

En número dedicado a: La provincia de Alicant

Diseño de la imagen corporativa y las aplicaciones de la empresa Representaciones Erickza S.A.

Se ha creado la imagen corporativa de la empresa Representaciones Erickza S.A, situada en Ecuador y dedicada a la importación y exportación de productos. A su vez, también se ha diseñado todas las aplicaciones donde aparecerá el nuevo logotipo empresarial (productos de papelería, vehículos, obsequios para los clientes, uniformes de trabajo, folletos informativos, página web...

Glucagon regulation of oxidative phosphorylation requires an increase in matrixadenine nucleotide content through Ca2+-activation of the mitochondrial ATPMg/Pi carrier SCaMC-3

13 p.-6 fig.-1 tab.It has been known for a long time that mitochondria isolated from hepatocytes treated with glucagon or Ca(2+)-mobilizing agents such as phenylephrine show an increase in their adenine nucleotide (AdN) content, respiratory activity, and calcium retention capacity (CRC). Here, we have studied the role of SCaMC-3/slc25a23, the mitochondrial ATP-Mg/Pi carrier present in adult mouse liver, in the control of mitochondrial AdN levels and respiration in response to Ca(2+) signals as a candidate target of glucagon actions. With the use of SCaMC-3 knock-out (KO) mice, we have found that the carrier is responsible for the accumulation of AdNs in liver mitochondria in a strictly Ca(2+)-dependent way with an S0.5 for Ca(2+) activation of 3.3 ± 0.9 μm. Accumulation of matrix AdNs allows a SCaMC-3-dependent increase in CRC. In addition, SCaMC-3-dependent accumulation of AdNs is required to acquire a fully active state 3 respiration in AdN-depleted liver mitochondria, although further accumulation of AdNs is not followed by increases in respiration. Moreover, glucagon addition to isolated hepatocytes increases oligomycin-sensitive oxygen consumption and maximal respiratory rates in cells derived from wild type, but not SCaMC-3-KO mice and glucagon administration in vivo results in an increase in AdN content, state 3 respiration and CRC in liver mitochondria in wild type but not in SCaMC-3-KO mice. These results show that SCaMC-3 is required for the increase in oxidative phosphorylation observed in liver mitochondria in response to glucagon and Ca(2+)-mobilizing agents, possibly by allowing a Ca(2+)-dependent accumulation of mitochondrial AdNs and matrix Ca(2+), events permissive for other glucagon actions.This work was supported in part by Ministerio de Educación y Ciencia Grants BFU2008-04084/BMC and BFU2011-30456, European Union Grant LSHMCT- 2006-518153, and CIBERER Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (an initiative of the ISCIII Instituto de SaludCarlos III) (to J. S.), Comunidad de Madrid Grants S-GEN-0269-2006 and S2010/BMD-2402 MITOLAB-CM (to J. S., E. R., and A. S.), by ISCIII Grant PI080610 (to A. delA), and an institutional grant from the Fundación Ramon Areces to the Centro de Biología Molecular Severo Ochoa.Peer reviewe

Effects of Myofascial Induction Therapy on Ankle Range of Motion and Pressure Pain Threshold in Trigger Points of the Gastrocnemius—A Clinical Trial

[Abstract] Background: The myofascial induction technique (MIT) has been shown to increase shoulder range of motion (ROM) in breast cancer survivors and decrease pain pressure threshold over the radial nerve in patients with epicondylalgia. To the authors’ best knowledge, no study on trigger points and MIT has been published to date. The effect on ROM of latent trigger points is also unknown. Methods: A total of 20 twins with one latent trigger point of the gastrocnemius muscle were evaluated pre- and post-MIT in the calf. We measured static footprint variables in a pre–post study. Results: We found differences in PPT (p = 0.001) and no differences in ROM with knee flexed (p = 0.420) or stretched (p = 0.069). Conclusions: After Calf MIT, latent myofascial trigger points improve PPT but no change in ankle dorsiflexion with knee bent or knee flexed were found in non-restriction healthy subjects

Curriculum de Ciencias de la Computación en Canarias

En 2016, se puso en marcha el Aula Cultural de Pensamiento Computacional de la Universidad de La Laguna para dar respuesta social a la confusión que surge al integrar las Tecnologías de la Información y las Comunicaciones en la educación. Es importante distinguir entre los términos “Alfabetización Digital”, “Pensamiento Computacional” y “Ciencias de la Computación”. Las habilidades digitales se centran en el uso de la tecnología, mientras que el Pensamiento Computacional implica comprender los fundamentos de las Ciencias de la Computación. Esta materia disuade especialmente a las mujeres de perseguir carreras tecnológicas. En 2021 se puso en marcha el “Proyecto C**4: Curriculum de Ciencias de la Computación en Canarias” para promover las Ciencias de la Computación en los estudios preuniversitarios a través del Pensamiento Computacional. El proyecto, en desarrollo hasta 2024, cuenta con dos acciones: un diagnóstico del sistema educativo en Canarias sobre recursos, formación docente y percepción de los estudiantes; y una hoja de ruta que analice cómo la recién aprobada reforma educativa se adapta a esta realidad. También busca impulsar el conocimiento y la participación de la minoría, abordando las barreras existentes y mejorando la educación en Ciencias de la Computación

Análisis de costos del control prenatal y atención obstétrica en mujeres embarazadas con peso normal y obesidad

El sobrepeso y la obesidad han ido en aumento en todo el mundo durante los últimos 30 años, convirtiéndose en un problema de salud pública y de interés para los dirigentes en este sector. La obesidad materna se define por exceso de tejido adiposo, definida por un índice de masa corporal (IMC) mayor o igual a 30 kg/m, es la comorbilidad más frecuente durante del embarazo y se asocia con un aumento del riesgo de morbilidad y mortalidad materna. En países como México más de 50% de la población adulta tiene sobrepeso u obesidad. La prevalencia de obesidad abdominal en México es 74.0%, mayor en mujeres (82.8%) que en hombres (64.5%).Antecedentes: La obesidad es el principal factor de riesgo modificable para el desarrollo de enfermedades crónicas no transmisibles, como diabetes mellitus y enfermedad cardiovascular. En las últimas tres décadas la prevalencia de obesidad ha aumentado en el ámbito mundial. Para el 2008 en México los costos atribuibles a la obesidad fueron de 42,000 millones de pesos, equivalente al 13% del gasto total de salud y al 0.3 del PIB. Sin embargo en México existe poca información en cuanto al costo adicional que se deriva de embarazos en mujeres con obesidad. Objetivo: Determinar y comparar el costo del control prenatal y de atención obstétrica en mujeres embarazadas con peso normal y con obesidad. Métodos: Se estudiaron mujeres embarazadas de Enero a Diciembre de 2012. El rango de edad fue 19-37 anos de edad y con índice de masa corporal pregestacional (IMCPG) normal ˜ ( 30 kg/m2). Se costeo el control prenatal (basado en el número de consultas), la atención obstétrica, la vía de resolución y la hospitalización en pesos mexicanos al momento del estudio. Resultados: Hubo 34 pacientes con IMCPG normal, y 48 pacientes con obesidad. La edad promedio fue de 27 anos. Comparando con el grupo normal, los costos en el grupo obesidad se ˜ incrementaron 57% en la atención obstétrica (media en pesos mexicanos 3029.41 para el grupo normal vs. 4770.83 grupo obesidad p < 0.0001), en la vía de resolución se incrementaron 15%, (6221.41 vs. 7128.56 respectivamente, p < 0.001); en la hospitalización se incrementaron 43%, (1407.56 vs. 2012.50 respectivamente p < 0.0001). El costo total se incrementó 23% (16,992 vs. 20,828.56, p < 0.0001). Conclusión: Los costos en mujeres con obesidad embarazadas son mayores que en las mujeres con peso normal por lo que se sugiere la implementación de un programa dirigido al control de peso pregestacional y gestacional para así disminuir costos adicionales

Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score ? 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score

Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

PROBAC REIPI/GEIH-SEIMC/SAEI Group.The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020

Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score # 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score.8 página